(3.236.214.19) 您好!臺灣時間:2021/05/09 23:16
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果

詳目顯示:::

我願授權國圖
: 
twitterline
研究生:楊智翔
研究生(外文):Jr-shiang Yang
論文名稱:點帶石斑魚抗病毒基因viperin分子選殖及其特性分析
論文名稱(外文):Molecular cloning and characterization of viperin gene in orange-spotted grouper (Epinephelus coioides)
指導教授:陸振岡
指導教授(外文):Jenn-Kan Lu
學位類別:碩士
校院名稱:國立臺灣海洋大學
系所名稱:水產養殖學系
學門:農業科學學門
學類:漁業學類
論文種類:學術論文
論文出版年:2008
畢業學年度:96
語文別:中文
論文頁數:129
中文關鍵詞:點帶石斑抗病毒基因先天性免疫中草藥神經壞死病毒
外文關鍵詞:viperinPoly I:CLPSpeptidoglycanbeta-13-glucan
相關次數:
  • 被引用被引用:5
  • 點閱點閱:299
  • 評分評分:系統版面圖檔系統版面圖檔系統版面圖檔系統版面圖檔系統版面圖檔
  • 下載下載:0
  • 收藏至我的研究室書目清單書目收藏:1
石斑魚為一種高經濟養殖魚種,但由於近年來病毒性疾病爆發,造成經濟上大規模損失,石斑魚的疾病防治成了一個重要的議題。Viperin基因為一個先天性免疫因子,可被不同形式干擾素與病毒所誘導表現且被證實具有抗病毒之活性。本研究目的是以分子生物學技術研究點帶石斑魚viperin基因生化特性及其抗病毒活性。利用已發表之其他物種viperin核酸與胺基酸序列,設計退化性引子。以點帶石斑頭腎之mRNA使用RT-PCR及RACE方法選殖出viperin基因序列,其全長為1367個核?酸,可轉譯出361個胺基酸。經由即時定量聚合?連鎖反應分析viperin基因各組織表現量,結果顯示點帶石斑viperin基因廣泛地表現於各組織當中,其中又以頭腎與脾臟的表現量為最高。注射Poly I:C後viperin基因在眼睛、腦與脾臟中表現量均有顯著增加,且均隨著時間增加而增加表現量;注射免疫刺激物LPS後,viperin基因表現量在鰓、頭腎與脾臟中均有顯著增加,且均隨著時間增加而增加表現量。而當點帶石斑感染神經壞死病毒 (NNV) 後,血液、腦、鰓、頭腎、脾臟、眼睛、鰭與心臟等組織中viperin基因表現量皆較未感染魚隻的來得高,且以血液與腦組織的表現量為最高。在點帶石斑魚苗發育時期中viperin基因表現量在2.3吋時期的表現量較石斑魚苗2吋的表現量來得高,顯示內生型免疫系統在2吋前的石斑魚苗中不完全發育。以其他免疫刺激物進行注射,發現魚苗時期viperin基因可被peptidoglycan所誘導;而中草藥處理實驗中則發現,甘草、金銀花、魚腥草可誘導viperin基因表現。抗病毒能力實驗中發現,甘草處理組可以增加經神經壞死病毒感染後魚苗之活存率。
Grouper is one of the most important aquacultured fish in Taiwan and disease prevention is a vital issue to grouper culturing as infectious viral diseases had caused great damages in grouper aquaculture. It has been demonstrated that viperin can be induced by type-I/II interferon and viruses, its antiviral activities also be proved. The goal of present study is cloning and characterization of viperin gene in orange-spotted grouper (Epinephelus coioides) and study its antiviral activity. A degenerated primers were designed base on known viperin amino acid and nucleic acids sequences. A full length grouper viperin gene cDNA is isolated from head kidney by using RT-PCR and 5’ and 3’ RACE techniques. Viperin gene cDNA consists of 1367 base pairs and can be deduced into 361 amino acids. Viperin gene mRNA was detected in multiple tissues, and highest mRNA level was detected in head kidney and spleen. Furthermore, dsRNA Poly I:C injections can induce viperin gene expression in eye, brain and spleen tissues of grouper, and with a time effect manner. Microbial LPS injections also can induce viperin gene expression in gill, spleen and head kidney tissues of grouper, and with a time effect manner. After infecting with NNV, higher expression level of viperin gene were detected in gill, head kidney, spleen, eye, fin and heart tissues, the highest level of viperin mRNA was detected in blood and brain. During grouper larval development stages, the viperin mRNA was increased significantly after the stage of 2.3 inch in length. Viperin gene expression arose significantly by injection of peptidoglycan and also by Chinese herbs treatment such as Glycyrrhiza glabra, Lonicera japonica and Houttuynia cordata. The result of NNV challenge test indicated that Glycyrrhiza glabra treatment could improve the survival rate of orange-spotted grouper following NNV infections.
