(3.238.7.202) 您好!臺灣時間:2021/03/04 03:04
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果

詳目顯示:::

我願授權國圖
: 
twitterline
研究生:沈秋宏
研究生(外文):Chiu-Hung Shen
論文名稱:非肥胖者不等程度減重對提昇胰島素敏感性的影響
論文名稱(外文):Effects of Different Degrees of Weight Loss to Promote the Insulin Sensitivity in Non-Obesity
指導教授:呂香珠呂香珠引用關係
指導教授(外文):Hsiang-Chu Leu
學位類別:碩士
校院名稱:國立臺中教育大學
系所名稱:體育學系碩士班
學門:教育學門
學類:專業科目教育學類
論文種類:學術論文
論文出版年:2008
畢業學年度:96
語文別:中文
論文頁數:126
中文關鍵詞:非肥胖者不等程度減重胰島素敏感性指數
相關次數:
  • 被引用被引用:1
  • 點閱點閱:620
  • 評分評分:系統版面圖檔系統版面圖檔系統版面圖檔系統版面圖檔系統版面圖檔
  • 下載下載:316
  • 收藏至我的研究室書目清單書目收藏:2
基於堆積多量脂肪的脂肪細胞會分泌脂肪激素或細胞激素,抑制細胞內的胰島素訊息傳遞作用,引起胰島素阻抗。因此,本研究旨在針對那些體重比年輕時至少增加6 kg以上、但未達肥胖程度者,透過運動與適度飲食控制,在體重減少2、4 kg後,探討其胰島素敏感性是否可被提昇,以及代謝症候群有關之血液生化值是否可更臻理想,最終目的在宣揚永保理想體重的理念。
經16週執行體重控制,成功減重達4 kg者有6位女生,年齡為48.17±10.07 yrs、BMI為24.01±1.38 kg/m2、腰圍77.50±6.32 cm,資料經統計結果如下:
(一)血液胰島素與胰島素敏感性指數方面:
血液胰島素前測、減2 kg時、減4 kg時分別為6.51±1.58 mU/l、6.32±1.62 mU/l、4.96±1.13 mU/l(分別減少2.91%、23.84%)。HOMA指數分別為1.57±0.38、1.49±0.46、1.10±0.32(分別減少5.09%、30.12%)。QUICKI指數分別為0.359±0.015、0.363±0.020、0.381±0.021(分別增加1.11%、6.28%)。McAuley指數分別為7.99±0.8、8.33±0.8、9.14±0.68(分別增加4.26%、14.46%)。經以相依樣本單因子變異數分析考驗此四項變數,結果皆達顯著差異(p<.05),進一步以費雪最小顯著差異法事後比較,胰島素、HOMA指數和QUICKI指數皆有一致的結果,即前測到減重2 kg未達顯著差異,前測到減重4 kg時以及減重2 kg到4 kg時達顯著差異,McAuley指數在每個階段皆達顯著差異。
(二)代謝症候群有關的血液生化值方面:
血糖、TC、HDL-C、LDL-C、TG、血壓值等以相依樣本單因子變異數分析,考驗結果除血壓值外,其餘皆達顯著差異(p<.05)。
結論:非肥胖且尚未出現代謝症候群症狀之成年人,經以運動配合適度飲食控制,當體重減輕超過2kg體脂肪些許下降,並回復到接近其過往理想體重時,可使其胰島素敏感性提昇及代謝症候群有關之血液生化值更臻理想。
Because of the adipocyte which accumulated abundant of fat might impair insulin signal transduction function by secreting adipokines or cytokines, and consequently induce the insulin resistance. Thus, the purpose of this study was to investigate whether the insulin sensitivity of adults, whose weights were 6 kg heavier than they were young but yet had not reached the obesity degree, would be more sensitive and their blood profiles concerning the metabolism syndrome would be better, after they lost their weight at 2 kg and 4 kg .
