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研究生:林克翰
研究生(外文):Ko-Han Lin
論文名稱:結合超音波影像導引與溫度回授之超音波熱手術系統開發
論文名稱(外文):Development of High-intensity Focused Ultrasound Thermal Surgery System with Ultrasound Imaging Guidance and Temperature Feedback
指導教授:林文澧林文澧引用關係
學位類別:碩士
校院名稱:國立臺灣大學
系所名稱:醫學工程學研究所
學門:工程學門
學類:綜合工程學類
論文種類:學術論文
論文出版年:2008
畢業學年度:96
語文別:中文
論文頁數:61
中文關鍵詞:高強度聚焦超音波熱手術系統診斷用超音波影像熱電偶
外文關鍵詞:High intensity focus ultrasoundThermal surgery systemB-mode ultrasound imageThermocouple
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本研究開發了搭配超音波影像與熱電偶溫度量測之聚焦式超音波熱手術系統,利用油壓缸與電腦控制伺服馬達將聚焦超音波換能器移動至目標區並由防水光學尺量測實際移動距離。熱手術系統將自動定位系統、聚焦超音波換能器、電功率放大器、超音波影像系統、熱電偶溫度量測系統整合至圖形化使用者介面。而熱手術治療流程包含利用由診斷用超因波波束與聚焦超音波波束所形成的聲干擾作為聚焦超音波焦點的影像導引,並將兩根熱電偶透過超音波影像導入蛋白仿體與豬肉組織體,用來量測溫度治療區溫度來監控受測體治療過程。而為了達到多點治療的目的,聚焦超音波換能器利用聲干擾焦點定位法導引移動至其他欲治療區並使用相同電功率和時間作治療。初步的蛋白仿體與豬肉組織實驗結果證明此熱手術系統能有效地完成所規劃的治療策略。
In this study, we developed a focused ultrasound (FUS) thermal therapy system with B-mode ultrasound image guidance and thermocouple temperature measurement feedback. Hydraulic position devices and computer-controlled servo motors were used to move the FUS transducer to the desired location with the measurement of actual movement by linear scale. The entire system integrated automatic position devices, FUS transducer, power amplifier, ultrasound image system, and thermocouple temperature measurement system into a graphical user interface. For the treatment procedure, thermocouples were implanted into a targeted treatment region in a tissue-mimicking phantom or pork tissue under ultrasound image guidance and then the acoustic interference pattern formed by image ultrasound beam and high-power FUS beam was employed as image guidance, to move the FUS transducer to the desired treatment region The measurement of temperature was used to monitor the status of sonication duration. For a multiple lesion formation, the FUS transducer was moved under the acoustic interference guidance to a new location and then it sonicated with the same power level and duration. The preliminary phantom and pork tissue experimental results demonstrated that the system could achieve the desired treatment plan effectively.
誌謝 I
摘要 II
Abstract III
目錄 IV
圖目錄 VI
表目錄 VII
第一章 緒論 1
1.1. 引言 1
1.2 超音波與生物物質相互作用的基本原理 1
1.2.1 機械效應 2
1.2.2 熱效應 2
1.2.3 空蝕化效應 2
1.2.4 溫度與熱劑量分析 3
1.3 超音波熱治療 4
1.4 超音波熱治療發展與應用 5
1.5 超音波熱治療系統概觀 6
1.6 研究動機與目的 9
第二章 超音波熱手術系統開發與製作 12
2.1 超音波熱手術系統組成 12
2.2 機構致動元件 13
2.3 防水光學尺位移量測 14
2.4 聲干擾焦點定位法 14
2.5 系統介面整合 15
2.5.1 高強度聚焦超音波介面 15
2.5.2 診斷用超音波影像與治療規劃介面 15
2.5.3 伺服馬達控制介面 16
2.5.4 熱電偶溫度量測介面 16
2.6 超音波熱手術系統架構 17
2.7 熱手術系統操作流程 18
第三章 實驗與材料方法 31
3.1. 實驗設備 31
3.1.1 高強度聚焦超音波和匹配電路 31
3.1.2 四頻道功率放大器 31
3.1.3 診斷用影像超音波 32
3.1.4 溫度量測儀 32
3.2 實驗材料 33
3.2.1 去氣水 33
3.2.2 蛋白仿體 33
3.2.3 豬肉組織體 34
3.3 熱手術系統測試實驗 35
3.3.1 燒灼焦斑直徑與位置在診斷用超音波影像與實際影像差異實驗 35
3.3.2 由診斷用超音波影像規劃熱手術 36
3.3.3 聲干擾焦點定位法與實際焦點位置誤差實驗 36
3.3.4 藉由聲干擾焦點定位法規劃並監控熱手術與溫度回授控制 37
第四章 系統測試與實驗結果 45
4.1 燒灼焦斑在診斷用超音波影像與CCD影像差異實驗 45
4.2 由診斷用超音波影像規劃熱手術 45
4.3 聲干擾焦點定位法與實際焦點位置誤差實驗 45
4.4 藉由聲干擾焦點定位法規劃並監控熱手術與溫度回授控制 46
第五章 討論 57
第六章 結論與未來展望 59
參考文獻 60
[1] Li Y.S., Reid C. N., McHale A. P. "Enhancing ultrasound-mediated cell membrane permeabilisation (sonoporation) using a high frequency pulse regime and implications for ultrasound-aided cancer chemotherapy." Cancer Letter, 2008; 266(2):156-162.

