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研究生:楊福麟
研究生(外文):Fwu-Lin Yang
論文名稱:利用清醒鼠模式探討戊巴比妥對內毒素休克造成器官損傷之保護機轉
論文名稱(外文):Mechanisms of Pentobarbital Involved in the Protection of Organ Injury Induced by Endotoxic Shock in Conscious Rats
指導教授:林欣榮林欣榮引用關係
指導教授(外文):Shinn Zong Lin
學位類別:博士
校院名稱:慈濟大學
系所名稱:醫學研究所
學門:醫藥衛生學門
學類:醫學學類
論文種類:學術論文
畢業學年度:95
語文別:中文
論文頁數:183
中文關鍵詞:器官損傷內毒素休克清醒鼠模式戊巴比妥腫瘤壞死因子
外文關鍵詞:TNF-aorgan injuryendotoxic shockconscious ratpentobarbital
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敗血症(sepsis)是加護病房死亡的主要原因,由於疾病的複雜度與高死亡率使其機制探討有極重要的急迫性,因此有大量的動物實驗與臨床研究,探討治療及預防敗血症的炎症反應,期能降低病患的死亡率。在動物實驗方面,將內毒素(endotoxin) 注射到麻醉的老鼠體內是研究敗血症非控制性分泌促發炎細胞激素(proinflammatory cytokine)的主要策略。麻醉劑已經被證實是可以影響免疫反應,而戊巴比妥(pentobarbital)是主要用於動物實驗的麻醉劑之一。因此戊巴比妥對於免疫反應如腫瘤壞死因子(TNF-α)的分泌必須詳加研究。本研究結果顯示,戊巴比妥會抑制腫瘤壞死因子的訊號傳遞的表現及其蛋白質的生成,這些現象可能來自於戊巴比妥對NF-kB以及AP-1的活性的抑制,以及對p38 MAPK表現的壓抑作用。在証實動物體內戊巴比妥對於腫瘤壞死因子活性的抑制後,進一步檢視在戊巴比妥給予與否的狀況下,內毒素對於體內細胞的毒殺作用;試驗結果亦顯示,在給予戊巴比妥麻醉劑後,可以顯著地抑制動物血漿中的器官損傷指標如ALT、AST、LDH、CPK、BUN以及amylase等。最後,以體外試驗研究戊巴比妥對於腫瘤壞死因子分泌造成細胞死亡的作用途徑;結果顯示,在腫瘤壞死因子作用下,戊巴比妥可以直接增加的細胞存活能力,並且也可以保護細胞免於deferoxamine mysylate (DFO)藥物導致細胞缺氧後的凋亡作用。
本研究結果顯示,戊巴比妥能顯著干擾腫瘤壞死因子誘發的發炎反應,也可以保護細胞免於腫瘤壞死因子直接及間接的毒殺作用。因比,以往敗血和去實驗中,一些研究藥物的抗發炎效果,有可能是來自戊巴比妥的協同作用。這一些訊息,提供了對於以戊巴比妥麻醉之動物實驗結果及臨床使用時,再一次審視評估的觀點。
Sepsis is the leading cause of death for intensive care patients. It is a matter of grate urgency to investigate the pathophysilogy of this disease, on the basis of its quite complexity and high mortality rate. A number of animal studies and clinical trails, facus on the prevention and treatment of the inflammatory responses, to anticipate the reduction of the mortality cause by sepsis. Lipopolysaccharide (LPS) administration to animals under anesthesia is a strategy for the study of uncontrolled release of proinflammatory cytokines. Anesthetics have been indicated that they can specific affect immune responses, such as the inflammatory response. Pentobarbital is an anesthetic used mainly in animal studies. The effect of pentobarbital on TNF-a release was determined. The results revealed that pentobarbital suppressed the expression of TNF-a mRNA and its proteins, which may result from the decrease in the activities of NF-kB and AP-1 and the reduction of the expression of p38 MAPK by pentobarbital. After the inhibitory activity of the pentobarbital for TNF-a release was proved in vivo, the cytotoxic effects of LPS were examined in vivo with or without pentobarbital treatments. In vivo results indicated that plasma levels of ALT, AST, LDH, CPK, BUN, and Amylase decreased dramatically in the anesthetic group with pentobarbital administration. Finally, the effect of pentobarbital on TNF-a related cell death was monitored in vitro and the results indicated that pentobarbital could directly enhance the viabilities of cells under the treatment of TNF-a and protected cells from apoptosis induced by deferoxamine mysylate (DFO)-induced hypoxia. These results suggest that pentobarbital significantly influences the LPS-induced inflammatory responses and protects cells from death directly and indirectly induced by TNF-a. The information provides a perspective to re-evaluate the results of the experiments in which animals were anesthetized with pentobarbital. The anti-inflammatory effects of the drugs might have been due to the synergistic effect of pentobarbital.
中文摘要…………………………………………………………………..
英文摘要…………………………………………………………………..
縮寫表..………………………………………………………………………
目錄..………………………………………………………………………
圖表目錄…………………………………………………………………..

第一章 前言………………………………………………………………
第二章 文獻探討…………………………………………………………
第一節 敗血症………………………………………………………..
第二節 麻醉劑與敗血症..…………………………………………....
第三節 戊巴比妥……………………………………………………..
第三章 動機與目的………………………………………………………
第一節 研究動機……………………………………………………..
第二節 研究目的……………………………………………………..