Only six females ( 48.17 ± 10.07 yrs, BMI 24.01 ± 1.38 kg/m2, waist circum 77.50 ± 6.32 cm) succeeded in losing 4 kg by exercise combining with moderate energy-restricted diet during 16 weeks. The results were shown as follows:
(1) Insulin and insulin sensitivity index aspect:
The insulin level of the subjects were 6.51 ± 1.58 mU/l, 6.32 ± 1.62 mU/l and 4.96 ± 1.13 mU/l at pre-test, 2 kg , and 4 kg , respectively (reduced 2.91% at 2 kg, 23.84% at 4 kg). The HOMA index were 1.57 ± 0.38, 1.49 ± 0.46 and 1.10 ± 0.32 (-5.09%, -30.12%); the QUICKI index were 0.359 ± 0.015, 0.363 ± 0.020 and 0.381 ± 0.021(+1.11%, +6.28%); the McAuley index were 7.99 ± 0.8, 8.33 ± 0.8 and 9.14 ± 0.68 (+4.26%; +14.46%). By dependent event of the one-way ANOVA analysis to test these four variables, the results all reached the level of significance (p<.05). Posteriori comparisons of the Fisher’s Least Significant Difference to test the insulin had the consistent results. Namely, the HOMA index and the QUICKI index did not reach the significant differences in the 2kg reduction stage but reached the significant differences in the stage of 2 kg to 4 kg reduction and in the stage of 4 kg reduction. Furthermore, the McAuley indexs all reached the significant differences in each stage.
(2) The blood profiles concerning the metabolism syndrome
Except the blood pressure, the blood glucose, TC, HDL-C, LDL-C, TG at 2 kg and 4 kg were all significant better (p< .05) than pre-test.
Conclusion: The insulin sensitivity of the adults who were non-obesity and no metabolism syndrome might be induced, and their blood profiles concerning the metabolism syndrome might become better after they lose their weight more than 2 kg.
目次

國科會授權書
國家圖書館授權書
考試委員會審定書
人體評估申請書
謝詞
中文摘要………………………………………………………………………………………Ⅰ
英文摘要………………………………………………………………………………………Ⅱ
目次……………………………………………………………………………………………Ⅲ
表目次…………………………………………………………………………………………Ⅴ
圖目次…………………………………………………………………………………………Ⅵ


本文部分
第一章 緒論
一、問題背景……………………………………………………………………1
二、研究問題……………………………………………………………………4
三、研究目的……………………………………………………………………6
四、研究假設……………………………………………………………………6
五、研究範圍……………………………………………………………………7
六、研究限制……………………………………………………………………7
七、操作性定義…………………………………………………………………7
第二章 文獻探討
一、胰島素與胰島素阻抗………………………………………………………9
二、胰島素、非胰島素依賴路徑與胰島素阻抗的關係………………………14
三、肥胖與胰島素敏感性之探討………………………………………………18
四、減重促進胰島素敏感性、改善代謝症候群之探討………………………23
五、總結…………………………………………………………………………31
第三章 研究方法與步驟
一、研究對象……………………………………………………………………32
二、研究時間、地點與實驗流程………………………………………………32
三、實驗設計……………………………………………………………………36
四、實驗檢測項目與方法………………………………………………………38
五、實驗控制……………………………………………………………………44
六、資料處理……………………………………………………………………45
第四章 結果
