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研究生:宋明樺
研究生(外文):Ming-Hua Sung
論文名稱:中鏈油對於STZ誘發之第2型糖尿病大鼠脂質代謝之影響機制的探討
論文名稱(外文):The effects of medium-chain triglyceride oil on lipid metabolism in streptozotocin induced type 2 diabetes mellitus rats
指導教授:簡怡雯簡怡雯引用關係
學位類別:碩士
校院名稱:臺北醫學大學
系所名稱:保健營養學研究所
學門:醫藥衛生學門
學類:營養學類
論文種類:學術論文
論文出版年:2007
畢業學年度:95
語文別:中文
論文頁數:104
中文關鍵詞:第2型糖尿病中鏈油長鏈油脂質代謝
外文關鍵詞:Type 2 diabetes mellitusmedium-chain triglyceride oillong-chain triglyceride oillipid metabolism
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中鏈油 (medium-chain triglyceride oil, MCT) 中所攜帶的為飽和及碳數介於6-12之間的脂肪酸鏈,由於MCT在體內的運輸途徑與氧化速率不同於長鏈油 (long-chain triglyceride oil, LCT),因此本次實驗係探討在低與高油飲食中利用MCT部分取代黃豆油對於第2型糖尿病大鼠體內脂質代謝相關酵素活性與脂質代謝的影響。實驗主要以32隻Sprague-Dawley大鼠為研究對象,以STZ誘發為第2型糖尿病後分為低黃豆油組 (Low soybean oil diet, LS)、低中鏈油組 (Low medium-chain triglyceride oil diet, LM)、高黃豆油組 (High soybean oil diet, HS) 與高中鏈油組 (High medium-chain triglyceride oil diet, HM)。實驗期8週後,分析血糖、血脂質、肝臟脂質及酵素活性,並將肝臟與生殖腺周圍白色脂肪組織進行H&E染色。結果顯示,在高油飲食中MCT的部份取代具有降低血液中LDL-C、NEFA與肝臟中TC濃度;且具有提升血液中HDL-C與HDL-C/LDL-C比值的效果。由上述結果推論MCT的給予可能藉由降低大鼠體重、調節肝臟中Acyl-CoA carboxylase、HMG-CoA reductase、Acyl-CoA oxidase與Carnitine palmitoyltransferase酵素活性達到降低血脂質與肝脂質的效果;且MCT改善效果在高油飲食中較為顯著。
MCT (medium-chain triglyceride oil), with six to twelve carbons in length, differ from other triglyceride. MCT and long-chain triglyceride oil (LCT) are absorbed and oxidize in different ways. The aim of this study was to assess replacement of soybean oil with MCT in low- or high-fat diet on lipid metabolism in STZ-induced type 2 diabetes mellitus (T2DM) rats. Thirty-two T2DM Sprague-Dawley rats were divided into low soybean oil diet (LS), low medium-chain triglyceride oil diet (LM), high soybean oil diet (HS), and high medium-chain triglyceride oil diet (HM) groups. After eight weeks, blood sugar, serum lipids, hepatic lipids and enzymes activities were measured. Results revealed that under high-fat diet, replacement of soybean oil with MCT can lower serum LDL-C, serum NEFA, and hepatic total cholesterol levels, and increase serum HDL-C concentration and HDL-C/LDL-C ratio. In conclusion, MCT reduced serum and hepatic lipids accompanied losing body weight and regulation hepatic acyl-CoA carboxylase, HMG-CoA reductase, acyl-CoA oxidase and carnitine palmitoyltransferase activities in T2DM rats. Besides, the effects are much more significant in T2DM rats fed high-fat diet.
