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研究生:鄭靜宜
研究生(外文):Ching Yi Cheng
論文名稱:探討基質金屬蛋白分解酶-9與尿液纖維蛋白原活化酶在輪部上皮細胞與羊膜之體外共同培養與肺癌的兩種模式中扮演的角色
論文名稱(外文):Role of Matrix Metalloproteinase-9 and Urokinase Plasminogen Activator in Both Models of Intact Amniotic Membrane-Expanded Limbal Epithelial Cells and Lung Cancer
指導教授:楊春茂楊春茂引用關係
指導教授(外文):C. M. Yang
學位類別:博士
校院名稱:長庚大學
系所名稱:生物醫學研究所
學門:工程學門
學類:生醫工程學類
論文種類:學術論文
論文出版年:2009
畢業學年度:97
論文頁數:271
中文關鍵詞:角膜移植基質金屬蛋白分解酶-9尿液纖維蛋白原活化酶肺癌
外文關鍵詞:Corneal transplantationMMP-9Urokinase-type plasminogen activatorLung cancer
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Matrix metalloproteinases (MMPs)分解細胞外基質可能釋放潛在流動的物質與體幹細胞遷移及上皮細胞生長有關。早期我們發現在輪部上皮細胞與羊膜之體外共同培養模式中MMP-9扮演重要的角色。這次我們進一步探討在此模式中MMP-9活性的是受plasminogen activator (PA)/plasminn調控並參與羊膜基質成份laminin 5 (Ln5)的分解並幫助細胞生長。因此,接下來我們想瞭解在此一培養模式中,有那些細胞-細胞外基質交互作用所引起的訊息傳遞路徑參與調控MMP-9的表現及細胞的生長。由結果發現PI3-K及MAPKs均可影響細胞的生長,但是只有PI3-K/Akt/JNK1/2的訊息傳遞路徑透過活化NF-kB參與調控MMP-9的表現。另外,我們也建立β1或β4 integrin與uPAR/epidermal growth factor (EGFR)結合的重要性-與相關活化的FAK、Src及鈣離子依賴型PKC訊號傳遞分子皆可影響輪部細胞的生長。綜合以上結果,本研究將有助於瞭解在羊膜上培養輪部上皮細胞的模式中,關於MMP-9表現及其分子調控之機制。
許多蛋白水解酶參與細胞外基質分解其主要包括uPA系統及MMPs,它們主要與癌症細胞轉移有關。有許多報導指出在肺癌病人的血漿中IL-1β,PA/plasmin及MMP-9的含量有顯著地增高並與癌細胞移行有關。因此我們想探討是否IL-1β誘發uPA及MMP-9的表現參與肺癌的病程。在此研究結果中發現IL-1β誘發uPA的表現與癌細胞的移行有關,並經由PKCa-JNK-NIK的活化刺激p65磷酸化及核轉位並伴隨著IκBα磷酸化及隨後IκBα的分解。除了uPA,在早期研究我們發現IL-1β也可誘發MMP-9表現並透過MAPKs、NF-κB及AP-1。除了這些路徑外,IL-1β也可透過轉活化Src,EGFR,PDGFR及PI3-K/Akt的路徑誘導發炎蛋白的表現與細胞移行有關。由結果發現,IL-1β誘發MMP-9的表現與A549癌細胞的移行有關,此過程是透過轉活化Src並與PDGFR或EGFR形成複合物,進一步造成Akt磷酸化並促進NF-kB 啟動轉錄活性引發MMP-9基因的表現。本篇論文探討在A549癌細胞中,關於IL-1β誘發蛋白水解酶(像uPA及MMP-9)的表現及其分子調控之機制,有助於肺癌病理過程的研究。因此瞭解調控uPA及MMP-9表現的訊息傳遞分子有助於對未來發展出更適當的抗肺癌的新療程。
Matrix metalloproteases (MMPs)-mediated extracellular matrix (ECM) degradation potentially releases cryptic motility factors involved in somatic SC migration and epithelial outgrowth. We have previously demonstrated that MMP-9 plays an important role in LECs cultivated on AM. Here, we further investigated that MMP-9 activity was up-regulated by PA/plasmin which processed Ln5 r2-chain to facilitate limbal outgrowth on intact AM. Furthermore, the mechanisms underlying cell-ECM interaction-induced MMP-9 expression and cell outgrowth were investigated. The results suggested that both MAPKs and PI3-K/Akt are required for limbal epithelial outgrowth on intact AM, only the PI3-K/Akt/JNK is essential for MMP-9 expression mediated through activation of NF-κB in this model. In addition, we established the roles of uPAR/EGFR/β1 or β4 integrin clustering-related FAK, Src and Ca2+-dependent PKC activation signals are involved in the outgrowth of intact AM-expanded LECs. Taken together, this study, at least in part, disclosed the signaling pathways underlying ex vivo expansion of human limbal explants cultivated on intact AM.
ECM breakdown is accomplished by the concerted action of several proteases, including the uPA-system and MMPs, which is crucial for cancer invasion and metastasis. Several reports have shown that the levels of IL-1β, PA/plasmin system and MMP-9 in plasma of the patients with lung cancer are significantly elevated and link to the invasion of tumor cells. Therefore, we investigated whether IL-1β-induced expression of uPA and MMP-9 participated in lung cancer progression. In this part of thesis, IL-1β significantly induced uPA expression association with tumor cell migration via PKCα-dependent JNK1/2 and NIK cascades, linking to IκB kinase (IKK)α/β activation, p65 translocation and transcription activity. In addition to uPA, IL-1β-induced MMP-9 expression has been shown to be regulated by MAPKs, NF-κB and AP-1 in previous study. In addition to these pathways, transactivation of non-receptor tyrosine kinases (Src), EGF receptor (EGFR), PDGF Receptor (PDGFR), and phosphatidylinositol 3-kinase (PI3K)/Akt has been shown to be implicated in the expression of inflammatory proteins associated with cell migration. Here, we investigated whether these different mechanisms participating in IL-1β-induced MMP-9 expression in lung A549 cells. The results suggested that in A549 cells, Akt phosphorylation-mediated through transactivation of Src-dependent EGFR/PDGFR promotes the transcriptional NF-kB activity and leads to MMP-9 expression associated with cell migration induced by IL-1β. Increased understanding of signal transduction mechanisms underlying regulation of uPA and MMP-9 expression will create opportunities for the development of therapeutic interventions against progression of lung cancer.