一、受試者前測背景資料及同質性考驗………………………………………46
二、實驗組胰島素及胰島素敏感性指數之變化………………………………52
三、實驗組血液生化值、血壓之變化…………………………………………61
四、控制組前測、後測之變化…………………………………………………70
第五章 討論與結論
一、不等程度減重後對胰島素與胰島素敏感性指數之影響…………………72
二、不等程度減重後與代謝症候群有關血液生化值之影響…………………77
三、結論…………………………………………………………………………81

參考書目
一、 中文部分………………………………………………………………………………82
二、 外文部分………………………………………………………………………………83

附 錄
一 運動安全問卷調查表…………………………………………………………………92
二 受試者須知……………………………………………………………………………93
三 受試者同意書…………………………………………………………………………94
四 減重計畫………………………………………………………………………………95
五 好消息!享受‧想「瘦」專案………………………………………………………98
六 人體測量及採血之流程………………………………………………………………99
七 每週能量釋放執行統計表……………………………………………………………100
八 血液生化值檢測及計算方法…………………………………………………………101
九 受試者身體組成前測原始資料………………………………………………………106
十 受試者實驗結果原始資料……………………………………………………………107
十一 實驗組不等程度減重血液生化值事後比較結果…………………………………124

表 目 次

表4-1 受試者前測背景資料與代謝症候群定義對照表…………………………………48
表4-2 受試者胰島素、胰島素敏感指數與學者相關研究對照表………………………50
表4-3 實驗組與控制組同質性考驗結果…………………………………………………51
表4-4 實驗組減重兩公斤時身體組成檢定結果…………………………………………54
表4-5 實驗組減重兩公斤時胰島素與胰島素敏感性指數檢定結果……………………55
表4-6 實驗組不等程度減重在血液胰島素one-way ANOVA分析摘要表……………56
表4-7 實驗組不等程度減重血液胰島素事後比較結果…………………………………56
表4-8 實驗組不等程度減重HOMA指數one-way ANOVA分析摘要表…………………58
表4-9 實驗組不等程度減重HOMA指數事後比較結果…………………………………58
表4-10 實驗組不等程度減重QUICKI指數one-way ANOVA分析摘要表……………59
表4-11 實驗組不等程度減重QUICKI指數事後比較結果……………………………59
表4-12 實驗組不等程度減重McAuley數one-way ANOVA分析摘要表………………61
表4-13 實驗組不等程度減重McAuley指數事後比較結果……………………………61
表4-14 減重兩公斤時實驗組血液生化值檢定結果……………………………………63
表4-15 實驗組不等程度減重在血糖one-way ANOVA分析摘要表……………………64
表4-16 實驗組不等程度減重在血液TC one-way ANOVA分析摘要表………………65
表4-17 實驗組不等程度減重在血液HDL-C one-way ANOVA分析摘要表……………66
表4-18 實驗組不等程度減重在血液LDL-C one-way ANOVA分析摘要表……………67
表4-19 實驗組不等程度減重在血液TG one-way ANOVA分析摘要表…………………68
表4-20 實驗組減重兩公斤時血壓檢定結果………………………………………………69
表4-21 控制組身體組成檢定結果………………………………………………………71
表4-22 控制組血液生化值、血壓、胰島素敏感性指數檢定結果…………………71







圖 目 次
圖3-1 研究計畫說明會…………………………………………………………………33
圖3-2 第一次採血情形…………………………………………………………………33
圖3-3 人體組成測量情形………………………………………………………………34
圖3-4 大步快走運動訓練情形…………………………………………………………34
圖3-5 阻力運動訓練情形………………………………………………………………34
圖3-6 實驗流程圖………………………………………………………………………35
圖3-7 測量血壓前的休息情形…………………………………………………………38
圖3-8 實驗檢測程序及流程圖…………………………………………………………39
圖3-9 血液生化檢測情形………………………………………………………………41
圖3-10 ELISA Reader分光光譜儀……………………………………………………41
圖3-11 BIO-RAD SmartSpec Plus分光光譜儀………………………………………42
圖4-1 實驗組減重兩公斤時血液胰島素變化……………………………………………52
圖4-2 實驗組減重兩公斤時HOMA指數變化……………………………………………53
圖4-3 實驗組減重兩公斤時QUICKI指數變化…………………………………………53
圖4-4 實驗組減重兩公斤時McAuley指數變化………………………………………54
圖4-5 實驗組不等程度減重血液胰島素變化情形………………………………………56
圖4-6 實驗組不等程度減重HOMA指數變化……………………………………………57
圖4-7 實驗組不等程度減重QUICKI指數變化…………………………………………59
圖4-8 實驗組不等程度減重McAuley指數變化………………………………………60
圖4-9 實驗組減重兩公斤時血糖變化…………………………………………………62