目錄
中文摘要 I
英文摘要 II
致謝 III
目錄 V
表目錄 X
圖目錄 XI
第一章 緒論 1
第二章 文獻回顧 3
第一節 糖尿病 3
一、糖尿病的種類與發生率 3
二、T2DM的危險因子 4
三、T2DM生理異常症狀 4
四、T2DM與脂質代謝異常相關性 5
五、T2DM與併發症的相關性 7
第二節 T2DM的誘發模式 8
一、單純藥物誘發模式 8
二、合併高脂飲食與藥物誘發模式 8
第三節 肥胖 9
一、肥胖發生率與病因 9
二、肥胖與體內代謝異常之相關性 10
三、肥胖與其它併發症的相關性 11
第四節 T2DM與肥胖之相關性 11
一、訊息傳導因素 11
二、NEFA 11
三、腫瘤壞死因子-α (Tumor necrosis factor-α, TNF-α) 12
第五節 中鏈油 (medium-chain triglyceride oil, MCT) 12
一、結構與特性 12
二、消化吸收及氧化 13
三、與巨量營養素的關係 13
四、與其他脂肪酸氧化作用的比較 14
五、與體重體脂肪之相關性 15
六、與血脂相關性 15
七、與糖尿病相關研究 15
第六節 低脂飲食 (low-fat diet, LFD) 16
ㄧ、定義 16
二、與體重及體脂相關研究 16
三、與糖尿病的相關研究 17
第三章 實驗設計與材料方法 18
第一節 實驗流程 18
第二節 實驗材料 19
ㄧ、實驗對象與飼養方法: 19
二、第2型糖尿病誘發模式與實驗動物分組: 19
三、飼料組成與配製: 20
四、劑量設計概念: 22
第三節 腹腔注射葡萄糖耐受性測試 (Intraperitoneal glucose
tolerance test, IPGTT) 23
第四節 分析項目及方法 24
一、動物犧牲及樣品收集 24
二、血糖與胰島素分析 25
三、血脂質分析 26
四、血液GPT與GOT分析 31
五、肝臟脂質分析 33
六、脂質生成相關酵素活性測定 36
七、脂質分解相關酵素活性測定 42
八、內生性膽固醇生成相關酵素活性測定 48
九、生殖腺周圍白色脂肪組織 (Reproductive white adipose tissue, RDWAT) 及肝臟組織H&E (hematoxylin and eosin solution) 染色 51
十、油脂脂肪酸分析 51
第五節、統計分析 52
第四章 結果 53
第一節 攝食和生長狀況 53
第二節 葡萄糖耐受試驗 56
第三節 血糖、胰島素與脂質濃度分析 58
第四節 血清中GOT與GPT濃度分析 66
第五節 肝臟脂質分析 69
第六節 肝臟中酵素活性測定 73
第七節 實驗動物生殖腺周圍白色脂肪 (RDWAT)、肝臟組織染色切片 81
第八節 中鏈油和黃豆油脂肪酸分析 84
第五章 討論 86
第一節 實驗飲食對於糖尿病大鼠體重、體脂肪之影響 86
第二節 腹腔注射葡萄糖耐受試驗 86
第三節 實驗飲食對於糖尿病大鼠血脂質之影響 87
第四節 實驗飲食對於糖尿病大鼠肝脂質與肝臟相關酵素活性之影響 90
第五節 實驗飲食對於糖尿病大鼠肝功能之影響 92
第六節 實驗飲食對於糖尿病大鼠生殖腺周圍脂肪 (RDWAT) 與肝臟組織切片之影響 92
第六章 結論 94
第七章 文獻回顧 95
附錄一 104




























表目錄
第三章
表3-1 實驗飼料組成 22
第四章
表4-1 四種實驗飲食所提供每日蛋白質、脂質、醣類及熱量 54
表4-2 體重和各組織重量 55
表4-3 各組血糖、胰島素、三酸甘油酯、總膽固醇濃度 61
表4-4 中鏈油和大豆油脂肪酸組成 85






















圖目錄
第二章
圖2-1 中鏈油的基本結構 12
第四章
圖4-1 各組腹腔注射葡萄糖耐受試驗 (葡萄糖濃度曲線下面積) 57
圖4-2 各組血清低密度脂蛋白膽固醇濃度 62
圖4-3 各組血清高密度脂蛋白膽固醇濃度 63
圖4-4 各組血清高密度脂蛋白膽固醇/低密度脂蛋白膽固醇濃度 64
圖4-5 各組血清中游離脂肪酸濃度 65
圖4-6 各組血清中GPT濃度 67
圖4-7 各組血清中GOT濃度 68
圖4-8 各組每克肝臟中三酸甘油酯含量 70
圖4-9 各組每克肝臟中總膽固醇含量 71
圖4-10 各組每克肝臟中游離脂肪酸含量 72
圖4-11 各組肝臟中Fatty acid synthase (FAS) 活性 76
圖4-12 各組肝臟中Acyl-CoA carboxylase (ACC) 活性 77
圖4-13 各組肝臟中Acyl-CoA oxidase (ACO) 活性 78
圖4-14 各組肝臟中Carnitine palmitoyltransferase (CPT) 活性 79
圖4-15 各組肝臟中HMG-CoA reductase活性 80
圖4-16 以H&E染色觀察小鼠生殖腺周圍白色脂肪組織 (RDWAT) 切片 (10 X × 10X) 82
圖4-17 以H&E染色觀察小鼠肝臟組織切片 (10 X × 10X) 83
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