臺灣博碩士論文加值系統

本研究的主要目的是探討以人體試驗評估海藻複方調節體重及血脂之功能，受試者共40人分為四組，每組10人，對照組(Ⅰ)，每人每次給予8顆安慰劑，每天二次，低劑量組(Ⅱ)，每人每次給予2顆海藻錠及6顆安慰劑，每天二次，中劑量組(Ⅲ)，每人每次給予5顆海藻錠及3顆安慰劑，每天二次，高劑量組(Ⅳ)，每人每次給予8顆海藻錠，每天二次。實驗期間三個月，每隔一個月，做一次體重、身體質量指數、體脂肪百分比、腰臀比、血清總膽固醇、血清三酸甘油酯、血清低密度脂蛋白膽固醇、血清高密度脂蛋白膽固醇及血清氧化型低密度脂蛋白濃度的測定。實驗三個月後，結果顯示，體重、身體質量指數、體脂肪百分比、腰臀比，低、中、高劑量組，皆無顯著差異。而血清總膽固醇、血清三酸甘油酯、血清低密度脂蛋白膽固醇及血清氧化型低密度脂蛋白的濃度皆有顯著降低(P＜0.05)。血清高密度脂蛋白膽固醇濃度有顯著上升(P＜0.05)。由本研究成果得知，補充海藻錠可降低血清總膽固醇、血清三酸甘油酯、血清低密度脂蛋白膽固醇的濃度，及提升血清高密度脂蛋白膽固醇濃度，同時延緩血清低密度脂蛋白的氧化。

The objective of this research is to evaluate the influence of dietary supplement of mixed algae formulation with respect to body weight and blood lipid regulation by human subject experiments. Forty healthy adults volunteered to participate in the experiments; that are categorized into 4 groups, 10 persons per group. GroupⅠ: eight placebo tablets were taken twice a day. GroupⅡ: two seaweed and six placebo tablets were taken twice a day. GroupⅢ: five seaweed and three placebo tablets were taken twice a day. GroupⅣ: eight seaweed tablets were taken twice a day. The trial lasts for three months. During the period, the body weight, BMI, body fat percentage, waist-hip ratio, serum total cholesterol, serum triglyceride, serum LDL-C, serum HDL-C, and serum OX-LDL of each volunteer were measured and recorded every month.Within three months, the data been collected and analyzed indicates that in groupⅡ, Ⅲ and Ⅳ, the body weight, BMI, body fat percentage and waist-hip ratio have no significant differences among others. In the mean time, the serum total cholesterol, serum triglyceride and serum LDL-C, serum OX-LDL, have decreased dramatically (P＜0.05) while serum HDL-C concentration has increased on the contrary (P＜0.05). Therefore, this trial explicates that seaweed tablets are able to reduce the concentration of serum total cholesterol, serum triglyceride and serum LDL-C in serum and increase the concentration of serum HDL-C on the other hand. Meanwhile, seaweed tablets are capable of delaying LDL oxidation as well.

中文摘要 1
ABSTRACT 2
壹、前言 3
貳、文獻整理 5
ㄧ、肥胖症 5
二、調節體重的方法 5
1.運動處方減肥法 5
2.極低熱量飲食法 5
3.減肥藥物之使用 6
4.商業性代餐之減重法 6
三、肥胖對血脂的影響 7
四、調節血脂的方法 8
1.調節飲食結構 8
2.改善生活方式 8
3.藥物治療 8
五、海藻的組成物質 9
1.海藻多醣 9
2.胺基酸 11
3.脂肪酸 11
4.食物纖維 11
5.抗氧化色素 12
6.無機元素 12
7.維生素 13
六、複方海藻錠成分 13
1.石花菜 13
2.龍鬚菜 14
3.紫菜 16
4.石蓴 17
5.綠藻 19
6.馬尾藻 22
7.螺旋藻 23
參、實驗材料 25
一、實驗藥品 25
二、儀器設備 25
三、實驗材料 25
四、海藻錠之製備 26
肆、實驗設計 27
一、 人體試驗時程圖 28
二、人體試驗流程圖 29
伍、實驗方法 30
一、研究對象的招募 30
二、實驗進行方法 30
三、飲食衛教 31
四、生化檢查 33
五、體位之測定 39
六、統計方法 40
陸、結果與討論 42
一、海藻複方調節體重功能的結果 42
二、海藻複方調節血漿中脂質濃度的結果 44
柒、結論 52
捌、藥品危害回報系統 53
玖、參考文獻 54
拾、附錄 75

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