目錄
謝辭 ................................................... i
中文摘要 ................................................ iii
英文摘要 ................................................ iv
目錄 .................................................... v
表目錄 .................................................. ix
圖目錄 .................................................. x
壹、前言 ................................................ 1
1、石斑魚介紹與養殖概況 ............................... 1
2、石斑魚病毒性疾病 ................................... 3
3、魚類免疫系統 ...................................... 4
4、viperin 基因特性及其特性分析........................ 10
5、viperin 基因其抗病毒與抗病毒機制..................... 11
6、營養基因體學 (nutrigenomics) ...................... 12
7、中草藥抗病特性簡述.................................. 13
8、本研究之目標 ...................................... 15
貳、實驗材料 ............................................. 18
參、實驗方法 ............................................. 19
一、點帶石斑viperin 基因cDNA 選殖...................... 19
二、點帶石斑viperin 基因全長cDNA 之選殖................. 27
三、點帶石斑viperin 基因在各組織間之表現模式
(expression pattern) ............................. 32
四、注射不同濃度之Poly I:C 下,點帶石斑魚viperin 基因
之表現模式 (expression pattern) .................. 35
五、注射Poly I:C 後,不同時間點下點帶石斑魚viperin 基
因之表現模式 (expression pattern) ................ 36
六、注射不同濃度之LPS (Lipopolysaccharide) 下,點帶石
斑魚viperin 基因之表現模式(expression pattern) .... 37
七、注射LPS (Lipopolysaccharide) 後,不同時間點下點帶
石斑魚viperin 基因之表現模式 (expression pattern) . 37
八、注射神經壞死病毒 (NNV) 後,點帶石斑魚viperin 基
因各組織間之表現模式 (expression pattern) ......... 38
九、不同發育時期點帶石斑魚viperin 基因之表現模式
(expression pattern) ............................. 42
十、不同免疫刺激物在不同時間點下,對於點帶石斑魚苗
viperin 基因之表現模式 (expression pattern) ....... 42
十一、以中草藥做為免疫刺激物,不同時間點下對於點帶
石斑魚viperin 基因之表現模式 (expression pattern).. 43
十二、免疫刺激物與中草藥對viperin 基因表現及抗神經壞
死病毒能力之影響 ................................. 44
肆、結果 ................................................ 45
一、分子選殖點帶石斑viperin cDNA 全長及與其他物種之
比對 ............................................ 45
二、分析點帶石斑魚viperin 蛋白質2、3-D 結構 ............ 46
三、viperin 基因在點帶石斑魚各組織之表現情形 ............ 47
四、注射不同濃度之Poly I:C 誘導點帶石斑魚viperin 基因
表現量 ........................................... 47
五、點帶石斑魚viperin 基因在Poly I:C 誘導下不同時間點
的表現量 ......................................... 47
六、注射不同濃度之LPS (Lipopolysaccharide) 誘導點帶石
斑魚viperin 基因表現量 ............................ 48
七、點帶石斑魚viperin 基因在LPS (Lipopolysaccharide) 誘
導下不同時間點的表現量 ............................. 49
八、點帶石斑魚受到神經壞死病毒 (NNV) 病毒感染下,
viperin 基因在各組織之表現模式 ..................... 49
九、點帶石斑魚發育各時期viperin 基因表現 ............... 49
十、利用四種常見免疫刺激物誘導點帶石斑魚苗viperin
基因之表現 ....................................... 50
十一、浸泡常見抗病之中草藥,誘導點帶石斑魚viperin
基因表現量 ....................................... 50
十二、免疫刺激物與中草藥對viperin 基因表現及抗神經壞
死病毒能力之影響 .................................. 51
伍、討論 ................................................ 52
一、分子選殖點帶石斑魚viperin cDNA 全長及與其他物種
之比對 ........................................... 52
二、分析點帶石斑魚viperin 蛋白質2、3-D 結構 ............ 52
三、viperin 基因在點帶石斑魚各組織之表現情形 ............ 54
四、注射不同濃度之Poly I:C 誘導點帶石斑魚viperin 基因
表現量 ........................................... 55
五、點帶石斑魚viperin 基因在Poly I:C 誘導下不同時間點
的表現量 ..........................................56
六、注射不同濃度之LPS (Lipopolysaccharide) 誘導點帶石
斑魚viperin 基因表現量 ............................ 57
七、點帶石斑魚viperin 基因在LPS (Lipopolysaccharide) 誘
導下不同時間點的表現量 ............................. 57
八、點帶石斑魚受到神經壞死病毒病毒 (NNV) 誘導下,
viperin 基因在各組織之表現模式 ..................... 58
九、點帶石斑魚發育各時期viperin 基因表現 ............... 60
十、利用四種常見免疫刺激物誘導點帶石斑魚苗viperin
基因之表現 ....................................... 61
