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研究生(外文):Vu Ha Hai
論文名稱(外文):Fluid Analysis inside Left Ventricular AssistDevices with Non-Newtonian TheoryFluid Analysis inside Left Ventricular Assist Devices with Non-Newtonian theory
指導教授(外文):Lin, Cheung-Hsian
外文關鍵詞:LVADsNon-Newtonianshear stress
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左心室輔助器(LVADs)至1986年開始研究關於血液方面的理論。大部份研究結果指出血液是屬於一種有黏滯性的牛頓流體。由於這個原則,科學家一直進行很多實驗與分析,他們已經成功的發展出許多種左心室輔助器(LVADs)。但是由於血液的複雜現象,在進行生物體移植之後,左心室輔助器的所能持續使用的時間對研究者仍然是一個很大的問題。在我們的研究過程中,血液被塑造為一種非牛頓黏性不恆定的流體並且被視為一個變性的函數。為了刺激血流的hemodynamic 的特性,Fluent (流體力學)軟體與有限元法一起被利用來分析三維的雷諾茲平均的Navier-Stokes方程式。我們著重於區分牛頓的和非牛頓流動之間的剪應力差別。這些分析結果將提供更好的參數,優化左心室輔助器(LVADs)外殼的形狀,葉輪以其他部份,從而增加設備的耐久性。

關鍵字︰ LVADs,非牛頓定律,剪應力,流體力學
Left Ventricular Assistant Devices (LVADs) have been researching since 1986 based on many various theories about blood. Most of studies recognized that blood belongs to type of Newtonian fluid with constant viscosity. With this principle, scientists carried out many experiments, analysis and succeeded in manufacturing several kinds of LVADs. However, because of complex phenomenon of blood, duration of these devices after implanting into living organism is still big problem with researchers. In our research, blood was modeled as Non-Newtonian fluid whose viscosity is not constant, but be a function of deformation. Fluent software with finite element methods is utilized to simulate the hemodynamic characteristics of blood flow and analyze the flow. We focus on how different between Newtonian fluid and Non-Newtonian one The study found that Non-Newton fluid gave more precise results and was successful in increasing head pressure of device to larger than 120 mmHg (arterial blood pressure). These analysis results will provide better parameters to optimize the shape of casing, impeller as well as other parts of LVADs and therefore increasing the durability of devices.

Keywords:LVADs, Non-Newtonian, shear stress

Chapter 1 Introduction 1
1.1 Basic knowledge about natural heart 1
1.1.1 Basic concepts 1
1.1.2 The Clinical need 3
1.2 A brief introduction about artificial heart 4
1.2.1 Jarvik-7 Total Artificial Heart 4
1.2.2 Pulsatile Assistant Devices 6
1.2.3 Non-pulsatile Ventricle Assistant Devices 7
1.2.4 Non-contact magnetic bearings micro pump 8
1.3 Determine the research direction 9
1.3.1 Composition and Rheology of Blood 9
1.3.2 Hemolysis 10
1.3.3 Platelet Activation 11
1.3.4 Thrombosis and the Coagulation Cascade 12
1.3.5 Direction for current research 12
Chapter 2 Methods 13
2.1 Governing equations 13
2.2 Turbulence model 13
2.3 Computational Fluid Dynamics using Fluent 16
2.3.1 Introduction to FLUENT 16 Program Structure 16 Program Capabilities 19
2.3.2 Apply Fluent for solving the Non-Newtonian problem 20 Non-Newtonian Fluid 20 Power law for Non-Newtonian Viscosity 21 The Carreau Model for Pseudo-Plastics 21 Cross Model 22
Chapter 3 Results and Discussions 23
3.1 Physical model 23
3.1.1 Impeller Model 23
3.1.2 Casing Model 31
3.2 Simulation model 35
3.2.1 Impeller Model built in CFX 35
3.2.2 Casing Model built in ANSYS CFX 36
3.3 Flow analysis 38
3.3.1 Assumption of blood 38
3.3.2 Flow analysis results with Power law for Non-Newtonian Viscosity 39
3.3.3 Flow analysis results with The Carreau Model 50
3.3.4 Flow analysis results with The Cross Model 62
3.4 Discussions 73
Chapter 4 Conclusions 77
4.1 Flow analysis results with Newtonian theory 77
4.2 Compare analysis results between Newtonian and Non-Newtonian model 87
4.3 Conclusions 92
Chapter 5 Future work 95


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