圖4-10 實驗組減重兩公斤時血液TC變化…………………………………………………62
圖4-11 實驗組減重兩公斤時血液HDL-C變化……………………………………………62
圖4-12 實驗組減重兩公斤時血液LDL-C變化……………………………………………62
圖4-13 實驗組減重兩公斤時血液TG變化………………………………………………63
圖4-14 實驗組不等程度減重血糖變化情形………………………………………………64
圖4-15 實驗組不等程度減重血液TC變化情形…………………………………………65
圖4-16 實驗組不等程度減重血液HDL-C變化情形……………………………………66
圖4-17 實驗組不等程度減重血液LDL-C變化情形……………………………………67
圖4-18 實驗組不等程度減重血液TG變化情形………………………………………68
圖4-19 實驗組減重兩公斤時收縮壓變化………………………………………………69
圖4-20 實驗組減重兩公斤時舒張壓變化………………………………………………69
參考書目
一、中文部分
行政院衛生署國民健康局 (2005)。衛生統計資訊網--中華民國九十四年死因統計結果摘要 。 2006年12月七日,取自http://www.doh.gov.tw/statistic/index.htm
行政院衛生署國民健康局 (2006)。代謝症候群臨床診斷準則(2003台灣)。2006年9月15日,取自http://www.bhp.doh.gov.tw/BHP/do/www/themeParkDocRead?themeParkDocumentId=59416&type=document&themeParkId=826
行政院衛生署國民健康局 (2007)。修正我國代謝症候群之判定標準。2007年03月31日,取自http://www.doh.gov.tw/CHT2006/infonews/news_main01_p01.aspx?class_no=25&now_fod_list_no=8714&array_fod_list_no=&level_no=2&doc_no=48380&show=&qy=2007
林瑞興 (2002)。運動訓練及飲食教育計畫介入對體重過重大學生的效果探討。未出版博士論文,國立台灣師範大學體育學系,台北市。
柳家勛、陳亮恭、陳稚均、陳振文、黃信彰與邱淑媞 (2005)。宜蘭地區中老年民衆身體質量指數與胰島素抗性相關性之探討。北市醫學雜誌,2(2),138-145。
陳怡如、吳至行、張秦松、張尹凡、吳坤陵與張智仁 (2005)。不同減重程度對非糖尿病肥胖者代謝症候群的影響。台灣家庭醫學雜誌,15(4),220-231。
陳金柱、李思遠與郭宗正 (2006)。胰島素阻抗之病理生理學。台灣醫界,49(9),28-34。
陳國群(1997)。最新糖尿病精要 (第一版)。台北市:藝軒圖書出版社。
陳嬿如、黃麗卿 (2005)。胰島素敏感性及抗性之測定方法。基層醫學,20(10),253-259。
彭仁奎、黃國晉與陳慶餘(2006)。肥胖與代謝症候群。基層醫學,21(12),367-371。
詹欣隆、黃麗卿 (2006)。過重者代謝症候群與胰島素阻抗之相關性探討。台灣家庭醫學雜誌,16(3 ),181-189。
劉美媛 (1997)。不同程度女性減重前後之體組成,熱量代謝及血液生化值之研究。未出版碩士論文,台北醫學院,台北市。
潘恆嘉、黃國晉與陳慶餘 (2006)。胰島素阻抗與代謝症候群。基層醫學,21(10),273-277。
鍾春芳、朱德明 (2005)。代謝症候群--現代人的文明病。台灣醫界,48,306-308。
簡盟月、吳英黛 (2006)。胰島素阻抗與運動訓練的效果-細胞與分子層面之探討。物理治療,31(2),130-141。

二、外文部分
Ahmed, I., & Goldstein, B. J. (2006). Cardiovascular Risk in the Spectrum of Type 2 Diabetes Mellitus. The Mount Sinai Journal of Medicine, 73(5), 759-768.
Alberti, G., Zimmet, P., & Shaw, J. (2005). A new IDF worldwide definition of the metabolic syndrome: the rationale and the results. DiabetesVoice, 50(3), 31-33.
Alberti, K. G., & Zimmet, P. Z. (1998). Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabetic Medicine : a Journal of the British Diabetic Association., 15(7), 554-557.
Arias, E. B., Gosselin, L. E., & Cartee, G. D. (2001). Exercise Training Eliminates Age-Related Differences in Skeletal Muscle Insulin Receptor and IRS-1 Abundance in Rats. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences., 56(10), B449-455.
Ascaso, J. F., Pardo, S., Real, J. T., Lorente, R. I., Priego, A., & Carmena, R. (2003). Diagnosing Insulin Resistance by Simple Quantitative Methods in Subjects With Normal Glucose Metabolism. Diabetes Care, 26(12), 3320-3325.