Page (頁數)
指導教授推薦書……………………………………………………………….i
口試委員會審定書…………………………………………………………….ii
博士論文著作授權書………………………………………………………….iii
Acknowledgements (誌謝)……………………………………………….iv
Abbreviations (縮寫表)………………………………………………….v
Pharmacological inhibitors (藥理抑制劑)…………………………ix
Abstract in Chinese (中文摘要)………………………………………x
Abstract in English (英文摘要)………………………………………xiv
Table of Contents (目錄)………………………………………………xix
CHAPTER I INTRODUCTION………………………………………………1
SECTION 1. Background and significance………………………2
SECTION 2. Specific aims……………………………………………43
SECTION 3. Figures and tables……………………………………45
CHAPTER II MATERIALS AND METHODS……………………………..62
SECTION 1. Materials…………………………………………………63
SECTION 2. Methods……………………………………………………65
CHAPTER III ……………………………………………………………….74
Novel laminin 5 r2-chain fragments potentiate the limbal epithelial cell outgrowth on amniotic membrane
SECTION 1: Background………………………………………………….75
SECTION 2: Results………………………………………………………77
SECTION 3: Discussion………………………………………………….81
SECTION 4: Figures and legends…………………………………….84
CHAPTER IV ………………………………………………………….…….93
PI3-K/Akt/JNK/NF-κB Pathway Regulates MMP-9 Expression in Amniotic Membrane-Expanded Human Limbal Epithelial Cells
SECTION 1: Background……………………………………………………94
SECTION 2: Results……………………………………………………….97
SECTION 3: Discussion……………………………………………………100
SECTION 4: Figures and legends………………………………………104
CHAPTER V …………………………………………………………………….115
Integrins Coupling with EGFR and uPAR Contribute to the Expansion of Human Limbal Epithelial Cells on Aminiotic Membrane
SECTION 1: Background……………………………………………………116
SECTION 2: Results………………………………………………………..118
SECTION 3: Discussion……………………………………………………123
SECTION 4: Figures and legends………………………………………127
CHAPTER VI…………………………………………………………………….140
IL-1B induces urokinse-plasminogen activator expression and cell migration through PKCα, JNK1/2, and NF-κB in A549 cells
SECTION 1: Background……………………………………………………141
SECTION 2: Results……………………………………………………….143
SECTION 3: Discussion……………………………………………………148
SECTION 4: Figures and legends………………………………………152
CHAPTER VII…………………………………………………...…………..166
IL-1B induces MMP-9 expression associated with cell migration via a c-Src-dependent PDGFR/EGFR transactivation in A549 cells
SECTION 1: Background……………………………………………………167
SECTION 2: Results……………………………………………………….169
SECTION 3: Discussion……………………………………………………174
SECTION 4: Figures and legends………………………………………178
CHAPTER VIII CONCLUSION AND PERSPECTIVES...............193
SECTION 1: Conclusion..............................................194
SECTION 2: Perspectives............................................197
SECTION 3: Schemes……………………………………………………….199
PUBLICATIONS……………………………………………………………....200
REFERENCES .............................................202
Adinolfi M, Akle CA, McColl I, Fensom AH, Tansley L, Connolly P, Hsi BL, Faulk WP, Travers P, Bodmer WF (1982). Expression of HLA antigens, 2-microglobulin and enzymes by human amniotic epithelial cells. Nature 295:325-327.
Aguirre Ghiso JA (2002). Inhibition of FAK signaling activated by urokinase receptor induces dormancy in human carcinoma cells in vivo. Oncogene 21:2513-2524.
Aguirre Ghiso JA, Kovalski K, Ossowski L (1999). Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling 101. J Cell Biol 147:89-104.
Aguirre-Ghiso JA, Liu D, Mignatti A, Kovalski K, Ossowski L (2001). Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo. Mol Biol Cell 12:863-879.
Aikin R, Maysinger D, Rosenberg L (2004). Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets 57. Endocrinology 145:4522-4531.
Akle CA, Adinolfi M, Welsh KI, Leibowitz S, McColl I (1981). Immunogenicity of human amniotic epithelial cells after transplantation into volunteers. Lancet 2:1003-1005.
Alexander CM, Hansell EJ, Behrendtsen O, Flannery ML, Kishnani NS, Hawkes SP, Werb Z (1996). Expression and function of matrix metalloproteinases and their inhibitors at the maternal-embryonic boundary during mouse embryo implantation. Development 122:1723-1736.
Alexander CM, Selvarajan S, Mudgett J, Werb Z (2001). Stromelysin-1 regulates adipogenesis during mammary gland involution. J Cell Biol 152:693-703.
Alfano D, Franco P, Vocca I, Gambi N, Pisa V, Mancini A, Caputi M, Carriero MV, Iaccarino I, Stoppelli MP (2005). The urokinase plasminogen activator and its receptor: role in cell growth and apoptosis. Thromb Haemost 93:205-211.
al-Ramadi BK, Welte T, Fernandez-Cabezudo MJ, Galadari S, Dittel B, Fu XY, Bothwell AL (2001). The Src-protein tyrosine kinase Lck is required for IL-1-mediated costimulatory signaling in Th2 cells. J Immunol 167:6827-6833.
Alrutz MA, Isberg RR (1998). Involvement of focal adhesion kinase in invasin-mediated uptake. Proc Natl Acad Sci U S A 95:13658-13663.
Al-Salihi MA, Ulmer SC, Doan T, Nelson CD, Crotty T, Prescott SM, Stafforini DM, Topham MK (2007). Cyclooxygenase-2 transactivates the epidermal growth factor receptor through specific E-prostanoid receptors and tumor necrosis factor- converting enzyme. Cell Signal 19:1956-1963.
Amos S, Mut M, diPierro CG, Carpenter JE, Xiao A, Kohutek ZA, Redpath GT, Zhao Y, Wang J, Shaffrey ME, Hussaini IM (2007). Protein kinase C--mediated regulation of low-density lipoprotein receptor related protein and urokinase increases astrocytoma invasion. Cancer Res 67:10241-10251.
Amour A, Knight CG, Webster A, Slocombe PM, Stephens PE, Knauper V, Docherty AJ, Murphy G (2000). The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3. FEBS Lett 473:275-279.
Andreasen PA, Georg B, Lund LR, Riccio A, Stacey SN (1990). Plasminogen activator inhibitors: hormonally regulated serpins. Mol Cell Endocrinol 68:1-19.
Andreev J, Galisteo ML, Kranenburg O, Logan SK, Chiu ES, Okigaki M, Cary LA, Moolenaar WH, Schlessinger J (2001). Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade 68. J Biol Chem 276:20130-20135.
Appella E, Robinson EA, Ullrich SJ, Stoppelli MP, Corti A, Cassani G, Blasi F (1987). The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases. J Biol Chem 262:4437-4440.
Asada M, Yasuda H, Ebihara S, Tomita N, Suzuki S, Sato M, Kubo H, Yamaya M (2006). Interleukin-1 gene polymorphisms associated with risk of lung cancer in Japanese. Lung Cancer 54:261-263.
Asakura M, Kitakaze M, Takashima S, Liao Y, Ishikura F, Yoshinaka T, Ohmoto H, Node K, Yoshino K, Ishiguro H, Asanuma H, Sanada S, Matsumura Y, Takeda H, Beppu S, Tada M, Hori M, Higashiyama S (2002). Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy. Nat Med 8:35-40.
Asehnoune K, Strassheim D, Mitra S, Yeol KJ, Abraham E (2005). Involvement of PKC/ in TLR4 and TLR2 dependent activation of NF-B. Cell Signal 17:385-394.
