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研究生:葉瑜珊
研究生(外文):Yu-shan Yeh
論文名稱:早期荷爾蒙操弄對於自發性高血壓大鼠注意力以及衝動發展之影響
論文名稱(外文):Effects of early sex hormones on development of attention and impulsivity in Spontaneous Hypertension Rats
指導教授:李季湜李季湜引用關係
指導教授(外文):Jay-shake Li
學位類別:碩士
校院名稱:國立中正大學
系所名稱:心理學所
學門:社會及行為科學學門
學類:心理學類
論文種類:學術論文
論文出版年:2009
畢業學年度:97
語文別:中文
論文頁數:58
中文關鍵詞:5-CSRTT睪固酮Spontaneously hypertensive rat衝動注意力不足過動症
外文關鍵詞:Spontaneously hypertensive rat5 –CSRTTimpulsivityCastrationADHDTestosterone
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注意力不足過動症(Attention-deficit hyperactivity disorder;ADHD)主要有三項以上神經心理症狀,包括:衝動、過動、注意力不集中。自發性高血壓大鼠(Spontaneous Hypertension Rats, SHR)因為具有ADHD三種主要特徵,為目前應用最廣泛的動物模式。ADHD的發生有懸殊的性別比例,發展早期的雄性荷爾蒙可能是主要原因。先前研究發現發展早期的雄性荷爾蒙操弄對SHR的自發性活動量有影響,但到目前為止,尚無研究探討剝奪發展早期的雄性荷爾蒙來探討SHR成年後的注意力及衝動發展的影響。因此,本實驗在SHR大鼠和其對照組Wistar大鼠出生後第七天摘除其雙側睪丸,並觀察出生後第45天在測量注意力和衝動的5-choice serial reaction time test(5-CSRTT)作業中的學習過程。實驗結果顯示,雖然SHR和Wistar大鼠的正確率沒有差異,但SHR大鼠有較多遺漏錯誤,表現出較差的視覺空間記憶;且Wistar大鼠有較SHR大鼠更衝動的反應。去勢同時減少SHR和Wistar大鼠的衝動反應以及造成注意力的損傷。本研究結論:SHR表現出較差的視覺空間記憶,但卻沒表現出較衝動的行為,顯示5-CSRTT測量到的可能是和先前實驗不同建構的衝動反應。去勢可減少衝動反應,但和品系沒有交互作用,顯示去勢雖對行為有影響,但並不單獨影響ADHD的發生。
Higher testosterone level in males is one of the most obvious possible causes for a clear gender difference in Attention-deficit hyperactivity disorder. The present study focused on the influence of androgen manipulations in the early developmental stage on attention deficit and impulsivity features of ADHD. We used the spontaneously hypertensive rat (SHR) as an animal model for ADHD, and the Wistar rat as the control strain. New born male rats were castrated on post natal day seven (PND 7). Beginning on PND45, they underwent a 30 days long of training in a five choices serial reaction time task (5-CSRTT), with daily 100 trials session. The results revealed that SHR exhibit less premature responses and more omission errors than Wistar rats do. In addition, castrated animals of both strains showed less premature responses than controls when the inter-trial interval was changed from 5 to 2 seconds. They also showed more omission errors than controls in latter stages. In conclusion, early androgen depletion in the early developmental stage improves behavior inhibition but impairs shifting and visuospatial attention. Moreover, the influences were not strain specific because it was observed in both castrated SHR and Wistar rats.
摘要 I
Abstract II
目次 III
第一章 緒論 1
1.1 ADHD(attention deficit hyperactivity disorder)簡介 1
1.2 雄性荷爾蒙和ADHD之關係 3
1.3 SHR作為ADHD動物模式之效度 5
1.4 SHR與雄性荷爾蒙操弄 7
1.5 注意力及衝動在5-CSRTT中之研究 8
1.6 實驗目的 9
第二章 材料及方法 11
2.1 受試動物 11
2.2 儀器設備 11
2.3 實驗設計以及分組 13
2.4 手術程序 13
2.5 行為觀察實驗 14
2.6 5-CSRTT訓練程序 14
2.7 分析方法 18
第三章 結果 20
第四章 討論 25
第五章 總結與未來展望 35
參考文獻 38
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