Ascaso, J. F., Romero, P., Real, J. T., Priego, A., Valdecabres, C., & Carmena, R. (2001). Insulin resistance quantification by fasting insulin plasma values and HOMA index in a non-diabetic population. Medicina Clínica.(Barc), 117(14), 530-533.
Bergman, R. N., Finegood, D. T., & Ader, M. (1985). Asessment of insulin sensitivity in vivo. Endocrine Reviews., 6, 45-86.
Blaak, E. E. (2004). Basic disturbances in skeletal muscle fatty acid metabolism in obesity and type 2 diabetes mellitus. The Proceedings of the Nutrition Society., 63(2), 323-330.
Bloem, C. J., & Chang, A. M. (2007). Short-term Exercise Improves {beta}-cell Function and Insulin Resistance in Older People with Impaired Glucose Tolerance. The Journal of Clinical Endocrinology and Metabolism., jc.2007-1734.
Bloomgarden, Z. T. (2003). American Association of Clinical Endocrinologists (AACE) Consensus Conference on the Insulin Resistance Syndrome: 25-26 August 2002, Washington, DC. Diabetes Care, 26(4), 1297-1303.
Bruce, C. R., & Hawley, J. A. (2004 ). Improvements in insulin resistance with aerobic exercise training: a lipocentric approach. Medicine and Science in Sports and Exercise., 36(7), 1196-1201.
Chen, D., Elmendorf, J. S., Olson, A. L., Li, X., Earp, H. S., & Pessin, J. E. (1997). Osmotic Shock Stimulates GLUT4 Translocation in 3T3L1 Adipocytes by a Novel Tyrosine Kinase Pathway. The Journal of Biological Chemistry., 272(43), 27401-27410.
Church, T. S., Earnest, C. P., Skinner, J. S., & Blair, S. N. (2007). Effects of Different Doses of Physical Activity on Cardiorespiratory Fitness Among Sedentary, Overweight or Obese Postmenopausal Women With Elevated Blood Pressure: A Randomized Controlled Trial. Journal of the American Medical Association., 297(19), 2081-2091.
Dandona, P., Aljada, A., & Bandyopadhyay, A. (2004). Inflammation: the link between insulin resistance, obesity and diabetes. Trends in Immunology, 25(1), 4-7.
DeFronzo, R. A. (1988). Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes, 37(6), 667-687.
Eckel, R. H., Grundy, S. M., & Zimmet, P. Z. (2005). The metabolic syndrome. The Lancet, 365(9468), 1415-1428.
Esposito, K., Giugliano, F., Di Palo, C., Giugliano, G., Marfella, R., D'Andrea, F., et al. (2004). Effect of Lifestyle Changes on Erectile Dysfunction in Obese Men: A Randomized Controlled Trial. Journal of the American Medical Association., 291(24), 2978-2984.
Esposito, K., Pontillo, A., Di Palo, C., Giugliano, G., Masella, M., Marfella, R., et al. (2003). Effect of Weight Loss and Lifestyle Changes on Vascular Inflammatory Markers in Obese Women: A Randomized Trial. Journal of the American Medical Association., 289(14), 1799-1804.
Farese, R. V., Sajan, M. P., & Standaert, M. L. (2005). Insulin-Sensitive Protein Kinases (Atypical Protein Kinase C and Protein Kinase B/Akt): Actions and Defects in Obesity and Type II Diabetes. Experimental Biology and Medicine, 230(9), 593-605.
Ferrara, C. M., Goldberg, A. P., Ortmeyer, H. K., & Ryan, A. S. (2006). Effects of Aerobic and Resistive Exercise Training on Glucose Disposal and Skeletal Muscle Metabolism in Older Men. The journals of gerontology. Series A, Biological Sciences and Medical Sciences., 61(5), 480-487.
Fontbonne, A., Eschwège, E., Cambien, F., Richard, J. L., Ducimetière, P., Thibult, N., et al. (1989). Hypertriglyceridaemia as a risk factor of coronary heart disease mortality in subjects with impaired glucose tolerance or diabetes. Results from the 11-year follow-up of the Paris Prospective Study. Diabetologia., 32(5), 300-304.
Frosig, C., Jorgensen, S. B., Hardie, D. G., Richter, E. A., & Wojtaszewski, J. F. P. (2004). 5'-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscle. Am J Physiol Endocrinol Metab, 286(3), E411-417.