第四章 以戊巴比妥治療清醒鼠模式下因內毒素休克引發器官
損傷的研究……………………………………………………..
第一節 研究背景..……………………………………………………
第二節 實驗設計…..…………………………………………………
第三節 材料與方法..…………………………………………………
第四節 統計與分析…………………………………………………………..
第五節 結果…………………………………………………………..
第六節 討論…………………………………………………………..
第七節 結論…………………………………………………………..
第五章 戊巴比妥作用機轉之體外試驗…………………………………
第一節 研究背景..……………………………………………………
第二節 實驗設計…....…………………………………………..……
第三節 材料與方法..…………………………………………………
第四節 統計與分析…………………………………………………………..
第五節 結果…………………………………………………………..
第六節 討論…………………………………………………………..
第七節 結論…………………………………………………………..
第六章 綜合討論、總結論及展望………………………………………
第一節 綜合討論……………………………………………………..
第二節 總結論………………………………………………………..
第三節 展望……………………………………………………………
參考文獻..…………………………………………………………………
圖表說明…………………………………………………………………..
附件(畢業相關著作) ………………………………………………………
Aarts L, van der Hee R, Dekker I, de Jong J, Langemeijer H, Bast A. The widely used anesthetic agent propofol can replace alpha-tocopherol as an antioxidant. FEBS Lett 1995;357(1):83-5.
Alexander C, Rietschel ET. Bacterial lipopolysaccharides and innate immunity. J Endotoxin Res 2001;7(3):167-202.
Alkire MT, Haier RJ, Barker SJ, Shah NK, Wu JC, Kao YJ. Cerebral metabolism during propofol anesthesia in humans studied with positron emission tomography. Anesthesiology 1995; 82(2):393-403.
Altura BT, Turlapaty PD, Altura BM. Pentobarbital sodium inhibits calcium uptake in vascular smooth muscle. Biochim Biophys Acta 1980;595(2):309-12.
Anderson PO. Drugs and breast feeding - a review. Drug Intell Clin Pharm 1977;11: 208.
Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001;29(7):1303-10.
Anker-Moller E, Spangsberg N, Arendt-Nielsen L, Schultz P, Kristensen MS, Bjerring P. Subhypnotic doses of thiopentone and propofol cause analgesia to experimentally induced acute pain. Br J Anaesth 1991;66(2):185-8.
Annane D, Sanquer S, Sebille V, Faye A, Djuranovic D, Raphael JC, Gajdos P, Bellissant E. Compartmentalised inducible nitric-oxide synthase activity in septic shock. Lancet 2000;355(9210):1143-8.
Annane D, Sebille V, Charpentier C, Bollaert PE, Francois B, Korach JM, Capellier G, Cohen Y, Azoulay E, Troche G, Chaumet-Riffaut P, Bellissant E. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002;288(7):862-71.
Araki T, Kogure K, Nishioka K. Comparative neuroprotective effects of pentobarbital, vinpocetine, flunarizine and ifenprodil on ischemic neuronal damage in the gerbil hippocampus. Res Exp Med (Berl) 1990;190(1):19-23.
Archer LT, Beller-Todd B, Elmore O, White GL, Hinshaw LB. Does sodium pentobarbital anesthesia compromise clearance of bacteria or survival of dogs in lethal E coli shock? Circ Shock 1981;8(1):59-67.
Archer LT, White GL, Beller-Todd B, Elmore OF, Glasgow JS, Hinshaw LB. Does sodium pentobarbital anesthesia compromise phagocytosis of E coli in vitro? Circ Shock 1980;7(4):425-33.
Baeuerle PA, Baltimore D. Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor. Cell 1988; 53(2): 211-7.
Baldwin AS Jr. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 1996;14:649-83.


Barrientos-Vega R, Mar Sanchez-Soria M, Morales-Garcia C, Robas-Gomez A, Cuena-Boy R, Ayensa-Rincon A. Prolonged sedation of critically ill patients with midazolam or propofol: impact on weaning and costs. Crit Care Med 1997;25(1):33-40.
Beckman JS. The double-edged role of nitric oxide in brain function and superoxide-mediated injury. J Dev Physiol 1991;15(1):53-9.
Beg AA, Finco TS, Nantermet PV, Baldwin AS Jr. Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation. Mol Cell Biol 1993;13(6):3301-10.
Ben-Eliyahu S, Shakhar G, Rosenne E, Levinson Y, Beilin B.Hypothermia in barbiturate-anesthetized rats suppresses natural killer cell activity and compromises resistance to tumor metastasis: a role for adrenergic mechanisms. Anesthesiology 1999;91(3):732-40.
Bennett WM, Singer I, Golper T, Feig P, Coggins CJ. Guidelines for drug therapy in renal failure. Ann Intern Med 1977;86(6):754-83.
Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriquez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, Fisher CJ Jr; Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PrOWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001;344(10):699-709.