Atkinson JJ, Senior RM (2003). Matrix metalloproteinase-9 in lung remodeling. Am J Respir Cell Mol Biol 28:12-24.
Auron PE (1998). The interleukin 1 receptor: ligand interactions and signal transduction. Cytokine Growth Factor Rev 9:221-237.
Avila MA, Berasain C, Sangro B, Prieto J (2006). New therapies for hepatocellular carcinoma. Oncogene 25:3866-3884.
Baeuerle PA (1991). The inducible transcription activator NF-B: regulation by distinct protein subunits. Biochim Biophys Acta 1072:63-80.
Baeuerle PA, Baltimore D (1988). IB: a specific inhibitor of the NF-B transcription factor. Science 242:540-546.
Baker AH, Edwards DR, Murphy G (2002). Metalloproteinase inhibitors: biological actions and therapeutic opportunities. J Cell Sci 115:3719-3727.
Baker SE, Hopkinson SB, Fitchmun M, Andreason GL, Frasier F, Plopper G, Quaranta V, Jones JC (1996). Laminin-5 and hemidesmosomes: role of the 3 chain subunit in hemidesmosome stability and assembly. J Cell Sci 109:2509-2520.
Balbin M, Fueyo A, Tester AM, Pendas AM, Pitiot AS, Astudillo A, Overall CM, Shapiro SD, Lopez-Otin C (2003). Loss of collagenase-2 confers increased skin tumor susceptibility to male mice. Nat Genet 35:252-257.
Baldwin AS, Jr. (1996). The NF-B and IB proteins: new discoveries and insights. Annu Rev Immunol 14:649-683.
Bannikov GA, Karelina TV, Collier IE, Marmer BL, Goldberg GI (2002). Substrate binding of gelatinase B induces its enzymatic activity in the presence of intact propeptide. J Biol Chem 277:16022-16027.
Bansal V, Roychoudhury PK (2006). Production and purification of urokinase: a comprehensive review. Protein Expr Purif 45:1-14.
Bargagna-Mohan P, Strissel KJ, Fini ME (1999). Regulation of gelatinase B production in corneal cells is independent of autocrine IL-1. Invest Ophthalmol Vis Sci 40:784-789.
Barksby HE, Lea SR, Preshaw PM, Taylor JJ (2007). The expanding family of interleukin-1 cytokines and their role in destructive inflammatory disorders. Clin Exp Immunol 149:217-225.
Bartoloni A, Cutts F, Leoni S, Austin CC, Mantella A, Guglielmetti P, Roselli M, Salazar E, Paradisi F (1998). Patterns of antimicrobial use and antimicrobial resistance among healthy children in Bolivia. Trop Med Int Health 3:116-123.
Bartoloni A, Cutts FT, Guglielmetti P, Brown D, Bianchi Bandinelli ML, Hurtado H, Roselli M (1997). Response to measles revaccination among Bolivian school-aged children. Trans R Soc Trop Med Hyg 91:716-718.
Basti S, Rao SK (2000). Current status of limbal conjunctival autograft. Curr Opin Ophthalmol 11:224-232.
Baum J (2002). Thygeson lecture. Amniotic membrane transplantation: why is it effective ? Cornea 21:339-341.
Bauman JE, Eaton KD, Martins RG (2007). Antagonism of platelet-derived growth factor receptor in non small cell lung cancer: rationale and investigations. Clin Cancer Res 13:s4632-s4636.
Bdeir K, Kuo A, Sachais BS, Rux AH, Bdeir Y, Mazar A, Higazi AA, Cines DB (2003). The kringle stabilizes urokinase binding to the urokinase receptor. Blood 102:3600-3608.
Beare AH, O'Kane S, Krane SM, Ferguson MW (2003). Severely impaired wound healing in the collagenase-resistant mouse. J Invest Dermatol 120:153-163.
Bennett BL, Sasaki DT, Murray BW, O'Leary EC, Sakata ST, Xu W, Leisten JC, Motiwala A, Pierce S, Satoh Y, Bhagwat SS, Manning AM, Anderson DW (2001). SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci U S A 98:13681-13686.
Berasain C, Castillo J, Perugorria MJ, Prieto J, Avila MA (2007a). Amphiregulin: a new growth factor in hepatocarcinogenesis. Cancer Lett 254:30-41.
Berasain C, Castillo J, Prieto J, Avila MA (2007b). New molecular targets for hepatocellular carcinoma: the ErbB1 signaling system. Liver Int 27:174-185.
Berasain C, Perugorria MJ, Latasa MU, Castillo J, Goni S, Santamaria M, Prieto J, Avila MA (2009). The epidermal growth factor receptor: a link between inflammation and liver cancer. Exp Biol Med 234:713-725.
Beraud C, Henzel WJ, Baeuerle PA (1999). Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-B activation. Proc Natl Acad Sci U S A 96:429-434.
Bernik MB, Kwaan HC (1969). Plasminogen activator activity in cultures from human tissues. An immunological and histochemical study. J Clin Invest 48:1740-1753.
Bernstein AM, Greenberg RS, Taliana L, Masur SK (2004). Urokinase anchors uPAR to the actin cytoskeleton. Invest Ophthalmol Vis Sci 45:2967-2977.
Bieniasz M, Bartkowiak J, Szemraj J (2008). Expression of bone morphogenetic proteins, matrix metalloproteinases and inhibitors of matrix metalloproteinases in lung cancers and their prognostic significance. Postepy Biochem 54:82-90.
Biscardi JS, Maa MC, Tice DA, Cox ME, Leu TH, Parsons SJ (1999). c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function. J Biol Chem 274:8335-8343.
Blasi F, Carmeliet P (2002). uPAR: a versatile signalling orchestrator. Nat Rev Mol Cell Biol 3:932-943.
Block ER, Matela AR, SundarRaj N, Iszkula ER, Klarlund JK (2004). Wounding induces motility in sheets of corneal epithelial cells through loss of spatial constraints: role of heparin-binding epidermal growth factor-like growth factor signaling. J Biol Chem 279:24307-24312.
Bode W (2003). Structural basis of matrix metalloproteinase function. Biochem Soc Symp1-14.
Bond M, Fabunmi RP, Baker AH, Newby AC (1998). Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF-B. FEBS Lett 435:29-34.
Boudreau N, Sympson CJ, Werb Z, Bissell MJ (1995). Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science 267:891-893.
Boudreau N, Werb Z, Bissell MJ (1996). Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle. Proc Natl Acad Sci U S A 93:3509-3513.
Bouloumie A, Sengenes C, Portolan G, Galitzky J, Lafontan M (2001). Adipocyte produces matrix metalloproteinases 2 and 9: involvement in adipose differentiation. Diabetes 50:2080-2086.
Breuhahn K, Longerich T, Schirmacher P (2006). Dysregulation of growth factor signaling in human hepatocellular carcinoma. Oncogene 25:3787-3800.
Brew K, Dinakarpandian D, Nagase H (2000). Tissue inhibitors of metalloproteinases: evolution, structure and function. Biochim Biophys Acta 1477:267-283.
