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研究生:陳芝君
論文名稱:光纖式表面電漿生物感測器之製作與研究
論文名稱(外文):Fabrication and study of optical fiber biosensor based on surface plasmon resonance
指導教授:江海邦
指導教授(外文):Hai-Pang Chiang
學位類別:碩士
校院名稱:國立臺灣海洋大學
系所名稱:光電科學研究所
學門:工程學門
學類:電資工程學類
論文種類:學術論文
論文出版年:2008
畢業學年度:96
語文別:中文
論文頁數:61
中文關鍵詞:表面電漿共振光纖生物感測
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我們製作光纖式表面電漿感測器並以此感測器測量葡萄糖的濃
度變化。光纖式表面電漿感測器是將光纖側邊研磨至核心的部份,然
後在其上使用熱蒸鍍分別鍍上40 nm的金薄膜和50 nm的銀薄膜。利
用表面電漿波長的移動來量測光纖表面的折射率變化,折射率會隨著
葡萄糖濃的增加而改變。本論文中我們設立了幾項實驗:改變葡萄糖
濃度、改變外界環境溫度的變化、 嘗試用聚苯乙烯奈米球改變表面
形貌。利用此感測器測量葡萄糖的濃度變化,我們發現感測器的靈敏
度可達 2.355×10^(-6)(RIU),而改變外界環境溫度的實驗似乎觀
察不出有表面電漿的情形。
A side-polished multimode fiber sensor based on surface plasmon resonance (SPR) is set up with a halogen light source. The SPR fiber sensor is side polished until half the core then coated with 50 nm silver thin film and 40 nm gold thin film separately by using thermal evaporator. The SPR dip shifted in wavelength is used as a measure of the refractive index (RI) change at a surface, and this RI change varies directly with concentration of glucose solution at the surface. We also demonstrate the following experiments: change of glucose solution, change of environmental temperature and surface patterning with polystyrene. The interrogational result of SPR sensitivity is 2.355 x 10^(-6) refractive index units (RIUs). The all-fiber multimode SPR sensor, which has the advantages of being low cost, being disposable, having high stability and linearity, being free of labeling, and having potential for real-time detection, permit the sensor and system to be used in biochemical sensing and environmental monitoring.
中文摘要………………………………………………………………Ⅰ
英文摘要………………………………………………………………Ⅱ
目錄……………………………………………………………………Ⅲ
表目錄…………………………………………………………………Ⅵ
圖目錄…………………………………………………………………VII
第一章 前言…………………………………………………………1
第二章 表面電漿共振理論………………………………………5
2.1 表面電漿共振簡介……………………………………………5
2.2 表面電漿波傳播函數…………………………………………7
2.3 色散曲線之探討………………………………………………10
2.4 激發表面電漿的方法…………………………………………13
2.5 表面電漿多層系統的反射率及相位…………………………15
2.5.1 多層系統的反射係數…………………………………16
2.5.2 多層系統的相位……………………………………18
2.6 表面電漿與溫度的關係………………………………………19
2.6.1 溫度模型………………………………………………19
2.6.2 溫度與介電常數的關係………………………………19
第三章 光纖生物感測器
3.1 光纖生物感測器 …………………………………………22
3.2 光纖傳導理論……………………………………… 25
3.3 靈敏度的計算方式……………………………………29
第四章 實驗架構與步驟……………………………………30
4.1 光纖式表面電漿對外界折射率感測實驗………………30
4.2 實驗蒸鍍製程……………………………………32
4.3 光纖式表面電漿對外界溫度感測實驗…………………34
4.4 感測光纖上製作奈米球微影術(Nanosphere Lithography-
NSL)偵測外界折射率之變化…………………………36
4.1.1 直徑1300nm奈米球+蒸鍍銀50nm(未舉離)…………………37
4.1.2 直徑430 nm奈米球+蒸鍍銀50nm(未舉離)…………38
4.1.3 蒸鍍50nm銀+撲300nm奈米球+蒸鍍50nm銀…………38
第五章 實驗結果與討論……………………………………39
5.1 光纖式表面電漿(金)對外界折射率感測實驗 …………… 39
5.2 光纖式表面電漿(銀)對外界折射率感測實驗………………41
5.3 光纖式表面電漿對外界溫度感測實驗……………… 45
5.4 感測光纖上製作奈米球微影術(Nanosphere Lithography-
NSL)偵測外界折射率之變化……………………… 46
5.4.1 1300nm奈米球+蒸鍍銀50nm(未舉離)……………………47
5.4.2 430nm奈米球+50nm銀(未舉離)…………………… 47
5.4.3 50nm銀+300nm奈米球+50nm銀(未舉離)……………51
5.5 實驗結果討論…………………………………………………54
第六章 結論…………………………………………………………58
參考文獻……………………………………………………59
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