十一、浸泡常見抗病毒之中草藥,誘導點帶石斑魚viperin
基因表現量 ....................................... 62
十二、免疫刺激物與中草藥對viperin 基因表現及抗神經壞
死病毒能力之影響 .................................. 64
陸、參考文獻 ............................................. 67
圖表 .................................................... 79
附錄 ................................................... 110
行政院農業委員會漁業署。2007。民國95年 (2006年) 漁業年報。
網址:http://www.fa.gov.tw/chn/statistics_price/year_book/2006yb.php。
2008-08-02
王志玉。1996。大黃醇提液的抗?疹病毒作用。中國中藥雜誌21卷6期。
364頁。
王長雲,管華詩。2000。多糖抗病毒作用研究進展Ⅱ,硫酸多糖抗病
毒作用。生物工程進展20卷2期。3∼7頁。
王長雲,管華詩。2000。多糖抗病毒作用研究進展Ⅲ,卡拉膠及其抗
病毒作用。生物工程進展20卷3期。39∼42頁。
王俊傑。2002。海鱺rag-1與Ig基因之選殖及其在發育過程之表現。碩
士論文。國立成功大學生物科技研究所。
石鉞,石任兵,劉斌。2001。銀翹散抗流感病毒有效部位群中黃酮類
成分研究。中國中藥雜誌26卷5期。320~323頁。
石學魁,王雅賢,張曉莉,唐小雲。2004。芍葯甘草湯免疫學研究。
牡丹江醫學院學報2期。32∼34頁。
李劍勇,趙榮林,孟憲松。1999。中草藥誘生干擾素的研究進展。中
獸醫醫藥雜誌3卷。16∼18頁。
李家實。2002。中藥鑒定學。上海科學技術出版社。
李檸。1988。篩選抗病毒中草藥的研究。中獸醫醫藥雜誌3卷。6∼9期。
李鐵民。1994。甘草提取物及其衍生物的抗病毒研究進展。中草藥25
卷12期。655∼657頁。
何立巍、李祥、陳建偉。2005。板藍根抗病毒有效成分研究進展。中
醫藥資訊22卷。34∼40頁。
邱子庭。2006。草蝦抗菌?之?究。博士論文。國立臺灣海洋大學水
產養殖研究所。
68
吳明峰。2001。石斑魚虹彩病毒之分子特性及其疫苗之開發。碩士論
文。國立臺灣大學獸醫學研究所。
周靚。1997。多糖及其衍生物抗病毒作用研究進展。應用與環境生物
學報3卷1期。82∼90頁。
周凱雯。2006。重組免疫球蛋白IgM重鏈恆定區之表現、純化及其抗體
之製造。碩士論文。國立臺灣海洋大學水產養殖研究所。
孫考祥。2001。氯原酸體外抗病毒作用研究。哈爾濱醫科大學學報35
卷6期。430∼432頁。
姜宏,聞良珍。1999。中藥「熱毒清」對人巨細胞病毒抑製作用的實
驗與臨床研究。中華實驗和臨床病毒學雜誌13卷2期。175∼179頁。
殷平善。2006。黃耆的臨床應用及其藥理中的整體系統思維。時珍國
醫國藥17卷。1313∼1315頁。
柳紀省,王超英,白銀梅。1998。黃?等10種天然藥物對雛雞ND-HI
抗體效價免疫器官係數及增重的影響。中國獸醫科技28卷12期。
30∼32頁。
范瑞強,李紅霞。2001。中藥抗病毒膠囊對豚鼠生殖器?疹模型神經
節及大腦影響的電鏡和定量PCR研究。嶺南皮膚性病科雜誌8卷1
期。8∼11頁。
陳冠民。2008。神經壞死病毒及各種免疫誘發因子對於石斑魚內生型
免疫基因調控之影響。碩士論文。國立臺灣海洋大學水產養殖研
究所。
張月昔,劉樂光。2002。草藥飼料添加劑應用及機制研究概述。山東
家禽。10卷。40∼41頁。
張信之。1999。病毒世界:現代分子病毒學大綱。藝軒圖書公司。
張喜平,李宗芳。2001。黃芩素的藥理學研究概況。中國藥理學通報
17卷6期。711∼713頁。
張壓西。2005。復方甘草酸?治療慢性乙型肝炎的臨床療效及抗病毒
作用觀察。傳染病信息18卷2期。89頁。
許樹銀。2001。臨床用藥精要。北京:人民衛生出版社。
69
黃貴民。1999。實用石斑魚養殖。水產出版社。1∼89頁。
黃淑敏。2006。臺灣石斑魚虹彩病毒基因分型。行政院農業委員會家
畜衛生試驗所。第734次研討會。
楊子峰、黃碧松、劉妮、王艷芳、朱宇同。2005。銀翹散抗甲1型流感
病毒作用的實驗研究。中國熱帶醫學05卷。1423∼1425頁。
鄭敏,陳鴻珊。1998。中草藥及其有效成分抗病毒研究進展。中草藥
29卷9期。631∼634頁。
賴政宏。2006。龍膽石斑魚內生型免疫因子Mx與抗菌?基因分子選殖
及對於不同免疫誘發因子表現之影響。碩士論文。國立臺灣海洋
大學水產養殖研究所。
顧靜蓉、馮莉莉、羅建偉、毛慶秋。2006。魚腥草的藥理作用及臨床
應用新進展。海峽藥學18卷。121∼123頁。
蘆緒芳。2006。金銀花的研究現狀。時珍國醫國藥17卷。843∼844頁。
Abel, G., Czop, J.K., 1992. Stimulation of human monocyte beta-glucan receptors by
glucan particles induces production of TNF-alpha and IL-1 beta. International
journal of immunopharmacology. 14, 1363-1373.
Altmann, S.M., Mellon, M.T., Distel, D.L., Kim, C.H., 2003. Molecular and functional
analysis of an interferon gene from the zebrafish, Danio rerio. Journal of Virology.
77, 1992-2002.
Andrew C. Oates, Patrik Wollberg, Stephen J., Pratt Barry H., Paw Stephen L.,
Johnson Robert K., Ho John H., Postlethwait Leonard I., Zon Andrew F., Wilks,
1999. Zebrafish stat3 is expressed in restricted tissues during embryogenesis and
stat1 rescues cytokine signaling in a STAT1-deficient human cell line.
Developmental dynamics : an official publication of the American Association of
Anatomists. 215, 352-370.
Bach, E., Aguet, M., Schreiber, R., 1997. The IFNγ receptor: a paradigm for cytokine
receptor signaling. Annual Review of Immunology. 15, 563-591.
Ball, L.A., 1997. Nodavirus RNA recombination. Seminar in Virology. 8,95-100.
Bass, B.L., 1997. RNA editing and hypermutation by adenosine deamination. Trends
in biochemical sciences. 22, 157-162.
Bass, B.L., Nishikura, K., Keller, W., Seeburg, P.H., Emeson, R.B., O'Connell, M.A.,
Samuel, C.E., Herbert, A., 1997. A standardized nomenclature for adenosine
deaminases that act on RNA. RNA. 3, 947-949.