Brinckerhoff CE, Matrisian LM (2002). Matrix metalloproteinases: a tail of a frog that became a prince. Nat Rev Mol Cell Biol 3:207-214.
Brooks PC, Clark RA, Cheresh DA (1994). Requirement of vascular integrin v3 for angiogenesis. Science 264:569-571.
Brunner G, Simon MM, Kramer MD (1990). Activation of pro-urokinase by the human T cell-associated serine proteinase HuTSP-1. FEBS Lett 260:141-144.
Bruns CJ, Solorzano CC, Harbison MT, Ozawa S, Tsan R, Fan D, Abbruzzese J, Traxler P, Buchdunger E, Radinsky R, Fidler IJ (2000). Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res 60:2926-2935.
Buchanan FG, Wang D, Bargiacchi F, DuBois RN (2003). Prostaglandin E2 regulates cell migration via the intracellular activation of the epidermal growth factor receptor. J Biol Chem 278:35451-35457.
Bullard KM, Lund L, Mudgett JS, Mellin TN, Hunt TK, Murphy B, Ronan J, Werb Z, Banda MJ (1999). Impaired wound contraction in stromelysin-1-deficient mice. Ann Surg 230:260-265.
Burgel PR, Nadel JA (2008). Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases. Eur Respir J 32:1068-1081.
Cabodi S, Moro L, Bergatto E, Boeri EE, Di SP, Turco E, Tarone G, Defilippi P (2004). Integrin regulation of epidermal growth factor (EGF) receptor and of EGF-dependent responses. Biochem Soc Trans 32:438-442.
Canete SR, Gui YH, Linask KK, Muschel RJ (1995b). Developmental expression of MMP-9 (gelatinase B) mRNA in mouse embryos. Dev Dyn 204:30-40.
Canete SR, Gui YH, Linask KK, Muschel RJ (1995a). MMP-9 (gelatinase B) mRNA is expressed during mouse neurogenesis and may be associated with vascularization. Brain Res Dev Brain Res 88:37-52.
Carriero MV, Del VS, Capozzoli M, Franco P, Fontana L, Zannetti A, Botti G, D'Aiuto G, Salvatore M, Stoppelli MP (1999). Urokinase receptor interacts with  v5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer. Cancer Res 59:5307-5314.
Carter WG, Ryan MC, Gahr PJ (1991). Epiligrin, a new cell adhesion ligand for integrin 31 in epithelial basement membranes. Cell 65:599-610.
Caruthers SD, Paschal CB, Pou NA, Roselli RJ, Harris TR (1998). Regional measurements of pulmonary edema by using magnetic resonance imaging. J Appl Physiol 84:2143-2153.
Cejkova J, Cejka C, Zvarova J (2005). Effects of inhibition of urokinase-type plasminogen activator (u-PA) by amiloride in the cornea and tear fluid of eyes irradiated with UVB. Acta Histochem 107:77-86.
Chapman HA, Jr., Vavrin Z, Hibbs JB, Jr. (1982). Macrophage fibrinolytic activity: identification of two pathways of plasmin formation by intact cells and of a plasminogen activator inhibitor. Cell 28:653-662.
Chee KY, Kicic A, Wiffen SJ (2006). Limbal stem cells: the search for a marker. Clin Experiment Ophthalmol 34:64-73.
Chen JJ, Tseng SC (1990). Corneal epithelial wound healing in partial limbal deficiency. Invest Ophthalmol Vis Sci 31:1301-1314.
Chen JJ, Tseng SC (1991). Abnormal corneal epithelial wound healing in partial-thickness removal of limbal epithelium. Invest Ophthalmol Vis Sci 32:2219-2233.
Chen Z, de Paiva CS, Luo L, Kretzer FL, Pflugfelder SC, Li DQ (2004). Characterization of putative stem cell phenotype in human limbal epithelia. Stem Cells 22:355-366.
Cheng CY, Hsieh HL, Sun CC, Lin CC, Luo SF, Yang CM (2009a). IL-1 induces urokinase-plasminogen activator expression and cell migration through PKC, JNK1/2, and NF-B in A549 cells. J Cell Physiol 219:183-193.
Cheng CY, Sun CC, Yu WH, Hsieh HL, Ma DH, Su Pang JH, Yang CM (2009b). Novel laminin 5γ2-chain fragments potentiate the limbal epithelial cell outgrowth on amniotic membrane. Invest Ophthalmol Vis Sci.
Cheng K, Xie G, Raufman JP (2007). Matrix metalloproteinase-7-catalyzed release of HB-EGF mediates deoxycholyltaurine-induced proliferation of a human colon cancer cell line. Biochem Pharmacol 73:1001-1012.
Chiaradonna F, Fontana L, Iavarone C, Carriero MV, Scholz G, Barone MV, Stoppelli MP (1999). Urokinase receptor-dependent and -independent p56/59(hck) activation state is a molecular switch between myelomonocytic cell motility and adherence. EMBO J 18:3013-3023.
Chin JR, Werb Z (1997). Matrix metalloproteinases regulate morphogenesis, migration and remodeling of epithelium, tongue skeletal muscle and cartilage in the mandibular arch. Development 124:1519-1530.
Chrzanowska-Wodnicka M, Burridge K (1994). Tyrosine phosphorylation is involved in reorganization of the actin cytoskeleton in response to serum or LPA stimulation. J Cell Sci 107:3643-3654.
Chung BM, Dimri M, George M, Reddi AL, Chen G, Band V, Band H (2009). The role of cooperativity with Src in oncogenic transformation mediated by non-small cell lung cancer-associated EGF receptor mutants. Oncogene 28:1821-1832.
Cicenas J (2008). The potential role of Akt phosphorylation in human cancers. Int J Biol Markers 23:1-9.
Citri A, Yarden Y (2006). EGF-ERBB signalling: towards the systems level. Nat Rev Mol Cell Biol 7:505-516.
Coeshott C, Ohnemus C, Pilyavskaya A, Ross S, Wieczorek M, Kroona H, Leimer AH, Cheronis J (1999). Converting enzyme-independent release of tumor necrosis factor  and IL-1 from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3. Proc Natl Acad Sci U S A 96:6261-6266.
Colagrande S, Carmignani L, Roselli G, Villari N (1998). Hepatic artery sectorial enhancement as a sign of acute portal thrombosis. Report of 3 cases. Radiol Med 96:639-641.
Collen D, Lijnen HR (2005). Thrombolytic agents. Thromb Haemost 93:627-630.
Conese M, Nykjaer A, Petersen CM, Cremona O, Pardi R, Andreasen PA, Gliemann J, Christensen EI, Blasi F (1995). 2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)-dependent internalization of the urokinase receptor. J Cell Biol 131:1609-1622.
Cooper KL, Myers TA, Rosenberg M, Chavez M, Hudson LG (2004). Roles of mitogen activated protein kinases and EGF receptor in arsenite-stimulated matrix metalloproteinase-9 production. Toxicol Appl Pharmacol 200:177-185.
Corti A, Degasperi A, Colussi S, Mazza E, Amici O, Cristalli A, Prosperi M, Scaiola A, Vai S, Notaro P, Ceresa F, Roselli E, Settembre A, Santandrea E (1997). Evaluation of renal function during orthotopic liver transplantation. Minerva Anestesiol 63:221-228.
