臺灣博碩士論文加值系統

高價碘試劑由於是一種低毒性、易處理的反應試劑而廣泛被使用。其中的phenyliodine(III) diacetate (PIDA)、phenyliodine(III) bis(trifluoroacetate) (PIFA)及[hydroxyl(tosyloxy)iodo]benzene (HTIB)是最常被使用的高價碘化合物。
Room temperature ionic liquids(RTIL) 室溫離子溶媒是完全由離子組成的液體。事實上， 離子溶媒可以在室溫或室溫以下(甚至低到-90℃)保持液體，容易製造及處理。離子溶媒因為易於回收、不易燃、具有不揮發的性質，跟典型的分子性溶媒相較，離子溶媒是更環保有效的反應媒介。本研究利用高價碘(III)試劑及離子溶媒進行4-aryl-2-phenyloxazoles 及2-arylimidazo[1,2-a]pyrimidines的合成研究。

Hypervalent iodine reagents have been extensively used in organic syntheses due to their low toxicity, ready availability and easy handling. Phenyliodine(III) diacetate (PIDA), phenyliodine(III) bis(trifluoroacetate) (PIFA) and [hydroxyl(tosyloxy)iodo]benzene (HTIB) are the most frequently used and easily available reagents in the family of iodine compounds.
Room temperature ionic liquids (RTIL) are liquids that are composed entirely of ions. In fact, ionic liquids can now be produced which remain liquid at room temperature and below (even as low as -90℃) and appear to be undemanding to manufacture and easy to handle. Ionic liquids offer an attractive alterative to conventional organic liquids for clean synthesis, as they are easy to be recycled, lack of flammability, and possess effectively no vapour pressure. Compared with classical molecular solvents, the ionic liquids are environmentally benign reaction media. In this work, hypervalent iodine(III) reagents and ionic liquids will be applied to prepare 4-aryl-2-phenyloxazoles and 2-arylimidazo[1,2-a]pyrimidines.

中文摘要…………………………………………………………………1
英文摘要…………………………………………………………………2
第一章 總論……………………………………………………………3
第二章 各論……………………………………………………………14
第一節 利用高價碘(III)試劑HDNIB於離子溶媒[Bmim][PF6]中與aryl ketones反應形成α-[(2,4-dinitrobenzene)sulfonyl]oxy ketone中間體，再與benzamide反應合成4-Aryl-2-phenyl- oxazoles…………………………………………………………………14
第二節 利用高價碘(III)試劑HDNIB於離子溶媒[Bmim][PF6]中與aryl ketones反應形成α-[(2,4-dinitrobenzene)sulfonyl]oxy ketone中間體，再與2-Aminopyrimidine反應合成2-Arylimidazo[1,2-a]pyrimidines…………………………………………………19
第三章 結論…………………………………………………………23
第四章 實驗部分……………………………………………………25
第一節 儀器…………………………………………………………25
第二節 各化合物的製備……………………………………………26
參考文獻………………………………………………………………48

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