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研究生:莊美玲
研究生(外文):Mei-Ling Chuang
論文名稱:市售代餐中含麻黃鹼及咖啡因之調查
論文名稱(外文):A survey of ephedrines and caffeine in replacement meal
指導教授:許美智許美智引用關係
指導教授(外文):Mei-Chich Hsu
學位類別:碩士
校院名稱:國立臺灣體育大學(桃園)
系所名稱:運動科學研究所
學門:民生學門
學類:運動科技學類
論文種類:學術論文
論文出版年:2008
畢業學年度:96
語文別:中文
論文頁數:87
中文關鍵詞:串聯式液相層析質譜儀麻黃鹼咖啡因代餐食品及營養標示
外文關鍵詞:LC/MS/MSephedrinescaffeinereplacement mealfood and nutrition labeling
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市售代餐中含麻黃鹼及咖啡因之調查
摘要
  利用代餐食品減重是近年來流行的趨勢。代餐中若將麻黃鹼與咖啡因合併使用,則有減輕體重及抑制食慾的效果。麻黃鹼是世界反運動禁藥組織規範的運動禁藥,咖啡因是監控計畫物質。本研究的目在建立串聯式液相層析質譜儀(LC-MS-MS)方法以分析麻黃鹼與咖啡因及檢測市售代餐是否添加麻黃鹼及
咖啡因,並檢視代餐包裝標示是否符合食品衛生管理法的規定。結果顯示,建立的LC-MS-MS方法可以同時分析caffeine、norephedrine、cathine、ephedrine、pseudoephedrine及methylephedrine。norephedrine、ephedrine、pseudoephedrine及methylephedrine的最低偵測極限(LOD)為0.2 μg/mL。cathine與咖啡因的最低偵測極限(LOD)為0.4 μg/mL。norephedrine、ephedrine、pseudoephedrine及methylephedrine的線性範圍介於0.2-6.4 μg/mL,檢量線的相關係數為0.9992-1.0000。cathine與咖啡因的線性範圍介於0.4-6.4 μg/mL,檢量線的相關係數為0.9996-0.9998。由網際網路及藥妝店等通路購買共32件產品,均未檢測出含有麻黃鹼,有4件產品檢測出含有咖啡因,但卻未標示。有3件未依規定在產品外包裝以中文及通用符號提供「食品標示」及相關之訊息,7件未依規定標示「營養標示」。
A survey of ephedrines and caffeine in replacement meal
Abstract
  Replacement meal products have become a popular food for weight loss. Ephedrines and caffeine may be added into replacement meal products in order to get weight loss or appetite inhibition. According to the World Anti-doping Code, ephedrines are in the list of prohibited substances and caffeine is in the list of the monitoring program substance. The purposes of this study were to establish a liquid chromatography-tandem mass spectrometry (LC-MS-MS) method to analyze the ephedrines and caffeine in replacement meal products and to examine labels on the packages of replacement meal products according to the “Act Governing Food Sanitation”. The results showed the LC-MS-MS method can be used to detect caffeine, norephedrine, cathine, ephedrine, pseudoephedrine, and methylephedrine in a single chromatographic run. The LOD were 0.2μg/mL for norephedrine、ephedrine、pseudoephedrine and methylephedrine. The LOD were 0.4μg/mL for cathine and caffeine. Linearity was observed for norephedrine、ephedrine、pseudoephedrine and methylephedrine, concentrations ranging from 0.2 to 6.4μg/ml with a correlation coefficient of 0.9992 to 1.0000. Linearity was observed for cathine and caffeine, concentrations ranging from 0.4 to 6.4μg/ml with a correlation coefficient of 0.9996 to 0.9998. Thirty-two replacement meal products were purchased from the internet and drugstores. Ephedrines were not detected in any product. Four products were detected caffeine positive, however, no labeling was found on the packages of these products. Three products were not provided the information of food labeling in Chinese and common symbols on the package. Seven products were not marked nutrition labeling.
目錄
第壹章 緒論 1
第一節 研究動機 1
第二節 研究目的 2
第貳章 文獻探討 3
第一節 體重控制與運動表現 3
第二節 代餐的起源及現況 3
第三節 食品衛生管理法:食品標示及營養標示 5
第四節 麻黃鹼、咖啡因與減重的關係 7
第五節 麻黃鹼、咖啡因與運動禁藥 9
第六節 LC/MS/MS方法分析麻黃鹼與咖啡因 10
第七節 結語 11
第參章 材料與方法 12
第肆章 結果 21
第伍章 討論 45
第陸章 結論與建議 48
參考文獻 49
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