Cox G, Jones JL, O'Byrne KJ (2000). Matrix metalloproteinase 9 and the epidermal growth factor signal pathway in operable non-small cell lung cancer. Clin Cancer Res 6:2349-2355.
Crawford HC, Fingleton B, Gustavson MD, Kurpios N, Wagenaar RA, Hassell JA, Matrisian LM (2001). The PEA3 subfamily of Ets transcription factors synergizes with -catenin-LEF-1 to activate matrilysin transcription in intestinal tumors. Mol Cell Biol 21:1370-1383.
Cubellis MV, Wun TC, Blasi F (1990). Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1. EMBO J 9:1079-1085.
Curry TE, Jr., Osteen KG (2003). The matrix metalloproteinase system: changes, regulation, and impact throughout the ovarian and uterine reproductive cycle. Endocr Rev 24:428-465.
Czekay RP, Loskutoff DJ (2004). Unexpected role of plasminogen activator inhibitor 1 in cell adhesion and detachment. Exp Biol Med 229:1090-1096.
D'Alessio S, Blasi F (2009). The urokinase receptor as an entertainer of signal transduction. Front Biosci 14:4575-4587.
Danforth D, Hull RW (1958). The microscopic anatomy of the fetal membranes with particular reference to the detailed structure of the amnion. Am J Obstet Gynecol 75:536-547.
Dannenberg AJ, Lippman SM, Mann JR, Subbaramaiah K, DuBois RN (2005). Cyclooxygenase-2 and epidermal growth factor receptor: pharmacologic targets for chemoprevention. J Clin Oncol 23:254-266.
Dano K, Andreasen PA, Grondahl-Hansen J, Kristensen P, Nielsen LS, Skriver L (1985). Plasminogen activators, tissue degradation, and cancer. Adv Cancer Res 44:139-266.
Dano K, Behrendt N, Hoyer-Hansen G, Johnsen M, Lund LR, Ploug M, Romer J (2005). Plasminogen activation and cancer. Thromb Haemost 93:676-681.
Darieva Z, Lasunskaia EB, Campos MN, Kipnis TL, Da Silva WD (2004). Activation of phosphatidylinositol 3-kinase and c-Jun-N-terminal kinase cascades enhances NF-B-dependent gene transcription in BCG-stimulated macrophages through promotion of p65/p300 binding. J Leukoc Biol 75:689-697.
Dass K, Ahmad A, Azmi AS, Sarkar SH, Sarkar FH (2008). Evolving role of uPA/uPAR system in human cancers. Cancer Treat Rev 34:122-136.
Datta SR, Brunet A, Greenberg ME (1999). Cellular survival: a play in three Akts. Genes Dev 13:2905-2927.
Davanger M, Evensen A (1971). Role of the pericorneal papillary structure in renewal of corneal epithelium. Nature 229:560-561.
Davis GE, Pintar Allen KA, Salazar R, Maxwell SA (2001). Matrix metalloproteinase-1 and -9 activation by plasmin regulates a novel endothelial cell-mediated mechanism of collagen gel contraction and capillary tube regression in three-dimensional collagen matrices. J Cell Sci 114:917-930.
Davis JA, Reed RR (1996). Role of Olf-1 and Pax-6 transcription factors in neurodevelopment. J Neurosci 16:5082-5094.
De CD, Vallone D, Caracciolo A, Sassone-Corsi P, Nerlov C, Verde P (1995). Heterodimerization of c-Jun with ATF-2 and c-Fos is required for positive and negative regulation of the human urokinase enhancer. Oncogene 11:365-376.
de Leite CS, Paulino F, Roselli A (1961). Cystic dilatation of the common bile duct. Apropos of 4 operated cases. J Pediatr 26:143-148.
De VF, Orditura M, Auriemma A, Infusino S, Catalano G (1998). Serum concentrations of proinflammatory cytokines in advanced non small cell lung cancer patients. J Exp Clin Cancer Res 17:413-417.
de Witte H., Pappot H, Brunner N, Grondahl-Hansen J, Hoyer-Hansen G, Behrendt N, Guldhammer-Skov B, Sweep F, Benraad T, Dano K (1997). ELISA for complexes between urokinase-type plasminogen activator and its receptor in lung cancer tissue extracts. Int J Cancer 72:416-423.
De WO, Mareel M (2003). Role of tissue stroma in cancer cell invasion. J Pathol 200:429-447.
DeClerck YA, Imren S (1994). Protease inhibitors: role and potential therapeutic use in human cancer. Eur J Cancer 30A:2170-2180.
Derijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ (1994). JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76:1025-1037.
Desrivieres S, Lu H, Peyri N, Soria C, Legrand Y, Menashi S (1993). Activation of the 92 kDa type IV collagenase by tissue kallikrein. J Cell Physiol 157:587-593.
Didonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M (1997). A cytokine-responsive IB kinase that activates the transcription factor NF-B. Nature 388:548-554.
Dinarello CA (1997). Interleukin-1. Cytokine Growth Factor Rev 8:253-265.
DiPersio CM, Shao M, Di CL, Kreidberg JA, Hynes RO (2000). Mouse keratinocytes immortalized with large T antigen acquire 31 integrin-dependent secretion of MMP-9/gelatinase B. J Cell Sci 113:2909-2921.
Docherty AJ, O'Connell J, Crabbe T, Angal S, Murphy G (1992). The matrix metalloproteinases and their natural inhibitors: prospects for treating degenerative tissue diseases. Trends Biotechnol 10:200-207.
Dogru M, Tsubota K (2005). Survival analysis of conjunctival limbal grafts and amniotic membrane transplantation in eyes with total limbal stem cell deficiency. Am J Ophthalmol 140:305-306.
D'Orazio D, Besser D, Marksitzer R, Kunz C, Hume DA, Kiefer B, Nagamine Y (1997). Cooperation of two PEA3/AP1 sites in uPA gene induction by TPA and FGF-2. Gene 201:179-187.
Downward J (1998). Mechanisms and consequences of activation of protein kinase B/Akt. Curr Opin Cell Biol 10:262-267.
Dua HS, Gomes JA, King AJ, Maharajan VS (2004). The amniotic membrane in ophthalmology. Surv Ophthalmol 49:51-77.
Dua HS, zuara-Blanco A (2000). Limbal stem cells of the corneal epithelium. Surv Ophthalmol 44:415-425.
Dushku N, John MK, Schultz GS, Reid TW (2002). Republication of color figures. Arch Ophthalmol 120:234-237.
Ebato B, Friend J, Thoft RA (1987). Comparison of central and peripheral human corneal epithelium in tissue culture. Invest Ophthalmol Vis Sci 28:1450-1456.
Eeckhout Y, Vaes G (1977). Further studies on the activation of procollagenase, the latent precursor of bone collagenase. Effects of lysosomal cathepsin B, plasmin and kallikrein, and spontaneous activation. Biochem J 166:21-31.