Bertini R, Delgado R, Faggioni R, Gascon MP, Ythier A, Ghezzi P. Urinary TNF- binding protein (TNF soluble receptor) protects mice against the lethal effect of TNF and endotoxic shock. Eur Cytokine Netw 1993;4:39-42.
Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine Chest 1992;101(6):1644-55.
Borgeat A, Wilder-Smith OH, Suter PM. The nonhypnotic therapeutic applications of propofol. Anesthesiology 1994;80(3):642-56.
Borland RG, Nicholson AN. Comparison of the residual effects of two benzodiazepines (nitrazepam and flurazepam hydrochloride) and pentobarbitone sodium on human performance. Br J Clin Pharmacol 1975;2(1):9-17.
Breimer DD. Clinical pharmacokinetics of hypnotics. Clin Pharmacokinet 1977;2(2):93-109.
Brown RH, Greenberg RS, Wagner EM. Efficacy of propofol to prevent bronchoconstriction: effects of preservative. Anesthesiology 2001;94(5): 851-5.
Capellier G, Cohen Y, Azoulay E, Troche G, Chaumet-Riffaut P, Bellissant E. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002;288(7):862-71.
Cascorbi HF. Effect of anesthetics on the immune system. Int Anesthesiol Clin 1981;19(4):69-75.
Chapple IL. Reactive oxygen species and antioxidants in inflammatory diseases. J Clin Periodontol 1997;24(5):287-96.
Chen LW, Huang HL, Lee IT, Hsu CM, Lu PJ. Thermal injury-induced priming effect of neutrophil is TNF-alpha and P38 dependent. Shock 2006;26:69-76.
Chow CW, Rinco´NM, Cavanagh J, Dickens M, Davis RJ. Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway. Science 1997;278: 1638-41.
Claassen J, Hirsch LJ, Emerson RG, Mayer SA. Treatment of refractory status epilepticus with pentobarbital, propofol, or midazolam: a systematic review. Epilepsia 2002;43(2):146-53.
Cobb MH. MAP kinase pathways. Prog Biophys Mol Biol 1999;71(3-4):479-500.
Conti G, Dell'Utri D, Vilardi V, De Blasi RA, Pelaia P, Antonelli M, Bufi M, Rosa G, Gasparetto A. Propofol induces bronchodilation in mechanically ventilated chronic obstructive pulmonary disease (COPD) patients. Acta Anaesthesiol Scand 1993;37(1):105-9.
Crowther MA, Marshall JC. Continuing challenges of sepsis research. JAMA 2001;286(15):1894-6.
Danneman PJ, Mandrell TD. Evaluation of five agents/methods for anesthesia of neonatal rats. Lab Anim Sci 1997;47(4):386-95.
Davis B. Noninhalational anaesthetics. Adv Drug Res 1975;10:1-51.
De Backer D, Creteur J, Preiser JC, Dubois MJ, Vincent JL. Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med 2002; 166:98-104.
DeForge LE, Remick DG. Kinetics of TNF, IL-6, and IL-8 gene expression in LPS-stimulated human whole blood. Biochem Biophys Res Commun 1991; 174(1):18-24.
Deitch EA. Animal models of sepsis and shock: a review and lessons learned. Shock 1998;9(1):1-11.
Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J, Gea-Banacloche J, Keh D, Marshall JC, Parker MM, Ramsay G, Zimmerman JL, Vincent JL, Levy MM. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 2004;32:858-73.
Demiryurek AT, Cinel I, Kahraman S, Tecder-Unal M, Gogus N, Aypar U, Kanzik I. Propofol and intralipid interact with reactive oxygen species: a chemiluminescence study. Br J Anaesth 1998; 80(5):649-54.
Demopoulos HB, Flamm ES, Seligman ML, Jorgensen E, Ransohoff J. Antioxidant effects of barbiturates in model membranes undergoing free radical damage. Acta Neurol Scand Suppl 1977;64:152-3.
Dickerson RN, Fried RC, Daniel MG, Stein TP, Mullen JL, Buzby GP. Pentobarbital improves nitrogen retention in sepsis. JPEN J Parenter Enteral Nutr 1989;13(4):359-61.
Dinarello CA. Biologic basis for interleukin-1 in disease. Blood 1996; 87(6):2095-147.
Drummond JC, Cole DJ, Patel PM, Reynolds LW. Focal cerebral ischemia during anesthesia with etomidate, isoflurane, or thiopental: A comparison of the extent of cerebral injury. Neurosurgery 1995;37:742-8.
Eberhardt KE, Thimm BM, Spring A, Maskos WR. Dose-dependent rate of nosocomial pulmonary infection in mechanically ventilated patients with brain oedema receiving barbiturates: a prospective case study. Infection 1992;20: 12-8.
Ehrenbo M. Pharmacokinetics and distribution of pentobarbital after IV and oral administration. J Pharmacokin Biopharm 1973;1:5.
Ehrenbo M. Pharmacokinetics and distribution properties of pentobarbital. J Pharm Sci 1974;63:1114.
Eisenberg HM, Frankowski RF, Contant CF, Marshall LF, Walker MD. High-dose barbiturate control of elevated intracranial pressure in patients with severe head injury. J Neurosurg 1988;69(1):15-23.
Epstein J, Breslow MJ. The stress response of critical illness. Crit Care Clin 1999; 15:17-33.

Eriksson O. Effects of the general anaesthetic Propofol on the Ca2(+)-induced permeabilization of rat liver mitochondria. FEBS Lett 1991;279(1):45-8.
Esmon CT, Why do animal models (sometimes) fail to mimic human sepsis? Crit Care Med 2004;32[Suppl.]:S219-22.
Fink MP. Cytopathic hypoxia. Mitochondrial dysfunction as mechanism contributing to organ dysfunction in sepsis. Crit Care Clin 2001;17(1):219-37.
Fink MP, Heard SO. Laboratory models of sepsis and septic shock. J Surg Res 1990;49(2):186-96.
Flamm ES, Demopoulos HB, Seligman ML, Poser RG, Ransohoff J.Free radicals in cerebral ischemia. Stroke 1978;9(5):445-7.
Friedman G, Silva E, Vincent JL. Has the mortality of septic shock changed with time. Crit Care Med 1998;26(12):2078-86.
Fuentes JM, Talamini MA, Fulton WB, Hanly EJ, Aurora AR, De Maio A. General anesthesia delays the inflammatory response and increases survival for mice with endotoxic shock. Clin Vaccine Immunol 2006;13:281-8.
Fukumoto H, Fukomoto K. A case of fatal pentobarbital poisoning. Nippon Hoigaku Zasshi 1970;24:68-72.


Gainet J, Chollet-Martin S, Brion M, Hakim J, Gougerot-Pocidalo MA, Elbim C. Interleukin-8 production by polymorphonuclear neutrophils in patients with rapidly progressive periodontitis: an amplifying loop of polymorphonuclear neutrophil activation. Lab Invest 1998; 78(6):755-62.
Galdiero F, Bentivoglio C, Nuzzo I, Ianniello R, Capasso C, Mattera S, Nazzaro C, Galdiero M, Romano Carratelli C. Effects of benzodiazepines on immunodeficiency and resistance in mice. Life Sci 1995 ;57(26):2413-23.
Gao J, Zeng B, Zhou L. The protective effects of early treatment with propofol on endotoxin-induced acute lung injury in rats. Middle East J Anesthesiol 2003;17:379-401.
Gao J, Zeng BX, Zhou LJ, Yuan SY. Protective effects of early treatment with propofol on endotoxin-induced acute lung injury in rats. Br J Anaesth 2004;92:277-9.
Gardner DJ, Davis JA, Weina PJ, Theune B. Comparison of tribromoethanol, ketamine/acetylpromazine, Telazol/xylazine, pentobarbital, and methoxyflurane anesthesia in HSD:ICR mice. Lab Anim Sci 1995;45(2):199-204.
Garrington TP, Johnson GL Organization and regulation of mitogen-activated protein kinase signaling pathways. Curr Opin Cell Biol 1999;11(2):211-8.
Gille H, Sharrocks AD, Shaw PE. Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature 1992;358: 414-7.
Gilman AG, Goodman LS, Gilman A (eds). The Pharmacological Basis of Therapeutics, 6th ed. Macmillan Publishing Co, New York, NY, 1980.
Gilman AG, Rall TW, Nies AS et al (eds). Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed. Pergamon Press, New York, NY, 1990.
Glen JB, Hunter SC. Pharmacology of an emulsion formulation of ICI 35 868. Br J Anaesth 1984;56(6):617-26.
Godin DV, Garnett ME. Effects of various anesthetic regimens on tissue antioxidant enzyme activities. Res Commun Chem Pathol Pharmacol 1994;83(1):93-101.
Goodman LS & Gilman A (eds). The pharmacological basis of therapeutics, 5th ed. Macmillan Publishing Co, New York, NY, 1975.
Gotsch U, Jager U, Dominis M, Vestweber D. Expression of P-selectin on endothelial cells is upregulated by LPS and TNF-alpha in vivo. Cell Adhes Commun 1994;2:7-14.
Green TR, Bennett SR, Nelson VM. Specificity and properties of propofol as an antioxidant free radical scavenger. Toxicol Appl Pharmacol 1994;129(1):163-9.
Grundmann HJ, Hahnle U, Hegenscheid B, Sahlmuller G, Bienzle U, Blitstein-Willinger E. Inhibition of endotoxin-induced macrophage tumor necrosis factor expression by a prostacyclin analogue and its beneficial effect in experimental lipopolysaccharide intoxication. J Infect Dis 1992;165:569-73.

