(3.227.0.150) 您好!臺灣時間:2021/05/08 10:46
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果

詳目顯示:::

: 
twitterline
研究生:賴建旭
研究生(外文):Chien-Hsu Lai
論文名稱:台灣運動神經元疾病之流行病學與醫療支出研究
論文名稱(外文):Epidemiology and Medical Expenses of Motor Neuron Diseases in Taiwan
指導教授:譚秀芬譚秀芬引用關係
學位類別:碩士
校院名稱:長榮大學
系所名稱:醫學研究所
學門:醫藥衛生學門
學類:醫學學類
論文種類:學術論文
論文出版年:2008
畢業學年度:96
語文別:中文
論文頁數:86
中文關鍵詞:運動神經元疾病醫療支出台灣漸凍人流行病學發生率
外文關鍵詞:Motor neuron diseasesamyotrophic lateral sclerosisTaiwanepidemiologyincidence
相關次數:
  • 被引用被引用:2
  • 點閱點閱:434
  • 評分評分:系統版面圖檔系統版面圖檔系統版面圖檔系統版面圖檔系統版面圖檔
  • 下載下載:69
  • 收藏至我的研究室書目清單書目收藏:0
研究目的:探討台灣運動神經元疾病之流行病學與醫療支出。
方法:從台灣的健保資料庫中,篩選出同時有運動神經元疾病診斷碼與重大傷病身分的就醫資料。所篩選的資料範圍從2000年1月到2005年12月。求得各年齡層與男女性別的個案數,再由新發生的個案數除以內政部所公告的各年齡層與性別人口數,即可得知各年齡層與性別的發生率。由健保資料庫中的數據也可得知醫療支出。
結果:在2000-2005這六年當中,共有1554位運動神經元疾病患者。平均發生率為每年每十萬人口1.05人(從0.95到1.17)。男比女的比率為1.51。男性的平均發生率為每年每十萬人口1.25人,女性為每年每十萬人口0.84人。此發生率會隨著年齡增加而增加,男性到65-69歲這個年齡層達到最高點,女性的發生率則在70-74歲這個年齡層達到最高點,在更老的年齡層發生率則會下降。運動神經元疾病患者的就醫次數與醫療支出,逐年遞增,但住院部分在2005年突然下降。
結論:在2001-2005年當中,台灣的運動神經元疾病平均發生率為每年每十萬人口1.05人。此數據低於白種人的數據。男性的發生率略高於女性,且發生率隨著年齡而增加。隨著台灣人口結構逐漸老化,運動神經元疾病的病患數目與醫療支出在未來數十年當中,預期也會增加。
Objective: To investigate the epidemiology and associated medical expenses of motor neuron diseases in Taiwan.
Methods: Data from the National Health Insurance Research Database involving diagnoses of motor neuron diseases and Certificates of Serious Accidents and Diseases were retrieved for January 2000 to December 2005. Age and sex specific incidences of motor neuron diseases were estimated by dividing the incidence number by population data obtained from the Department of Statistics, Ministry of the Interior. Medical expenses associated with the disease and incidence trends were also described during this period.
Results: During this six-year period, 1554 patients with motor neuron diseases were identified. The average yearly incidence was 1.05 per 100,000 (range 0.95-1.17). The male to female ratio was 1.51. The incidence rate, which was 1.25 in men and 0.84 in women, tended to increase with age and peaked at the 65-69 range in men and the 70-74 range in women; it decreased thereafter. The counts and expenses of the medical services associated with motor neuron diseases increased year by year, except for a sudden drop in inpatient expenses in 2005.
Conclusions: The incidence of motor neuron diseases in Taiwan during 2001-2005 was 1.05 per 100,000/year, which was lower than that of Caucasians. Incidence had moderate male predominance and increased with age. With Taiwan’s aging population, case numbers and medical expenses associated with these diseases are expected to rise in future decades.
中文摘要 2
英文摘要 3
重要英文名詞縮寫對照 5
第一章 緒論 6
第二章 研究材料與方法 17
第三章 結果 24
第四章 討論 29
第五章 結論 37
參考文獻 38
表目錄 43
圖目錄 53
附錄一:全民健保重大傷病範圍 58
附錄二:重大傷病申請書 73
附錄三:全民健康保險研究資料庫使用申請書一般需求檔案清單 75
附錄四:全民健康保險研究資料庫使用申請書特殊需求部份 84
1.RH RAB. Motor System Disease: McGraw-Hill, 2005. 939-47.
2.Maragakis NJ G-JN. Epidemiology and pathogenesis of amyotrophic lateral sclerosis. In: UpToDate.
3.Worms PM. The epidemiology of motor neuron diseases: a review of recent studies. J Neurol Sci 2001;191:3-9.
4.Chancellor AM, Warlow CP. Adult onset motor neuron disease: worldwide mortality, incidence and distribution since 1950. J Neurol Neurosurg Psychiatry 1992;55:1106-1115.
5.Noonan CW, White MC, Thurman D, Wong LY. Temporal and geographic variation in United States motor neuron disease mortality, 1969-1998. Neurology 2005;64:1215-1221.
6.Roman GC. Neuroepidemiology of amyotrophic lateral sclerosis: clues to aetiology and pathogenesis. J Neurol Neurosurg Psychiatry 1996;61:131-137.
7.Chio A, Magnani C, Schiffer D. Gompertzian analysis of amyotrophic lateral sclerosis mortality in Italy, 1957-1987; application to birth cohorts. Neuroepidemiology 1995;14:269-277.
8.Galasko D, Salmon D, Gamst A, et al. Prevalence of dementia in Chamorros on Guam: relationship to age, gender, education, and APOE. Neurology 2007;68:1772-1781.
9.Kuzuhara S. [Revisit to Kii ALS--the innovated concept of ALS-Parkinsonism-dementia complex, clinicopathological features, epidemiology and etiology]. Brain Nerve 2007;59:1065-1074.