Bilodeau-Bourgeois, L., Bosworth, B.G., Peterson, B.C., 2008. Differences in
mortality, growth, lysozyme, and toll-like receptor gene expression among
70
genetic groups of catfish exposed to virulent Edwardsiella ictaluri. Fish &
shellfish immunology. 24, 82-89.
Bilodeau, A.L., Waldbieser, G.C., 2005. Activation of TLR3 and TLR5 in channel
catfish exposed to virulent Edwardsiella ictaluri. Developmental and comparative
immunology. 29, 713-721.
Blazer, V.S., 1991. Piscine Macrophage Function and Nutritional Influences: A
Review. Journal of Aquatic Animal Health. 3, 523-534.
Bloch, B., Gravningen, K., Larsen, J.L., 1991. Encephalomyelitis among turbot
associated with a picornavirus-like agent. Diseases of Aquatic organisms. 10,
65-70.
Boehm, U., Klamp, T., Groot, M., Howard, J.C., 1997. Cellular responses to
interferon-γ. Annual Review of Immunology. 15, 749-95.
Boudinot, P., Massin, P., Blanco, M., Riffault, S., Benmansour, A., 1999. vig-1, a new
fish gene induced by the rhabdovirus glycoprotein, has a virus-induced
homologue in humans and shares conserved motifs with the MoaA family.
Journal of virology. 73, 1846-1852.
Bruce, T., John N., B., Robert W., K., 1986. Astrocytes Produce Interferon That
Enhances the Expression of H-2 Antigens on a Subpopulation of Brain Cells. The
Journal of Cell Biology. 102, 2244-2253.
Chebath, J., Benech, P., Revel, M., Vigneron, M., 1987. Constitutive expression of
(2'–5') oligo A synthetase confers resistance to picornavirus infection. Nature. 330,
587 - 588.
Chi, S.C., Lo, C.F., Kou, G.H., Chang, P.S., Peng, S.E., Chen, S.N., 1997. Detection of
nervous necrosis virus (NNV) in the eggs, larvae and juveniles of the
hatchery-reared groupers, Epinephelus fuscugutatus and Epinepphelus akaara
(Temminck & Schlegel) by polymerase chain reaction. Methodology in Fish
Disease Research. 259-264.
Chin, K.C., Cresswell, P., 2001. Viperin (cig5), an IFN-inducible antiviral protein
directly induced by human cytomegalovirus. Proceedings of the National
Academy of Sciences of the United States of America. 98, 15125-15130.
Chou, H.Y., Hsu, C.C., Peng, T.Y., 1998. Isolation and characterization of a
pathogenic iridovirus from cultured grouper (Epinphelus sp.) in taiwan. Fish
Pathology. 33, 201-206.
Cinatl, J., Morgenstern, B., Bauer, G., Chandra, P., Rabenau, H., Doerr, H.W., 2003a.
Glycyrrhizin, an active component of liquorice roots, and replication of
SARS-associated coronavirus. The Lancet. 361, 2045-2046.
Clemens, M.J., Elia, A., 1997. The double-stranded RNA-dependent protein kinase
PKR: structure and function. Journal of interferon & cytokine research. 17,
503-24.
Corripio-Miyar, Y., Bird, S., Treasurer, J.W., Secombes, C.J., 2007. RAG-1 and IgM
71
genes, markers for early development of the immune system in the gadoid
haddock, Melanogrammus aeglefinus, L. Fish & shellfish immunology. 23, 71-85.
Covert, M.W., Leung, T.H., Gaston, J.E., Baltimore, D., 2005. Achieving stability of
lipopolysaccharide-induced NF-kappaB activation. Science. 309, 1854-1857.
Dacanay, A., Bentley, B.E., Brown, L.L., Roberts, A.J., Johnson, S.C., 2006. Unique
multimeric immunoglobulin crosslinking in four species from the family Gadidiae.
Fish & Shellfish Immunology. 21, 215.
Dang, O., Navarro, L., David, M., 2004. Inhibition of lipopolysaccharide-induced
interferon regulatory factor 3 activation and protection from septic shock by
hydroxystilbenes. Shock (Augusta, Ga.). 21, 470-475.
de Kinkelin, P., Dorson, M., 1973. Interferon production in rainbow trout (Salmo
gairdneri) experimentally infected with Egtved virus. The Journal of general
virology. 19, 125-127.
DeWitte-Orr, S.J., Leong, J.A., Bols, N.C., 2007. Induction of antiviral genes, Mx and
vig-1, by dsRNA and Chum salmon reovirus in rainbow trout
monocyte/macrophage and fibroblast cell lines. Fish & Shellfish Immunology. 23,
670-682.
Doolittle, R.F., 1987. The evolution of the vertebrate plasma proteins. The Biological
bulletin. 172, 269-283.
Eisenburg., J., 1992. Treatment of chronic hepatitis B. Part 2: Effect of glycyrrhizic
acid on the course of illness. Fortschritte der Medizin. 110, 395-8.
Fange, R., 1986. Lymphoid organs in sturgeons (Acipenseridae). Veterinary
immunology and immunopathology. 12, 153-161.
Feng, Y., Zhu, T., 1986. Effect of glycyrrhizin on the production of g-interferon (IFN)
from human spleen cells. Zhonghua Weishengwuxue He Mianyixue Zazhi. 6,
99-102.
Floyd-Smith, G., Slattery, E., Lengyel, P., 1981. Interferon action: RNA cleavage
pattern of a (2'-5')oligoadenylate-dependent endonuclease. Science. 212,
1030-1032.