Guha M, Mackman N. LPS induction of gene expression in human monocytes. Cell Signal 2001;13(2):85-94.
Hara M, Kai Y, Ikemoto Y. Propofol activates GABAA receptor-chloride ionophore complex in dissociated hippocampal pyramidal neurons of the rat. Anesthesiology 1993;79(4):781-8.
Harkness JE & Wagner JE. Clinical procedures. The biology and medicine of rabbits and rodents. 4th edited. Williams & Wilkins. Baltimore, 1995.
Harris CE, Grounds RM, Murray AM, LumLey J, Royston D, Morgan M. Propofol for long-term sedation in the intensive care unit. A comparison with papaveretum and midazolam. Anaesthesia 1990;45(5):366-72.
Heine J, Leuwer M, Scheinichen D, Arseniev L, Jaeger K, Piepenbrock S.Flow cytometry evaluation of the in vitro influence of four i.v. anaesthetics on respiratory burst of neutrophils. Br J Anaesth 1996;77(3):387-92.
Heinemeyer G, Roots I, Rudiger D. Monitoring of pentobarbital plasma levels in critical care patients suffering from increased intracranial pressure. Ther Drug Monit 1986;8:145-50.
Helmy SA, Al-Attiyah RJ. The immunomodulatory effects of prolonged intravenous infusion of propofol versus midazolam in critically ill surgical patients. Anaesthesia 2001;56(1):4-8.

Helmy SA, Wahby MA, El-Nawaway M. The effect of anaesthesia and surgery on plasma cytokine production. Anaesthesia 1999;54(8):733-8.
Henkel T, Machleidt T, Alkalay I, Kronke M, Ben N, Baeuerle PA. Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B. Nature 1993;365:182-5.
Ho IK, Harris RA. Mechanism of action of barbiturates. Annu Rev Pharmacol Toxicol 1981;21:83-111.
Hobbs W, Rall T, Verdoorn T. Hypnotics and sedatives: ethanol. In: Hardman J & Limbird L (eds). Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th ed. McGraw-Hill, New York, NY; 1995:361-96.
Hofbauer R, Frass M, Salfinger H, Moser D, Hornykewycz S, Gmeiner B, Kapiotis S. Propofol reduces the migration of human leukocytes through endothelial cell monolayers. Crit Care Med 1999;27(9):1843-7.
Holmes GL, Riviello JJ Jr. Midazolam and pentobarbital for refractory status epilepticus. Pediatr Neurol 1999;20(4):259-64.
Hoque AM, Marczin N, Catravas JD, Fuchs LC. Anesthesia with sodium pentobarbital enhances lipopolysaccharide-induced. cardiovascular dysfunction in rats. Shock 1996;6(5):365-70.


Horn DL, Opal SM, Lomastro E. Antibiotics, cytokines, and endotoxin: a complex and evolving relationship in gram-negative sepsis. Scand J Infect Dis Suppl 1996;101:9-13.
Hotchkiss RS, Karl I E. The pathophysiology and treatment of sepsis. N Engl J Med 2003;348(2):138-50.
Ichiyama T, Nishikawa M, Lipton JM, Matsubara T, Takashi H, Furukawa S. Thiopental inhibits NF-kappaB activation in human glioma cells and experimental brain inflammation. Brain Res 2001;911(1):56-61.
Im SH, Rao A. Activation and deactivation of gene expression by Ca2+/ calcineurin- NFAT-mediated signaling. Mol Cells 2004;18(1):1-9.
Imai T, Takahashi K, Masuo F, Goto F. Anaesthesia affects outcome of sepsis in mice. Can J Anaesth 1998;45(4):360-6.
Ince C. The microcirculation is the motor of sepsis. Critical Care 2005;9(suppl 4):S13-9.
Irvine RE, Grove J, Toseland PA, Trounce JR. The effect of age on the hydroxylation of amylobarbitone sodium in man. Br J Clin Pharmacol 1974;1:41-3.
Ishikawa K, Tanaka H, Takaoka M, Ogura H, Shiozaki T, Hosotsubo H, Shimazu T, Yoshioka T, Sugimoto H. Granulocyte colony-stimulating factor ameliorates life-threatening infections after combined therapy with barbiturates and mild hypothermia in patients with severe head injuries. J Trauma 1999;999-1007.