Ginsberg, H. N. (2000). Insulin resistance and cardiovascular disease. The Journal of Clinical Investigation., 106(4), 453-458.
Goldstein, D. J. (1992). Beneficial health effects of modest weight loss. International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity., 16(6), 397-415.
Greenberg, A. S., & Obin, M. S. (2006). Obesity and the role of adipose tissue in inflammation and metabolism. The American Journal of Clinical Nutrition, 83(2), 461S-465S.
Grundy, S. M., Brewer, H. B., Jr., Cleeman, J. I., Smith, S. C., Jr., Lenfant, C., & for the Conference, P. (2004). Definition of Metabolic Syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition. Circulation, 109(3), 433-438.
Harris, M. I., Flegal, K. M., & Cowie, C. C. (1998). Prevalence of diabetes, impaired fasting glucose and impaired glucose tolerance in US adults. Diabetes Care, 21, 518-524.
Hawley, S. A., Pan, D. A., Mustard, K. J., Ross, L., Bain, J., Edelman, A. M., et al. (2005). Calmodulin-dependent protein kinase kinase-[beta] is an alternative upstream kinase for AMP-activated protein kinase. Cell Metabolism, 2(1), 9.
He, J., Goodpaster, B. H., & Kelley, D. E. (2004). Effects of Weight Loss and Physical Activity on Muscle Lipid Content and Droplet Size. Obesity Research., 12(5), 761-769.
Henry, R. R., & Mudaliar, S. (2003). Obesity and TypeⅡ Diabetes Mellitus. In R. H. Eckel (Ed.), Obesity Mechanisms and Clinical Management (pp. 229-272). Philadelphia, USA: Lippincott William & Wilkins.
Holloszy, J. O. (2005). Exercise-induced increase in muscle insulin sensitivity. Journal of Applied Physiology., 99(1), 338-343.
Houmard, J. A., Tanner, C. J., Yu, C., Cunningham, P. G., Pories, W. J., MacDonald, K. G., et al. (2002). Effect of Weight Loss on Insulin Sensitivity and Intramuscular Long-Chain Fatty Acyl-CoAs in Morbidly Obese Subjects. Diabetes, 51(10), 2959-2963.
Hrebicek, J., Janout, V., Malincikova, J., Horakova, D., & Cizek, L. (2002). Detection of Insulin Resistance by Simple Quantitative Insulin Sensitivity Check Index QUICKI for Epidemiological Assessment and Prevention. American Journal of Physiology. Endocrinology and Metabolism., 87(1), 144-.
Itoh, K., Imai, K., Masuda, T., Abe, S., Tanaka, M., Koga, R., et al. (2002). Relationship between changes in serum leptin levels and blood pressure after weight loss. Hypertension Research : Official Journal of the Japanese Society of Hypertension., 25, 881-886.
Ivy, J. L. (2004). Muscle insulin resistance amended with exercise training: role of GLUT4 expression. Medicine and Science in Sports and Exercise, 36(7), 1207-1211.
Jennings, G., Deakin, G., Korner, P., Meredith, I., Kingwell, B., & Nelson, L. (1991). What is the dose-response relationship between exercise training and blood pressure? Annals of Medicine., 23(3), 313-318.
Kahn, C. R., CHhen, L., & Cohen, S. E. (2000). Unraveling the mechanism of action of thiazolidinediones. The Journal of Clinical Investigation., 106, 1305-1307.
Kannel, W. B., D'Agostino, R. B., & Cobb, J. L. (1996). Effect of weight on cardiovascular disease. The American Journal of Clinical Nutrition, 63(3 Suppl), 419S-422S.
Kasuga, M. (2006). Insulin resistance and pancreatic {beta} cell failure. The Journal of Clinical Investigation., 116(7), 1756-1760.
Katz, A., Nambi, S. S., Mather, K., Baron, A. D., Follmann, D. A., Sullivan, G., et al. (2000). Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans. American Journal of Physiology. Endocrinology and Metabolism., 85(7), 2402-2410.