Gale, M., Jr., Tan, S.-L., Katze, M.G., 2000. Translational Control of Viral Gene
Expression in Eukaryotes. Microbiology and molecular biology reviews. 64,
239-280.
Ganz, T., 2003. The Role of Antimicrobial Peptides in Innate Immunity. Integrative
and comparative biology. 43, 300-304.
Graham, S., Secombes, C.J., 1988. The production of a macrophage-activating factor
from rainbow trout Salmo gairdneri leucocytes. Immunology. 65, 293-297.
Hanif, A., Bakopoulos, V., Dimitriadis, G.J., 2004. Maternal transfer of humoral
specific and non-specific immune parameters to sea bream (Sparus aurata) larvae.
Fish & shellfish immunology. 17, 411-435.
72
Hansen, J.D., 1997. Characterization of rainbow trout terminal deoxynucleotidyl
transferase structure and expression. TdT and RAG1 co-expression define the
trout primary lymphoid tissues. Immunogenetics. 46, 367-375.
Hansen, J.D., Kaattari, S.L., 1995. The recombination activation gene 1 (RAG1) of
rainbow trout (Oncorhynchus mykiss): cloning, expression, and phylogenetic
analysis. Immunogenetics. 42, 188-195.
Hansen, J.D., Kaattari, S.L., 1996. The recombination activating gene 2 (RAG2) of the
rainbow trout Oncorhynchus mykiss. Immunogenetics. 44, 203-211.
Hanzelmann, P., Schindelin, H., 2004. Crystal structure of the S-adenosylmethionine
dependent enzyme MoaA and its implications for molybdenum cofactor
deficiency in humans. Proceedings of the National Academy of Sciences of the
United States of America. 101, 12870-12875.
Helbig, K.J., Lau, D.T., Semendric, L., Harley, H.A., Beard, M.R., 2005. Analysis of
ISG expression in chronic hepatitis C identifies viperin as a potential antiviral
effector. Hepatology. 42, 702-710.
Hille, R., 2002. Molybdenum and tungsten in biology. Trends in Biochemical Sciences.
27, 360-367.
Honda, K., Yanai, H., Negishi, H., Asagiri, M., Sato, M., Mizutani, T., Shimada, N.,
Ohba, Y., Takaoka, A., Yoshida, N., Taniguchi, T., 2005. IRF-7 is the master
regulator of type-I interferon-dependent immune responses. Nature. 434, 772.
Hou, Y., Ma, G., Wu, S., 1981. Effect of Radix Astragali seu Hedysari on the
interferon system. Chinese medical journal (English). 94, 35-40.
Hu, C.Y., Zhang, Y.B., Huang, G.P., Zhang, Q.Y., Gui, J.F., 2004. Molecular cloning
and characterisation of a fish PKR-like gene from cultured CAB cells induced by
UV-inactivated virus. Fish & shellfish immunology. 17, 353-366.
Huttenhuis, H.B., Huising, M.O., van der Meulen, T., van Oosterhoud, C.N., Sanchez,
N.A., Taverne-Thiele, A.J., Stroband, H.W., Rombout, J.H., 2005. Rag
expression identifies B and T cell lymphopoietic tissues during the development
of common carp (Cyprinus carpio). Developmental and comparative immunology.
29, 1033-1047.
Jayalakshmi, K., Kumar, S., Masa, T., Gwang, L., Sangdun, C., 2007. Toll-like
receptor signal transduction. Experimental & molecular medicine. 39, 421-438.
Jia, W., Guo, Q., 2007. Cloning and characterization of interferon stimulated genes
Viperin and ISG15, and their promoters from snakehead Channa argus. Progress
in Natural Science. 17, 1425-1435.
Johnson, K., Shapiro-Shelef, M., Tunyaplin, C., Calame, K., 2005. Regulatory events
in early and late B-cell differentiation. Molecular immunology. 42, 749-761.
Just, F.T., Essbauer, S.S., 2001. Characterization of an iridescent virus isolated from
Gryllus bimaculatus (Orthoptera: Gryllidae). Journal of invertebrate pathology. 77,
51-61.
73
Kawai, T., Akira, S., 2006. TLR signaling. Cell death and differentiation. 13, 816-825.
Khaiboullina, S.F., Rizvanov, A.A., Holbrook, M.R., St Jeor, S., 2005. Yellow fever
virus strains Asibi and 17D-204 infect human umbilical cord endothelial cells and
induce novel changes in gene expression. Virology. 342, 167-176.
Lau, D.T., Fish, P.M., Sinha, M., Owen, D.M., Lemon, S.M., Gale, M., Jr., 2008.
Interferon regulatory factor-3 activation, hepatic interferon-stimulated gene
expression, and immune cell infiltration in hepatitis C virus patients. Hepatology.
47, 799-809.
Laver, T., Nozell, S.E., Benveniste, E.N., 2008. IFN-beta-mediated inhibition of IL-8
expression requires the ISGF3 components Stat1, Stat2, and IRF-9. Journal of
interferon & cytokine research : the official journal of the International Society
for Interferon and Cytokine Research. 28, 13-23.
Lelania, B.-B., Brian G., B., Brian C., P., 2008. Differences in mortality, growth,
lysozyme, and Toll-like receptor gene expression among genetic groups of catfish
exposed to virulent Edwardsiella ictaluri. Fish & Shellfish Immunology. 24,
82-89.
