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研究生:袁偉城
研究生(外文):Yuan, Wei-Chen
論文名稱:建立穴位電刺激與誘發電位相關性研究之發展系統
論文名稱(外文):Implementation of a Development System for Investigating the Relationship Between Acupoint Electrical Stimulation and Evoked Potentials
指導教授:梁治國
指導教授(外文):Liang, Chih-Kuo
學位類別:碩士
校院名稱:南台科技大學
系所名稱:電機工程系
學門:工程學門
學類:電資工程學類
論文種類:學術論文
論文出版年:2007
畢業學年度:95
語文別:中文
論文頁數:64
中文關鍵詞:穴位電刺激經皮神經電刺激器誘發電位弗理曼變異數分析
外文關鍵詞:Aupoint stimulationTranscutaneous nerve electrical stimulatorEvoked potentialFriedman variance analysis
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根據中醫經絡理論與實證經驗,若對穴位施以刺激(如針灸、電針、指壓按摩等),在某些疾病方面可達到保健與治療的效果;而西醫的腦神經科學理論,也說明了刺激所產生的誘發電位可用來評估人體的中樞神經系統是否異常,更有許多相關的研究證實,穴位刺激與中樞神經系統變化有關。
基於上述論點,本研究已自行開發出一套穴位電刺激與誘發電位擷取功能之發展系統,以利於穴位刺激科學化研究之進行。本系統硬體主要含有兩個子系統:(1)類針灸式經皮神經刺激器:具有雙相定電流輸出,五段手動振幅調變,以及用人機介面直接設定波寬與頻率之功能;(2) 八通道腦波放大器:具有濾波頻寬0.1~50 Hz 及放大倍率x13500之功能。而系統之軟體人機介面是由LabVIEW所開發完成,此介面具有即時之時/頻域分析、刺激時序控制與資料儲存等功能,儲存後之腦波訊號再以EEGLAB做誘發電位之離線分析。經初步驗證得知,此發展系統之穴位電刺激與腦波量測分析等功能符合相關需求。
系統建置完成後,我們選若干受測者對其右手合谷穴進行刺激,所得到的體感覺誘發電位(SEP)之成份(N20與N80)與NeuroScan系統得到的相符。其次,利用LabVIEW撰寫棋盤翻轉刺激程式並配合耳朵眼穴刺激,來觀察視覺誘發電位(VEP)之變化,發現視覺誘發電位主要有N100、P135與N160等成份此與NeuroScan系統所得到的亦相當。接著,設計弗理曼變異數分析實驗,得到在電刺激耳朵眼穴之前後,所得的視覺誘發電位成分潛伏期並未有顯著的改變。
According to the meridian theory and clinical evidences of Chinese medicine, acupoint stimulation utilizing such as manual acupuncture, electrical acupuncture, and massage to acupoints is well-known to have healthcare or therapeutic effects on some diseases. Next, in Western neuroscience medicine, evoked potentials induced through stimulation are also known to be used for checking the state of central nervous system of the human being. Except these evidences, many other studies have been verified that acupoint stimulation has related to the variety of evoked potentials of central nervous system.
Based on the previous viewpoints, this study will develop a system with acupoint electrical stimulation and evoked potentials extraction functions. By this system, we can make such an acupuncture scientific research. The hardware of the system mainly includes two subsystems: (1) an acupuncture-like transcutaneous nerve electrical stimulator (AL-TENS): It can generate biphasic current stimulation waveform and can make five-section manual amplitude adjustment. It also can setup the duration and frequency directly via the developed graphical user interface; (2) an eight-channel EEG frond-end amplifier: It has a filter bandwidth of 0.1-50 Hz and an amplification rate of x13500. Moreover, the system GUI was developed by LabVIEW. It has the functions of real-time time / frequency domain analysis, time control of stimulation and data storage. The stored EEG data then were used for off-line evoked potentials extraction analysis via the EEGLAB software. Totally speaking, the acupoint stimulation and EEG measurement functions of the development system are basically satisfactory.

After completing the system, we utilize it to stimulate some subject’s right hand Huge acupoints and then to examine their SEP. We found that the components of N20 and N80 are similar to the results obtained by a NeuroScan’s machine under the same testing condition. Next, we use a written LabVIEW-based pattern reversal stimulation program and select an Eye acupoint on the ears to stimulate in order to do the study of VEP variety. The results show that the N100, P135 and N160 components of VEP are also close to the test results obtained by the NeuroScan’s machine. Finally, using the Friedman variance analysis we find that the latency of VEP components has not apparent change before and after stimulation to the Eye acupoint of ears.
目 次
第一章 緒論 1
1-1 背景與研究動機 1
1-2 研究目的 4
1-3 各章節內容概要 5
第二章 相關文獻回顧與基本理論 6
2-1 穴位刺激治療 6
2-2 類針灸式電刺激(AL-TENS) 9
2-3 腦波量測與誘發電位擷取 14
2-4 刺激假象與記錄 19
2-5 EEGLAB介紹 21
2-6 SPSS統計分析 22
第三章 材料與方法 23
3-1 系統架構 23
3-2 硬體設計與製作 24
3-2-1 類針灸式電刺激器 24
3-2-2 EEG前端放大器 27
3-2-3 類比開關電路 29
3-2-4 NI資料擷取卡 30
3-3 軟體設計 31
3-3-1 LabVIEW人機介面控制 32
3-3-2 EEGLAB訊號分析 37
3-4 實驗設計 39
3-4-1 EEG量測前處理 40
3-4-2 SEP實驗設計 40
3-4-3 VEP實驗設計 41
第四章 結果與討論 42
4-1 雙通道電刺激子系統特性 43
4-2 八通道腦波量測子系統特性 46
4-3 SEP量測與分析 48
4-4 VEP量測與分析 51
4-5 相關性討論 54
第五章 結論與未來展望 55
5-1 結論 55
5-2 未來發展方向 56
參考文獻 57
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