Egan LJ, de LA, Lehrman ED, Myhre GM, Eckmann L, Kagnoff MF (2003). Nuclear factor-B activation promotes restitution of wounded intestinal epithelial monolayers. Am J Physiol Cell Physiol 285:C1028-C1035.
Egeblad M, Werb Z (2002). New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2:161-174.
Ellerbroek SM, Halbleib JM, Benavidez M, Warmka JK, Wattenberg EV, Stack MS, Hudson LG (2001). Phosphatidylinositol 3-kinase activity in epidermal growth factor-stimulated matrix metalloproteinase-9 production and cell surface association. Cancer Res 61:1855-1861.
Ellis V, Behrendt N, Dano K (1991). Plasminogen activation by receptor-bound urokinase. A kinetic study with both cell-associated and isolated receptor. J Biol Chem 266:12752-12758.
Ellis V, Dano K (1993). Potentiation of plasminogen activation by an anti-urokinase monoclonal antibody due to ternary complex formation. A mechanistic model for receptor-mediated plasminogen activation. J Biol Chem 268:4806-4813.
Ellis V, Scully MF, Kakkar VV (1989). Plasminogen activation initiated by single-chain urokinase-type plasminogen activator. Potentiation by U937 monocytes. J Biol Chem 264:2185-2188.
Endo K, Nakamura T, Kawasaki S, Kinoshita S (2004). Human amniotic membrane, like corneal epithelial basement membrane, manifests the 5 chain of type IV collagen. Invest Ophthalmol Vis Sci 45:1771-1774.
Estrella VC, Eder AM, Liu S, Pustilnik TB, Tabassam FH, Claret FX, Gallick GE, Mills GB, Wiener JR (2007). Lysophosphatidic acid induction of urokinase plasminogen activator secretion requires activation of the p38MAPK pathway
209. Int J Oncol 31:441-449.
Fabregat I, Roncero C, Fernandez M (2007). Survival and apoptosis: a dysregulated balance in liver cancer. Liver Int 27:155-162.
Fan H, Derynck R (1999). Ectodomain shedding of TGF- and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades. EMBO J 18:6962-6972.
Farley SM, Purdy DE, Ryabinina OP, Schneider P, Magun BE, Iordanov MS (2008). Fas ligand-induced proinflammatory transcriptional responses in reconstructed human epidermis. Recruitment of the epidermal growth factor receptor and activation of MAP kinases. J Biol Chem 283:919-928.
Fatima A, Sangwan VS, Iftekhar G, Reddy P, Matalia H, Balasubramanian D, Vemuganti GK (2006). Technique of cultivating limbal derived corneal epithelium on human amniotic membrane for clinical transplantation. J Postgrad Med 52:257-261.
Fernandes M, Sangwan VS, Vemuganti GK (2004). Limbal stem cell deficiency and xeroderma pigmentosum: a case report. Eye 18:741-743.
Filenius S, Hormia M, Rissanen J, Burgeson RE, Yamada Y, raki-Sasaki K, Nakamura M, Virtanen I, Tervo T (2001). Laminin synthesis and the adhesion characteristics of immortalized human corneal epithelial cells to laminin isoforms. Exp Eye Res 72:93-103.
Filenius S, Tervo T, Virtanen I (2003). Production of fibronectin and tenascin isoforms and their role in the adhesion of human immortalized corneal epithelial cells. Invest Ophthalmol Vis Sci 44:3317-3325.
Fini ME, Bartlett JD, Matsubara M, Rinehart WB, Mody MK, Girard MT, Rainville M (1994). The rabbit gene for 92-kDa matrix metalloproteinase. Role of AP1 and AP2 in cell type-specific transcription. J Biol Chem 269:28620-28628.
Fini ME, Girard MT (1990). Expression of collagenolytic/gelatinolytic metalloproteinases by normal cornea. Invest Ophthalmol Vis Sci 31:1779-1788.
Fini ME, Girard MT, Matsubara M, Bartlett JD (1995). Unique regulation of the matrix metalloproteinase, gelatinase B. Invest Ophthalmol Vis Sci 36:622-633.
Fini ME, Parks WC, Rinehart WB, Girard MT, Matsubara M, Cook JR, West-Mays JA, Sadow PM, Burgeson RE, Jeffrey JJ, Raizman MB, Krueger RR, Zieske JD (1996). Role of matrix metalloproteinases in failure to re-epithelialize after corneal injury. Am J Pathol 149:1287-1302.
Fischer K, Lutz V, Wilhelm O, Schmitt M, Graeff H, Heiss P, Nishiguchi T, Harbeck N, Kessler H, Luther T, Magdolen V, Reuning U (1998). Urokinase induces proliferation of human ovarian cancer cells: characterization of structural elements required for growth factor function. FEBS Lett 438:101-105.
Fischer OM, Hart S, Gschwind A, Ullrich A (2003). EGFR signal transactivation in cancer cells. Biochem Soc Trans 31:1203-1208.
Folgueras AR, Pendas AM, Sanchez LM, Lopez-Otin C (2004). Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies. Int J Dev Biol 48:411-424.
Fontanini G, De Laurentiis M, Vignati S, Chine S, Lucchi M, Silvestri V, Mussi A, De PS, Tortora G, Bianco AR, Gullick W, Angeletti CA, Bevilacqua G, Ciardiello F (1998). Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non-small-cell lung cancer: amphiregulin and microvessel count are independent prognostic indicators of survival. Clin Cancer Res 4:241-249.
Fu X, Parks WC, Heinecke JW (2008). Activation and silencing of matrix metalloproteinases. Semin Cell Dev Biol 19:2-13.
Fukata M, Abreu MT (2008). Role of Toll-like receptors in gastrointestinal malignancies. Oncogene 27:234-243.
Fukata M, Chen A, Vamadevan AS, Cohen J, Breglio K, Krishnareddy S, Hsu D, Xu R, Harpaz N, Dannenberg AJ, Subbaramaiah K, Cooper HS, Itzkowitz SH, Abreu MT (2007). Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors. Gastroenterology 133:1869-1881.
Fukuda K, Chikama T, Nakamura M, Nishida T (1999). Differential distribution of subchains of the basement membrane components type IV collagen and laminin among the amniotic membrane, cornea, and conjunctiva. Cornea 18:73-79.
Furuyama A, Hosokawa T, Mochitate K (2008). Interleukin-1 and tumor necrosis factor- have opposite effects on fibroblasts and epithelial cells during basement membrane formation. Matrix Biol 27:429-440.
Gao M, Yeh PY, Lu YS, Chang WC, Kuo ML, Cheng AL (2008). NF-B p50 promotes tumor cell invasion through negative regulation of invasion suppressor gene CRMP-1 in human lung adenocarcinoma cells. Biochem Biophys Res Commun 376:283-287.
Ghilardi G, Biondi ML, Caputo M, Leviti S, DeMonti M, Guagnellini E, Scorza R (2002). A single nucleotide polymorphism in the matrix metalloproteinase-3 promoter enhances breast cancer susceptibility. Clin Cancer Res 8:3820-3823.