Levraud, J.P., Boudinot, P., Colin, I., Benmansour, A., Peyrieras, N., Herbomel, P.,
Lutfalla, G., 2007. Identification of the zebrafish IFN receptor: implications for
the origin of the vertebrate IFN system. Journal of immunology. 178, 4385-4394.
Levy, D.E., 1999. Physiological significance of STAT proteins: investigations through
gene disruption in vivo. Cellular and molecular life sciences. 55, 1559-1567.
Lin, C.C., Lin, J.H.Y., Chen, M.S., Yang, H.L., 2007. An oral nervous necrosis virus
vaccine that induces protective immunity in larvae of grouper (Epinephelus
coioides). Aquaculture. 268, 265–273.
Liu, G., Zhai, Q.Z., Schaffner, D., Popova, T., Hayford, A., Bailey, C., Alibek, K.,
2004. Bacillus alcalophilus peptidoglycan induces IFN-α-mediated inhibition of
vaccinia virus replication. FEMS immunology and medical microbiology. 42,
197-204.
Liu, M.L., Lee, Y.P., Wang, Y.F., Lei, H.Y., Liu, C.C., Wang, S.M., Su, I.J., Wang,
J.R., Yeh, T.M., Chen, S.H., Yu, C.K., 2005. Type I interferons protect mice
against enterovirus 71 infection. The Journal of general virology. 86, 3263-3269.
Long, S., Wilson, M., Bengten, E., Bryan, L., Clem, L.W., Miller, N.W., Chinchar,
V.G., 2004. Identification of a cDNA encoding channel catfish interferon.
Developmental and comparative immunology. 28, 97-111.
MacKenzie, S., Balasch, J.C., Novoa, B., Ribas, L., Roher, N., Krasnov, A., Figueras,
A., 2008. Comparative analysis of the acute response of the trout, O. mykiss, head
kidney to in vivo challenge with virulent and attenuated infectious hematopoietic
necrosis virus and LPS-induced inflammation. BMC Genomics. 9, 141.
Magnadottir, B., Lange, S., Gudmundsdottir, S., Bogwald, J., Dalmo, R.A., 2005.
Ontogeny of humoral immune parameters in fish. Fish & shellfish immunology.
74
19, 429-439.
Mahardika, K., Zafran, Yamamoto, A., Miyazaki, T., 2004. Susceptibility of juvenile
humpback grouper Cromileptes altivelis to grouper sleepy disease iridovirus
(GSDIV). Diseases of aquatic organisms. 59, 1-9.
Marodi, L., Schreiber, S., Anderson, D.C., MacDermott, R.P., Korchak, H.M.,
Johnston, J., R.B., 1993. Enhancement of macrophage candidacidal activity by
interferon-gamma. Increased phagocytosis, killing, and calcium signal mediated
by a decreased number of mannose receptors. The Journal of clinical investigation.
91, 2596–2601.
Martino, G., Filippi, M., Martinelli, V., Brambilla, E., Gobbi, C., Comi, G., Grimaldi,
L.M.E., 1997. Interferon-gamma induced increases in intracellular calcium in T
lymphocytes from patients with multiple sclerosis precede clinical exacerbations
and detection of active lesions on MRI. Journal of neurology, neurosurgery, and
psychiatry. 63, 339-345.
Masko, I., Hideki, N., Nasanori, B., 1987. Inhibitory effect of glycyrrhizin on the in
vitro infectivity and cytopathic activity of the human immunodeficiency virus
[HIV (HTLV-III/LAV)]. Antiviral research. 7, 127.
Massa, P.T., Schimpl, A., Wecker, E., ter Meulen, V., 1987. Tumor necrosis factor
amplifies measles virus-mediated Ia induction on astrocytes. Proceedings of the
National Academy of Sciences of the United States of America. 84, 7242-7245.
Matsumoto, M., Funami, K., Oshiumi, H., Seya, T., 2004. Toll-Like Receptor 3: A
Link between Toll-Like Receptor, Interferon and Viruses. Microbiology and
immunology. 48, 147.
Matsuo., K., Takenaka., K., Shimomura., H., Fujii., N., Shinagawa., K., Kiura., K.,
Harada., M., 2001. Lamivudine and glycyrrhizin for treatment of
chemotherapy-induced hepatitis B virus (HBV) hepatitis in a chronic HBV carrier
with non-Hodgkin lymphoma. Leukemia & lymphoma. 41, 191-5.
McDade, T.W., 2005. The ecologies of human immune function. Annual Review of
Anthropology. 34, 495-521.
Meira, D.A., Pereira, P.C.M., Marcondes-Machado, J., Mendes, R.P., Barraviera, B.,
Pellegrino, J., Jr., Rezkallah-Iwasso, M.T., Peracoli, M.T.S., Castilho, L.M.,
Thomazini, I., da Silva, C.L., Foss, N.T., Curi, P.R., 1996. The Use of Glucan as
Immunostimulant in the Treatment of Paracoccidioidomycosis. The American
journal of tropical medicine and hygiene. 55, 496-503.
Menendez, C., Siebert, D., Brandsch, R., 1996. MoaA of Arthrobacter nicotinovorans
pAO1 involved in Mo-pterin cofactor synthesis is an Fe-S protein. FEBS letters.
391, 101-103.
Minato, N., L. Reid, H. Cantor, P. Lengyel, Bloom, B., 1980. Mode of regulation of
natural killer cell activity by interferon. The Journal of experimental medicine.
152, 124–137.
75
Mori, K., Nakai, T., Muroga, K., Arimoto, M., Mushiake, K., Furusawa, I., 1992.
Properties of a new virus belonging to nodaviridae found in larval striped jack
(Pseudocaranx dentex) with nervous necrosis. Virology. 187, 368-371.