James R, Glen JB. Synthesis, biological evaluation, and preliminary structure-activity considerations of a series of alkylphenols as intravenous anesthetic agents. J Med Chem 1980;23(12):1350-7.
Janeway CA, Jr, Medzhitov R. Innate immune recognition. Annu Rev Immunol 2002;20:197-216.
Jensen AG, Dahlgren C, Eintrei C. Propofol decreases random and chemotactic stimulated locomotion of human neutrophils in vitro. Br J Anaesth 1993;70(1):99-100.
Jewett BA, Gibbs LM, Tarasiuk A, Kendig JJ. Propofol and barbiturate depression of spinal nociceptive neurotransmission. Anesthesiology 1992;77(6):1148-54.
Joung YH, Lim EJ, Lee MY, Park JH, Ye SK, Park EU, Kim SY, Zhang Z, Lee KJ, Park DK, Park T, Moon WK, Yang YM: Hypoxia activates the cyclin D1 promoter via the Jak2/STAT5b pathway in breast cancer cells. Exp Mol Med 2005;37:353-64.
Kahraman S, Demiryurek AT. Propofol is a peroxynitrite scavenger. Anesth Analg 1997;84(5):1127-9.
Kahraman S, Kilinc K, Dal D, Erdem K. Propofol attenuates formation of lipid peroxides in tourniquet-induced ischaemia-reperfusion injury. Br J Anaesth 1997; 78(3):279-81.
Kanto J, Gepts E. Pharmacokinetic implications for the clinical use of propofol. Clin Pharmacokinet 1989;17(5):308-26.
Karin M, Lui ZG, Zandi E. AP-1 function and regulation. Curr Opin Cell Biol
1977;9:240-6.
Kawagoe J, Abe K, Kogure K. Reduction of HSP70 and HSC70 heat shock mRNA induction by pentobarbital after transient global ischemia in gerbil brain. J Neurochem 1993;61:254-60.
Kawasaki T, Ogata M, Kawasaki C, Ogata J, Inoue Y, Shigematsu A. Ketamine suppresses proinflammatory cytokine production in human whole blood in vitro. Anesth Analg 1999;89(3):665-9.
Kazerani HR, Furman BL. Comparison of urethane/chloralose and pentobarbitone anaesthesia for examining effects of bacterial lipopolysaccharide in mice. Fundam Clin Pharmacol 2006;20(4):379-84.
Kelly DF, Goodale DB, Williams J, Herr DL, Chappell ET, Rosner MJ, Jacobson J, Levy ML, Croce MA, Maniker AH, Fulda GJ, Lovett JV, Mohan O, Narayan RK. Propofol in the treatment of moderate and severe head injury: a randomized, prospective double-blinded pilot trial. J Neurosurg 1999;90(6):1042-52.
Kessler P, Kronemann N, Hecker M, Busse R, Schini-Kerth VB. Effects of barbiturates on the expression of the inducible nitric oxide synthase in vascular smooth muscle. J Cardiovasc Pharmacol. 1997;30(6):802-10.
Kharitonov SA, Yates D, Robbins RA, Logan-Sinclair R, Shinebourne EA, Barnes PJ. Increased nitric oxide in exhaled air of asthmatic patients. Lancet 1994; 343(8890):133-5.
Kharitonov VG, Sundquist AR, Sharma VS. Kinetics of nitric oxide autoxidation in aqueous solution. J Biol Chem 1994;269(8):5881-3.
Kim SO, Toda H, Nakamura K, Miyawaki I, Hirakata H, Hirata S, Mori K. Thiopental attenuates relaxation and cyclic GMP production in vascular smooth muscle of endotoxin-treated rat aorta, independent of nitric oxide production.Br J Anaesth 1998;81(4):601-2.
Kirschning CJ, Wesche H, Merrill Ayres T, Rothe M. Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide. J Exp Med 1998;188(11):2091-7.
Koga K, Ogata M, Takenaka I, Matsumoto T, Shigematsu A. Ketamine suppresses tumor necrosis factor-alpha activity and mortality in carrageenan-sensitized endotoxin shock model. Circ Shock 1994;44(3):160-8.
Kohno, M. Pouyssegur, J.Pharmacological inhibitors of the ERK signaling pathway : application as anticancer drugs. Progress in Cell Cycle Research 2003;5:219-24.
Kolata GB. Reye's syndrome: a medical mystery. Science 980;207(4438):1453-4.
Kolka AJ, Napolitano JP, Ecke GG. The ortho-alkylation of phenols. J Org Chem 1956;21:712-3.
Kolka AJ, Napolitano JP, Filbey AH, Ecke GG. The orthoalkylation of phenols. J Org Chem 1957;22:642-6.

Kotani N, Takahashi S, Sessler DI, Hashiba E, Kubota T, Hashimoto H, Matsuki A. Volatile anesthetics augment expression of proinflammatory cytokines in rat alveolar macrophages during mechanical ventilation. Anesthesiology 1999;91:187-97.
Kress HG, Eberlein T, Horber B, Weis KH. Suppression of neutrophil migration and chemiluminescence is due to the sulphur atom in the thiobarbiturate molecule. Acta Anaesthesiol Scand 1989;33(2):122-8.
Krumholz W, Demel C, Jung S, Meuthen G, Knecht J, Hempelmann G. The effects of thiopentone, etomidate, ketamine and midazolam on several bactericidal functions of polymorphonuclear leucocytes in vitro. Eur J Anaesthesiol 1995;12(2):141-6.
Kumar KT, Chandrika A, Sumanth KN, Sireesha P, Rao S, Rao A. Free radical toxicity and antioxidants in Guillain-Barre syndrome, a preliminary study. Clin Chim Acta 2004;346(2):205-9.
Kyriakis JM, Avruch J. Mammalian mitogen activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 2001;81:807–69.
Kyriakis JM, Avruch J.Sounding the Alarm: Protein kinase cascades activated by stress and inflammation. J Biol Chem 1996;271: 24313-24316.
Langley MS, Heel RC. Propofol. A review of its pharmacodynamic and pharmacokinetic properties and use as an intravenous anaesthetic. Drugs 1988; 35(4):334-72.
Larsen B, Hoff G, Wilhelm W, Buchinger H, Wanner GA, Bauer M.Effect of intravenous anesthetics on spontaneous and endotoxin-stimulated cytokine response in cultured human whole blood. Anesthesiology 1998;89(5):1218-27.

