臺灣博碩士論文加值系統

解耦控制技術(Decoupling Control Technique, DCT)是一種非侵入式量測彈性管動態壓力的技術。其特點是在感測器平均壓力等同彈性管內平均壓力的下壓位置，追縱變動的管內波動壓力，使彈性管波動行為獨立於周圍彈性組織的影響，此時，所追蹤的位移變化，即為彈性管的管徑變化。藉由識別彈性管的阻抗值，即可估測出實際管內動態壓力。
由於交變波動下彈性管阻抗值將隨時間持續變動，為維持量測之精確性，本文以自適應控制法則，自動調整系統控制參數，以適應不同的阻抗變化。經由Simulink程式模擬結果發現，在自適應控制法則的控制下，彈性管阻抗識別與動態壓力估測的最大誤差分別為9.1%及2.7%，說明解耦控制技術可有效運用於波動彈性管之即時特性監控與管內動態壓力量測。

The Decoupling Control Technique (DCT) is a noninvasive technique for measuring the dynamic pressure of a pulsating tube. The feature of the technique is to exclude the influences of peripheral pulsating tissues by tracking the variation of pulsating pressure at critical location where the mean pressure in the tube and the mean pressure measured by a pressure sensor are equal. Because pulsations of the tube are decoupled, the displacement measured on the skin of peripheral pulsating tissues is the variation of diameter. By identifying the impedance of the pulsating tube, we can estimate the dynamic pressure in the pulsating tube.
In order to maintain the measuring accuracy, we proposed an auto-tuning Control Method to measure the dynamic pressure of a pulsating tube. The results of simulation showed that the measuring error for the pulsating pressure was less than 2.7%, and the identifying error for the impedance of the pulsating tube was less than 9.1%, and explained that the measuring method for measuring the dynamic pressure and identifying the impedance of a pulsating tube is feasible.

誌謝............................................ii
中文摘要.......................................iii
Abstract........................................iv
目錄.............................................v
圖目錄.........................................vii
表目錄..........................................ix
符號表...........................................x
第一章 緒論......................................1
1.1 研究背景.....................................1
1.2 文獻回顧.....................................3
1.3 研究目的與方法 ..............................10
1.4 本文架構....................................11
第二章 理論探討.................................12
2.1 波動彈性管壓力傳遞模型......................12
2.1.1 波動彈性管之直流訊號分析..................15
2.1.2 波動彈性管之交流訊號分析..................15
2.2 解耦控制技術(DCT)...........................16
2.3彈性管機械特性識別...........................19
第三章 自適應控制器設計.........................20
3.1 Beat-to-Beat自調適控制法則..................20
3.2彈性管組抗識別與即時管內壓力估測.............21
3.3 Beat-to-Beat自調適控制法則之模擬驗證........22
3.3.1 模擬參數及資料說明........................22
3.3.2 Beat-to-Beat自調適控制法則之模擬結果......23
第四章 實驗架構.................................27
4.1血管特性量測儀之架構.........................27
4.1.1 血管特性量測儀之追蹤控制器設計............30
4.2 血管特性量測儀之控制器驗證..................31
4.2.1 實驗目的與方法............................31
4.2.2 實驗步驟..................................32
4.2.3 實驗結果與分析............................35
第五章 結論.....................................37
參考文獻........................................38
附錄A 人體實驗數據..............................41
附錄B壓力感測器及訊號處理器之規格...............44
附錄C精密壓電致動器之規格.......................45
附錄D Beat-to-Beat血管特性量測儀實驗記錄表......49