Munday, B.L., Langdon, J.S., Hyatt, A., Humphrey, J.D., 1992. Mass mortality
associated with a viral-induced vacuolating encephalopathy and retinopathy of
larval and juvenile barramundi, Lates calcarifer Bloch. Aquaculture. 103,
197-211.
Mutch, D.M., Wahli, W., Williamson, G., 2005. Nutrigenomics and nutrigenetics: the
emerging faces of nutrition. The FASEB journal. 19, 1602-1616.
Nelson, J.S., 2006. Fishes of the world. J.Wiley Press.New York.
Noel Masihi, K., Madaj, K., Hintelmann, H., Gast, G., Kaneko, Y., 1997.
Down-regulation of tumor necrosis factor-[alpha], moderate reduction of
interleukin-1[beta], but not interleukin-6 or interleukin-10, by glucan
immunomodulators curdlan sulfate and lentinan. International Journal of
Immunopharmacology. 19, 463.
Oates, A.C., Brownlie, A., Pratt, S.J., Irvine, D.V., Liao, E.C., Paw, B.H., Dorian, K.J.,
Johnson, S.L., Postlethwait, J.H., Zon, L.I., Wilks, A.F., 1999. Gene duplication
of zebrafish JAK2 homologs is accompanied by divergent embryonic expression
patterns: only jak2a is expressed during erythropoiesis. Blood. 94, 2622-2636.
Oh, K.W., Lee, C.K., Kim, Y.S., Eo, S.K., Han, S.S., 2000. Antiherpetic activities of
acidic protein bound polysacchride isolated from Ganoderma lucidum alone and
in combinations with acyclovir and vidarabine. Journal of ethnopharmacology. 72,
221-227.
Olofsson, P.S., Jatta, K., Wagsater, D., Gredmark, S., Hedin, U., Paulsson-Berne, G.,
Soderberg-Naucler, C., Hansson, G.K., Sirsjo, A., 2005. The antiviral
cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and
regulated by proinflammatory agents. Arteriosclerosis, thrombosis, and vascular
biology. 25, 113-116.
Ourth, D.D., 1986. Purification and Quantitation of Channel Catfish (Ictalurus
punctatus) Immunoglobulin M. Journal of Applied Ichthyology. 3, 140-143.
Paun, A., Reinert, J.T., Jiang, Z., Medin, C., Balkhi, M.Y., Fitzgerald, K.A., Pitha,
P.M., 2008. Functional characterization of murine interferon regulatory factor 5
(IRF-5) and its role in the innate antiviral response. The Journal of biological
chemistry. 283, 14295-14308.
Pelizon, A.C., Kaneno, R., Soares, A.M., Meira, D.A., Sartori, A., 2003.
Down-modulation of lymphoproliferation and interferon-gamma production by
beta-glucan derived from Saccharomyces cerevisiae. Memorias do Instituto
Oswaldo Cruz. 98, 1083-1087.
Peterson, B.C., Bosworth, B.G., Bilodeau, A.L., 2005. Differential gene expression of
IGF-I, IGF-II, and toll-like receptors 3 and 5 during embryogenesis in hybrid
(channel x blue) and channel catfish. Comparative biochemistry and physiology.
76
Molecular & integrative physiology. 141, 42-47.
Poisa-Beiro, L., Dios, S., Montes, A., Aranguren, R., Figueras, A., Novoa, B., 2008.
Nodavirus increases the expression of Mx and inflammatory cytokines in fish
brain. Molecular immunology. 45, 218-225.
Purcell, M.K., Smith, K.D., Hood, L., Winton, J.R., Roach, J.C., 2006. Conservation
of Toll-Like Receptor Signaling Pathways in Teleost Fish. Comparative
biochemistry and physiology. Genomics & proteomics. 1, 77-88.
Ralf R., M., Florian., B., 2006. Cell biology of molybdenum. Biochimica et
Biophysica Acta (BBA). Molecular Cell Research. 1763, 621-635.
Reimer, T., Brcic, M., Schweizer, M., Jungi, T.W., 2008. poly(I:C) and LPS induce
distinct IRF3 and NF-kappaB signaling during type-I IFN and TNF responses in
human macrophages. Journal of leukocyte biology. 83, 1249-1257.
Risso, A., 2000. Leukocyte antimicrobial peptides: multifunctional effector molecules
of innate immunity. Journal of leukocyte biology. 68, 785-792.
Rivieccio, M.A., Suh, H.S., Zhao, Y., Zhao, M.L., Chin, K.C., Lee, S.C., Brosnan,
C.F., 2006. TLR3 ligation activates an antiviral response in human fetal
astrocytes: a role for viperin/cig5. Journal of immunology. 177, 4735-4741.
Robertsen, B., 2006. The interferon system of teleost fish. Fish & shellfish
immunology. 20, 172-191.
Robertsen, B., Bergan, V., Rokenes, T., Larsen, R., Albuquerque, A., 2003. Atlantic
salmon interferon genes: cloning, sequence analysis, expression, and biological
activity. Journal of interferon & cytokine research:the official journal of the
International Society for Interferon and Cytokine Research. 23, 601-612.
Sakurai, F., Terada, T., Maruyama, M., Watanabe, Y., Yamashita, F., Takakura, Y.,
Hashida, M., 2003. Therapeutic effect of intravenous delivery of lipoplexes
containing the interferon-beta gene and poly I: poly C in a murine lung metastasis
model. Cancer gene therapy. 10, 661-668.