Lee MY, Hee Joung Y, Joung Lim E, Park JH, Ye SK, Park T, Zhang Z, Ki Park D, Jeon Lee K, Yang YM. Phosphorylation and activation of STAT proteins by hypoxia in breast cancer cells. Breast 2005;15:187-95.
Lee RP, Wang D, Lin NT, Chen HI. Physiological and chemical indicators for early and late stages of sepsis in conscious rats. J Biomed Sci 2002;9(6 Pt 2):613-21.
Lederer JA, Rodrick ML, Mannick JA. The effects of injury on the adaptive immune response. Shock 1999;11(3):153-9.
Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G, SCCM/ESICM/ACCP/ATS/SIS. 2001 SCCM/ESICM/ ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003;31(4):1250-6.
Lewis TS, Shapiro PS, Ahn NG. Signal transduction through MAP kinase cascades. Adv Cancer Res 1998;74:49-139.
Lindgren L. Anaesthetic activity and side effects of propofol. Curr Opinions Anaesthesiology 1994;7:321-5.
Loop T, Humar M, Pischke S, Hoetzel A, Schmidt R, Pahl HL, Geiger KK, Pannen BH. Thiopental inhibits tumor necrosis factor alpha-induced activation of nuclear factor kappaB through suppression of kappaB kinase activity. Anesthesiology 2003;99(2):360-7.
Marik PE. Propofol: therapeutic indications and side-effects. Curr Pharm Des 2004;10(29):3639-49.
Marik PE, Zaloga GP. Therapeutic sedation: has its time come? Crit Care Med 2002;30(4):949-52.
Marota JJ, Crosby G, Uhl GR. Selective effects of pentobarbital and halothane on c-fos and jun-B gene expression in rat brain. Anesthesiology 1992;77(2):365-71.
Mathiak G, Szewczyk D, Abdullah F, Ovadia P, Feuerstein G, Rabinovici R. An improved clinically relevant sepsis model in the conscious rat. Crit Care Med 2000;28(6):1947-52.
Matsumoto T, Ogata M, Koga K, Shigematsu A.Effect of peripheral benzodiazepine receptor ligands on lipopolysaccharide-induced tumor necrosis factor activity in thioglycolate-treated mice. Antimicrob Agents Chemother 1994;38(4):812-6.
Matthay MA. Severe sepsis--a new treatment with both anticoagulant and anti-inflammatory properties. N Engl J Med 2001;344(10):759-62.
McGilvray ID, Rotstein OD. Role of the coagulation system in the local and systemic inflammatory response. World J Surg 1998;22(2):179-86.
Michenfelder JD, Theye RA. The effects of anesthesia and hypothermia on canine cerebral ATP and lactate during anoxia produced by decapitation. Anesthesiology 1970;33:430-9.
Michie HR. The value of animal models in the development of new drugs for the treatment of the sepsis syndrome. Journal of Antimicrobial Chemotherapy 1998; 41 Suppl A:47-9.
Mikawa K, Akamatsu H, Nishina K, Shiga M, Maekawa N, Obara H, Niwa Y. Propofol inhibits human neutrophil functions. Anesth Analg 1998; 87(3):695-700.
Mikawa K, Nishina K, Kodama S, Obara H. Propofol attenuates diaphragmatic dysfunction induced by septic peritonitis in hamsters. Anesthesiology 2001; 94(4):652-60.
Miller LS, Morita Y, Rangan U, Kondo S, Clemens MG, Bulkley GB. Suppression of cytokine-induced neutrophil accumulation in rat mesenteric venules in vivo by general anesthesia. Int J Microcirc Clin Exp 1996;16:147-54.
Mirski MA, Williams MA, Hanley DF. Prolonged pentobarbital and phenobarbital coma for refractory generalized status epilepticus. Crit Care Med 1995; 23(2):400-4.
Mitchell PF, Aaron GB. Animal models of sepsis and septic shock. In: New Frontiers in Sepsis. 1999;596-613.
Miyabayashi M, Yasui K. Regulation of neutrophil O2- production by neutrophil-endothelial cell interaction via CD11b: its modulation by tumor necrosis factor-alpha (TNF-alpha) and lipopolysaccharide (LPS). Int J Hematol 1996;65:49-59.
Morimoto Y, Morimoto Y, Nishihira J, Kemmotsu O, Shibano T, Gando S, Shikama H. Pentobarbital inhibits apoptosis in neuronal cells. Crit Care Med 2000;28(6):1899-904.
Morrison DC, Ulevitch RJ. The effects of bacterial endotoxins on host mediation systems. A review. Am J Pathol 1978;93(2):526-617.
Muckart DJ, Bhagwanjee S. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference definitions of the systemic inflammatory response syndrome and allied disorders in relation to critically injured patients. Crit Care Med 1997;25(11):1789-95.
Murase K, Kato H, Kogure K. Limited but evident protective effects of K-801 and pentobarbital on neuronal damage following forebrain ischemia in the gerbil under normothermic conditions. Neurosci Lett 1993;149:229-32.
Murphy PG, Myers DS, Davies MJ, Webster NR, Jones JG. The antioxidant potential of propofol (2,6-diisopropylphenol). Br J Anaesth 1992;68(6):613-8.
Murphy SL. Deaths: final data for 1998. Natl Vital Stat Rep 2000;48(11):1-105.
Muzio M, Natoli G, Saccani S, Levrero M, Mantovani A. The human toll signaling pathway: divergence of nuclear factor kappa B and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor6 (TRAF6). J Exp Med 1998;187(12):2097-101.
Myers CL, Wertheimer SJ, Schembri-King J, Parks T, Wallace RW. Induction of ICAM-1 by TNF-alpha, IL-1 beta, and LPS in human endothelial cells after downregulation of PKC. Am J Physiol 1992;263:C767-72.

Nick JA, Avdi NJ, Young SK, Lehman LA, McDonald PP, Frasch SC, Billstrom MA, Henson PM, Johnson GL, Worthen GS. Selective activation and functional significance of p38alpha mitogen-activated protein kinase in lipopolysaccharide- stimulated neutrophils. J Clin Invest 1999;103:851-8.
Nishina K, Akamatsu H, Mikawa K, Shiga M, Maekawa N, Obara H, Niwa Y. The inhibitory effects of thiopental, midazolam, and ketamine on human neutrophil functions. Anesth Analg 1998;86(1):159-65.
Novaes MA, Knobel E, Bork AM, Pavao OF, Vogueira-Martins LA, Ferraz MD. Stressors in ICU: Perception of the patient, relatives and healthcare team. Intensive Care Med 1999;25:1421-6.
Oberholzer A, Oberholzer C, Moldawer LL. Sepsis syndromes: understanding
the role of innate and acquired immunity. Shock 2001;16(2):83-96.
Ono K, Han J. The p38 signal transduction pathway: activation and function.
Cell Signal 2000;12:1-13.
Pahl HL. Activators and target genes of Rel/NF-kappa B transcription factors. Oncogene 1999;18: 6853-66.
Parrillo JE. Pathogenetic mechanisms of septic shock. N Engl J Med 1993;328(20):1471-7.
Passegue E, Jochum W, Behrens A, Ricci R, Wagner EF. JunB can substitute for Jun in mouse development and cell proliferation. Nat Genet 2002;30(2):158-66.