Ghilardi G, Biondi ML, Erario M, Guagnellini E, Scorza R (2003). Colorectal carcinoma susceptibility and metastases are associated with matrix metalloproteinase-7 promoter polymorphisms. Clin Chem 49:1940-1942.
Ghosh S, May MJ, Kopp EB (1998). NF-B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16:225-260.
Giancotti FG, Ruoslahti E (1999). Integrin signaling. Science 285:1028-1032.
Giannelli G, Bergamini C, Fransvea E, Marinosci F, Quaranta V, Antonaci S (2001). Human hepatocellular carcinoma (HCC) cells require both 31 integrin and matrix metalloproteinases activity for migration and invasion. Lab Invest 81:613-627.
Giannelli G, Falk-Marzillier J, Schiraldi O, Stetler-Stevenson WG, Quaranta V (1997). Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5. Science 277:225-228.
Giatromanolaki A, Koukourakis M, O'Byrne K, Fox S, Whitehouse R, Talbot DC, Harris AL, Gatter KC (1996). Prognostic value of angiogenesis in operable non-small cell lung cancer. J Pathol 179:80-88.
Gibson PR, van de PE, Doe WF (1991). Cell associated urokinase activity and colonic epithelial cells in health and disease. Gut 32:191-195.
Gipson IK (1989). The epithelial basement membrane zone of the limbus. Eye 3:132-140.
Goldberg GI, Strongin A, Collier IE, Genrich LT, Marmer BL (1992). Interaction of 92-kDa type IV collagenase with the tissue inhibitor of metalloproteinases prevents dimerization, complex formation with interstitial collagenase, and activation of the proenzyme with stromelysin. J Biol Chem 267:4583-4591.
Goldfinger LE, Hopkinson SB, deHart GW, Collawn S, Couchman JR, Jones JC (1999). The 3 laminin subunit, 64 and 31 integrin coordinately regulate wound healing in cultured epithelial cells and in the skin. J Cell Sci 112:2615-2629.
Gomis-Ruth FX, Maskos K, Betz M, Bergner A, Huber R, Suzuki K, Yoshida N, Nagase H, Brew K, Bourenkov GP, Bartunik H, Bode W (1997). Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1. Nature 389:77-81.
Green WB, McGuire PG, Miska KB, Kusewitt DF (2001). Urokinase activity in corneal fibroblasts may be modulated by DNA damage and secreted proteins. Photochem Photobiol 73:318-323.
Greenfeder SA, Nunes P, Kwee L, Labow M, Chizzonite RA, Ju G (1995). Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex. J Biol Chem 270:13757-13765.
Greenlee RT, Hill-Harmon MB, Murray T, Thun M (2001). Cancer statistics, 2001. CA Cancer J Clin 51:15-36.
GROSS J, LAPIERE CM (1962). Collagenolytic activity in amphibian tissues: a tissue culture assay. Proc Natl Acad Sci U S A 48:1014-1022.
Grueterich M, Espana E, Tseng SC (2002b). Connexin 43 expression and proliferation of human limbal epithelium on intact and denuded amniotic membrane. Invest Ophthalmol Vis Sci 43:63-71.
Grueterich M, Espana EM, Touhami A, Ti SE, Tseng SC (2002a). Phenotypic study of a case with successful transplantation of ex vivo expanded human limbal epithelium for unilateral total limbal stem cell deficiency. Ophthalmology 109:1547-1552.
Grueterich M, Espana EM, Tseng SC (2003). Ex vivo expansion of limbal epithelial stem cells: amniotic membrane serving as a stem cell niche. Surv Ophthalmol 48:631-646.
Grushkin-Lerner LS, Trinkaus-Randall V (1991). Localization of integrin and syndecan in vivo in a corneal epithelial abrasion and keratectomy. Curr Eye Res 10:75-85.
Gschwind A, Zwick E, Prenzel N, Leserer M, Ullrich A (2001). Cell communication networks: epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission. Oncogene 20:1594-1600.
Gu Z, Kaul M, Yan B, Kridel SJ, Cui J, Strongin A, Smith JW, Liddington RC, Lipton SA (2002). S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death. Science 297:1186-1190.
Guan JL (1997). Role of focal adhesion kinase in integrin signaling. Int J Biochem Cell Biol 29:1085-1096.
Gueders MM, Foidart JM, Noel A, Cataldo DD (2006). Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in the respiratory tract: potential implications in asthma and other lung diseases. Eur J Pharmacol 533:133-144.
Guerin E, Ludwig MG, Basset P, Anglard P (1997). Stromelysin-3 induction and interstitial collagenase repression by retinoic acid. Therapeutical implication of receptor-selective retinoids dissociating transactivation and AP-1-mediated transrepression. J Biol Chem 272:11088-11095.
Guerrero J, Santibanez JF, Gonzalez A, Martinez J (2004). EGF receptor transactivation by urokinase receptor stimulus through a mechanism involving Src and matrix metalloproteinases. Exp Cell Res 292:201-208.
Guesdon F, Knight CG, Rawlinson LM, Saklatvala J (1997). Dual specificity of the interleukin 1- and tumor necrosis factor-activated  casein kinase. J Biol Chem 272:30017-30024.
Gum R, Lengyel E, Juarez J, Chen JH, Sato H, Seiki M, Boyd D (1996). Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences. J Biol Chem 271:10672-10680.
Guo W, Giancotti FG (2004). Integrin signalling during tumour progression. Nat Rev Mol Cell Biol 5:816-826.
Gutkind JS (1998). Cell growth control by G protein-coupled receptors: from signal transduction to signal integration. Oncogene 17:1331-1342.
Guttridge DC, Albanese C, Reuther JY, Pestell RG, Baldwin AS, Jr. (1999). NF-B controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol Cell Biol 19:5785-5799.
Gyetko MR, Sud S, Chen GH, Fuller JA, Chensue SW, Toews GB (2002). Urokinase-type plasminogen activator is required for the generation of a type 1 immune response to pulmonary Cryptococcus neoformans infection. J Immunol 168:801-809.
Hagglund AC, Ny A, Leonardsson G, Ny T (1999). Regulation and localization of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the mouse ovary during gonadotropin-induced ovulation. Endocrinology 140:4351-4358.
Hall PA, Watt FM (1989). Stem cells: the generation and maintenance of cellular diversity. Development 106:619-633.
Hamelin J, Sarmientos P, Orsini G, Galibert F (1993). Implication of cysteine residues in the activity of single-chain urokinase-plasminogen activator. Biochem Biophys Res Commun 194:978-985.
Hammer A, Hutter H, Blaschitz A, Mahnert W, Hartmann M, Uchanska-Ziegler B, Ziegler A, Dohr G (1997). Amnion epithelial cells, in contrast to trophoblast cells, express all classical HLA class I molecules together with HLA-G. Am J Reprod Immunol 37:161-171.
Han S, Ritzenthaler JD, Sitaraman SV, Roman J (2006). Fibronectin increases matrix metalloproteinase 9 expression through activation of c-Fos via extracellular-regulated kinase and phosphatidylinositol 3-kinase pathways in human lung carcinoma cells. J Biol Chem 281:29614-29624.