Kendall, D. M., & Harmel, A. P. (2002). The metabolic syndrome, type 2 diabetes, and cardiovascular disease: Understanding the role of insulin resistance. American Journal Of Managed Care, 8(20), S635-S653.
Kopp, H. P., Kopp, C. W., Festa, A., Krzyzanowska, K., Kriwanek, S., Minar, E., et al. (2003). Impact of Weight Loss on Inflammatory Proteins and Their Association With the Insulin Resistance Syndrome in Morbidly Obese Patients. Arteriosclerosis, Thrombosis, and Vascular Biology., 23(6), 1042-1047.
Kosaka, K., Noda, M., & Kuzuya, T. (2005). Prevention of type 2 diabetes by lifestyle intervention: a Japanese trial in IGT males. . Diabetes Research and Clinical Practice, 67(2), 152-162.
Krook, A., Wallberg-Henriksson, H., & Zierath, J. (2004). Sending the Signal: Molecular Mechanisms Regulating Glucose Uptake. Medicine and Science in Sports and Exercise, 36(7), 1212-1217.
Kubota, N., Tobe, K., Terauchi, Y., Eto, K., Yamauchi, T., Suzuki, R., et al. (2000). Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. Diabetes, 49(11), 1880-1889.
Long, Y. C., & Zierath, J. R. (2006). AMP-activated protein kinase signaling in metabolic regulation. Journal of Clinical Investigation, 116(7), 1776-1783.
Mahler, D. A., Froelicher, V. F., Miller, N. H., & York, T. D. (1995). ACSM's Guidelines for Exercise Testing and Prescription (5th ed.): American College of Sports Medicine.
McAuley, K. A., Williams, S. M., Mann, J. I., Walker, R. J., Lewis-Barned, N. J., Temple, L. A., et al. (2001). Diagnosing Insulin Resistance in the General Population. Diabetes Care, 24(3), 460-464.
McCarron, D. A., & Reusser, M. E. (1996). Body weight and blood pressure regulation. The American Journal of Clinical Nutrition, 63(3 Suppl), 423S-425S.
McFarlane, S. I., Banerji, M., & Sowers, J. R. (2001). Insulin Resistance and Cardiovascular Disease. The Journal of Clinical Endocrinology and Metabolism., 86(2), 713-718.
Menshikova, E. V., Ritov, V. B., Toledo, F. G. S., Ferrell, R. E., Goodpaster, B. H., & Kelley, D. E. (2005). Effects of weight loss and physical activity on skeletal muscle mitochondrial function in obesity. American journal of physiology. Endocrinology and Metabolism., 288(4), E818-825.
Mu, J., Brozinick, J. J. T., Valladares, O., Bucan, M., & Birnbaum, M. J. (2001). A Role for AMP-Activated Protein Kinase in Contraction- and Hypoxia-Regulated Glucose Transport in Skeletal Muscle. Molecular Cell, 7(5), 1085.
Murphy, M., Murtagh, E., Boreham, C., Hare, L., & Nevill, A. (2006). The effect of a worksite based walking programme on cardiovascular risk in previously sedentary civil servants [NCT00284479]. BMC Public Health, 6(1), 136.
Orchard, T. J., Temprosa, M., Goldberg, R., Haffner, S., Ratner, R., Marcovina, S., et al. (2005). The Effect of Metformin and Intensive Lifestyle Intervention on the Metabolic Syndrome: The Diabetes Prevention Program Randomized Trial. Annals of Internal Medicine., 142(8), 611-619.
Pessin, J. E., & Saltiel, A. R. (2000). Signaling pathways in insulin action: molecular targets of insulin resistance. The Journal of Clinical inVestigation., 106(2), 165-169.
Pi-Sunyer, F. X., & Maggio, C. A. (1997). The prevention and treatment of obesity :application to type Ⅱ diabetes. Diabetes care, 20, 744-766.
Reaven, G. M. (1988). Banting lecture 1988. Role of insulin resistance in human disease. Diabetes, 37(12), 1595-1607.
Recasens, M., Ricart, W., & Fernandez-Real, J. (2004). Obesity and inflammation. Revista de Medicina de la Universidad de Navarra., 48(2), 49-54.