[2] Khaibullina A, Jang B. S., Sun H, Le N, Yu S, Frenkel V, Carrasquillo J,A., Pastan I, Li K.C., Paik C. H. "Pulsed high-intensity focused ultrasound enhances uptake of radiolabeled monoclonal antibody to human epidermoid tumor in nude mice." J Nucl Med, 2008; 49(2):295-302.

[3] Chen H., Li X., Wan M., and Wang S., "High-speed observation of cavitation bubble cloud structures in the focal region of a 1.2 MHz high-intensity focused ultrasound transducer," Ultrason Sonochem, 2007;14: 291-297.

[4] Patil M. N. and Pandit A. B., "Cavitation - A novel technique for making stable nano-suspensions," Ultrason Sonochem, 2007 ;14 (5):519-530

[5] Dewey W. C., Hopwood L. E., Sapareto S. A., and Gerweck L. E., "Cellular responses to combinations of hyperthermia and radiation," Radiology, 1977; 123: 463-474

[6] Krantz B. F. J. C., "Sound waves are tried as cancer treatment," Arch Phys Ther, 1939; 20:370.

[7] Dewey W. C., Thrall D. E., and Gillette E. L., "Hyperthermia and radiation--a selective thermal effect on chronically hypoxic tumor cells in vivo," Int J Radiat Oncol Biol Phys, 1977; 2: 99-103

[8] Ebbini E. S., "Multiple-Focus Ultrasound Phased-Array Pattern Synthesis - Optimal Driving-Signal Distributions for Hyperthermia," IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control, 1989; 6: 540-548.

[9] Kennedy J. E., "High-intensity focused ultrasound in the treatment of solid tumours," Nat Rev Cancer, 2005; 5:321-327.

[10] Chaussy C., Thuroff S., Rebillard X., and Gelet A., "Technology insight: High-intensity focused ultrasound for urologic cancers," Nat Clin Pract Urol, 2005; 2:191-198.

[11] Hindley J., Gedroyc W. M., Regan L., Stewart E., Tempany C., Hynyen K., McDannold N., Inbar Y., Itzchak Y., Rabinovici J., Kim H. S., Geschwind J. F., Hesley G., Gostout B., Ehrenstein T., Hengst S., Sklair-Levy M., Shushan A., and Jolesz F., "MRI guidance of focused ultrasound therapy of uterine fibroids: early results," Am J Roentgenol, 2004; 183: 1713-1719.

[12] Song C. W., Park H. J., Lee C. K., and Griffin R., "Implications of increased tumor blood flow and oxygenation caused by mild temperature hyperthermia in tumor treatment," Int J Hyperthermia, 2005; 21: 761-767.

[13] Tempany C. M., Stewart E. A., McDannold N., Quade B. J., Jolesz F. A., and Hynynen K., "MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study," Radiology, 2003; 226: 897-905.

[14] Wu C. C., Chen C. N., Ho M. C., Chen W. S., Lee P. H., "Using the acoustic interference pattern to locate the focus of a high.intensity focused ultrasound (HIFU) transducer," Ultrasound in Medicine and Biology, 2008; 34(1):137-146.

[15] Hynynen K., Damianou C. A., Colucci V., Unger E., Cline H. H., and Jolesz F. A., "MR monitoring of focused ultrasonic surgery of renal cortex: experimental and simulation studies," J Magn Reson Imaging, 1995; 5: 259-66.

[16] Vaezy S, Andrew M, Kaczkowski P, Crum L., "Image-guided acoustic therapy," Annu Rev Biomed Eng, 2001; 3:375-390.

[17] Tung Y. S., Liu H. L., Wu C. C., Ju K. C., Chen W. S., and Lin W. L., "Contrast-agent-enhanced ultrasound thermal ablation," Ultrasound in Medicine and Biology, 2006; 32: 1103-1110.

[18] Takegami K., Kaneko Y., Watanabe T., Maruyama T., Matsumoto Y., and Nagawa H., "Polyacrylamide gel containing egg white as new model for irradiation experiments using focused ultrasound," Ultrasound in Medicine and Biology, 2004; 30: 1419-1422.
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