Paterson AA, Heys SD, Hunter J. Propofol and immunomodulation: An in-vitro study. Shock 1997;7(Suppl):167.
Pattison JH, Allen RP. Comparison of the hypnotic effectiveness of secobarbital, pentobarbital, methyprylon, and ethchlorvynol. J Am Geriatr Soc 1972;20:398.
Penner CG, Gang G, Wray C, Fischer JE, Hasselgren PO. The transcription factors NF-kappab and AP-1 are differentially regulated in skeletal muscle during sepsis. Biochem Biophys Res Commun 2001;281:1331-6.
Piper RD, Cook DJ, Bone RC, Sibbald WJ. Introducing Critical Appraisal to studies of animal models investigating novel therapies in sepsis. Crit Care Med 1996;24(12):2059-70.
Pirttikangas CO, Perttila J, Salo M. Propofol emulsion reduces proliferative responses of lymphocytes from intensive care patients. Intensive Care Med 1993;19(5):299-302.
Pittman T, Bucholz R, Williams D. Efficacy of barbiturates in the treatment of resistant intracranial hypertension in severely head-injured children. Pediatr Neurosci 1989;15(1):13-7.
Rashkin MC, Youngs C, Penovich P. Pentobarbital treatment of refractory status epilepticus. Neurology 1987;37(3):500-3.
Rea GL, Rockswold GL. Barbiturate therapy in uncontrolled intracranial hypertension. Neurosurgery 1983;12(4):401-4.

Read MA, Cordle SR, Veach RA, Carlisle CD, Hawiger J. Cell-free pool of CD14 mediates activation of transcription factor NF-kappa B by lipopoly- saccharide in human endothelial cells. Proc Natl Acad Sci USA 1993;90:9887-91.
Reidenberg MM, Lowenthal DT, Briggs W, Gasparo M. Pentobarbital elimination in patients with poor renal function. Clin Pharmacol Ther 1976;20:67-71.
Riss TL, Moravec RA. Comparison of MTT, XTT, and novel tetrazolium compound for MTS for in vitro proliferation and chemosensitivity assays. Mol Biol Cell 1992;3:184.
Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, TomLanovich M. Early Goal-Directed Therapy Collaborative Group. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001;345(19):1368-77.
Roach SK, Lee SB, Schorey JS. Differential activation of the transcription factor cyclic AMP response element binding protein (CREB) in macrophages following infection with pathogenic and nonpathogenic mycobacteria and role for CREB in tumor necrosis factor alpha production. Infect Immun 2005;73(1):514-22.
Rockoff MA, Marshall LF, Shapiro HM. High-dose barbiturate therapy in humans: a clinical review of 60 patients. Ann Neurol 1979;6(3):194-9.
Russell WMS, Bruch R. The Principles of Humane Experimental Technique. (1959).
Sakai T, Ichiyama T, Whitten CW, Giesecke AH, Lipton JM. Ketamine suppresses endotoxin-induced NF-kappaB expression. Can J Anaesth 2000;47(10):1019-24.
Salman H, Bergman M, Bessler H, Alexandrova S, Beilin B, Djaldetti M. Effect of sodium thiopentone anesthesia on the phagocytic activity of rat peritoneal macrophages. Life Sci 1998;63(25):2221-6.
Schalen W, Messeter K, Nordstrom CH. Complications and side effects during thiopentone therapy in patients with severe head injuries. Acta Anaesthesiol Scand 1992;36(4):369-77.
Scumpia PO, Sarcia PJ, Kelly KM, DeMarco VG, Skimming JW. Hypothermia induces anti-Inflammatory cytokines and inhibits nitric oxide and myeloperoxidase-mediated damage in the hearts of endotoxemic rats. Chest 2004;125;1483-91.
Sebel PS, Lowdon JD. Propofol: a new intravenous anesthetic. Anesthesiology 1989;71(2):260-77.
Selzman CH, Shames BD, Miller SA, Pulido EJ, Meng X, McIntyre RC Jr, Harken AH. Therapeutic implications of interleukin-10 in surgical disease. Shock 1998;10(5):309-18.
Shaulian E, Karin M. AP-1 in cell proliferation and survival. Oncogene 2001;20(19): 2390-400.
Shi Q, Wang J, Wang XL, VandeBerg JL. Comparative Analysis of Vascular Endothelial Cell Activation by TNF-alpha and LPS in Humans and Baboons. Cell Biochem Biophys 2004;40:289-304.

Shimazu T, Yoshioka T, Sugimoto H. Granulocyte colony-stimulating factor ameliorates life-threatening infections after combined therapy with barbiturates and mild hypothermia in patients with severe head injuries. J Trauma 1999;46:999-1007.
Silverman N, Maniatis T. NF-kB signaling pathways in mammalian and insect innate immunity. Genes Dev 2001;15:2321-42.
Smith DS, Rehncrona S, Westerberg E, Akesson B, Siesjo BK. Lipid peroxidation in brain tissue in vitro: antioxidant effects of barbiturates. Acta Physiol Scand 1979;105(4):527-9.
Smith I, White PF, Nathanson M, Gouldson R. Propofol. An update on its clinical use. Anesthesiology 1994;81(4):1005-43.
Smith RB, Dittert LW, Griffen WO Jr, Doluisio JT. Pharmacokinetics of pentobarbital after intravenousIV and oral administration. J Pharmacokinet Pharmacodynamics 1973;1:5-16.
Stevenson GW, Hall SC, Rudnick S, Seleny FL, Stevenson HC. The effect of anesthetic agents on the human immune response. Anesthesiology 1990;72(3):542-52.
Stotsky BA, Cole JO, Tang YT, Gahm IG. Sodium butabarbital (butisol sodium) as an hypnotic agent for aged psychiatric patients with sleep disorders. J Am Geriatric Soc 1971;19:860-70.