[1] 行政院衛生署95年衛生統計指標，網址: http://www.doh.gov.tw/statistic/index.htm
[2] Timothy S. Manning, Barbara E. Shykoff, Joseph L. Izzo, Jr, “Validity and Reliability of Diastolic Pulse Contour Analysis (Windkessel Model) in Humans.” Journal of the American Hypertension., Vol.39, pp 963-968, 2002.
[3] Vincent P Crabtree and Peter R Smith, “Physiological Models of the Human Vasculature and Photoplethysmography.” Electronic Systems and Control Division Research , pp.60-63, 2003.
[4] Bratteli, Christopher W., “Method and apparatus for calibrating and measuring arterial compliance and stroke volume.” Unites States Patent Application Publication, Pub. No.:US2004/0167413A1, Aug. 26, 2004.
[5] Cohn, Jay N., Morgan, Dennis J., Bratteli, Christopher W., “Apparatus and method for blood pressure pulse waveform contour analysis.”, International Application Published under the Patent Cooperation Treaty(PCT), International Patent Classification: G06F 17/00, A61B 5/021, International Publication Number: WO 99/48023, International Publication Date: 23 September 1999.
[6] Michael F. O’Rourke, Alfredo Pauca, Xiong-Jing Jiang, “Pulse wave analysis”, Journal of Hypertension, Blackwell Science Ltd Br Clin Pharmacol, Vol. 51, pp 507-522, 2001.
[7] The use’s guide of SphygmoCor, A Clinical Guide-Pulse wave analysis, AtCor Medical Pty Ltd.
[8] Paolo Salvia, Giuseppe Liob, Carlos Labatc, Enrico Riccid, Bruno Panniere and
Athanase Benetosc, “Validation of a new non-invasive portable tonometer for determining arterial pressure wave and pulse wave velocity:the PulsePen device”,Journal of Hypertension, Vol. 22 No 12, pp 2285-2293, 2004.
[9] Norman R. Searle MD, Jean Perrault PhD,Helene Ste-Marie RN, Charles Dupont MSC, “Assessment of the arterial tonometer (N-CAT) for the continuous blood pressure measurement in rapid atrial fibrillation.” Can J Anaesth Vol. 40, No. 4, pp 388-393, 1993.
[10] Todd J. Brinton, BS, Bruno Cotter, MD, Mala T. Kailasam, MBBS, David L. Brown, MD, Shiu-Shin Chio, PhD, Daniel T. O’Connor, MD, and Anthony N. DeMaria, MD, “Development and Validation of a Noninvasive Method to Determine Arterial Pressure and Vascular Compliance”, The American Journal of Cardiology Vol. 80, pp 323-330, August 1, 1997.

[11] Kumar Belani, Makoto Ozaki, James Hynson, Thomas Hartmann, Hugo Reyford, Jean-Marc Martino, Marius Poliac and Ronald Miller “A new noninvasive method to measure blood pressure: results of a multicenter trial.”, Lippincott Williams & Wilkins, Anesthesiology, Vol. 91, No. 3, September, 1999.
[12] J. Peñáz, “Photoelectric measurement of blood pressure, volume and flow in the finger”, Digest 10th Int. Conf. Med. Biol. Eng. (Dresden, Germany), pp.104, 1973.
[13] Ben P.M. Imholz, Wouter Wieling, Gert A. van Montfrans, Karel H. Wesseling, “Fifteen years experience with finger arterial pressure monitoring: assessment of the technology” CardioÍascular Research 38 pp 605–616, 1998.
[14] Ben P.M. Imholz, Gerard J. Langewouters, Gert A. van Montfrans, Gianfranco Parati, Jeroen van Goudoever, K.H. Wesseling,Wouter Wieling, and Giuseppe Mancia, “Feasibility of Ambulatory, Continuous 24-Hour Finger Arterial Pressure Recording” Hypertension Vol. 21, No. 1, pp.65-73, 1993.
[15] K. I. Yamakoshi, H. Shimazu and T.Togawa,“Indirect Measurement of Instantaneous arterial blood pressure in the human finger by the vascular unloading technique.”, IEEE Transactions on Biomedical Engineering, Vol. BME-27, No. 3, pp 150-155, 1980.
[16] K. I. Yamakoshi,“Sensors in Medicine and Health Care.” Edited by P. A. Oberg, T. Togawa, and F.A. Spelman, chapter 5, pp 107-122, and 2004.
[17] S. Tanaka, S. Gao, M. Nogawa and K. I. Yamakoshi,“Noninvasive Measurement of Instantaneous Radial Artery Blood Pressure.”, IEEE Engineering in Medicine and Biology Magazine, pp 32-37, 2005.
[18] Albert Chin-Yuh Lin, Huang-Nan Huang, Yi-Chang Su, Chih-Yuan Shiu, Yao-Horng Wang, Hao-Cheng Chiang, Hung Tung and Jui-Shan Lin, “On Measuring the Instantaneous Blood Pressure in an Artery via the Tissue Control Method”, Physiol. Meas., Vol. 28, pp 937-951, 2007.
[19] Albert Chin-Yuh Lin, Huang-Nan Huang, Yi-Chang Su, Chih-Yuan Shiu and Jui-Shan Lin, “A new noninvasive approach to detect the artery’s pulsating properties via Tissue Control Method. ”, IEEE EMBS, April 2007.
[20] Sky McKinley and Megan Levine, “Cubic Spline Interpolation.”, pp 1-15.
http://online.redwoods.cc.ca.us/instruct/darnold/laproj/Fall98/SkyMeg/Proj.PDF
[21] CJC Kruger, “Constrained Cubic Spline Interpolation for Chemical Engineering Applications.” pp 1-5.
[22] 陳奕佐，脈搏量測載具之設計與製作，逢甲大學自動控制工程學系專題論文，2008。
[23] 潘冠廷，非侵入式波動彈性管內壓力量測之實現，逢甲大學自動控制工程學系碩士論文，2008。