Rector, R. S., Warner, S. O., Liu, Y., Hinton, P. S., Sun, G., Cox, R. H., et al. (2007). Exercise and diet induced weight loss improves measures of oxidative stress and insulin sensitivity in adults with characteristics of the metabolic syndrome. American Journal of Physiology. Endocrinology and Metabolism., 00116.02007.
Saltiel, A. R. (2000). Series Introduction: The molecular and physiological basis of insulin resistance: emerging implications for metabolic and cardiovascular diseases. The Journal of Clinical Investigation., 106(2), 163-164.
Sesti, G., Federici, M., Hribal, M. L., Lauro, D., Sbraccia, P., & Lauro, R. (2001). Defects of the insulin receptor substrate (IRS) system in human metabolic disorders. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology., 15(12), 2099-2111.
Shoelson, S. E., Lee, J., & Goldfine, A. B. (2006). Inflammation and insulin resistance. The Journal of Clinical Investigation., 116(7), 1793-1801.
Short, K. R., Vittone, J. L., Bigelow, M. L., Proctor, D. N., Rizza, R. A., Coenen-Schimke, J. M., et al. (2003). Impact of Aerobic Exercise Training on Age-Related Changes in Insulin Sensitivity and Muscle Oxidative Capacity. Diabetes, 52(8), 1888-1896.
Summerfield, L. M. (2001). Nutrition, Exercise, and Behavior : an Integrated Approach to Weight Management. USA: Wadsworth/Thomson Learning.
Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report. (2002). Circulation, 106(25), 3143-3421.
Toledo, F. G. S., Menshikova, E. V., Ritov, V. B., Azuma, K., Radikova, Z., DeLany, J., et al. (2007). Effects of Physical Activity and Weight Loss on Skeletal Muscle Mitochondria and Relationship With Glucose Control in Type 2 Diabetes. Diabetes, 56(8), 2142-2147.
Uusitupa, M., Lindi, V., Louheranta, A., Salopuro, T., Lindstrom, J., & Tuomilehto, J. (2003). Long-Term Improvement in Insulin Sensitivity by Changing Lifestyles of People with Impaired Glucose Tolerance: 4-Year Results From the Finnish Diabetes Prevention Study. Diabetes, 52(10), 2532-2538.
Vogel, S., Mendelsohn, C. L., Mertz, J. R., Piantedosi, R., Waldburger, C., Gottesman, M. E., et al. (2001). Characterization of a New Member of the Fatty Acid-binding Protein Family That Binds All-trans-retinol. The Journal of Biological Chemistry., 276(2), 1353-1360.
Weiss, E. P., Racette, S. B., Villareal, D. T., Fontana, L., Steger-May, K., Schechtman, K. B., et al. (2006). Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial. The American Journal of Clinical Nutrition, 84(5), 1033-1042.
Widegren, U., Jiang, X. J., Krook, A., Chibalin, A. V., Bjornholm, M., Tally, M., et al. (1998). Divergent effects of exercise on metabolic and mitogenic signaling pathways in human skeletal muscle. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology., 12(13), 1379-1389.
Yu, M., Blomstrand, E., Chibalin, A. V., Wallberg-Henriksson, H., Zierath, J. R., & Krook, A. (2001). Exercise-associated differences in an array of proteins involved in signal transduction and glucose transport. Journal of Applied Physiology., 90(1), 29-34.
Yu, M., Stepto, N. K., Chibalin, A. V., Fryer, L. G. D., Carling, D., Krook, A., et al. (2003). Metabolic and mitogenic signal transduction in human skeletal muscle after intense cycling exercise. The Journal of Physiology., 546(2), 327-335.
Zhang, F., Lavan, B. E., & Gregoire, F. M. (2007). Selective Modulators of PPAR-γ Activity: Molecular Aspects Related to Obesity and Side-Effects. PPAR Research, 32696.
Zierath, J. R., A.Krook2, & H.Wallberg-Henriksson2. (2000). Insulin action and insulin resistance in human skeletal muscle. Diabetologia, 43, 821-835.
Zimmet, P. Z., Alberti, K. G., & Shaw, J. E. (2005 ). Mainstreaming the metabolic syndrome: a definitive definition. This new definition should assist both researchers and clinicians. The Medical Journal of Australia., 183(4), 175-176.
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top
系統版面圖檔 系統版面圖檔