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研究生:柯耀笎
研究生(外文):Yao Yuan Ko
論文名稱:安默西林在黑鯛體內殘留及對非特異性免疫反應之影響
論文名稱(外文):The effect of amoxicillin on tissue distribution and non-specific immune responses in black seabream (Acanthopagrus schlegelii).
指導教授:冉繁華冉繁華引用關係
指導教授(外文):Fan-Hua Nan
學位類別:碩士
校院名稱:國立臺灣海洋大學
系所名稱:水產養殖學系
學門:農業科學學門
學類:漁業學類
論文種類:學術論文
論文出版年:2008
畢業學年度:96
語文別:中文
論文頁數:72
中文關鍵詞:黑鯛安默西林藥物殘留非特異性免疫
外文關鍵詞:black seabreamamoxicillindistributionnon-specific immune
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本論文的研究目的係以安默西林(amoxicillin)注射黑鯛(Acanthopagrus schlegelii),觀察注射安默西林後不同時間點下黑鯛血漿、肌肉及肝臟組織中殘留情形,並觀察安默西林是否對黑鯛白血球的超氧陰離子、化學發光反應、吞噬率、吞噬指數及血清中白蛋白、球蛋白及白蛋白-球蛋白等非特異性免疫反應有所影響。
結果顯示,安默西林在黑鯛血漿及肝臟樣品中的最大殘留濃度皆出現在注射後第1小時(第一個採樣點) ,濃度分別為82.53 μg/ml、34.20 μg/g,隨後殘留濃度皆隨著時間增加而降低。安默西林在黑鯛肌肉樣品中的殘留濃度亦隨時間增加而增加,注射後第4小時達最大殘留,濃度為2.99μg/g,隨後殘留濃度隨時間增加而降低。安默西林在三種樣品中殘留濃度減少的量依序為血漿>肝臟>肌肉。黑鯛血漿中安默西林殘留濃度數據符合藥物動力學二室模式,以雙指數方程式計算(C = Ae-αt+Be-βt),可得一方程式表示C = 94.15e-0.24t+8.76e-0.07t,k12、k21、kel分別為0.03、0.08、0.21 (h-1),根據藥物動力學各項參數,推測大部份amoxicillin在中央室已排除,並未進入周圍室。非特異性免疫方面,黑鯛經注射安默西林後,黑鯛白血球超氧陰離子、化學發光反應、吞噬率、吞噬指數皆明顯受到抑制,黑鯛血清中白蛋白-球蛋白比數值亦無顯著差異,但白蛋白、球蛋白數值則皆有下降的趨勢。
Abstract

The prupose of this study was investigated blood, muscle and liver tissue distribution in the black seabream (Acanthopagrus schlegelii) after a single injection of amoxicillin. And investigated the effect on non-specific immune parameters such as superoxide anion (O2-), chemiluminescent response, phagocytic rate, phagocytic indexs, albumin, globulin and albumin / globulin ratio (A/G ratio).
The result in experiment showed that the blood and liver tissues were found peak concentrations of amoxicillin occurring at 1 h after single injection (first sampling time) and amoxicillin residual concentrations decresed as time passed. The peak concentrations of blood and liver tissues were 82.53 μg/ml, 34.20 μg/g respectively. The amoxicillin residual concentrations in muscle tissues was added as time passed and peak concentrations of amoxicillin occurring at 4 h after single injection. The peak concentrations of muscle tissues was 2.99 μg/g. Then the amoxicillin residual concentrations in muscle tissues was decresed as time passed. Amoxicillin tissue concentrations decreased in the order blood, liver, muscle. The date conformed to a two-compartment model. The blood concentrations versus time curves were calculated using the biexponential equation : C = Ae-αt+Be-βt, get a biexponential equation : C = 94.15e-0.24t+8.76e-0.07t, k12=0.03,k21=0.08,kel =0.21 (h-1). According to pharmacokinetic parameters of amoxicillin in black seabream calculate that most amoxicillin were eliminate from central compartment,not distributed to the peripheral compartment. The result in experiment showed that the superoxide anion production, chemiluminescent response, phagocytic rate, phagocytic indexs were suppress by amoxicillin. The result also showed that albumin / globulin ratio were no significance, but the albumin and globulin level were decreased.
目錄
頁次
謝辭----------------------------------------------i
中文摘要------------------------------------------ii
英文摘要------------------------------------------iii
目錄----------------------------------------------v
表目錄--------------------------------------------vi
圖目錄--------------------------------------------viii
前言----------------------------------------------1
文獻整理-------------------------------------------3
材料方法------------------------------------------14
結果----------------------------------------------21
討論----------------------------------------------35
結論----------------------------------------------44
參考文獻------------------------------------------46
附錄----------------------------------------------71
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