10.Plato CC, Garruto RM, Galasko D, et al. Amyotrophic lateral sclerosis and parkinsonism-dementia complex of Guam: changing incidence rates during the past 60 years. Am J Epidemiol 2003;157:149-157.
11.Yoshida S, Uebayashi Y, Kihira T, et al. Epidemiology of motor neuron disease in the Kii Peninsula of Japan, 1989-1993: active or disappearing focus? J Neurol Sci 1998;155:146-155.
12.Fong GC, Cheng TS, Lam K, et al. An epidemiological study of motor neuron disease in Hong Kong. Amyotroph Lateral Scler Other Motor Neuron Disord 2005;6:164-168.
13.Fong KY, Yu YL, Chan YW, et al. Motor neuron disease in Hong Kong Chinese: epidemiology and clinical picture. Neuroepidemiology 1996;15:239-245.
14.Moriwaka F, Okumura H, Tashiro K, et al. Motor neuron disease and past poliomyelitis. Geographic study in Hokkaido, the northern-most island of Japan. ALS Study Group. J Neurol 1993;240:13-16.
15.Okumura H, Moriwaka F, Tashiro K, et al. [Epidemiological study of motor neuron disease in Hokkaido island--its incidence, prevalence and regional distributions--ALS Study Group]. No To Shinkei 1992;44:727-732.
16.Cronin S, Hardiman O, Traynor BJ. Ethnic variation in the incidence of ALS: a systematic review. Neurology 2007;68:1002-1007.
17.Ince PG, Evans J, Knopp M, et al. Corticospinal tract degeneration in the progressive muscular atrophy variant of ALS. Neurology 2003;60:1252-1258.
18.Donaghy M. Classification and clinical features of motor neurone diseases and motor neuropathies in adults. J Neurol 1999;246:331-333.
19.Figlewicz DA, Orrell RW. The genetics of motor neuron diseases. Amyotroph Lateral Scler Other Motor Neuron Disord 2003;4:225-231.
20.Talbot K, Ansorge O. Recent advances in the genetics of amyotrophic lateral sclerosis and frontotemporal dementia: common pathways in neurodegenerative disease. Hum Mol Genet 2006;15 Spec No 2:R182-187.
21.Logroscino G, Traynor BJ, Hardiman O, et al. Descriptive epidemiology of amyotrophic lateral sclerosis: new evidence and unsolved issues. J Neurol Neurosurg Psychiatry 2008;79:6-11.
22.Beghi E, Millul A, Micheli A, Vitelli E, Logroscino G. Incidence of ALS in Lombardy, Italy. Neurology 2007;68:141-145.
23.Brooks BR. El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis. Subcommittee on Motor Neuron Diseases/Amyotrophic Lateral Sclerosis of the World Federation of Neurology Research Group on Neuromuscular Diseases and the El Escorial "Clinical limits of amyotrophic lateral sclerosis" workshop contributors. J Neurol Sci 1994;124 Suppl:96-107.
24.Chio A, Mora G, Leone M, et al. Early symptom progression rate is related to ALS outcome: a prospective population-based study. Neurology 2002;59:99-103.
25.Logroscino G, Beghi E, Zoccolella S, et al. Incidence of amyotrophic lateral sclerosis in southern Italy: a population based study. J Neurol Neurosurg Psychiatry 2005;76:1094-1098.
26.Preux PM, Druet-Cabanac M, Couratier P, et al. Estimation of the amyotrophic lateral sclerosis incidence by capture-recapture method in the Limousin region of France. J Clin Epidemiol 2000;53:1025-1029.
27.Traynor BJ, Codd MB, Corr B, Forde C, Frost E, Hardiman OM. Clinical features of amyotrophic lateral sclerosis according to the El Escorial and Airlie House diagnostic criteria: A population-based study. Arch Neurol 2000;57:1171-1176.
28.Miller RG, Mitchell JD, Lyon M, Moore DH. Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND). Cochrane Database Syst Rev 2007:CD001447.
29.The Scottish Motor Neuron Disease Register: a prospective study of adult onset motor neuron disease in Scotland. Methodology, demography and clinical features of incident cases in 1989. J Neurol Neurosurg Psychiatry 1992;55:536-541.
30.Traynor BJ, Codd MB, Corr B, Forde C, Frost E, Hardiman O. Incidence and prevalence of ALS in Ireland, 1995-1997: a population-based study. Neurology 1999;52:504-509.
31.Incidence of ALS in Italy: evidence for a uniform frequency in Western countries. Neurology 2001;56:239-244.
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top
無相關期刊
 
系統版面圖檔 系統版面圖檔