Stover JF, Stocker R. Barbiturate coma may promote reversible bone marrow suppression in patients with severe isolated traumatic brain injury. Eur J Clin Pharmacol 1998;54(7):529-34.
Sun J, Wang XD, Liu H, Xu JG. Ketamine suppresses intestinal NF-kappa B activation and proinflammatory cytokine in endotoxic rats. World J Gastroenterol 2004 ;10(7):1028-31.
Szabo C, Cuzzocrea S, Zingarelli B, O'Connor M, Salzman AL. Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite. J Clin Invest 1997; 100(3):723-35.
Szabo C, Mitchell JA, Thiemermann C, Vane JR. Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock. Br J Pharmacol 1993; 108(3):786-92.
Takeda K, Matsuzawa A, Nishitoh H, Ichijo H. Roles of MAPKKK ASK1 in stress-induced cell death. Cell Struct Funct 2003;28:23–9.
Takenaka I, Ogata M, Koga K, Matsumoto T, Shigematsu A. Ketamine suppresses endotoxin-induced tumor necrosis factor alpha production in mice. Anesthesiology 1994;80(2):402-8.
Taniguchi T, Kanakura H, Yamamoto K. Effects of posttreatment with propofol on mortality and cytokine responses to endotoxin-induced shock in rats. Crit Care Med 2002; 30(4):904-7.
Taniguchi T, Yamamoto K, Ohmoto N, Ohta K, Kobayashi T. Effects of propofol on hemodynamic and inflammatory responses to endotoxemia in rats. Crit Care Med 2000;28(4):1101-6.
Taniguchi T, Yamamoto K. Anti-inflammatory effects of intravenous anesthetics on endotoxemia. Mini Rev Med Chem 2005;5:241-5.
Taylor FB Jr. Response of anticoagulant pathways in disseminated intravascular coagulation. Semin Thromb Hemost 2001;27(6):619-31.
Taylor FB Jr, Toh CH, Hoots WK, Wada H, Levi M. Scientific Subcommittee on Disseminated Intravascular Coagulation (DIC) of the International Society on Thrombosis and Haemostasis (ISTH). Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost 2001;86(5):1327-30.
Terrar DA. Structure and function of calcium channels and the actions of anaesthetics. Br J Anaesth 1993; 71(1):39-46.
Timokhov VS, Iakovleva II, Kalashnikova EA, Ipat'eva EI. Plasma contents of cytokines (TNF-alpha, IL-1 beta, IL-6) and their clearance during continuous hemofiltration in patients with sepsis and multiple organ failure. Anesteziol Reanimatol 1997;3:59-62.
Tobias JD. Pentobarbital for sedation during mechanical ventilation in the pediatric ICU patient. J Intensive Care Med 2000;15:115-20.

Tracey KJ, Fong Y, Hesse DG, Manogue KR, Lee AT, Kuo GC, Lowry SF, Cerami A. Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature 1987;30(6149):662-4.
Trauner DA. Treatment of Reye syndrome. Ann Neurol 1980;7(1):2-4.
Tsuchiya M, Asada A, Maeda K, Ueda Y, Sato EF, Shindo M, Inoue M. Propofol versus midazolam regarding their antioxidant activities. Am J Respir Crit Care Med 2001;163(1):26-31.
Ulevitch RJ, Tobias PS. Recognition of gram-negative bacteria and endotoxin by the innate immune system. Curr Opin Immunol 1999;11(1):19-22.
Vallet B. Endothelial cell dysfunction and abnormal tissue perfusion. Crit Care Med 2002;30(suppl 5):S229-34.
Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M,Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R. Intensive insulin therapy in the critically ill patients. N Engl J Med 2001;345(19):1359-67.
Van der Linden P, Gilbart E, Engelman E, Schmartz D, de Rood M, Vincent JL. Comparison of halothane, isoflurane, alfentanil, and ketamine in experimental septic shock. Anesth Analg 1990;70(6):608-17.



Van Oosten M, Rensen PC, Van Amersfoort ES, Van Eck M, Van Dam AM, Breve JJ, Vogel T, Panet A, Van Berkel TJ, Kuiper J. Apolipoprotein E protects against bacterial lipopolysaccharide-induced lethality. A new therapeutic approach to treat gram-negative sepsis. J Biol Chem 2001; 276(12):8820-4.
Wachtel RE, Wegrzynowicz ES. Kinetics of nicotinic acetylcholine ion channels in the presence of intravenous anaesthetics and induction agents. Br J Pharmacol 1992;106(3):623-7.
Wang X, RON D. Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP kinase. Science 272: 1347–1349, 1996.
Warner DS, Takaoka S, Wu B, Ludwig PS, Pearlstein RD, Brinkhous AD, Dexter F. Electroencephalographic burst suppression is not required to elicit maximal neuroprotection from pentobarbital in a rat model of focal cerebral ischemia. Anesthesiology 1996;84:1475-84.
Weigand MA, Schmidt H, Zhao Q, Plaschke K, Martin E, Bardenheuer HJ. Ketamine modulates the stimulated adhesion molecule expression on human neutrophils in vitro. Anesth Analg 2000;90(1):206-12.
Weiss M, Buhl R, Medve M, Schneider EM. Tumor necrosis factor-alpha modulates the selective interference of hypnotics and sedatives to suppress N-formyl-methionyl-leucyl-phenylalanine-induced oxidative burst formation in neutrophils. Crit Care Med 1997;25(1):128-34.

Wermeling DP, Blouin RA, Porter WH, Rapp RP, Tibbs PA. Pentobarbital pharmacokinetics in patients with severe head injury. Drug Intell Clin Pharm 1987;21(5):459-63.
Winer JW, Rosenwasser RH, Jimenez F. Electroencephalographic activity and serum and cerebrospinal fluid pentobarbital levels in determining the therapeutic end point during barbiturate coma. Neurosurgery 1991;29(5):739-41.
Wixson SK, White WJ, Hughes HC Jr, Lang CM, Marshall WK. A comparison of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam anesthesia in adult male rats. Lab Anim Sci 1987;37(6):726-30.
Worek FS, Blumel G, Zeravik J, Zimmermann GJ, Pfeiffer UJ. Comparison of ketamine and pentobarbital anesthesia with the conscious state in a porcine model of Pseudomonas aeruginosa septicemia. Acta Anaesthesiol Scand 1988;32(7):509-15.
Yaffe K, Lowenstein DH. Prognostic factors of pentobarbital therapy for refractory generalized status epilepticus. Neurology 1993;43(5):895-900.
Yoshimura T, Kurita C, Nagao T, Usami E, Nakao T, Watanabe S, Kobayashi J, Yamazaki F, Tanaka H, Inagaki N, Nagai H. Inhibition of tumor necrosis factor-alpha and interleukin-1-beta production by beta-adrenoceptor agonists from lipopolysaccharide-stimulated human peripheral blood mononuclear cells. Pharmacology 1997;54:144-52.

Yu Y, Zhou Z, Xu J, Liu Z, Wang Y. Ketamine reduces NFkappaB activation and TNFalpha production in rat mononuclear cells induced by lipopolysaccharide in vitro. Ann Clin Lab Sci 2002;32(3):292-8.
Zaloga GP, Todd N, Levit P, Marik PE. Propofol-induced bronchodilation in patients with status asthmaticus. The Internet Journal of Emergency and Intensive Care Medicine [serial online]. 2001; 5: Available at: http://www.ispub.com/ostia/index.php?xmLFilePath=journals/ijaai/vol1n2/asthma.xmL
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