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研究生:莊傳年
研究生(外文):Chuan-Nien Chuang
論文名稱:檜葉寄生之化學成分及生物活性研究
論文名稱(外文):Chemical and Biological Investigations of Korthalsella japonica
指導教授:呂彥禮
指導教授(外文):Y. L. Leu
學位類別:碩士
校院名稱:長庚大學
系所名稱:天然藥物研究所
學門:醫藥衛生學門
學類:藥學學類
論文種類:學術論文
論文出版年:2008
畢業學年度:96
論文頁數:108
中文關鍵詞:檜葉寄生寄生
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檜葉寄生 ( Korthalsella japonica )為桑寄生科( Loranthaceae ) 檜葉寄生屬 ( Korthalsella ) 植物。為寄生小灌木,主要分佈於亞洲熱帶之中國南部,澳洲至玻利尼西亞等地區。
從新鮮檜葉寄生( K. japonica ) ( 1.2Kg )總共分得35個化合物,其中所分離得到的化合物與槲寄生( Viscum coloratum )相似,皆以黃酮類以及色酮類為其主要成份,其中有五個化合物為天然界首次分離得到之新化合物,分別為methyl-4-O-cinnamoylquinate ( 26 )、korthalin ( 28 )、korjaponin ( 29 )、6’,4’’-dihydroxy-2’,3’’ -dimethoxychalcone-4’- O-β-glucoside ( 30 )、viscolin 4’,4’’- di-O-β-D-glucoside ( 31 )等。
在生物活性方面,針對所分得的純化合物做抗發炎的活性測試,結果顯示viscolin具有顯著的抑制人類嗜中性白血球釋放超氧陰離子與elastase,但是korthalin、2’, 4’’-dihydroxy-6’, 3’’-dimethoxychalcone- 4’-O-β-glucoside、viscolin 4’,4’’-di-O-β-D-glucoside則不具有抑制活性。
Korthalsella japonica is one kind of specific Loranthoideae in Taiwan. It is a small parasitic subshrubs and mainly distribution in tropical Asia, Australia to Polynesia. Thirty-five compounds were isolated from the fresh Korthalsella japonica ( 1.2 kg ). The major components were flavanoids and chromones, which were similar with Viscum coloratum,. Among them, five new compounds, methyl-4-O- cinnamoyl- quinate ( 26 ), korthalin ( 28 ), korjaponin ( 29 ), 6’, 4’’-dihydroxy-2’,3’’- dimethoxychalcone-4’ -O-β- glucoside ( 30 ) and viscolin 4’,4’’-di-O-β- D-glucoside ( 31 ) were isolated for the first time from the natural source.
The isolated compounds were subjected to evaluate their bioactive- ties. The results of anti-inflammatory experiments showed that viscolin has significant inhibitory activities in the release of superoxide anion and elastase in fMLP/CB-activated human neutrophils. Korthalin, 6’, 4’’- di- hydroxy-2’, 3’’-dimethoxychalcone-4’-O-β-glucoside, viscolin 4’,4’’ -di- O-β-D glucoside showed no or minor anti-inflamatory activities.
誌謝.......iv
目錄........v
中文摘要....vii
英文摘要....viii
第一章......1
第二章......4
第三章......5
第四章......14
第五章......65
第六章......68
第七章......75
光譜數據整理.....77
參考文獻.........97
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