Samuel, C.E., 1993. The eIF-2 alpha protein kinases, regulators of translation in
eukaryotes from yeasts to humans. The Journal of biological chemistry. 268,
7603-7606.
Samuel, C.E., 2001. Antiviral actions of interferons. Clinical microbiology reviews. 14,
778-809.
Schneider, R.J., Shenk, T., 1987. Impact of Virus Infection on Host Cell Protein
Synthesis. Annual Review of Biochemistry. 56, 317-332.
Severa, M., Coccia, E.M., Fitzgerald, K.A., 2006. Toll-like receptor-dependent and
-independent viperin gene expression and counter-regulation by PRDI-binding
factor-1/BLIMP1. The Journal of biological chemistry. 281, 26188-26195.
Sofia, H.J., Chen, G., Hetzler, B.G., Reyes-Spindola, J.F., Miller, N.E., 2001. Radical
SAM, a novel protein superfamily linking unresolved steps in familiar
77
biosynthetic pathways with radical mechanisms: functional characterization using
new analysis and information visualization methods. Nucleic acids research. 29,
1097-1106.
Soltys, J., Quinn, M.T., 1999. Modulation of endotoxin- and enterotoxin-induced
cytokine release by in vivo treatment with beta-(1,6)-branched beta-(1,3)-glucan.
Infection and immunity. 67, 244-252.
Stefan Maas, A.R., 2000. Changing genetic information through RNA editing.
BioEssays. 22, 790-802.
Sun, B.J., Nie, P., 2004. Molecular cloning of the viperin gene and its promoter region
from the mandarin fish Siniperca chuatsi. Veterinary immunology and
immunopathology. 101, 161-170.
Taniguchi, T., Mantei, N., Schwarzstein, M., Nagata, S., Muramatsu, M., Weissmann,
C., 1980. Human leukocyte and fibroblast interferons are structurally related.
Nature. 285, 547.
Utke, K., Bergmann, S., Lorenzen, N., Klner, B., Ototake, M., Fischer, U., 2007.
Cell-mediated cytotoxicity in rainbow trout, Oncorhynchus mykiss, infected with
viral haemorrhagic septicaemia virus. Fish & Shellfish Immunology. 22, 182.
Verma, S., Ziegler, K., Ananthula, P., Co, J.K., Frisque, R.J., Yanagihara, R., Nerurkar,
V.R., 2006. JC virus induces altered patterns of cellular gene expression:
interferon-inducible genes as major transcriptional targets. Virology. 345,
457-467.
Walker, W.A., Blackburn, G., 2004. Symposium introduction: nutrition and gene
regulation. The Journal of nutrition. 134, 2434-2436.
Wang, Q., Dziarski, R., Kirschning, C.J., Muzio, M., Gupta, D., 2001. Micrococci and
Peptidoglycan Activate TLR2→MyD88 IRAK TRAF→NIK→IKK→NF-κB
Signal Transduction Pathway That Induces Transcription of Interleukin-8.
Infection and immunity. 69, 2270-2276.
Wang, X., Hinson, E.R., Cresswell, P., 2007. The interferon-inducible protein viperin
inhibits influenza virus release by perturbing lipid rafts. Cell Host Microbe. 2,
96-105.
Willett, C.E., Cherry, J.J., Steiner, L.A., 1997a. Characterization and expression of the
recombination activating genes (rag1 and rag2) of zebrafish. Immunogenetics. 45,
394-404.
Willett, C.E., Zapata, A.G., Hopkins, N., Steiner, L.A., 1997b. Expression of zebrafish
rag genes during early development identifies the thymus. Developmental biology.
182, 331-341.
Willett, C.E., Cortes, A., Zuasti, A., Zapata, A.G., 1999. Early hematopoiesis and
developing lymphoid organs in the zebrafish. Developmental dynamics : an
official publication of the American Association of Anatomists. 214, 323-336.
Witt, P.L., Marie, I., Robert, N., Irizarry, A., Borden, E.C., Hovanessian, A.G., 1993.
78
Isoforms p69 and p100 of 2',5'-oligoadenylate synthetase induced differentially
by interferons in vivo and in vitro. Journal of interferon research. 13, 17-23.
Yoshikoshi, K., Inoue, K., 1990. viral nervous necrosis in hatchery-reared larvae and
juveniles of Japanese parrotfish, Oplegnathus fasciatus (Temminck & Schlegel).
Fish Diesase. 13, 69-77.
Zhang, Y., Gui, J., 2003. Identification of antiviral-relevant genes in the cultured fish
cells induced by UV-inactivated virus. Chinese science bulletin. 48, 581-588.
Zhang, Y., Burke, C.W., Ryman, K.D., Klimstra, W.B., 2007a. Identification and
characterization of interferon-induced proteins that inhibit alphavirus replication.
Journal of virology. 81, 11246-11255.
Zhang, Y.B., Wang, Y.L., Gui, J.F., 2007b. Identification and characterization of two
homologues of interferon-stimulated gene ISG15 in crucian carp. Fish & shellfish
immunology. 23, 52-61.
Zhang, Y.B., Jiang, J., Chen, Y.D., Zhu, R., Shi, Y., Zhang, Q.Y., Gui, J.F., 2007c.
The innate immune response to grass carp hemorrhagic virus (GCHV) in cultured
Carassius auratus blastulae (CAB) cells. Developmental and comparative
immunology. 31, 232-243.
Zhao, X., Findly, R.C., Dickerson, H.W., 2008. Cutaneous antibody-secreting cells
and B cells in a teleost fish. Developmental and comparative immunology. 32,
500.
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top
無相關期刊
 
系統版面圖檔 系統版面圖檔