Han YP, Yan C, Zhou L, Qin L, Tsukamoto H (2007). A matrix metalloproteinase-9 activation cascade by hepatic stellate cells in trans-differentiation in the three-dimensional extracellular matrix. J Biol Chem 282:12928-12939.
Handsley MM, Edwards DR (2005). Metalloproteinases and their inhibitors in tumor angiogenesis. Int J Cancer 115:849-860.
Hanks SK, Calalb MB, Harper MC, Patel SK (1992). Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. Proc Natl Acad Sci U S A 89:8487-8491.
Hansen SK, Nerlov C, Zabel U, Verde P, Johnsen M, Baeuerle PA, Blasi F (1992). A novel complex between the p65 subunit of NF-B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene. EMBO J 11:205-213.
Hao Y, Ma DH, Hwang DG, Kim WS, Zhang F (2000). Identification of antiangiogenic and antiinflammatory proteins in human amniotic membrane. Cornea 19:348-352.
Hapke S, Kessler H, rroyo de PN, Benge A, Schmitt M, Lengyel E, Reuning U (2001). Integrin v3/vitronectin interaction affects expression of the urokinase system in human ovarian cancer cells. J Biol Chem 276:26340-26348.
Harper EG, Alvares SM, Carter WG (2005). Wounding activates p38 map kinase and activation transcription factor 3 in leading keratinocytes. J Cell Sci 118:3471-3485.
Harris RC, Chung E, Coffey RJ (2003). EGF receptor ligands. Exp Cell Res 284:2-13.
Hasegawa T, Sorensen L, Dohi M, Rao NV, Hoidal JR, Marshall BC (1997). Induction of urokinase-type plasminogen activator receptor by IL-1. Am J Respir Cell Mol Biol 16:683-692.
Hatamochi A, Kuroda K, Shinkai H, Kohma H, Oishi Y, Inoue S (1998). Regulation of matrix metalloproteinase (MMP) expression in cutis laxa fibroblasts: upregulation of MMP-1, MMP-3 and MMP-9 genes but not of the MMP-2 gene. Br J Dermatol 138:757-762.
He CS, Wilhelm SM, Pentland AP, Marmer BL, Grant GA, Eisen AZ, Goldberg GI (1989). Tissue cooperation in a proteolytic cascade activating human interstitial collagenase. Proc Natl Acad Sci U S A 86:2632-2636.
He H, Cho HT, Li W, Kawakita T, Jong L, Tseng SC (2006). Signaling-transduction pathways required for ex vivo expansion of human limbal explants on intact amniotic membrane. Invest Ophthalmol Vis Sci 47:151-157.
Hearing VJ, Law LW, Corti A, Appella E, Blasi F (1988). Modulation of metastatic potential by cell surface urokinase of murine melanoma cells. Cancer Res 48:1270-1278.
Heaton JH, Gelehrter TD (1989). Glucocorticoid induction of plasminogen activator and plasminogen activator-inhibitor messenger RNA in rat hepatoma cells. Mol Endocrinol 3:349-355.
Heiligenhaus A, Bauer D, Meller D, Steuhl KP, Tseng SC (2001). Improvement of HSV-1 necrotizing keratitis with amniotic membrane transplantation. Invest Ophthalmol Vis Sci 42:1969-1974.
Helenius G, Heydarkhan-Hagvall S, Siegbahn A, Risberg B (2004). Expression of fibrinolytic and coagulation factors in cocultured human endothelial and smooth muscle cells. Tissue Eng 10:353-360.
Hendler FJ, Ozanne BW (1984). Human squamous cell lung cancers express increased epidermal growth factor receptors. J Clin Invest 74:647-651.
Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB (2005). Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov 4:988-1004.
Herbert JM, Lamarche I, Carmeliet P (1997). Urokinase and tissue-type plasminogen activator are required for the mitogenic and chemotactic effects of bovine fibroblast growth factor and platelet-derived growth factor-BB for vascular smooth muscle cells. J Biol Chem 272:23585-23591.
Herbst RS, Kim ES, Harari PM (2001). IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody, for treatment of head and neck cancer. Expert Opin Biol Ther 1:719-732.
Herman MP, Sukhova GK, Kisiel W, Foster D, Kehry MR, Libby P, Schonbeck U (2001). Tissue factor pathway inhibitor-2 is a novel inhibitor of matrix metalloproteinases with implications for atherosclerosis. J Clin Invest 107:1117-1126.
Higashiyama S, Iwabuki H, Morimoto C, Hieda M, Inoue H, Matsushita N (2008). Membrane-anchored growth factors, the epidermal growth factor family: beyond receptor ligands. Cancer Sci 99:214-220.
Higashiyama S, Nanba D (2005). ADAM-mediated ectodomain shedding of HB-EGF in receptor cross-talk. Biochim Biophys Acta 1751:110-117.
Hill RE, Favor J, Hogan BL, Ton CC, Saunders GF, Hanson IM, Prosser J, Jordan T, Hastie ND, van H, V (1991). Mouse small eye results from mutations in a paired-like homeobox-containing gene. Nature 354:522-525.
Himelstein BP, Lee EJ, Sato H, Seiki M, Muschel RJ (1997). Transcriptional activation of the matrix metalloproteinase-9 gene in an H-ras and v-myc transformed rat embryo cell line. Oncogene 14:1995-1998.
Hintermann E, Quaranta V (2004). Epithelial cell motility on laminin-5: regulation by matrix assembly, proteolysis, integrins and erbB receptors. Matrix Biol 23:75-85.
Hiraoka N, Allen E, Apel IJ, Gyetko MR, Weiss SJ (1998). Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins. Cell 95:365-377.
Hiratsuka S, Nakamura K, Iwai S, Murakami M, Itoh T, Kijima H, Shipley JM, Senior RM, Shibuya M (2002). MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis. Cancer Cell 2:289-300.
Holland EJ, Schwartz GS (1996). The evolution of epithelial transplantation for severe ocular surface disease and a proposed classification system. Cornea 15:549-556.
Holmbeck K, Bianco P, Caterina J, Yamada S, Kromer M, Kuznetsov SA, Mankani M, Robey PG, Poole AR, Pidoux I, Ward JM, Birkedal-Hansen H (1999). MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover. Cell 99:81-92.
Hotchin NA, Hall A (1995). The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases. J Cell Biol 131:1857-1865.
Houlihan JM, Biro PA, Harper HM, Jenkinson HJ, Holmes CH (1995). The human amnion is a site of MHC class Ib expression: evidence for the expression of HLA-E and HLA-G. J Immunol 154:5665-5674.
Hsi BL, Samson M, Grivaux C, Fenichel P, Hunt JS, Yeh CJ (1988). Topographical expression of class I major histocompatibility complex antigens on human amniotic epithelium. J Reprod Immunol 13:183-191.
Hsieh HL, Wu CY, Yang CM (2008). Bradykinin induces matrix metalloproteinase-9 expression and cell migration through a PKC-dependent ERK/Elk-1 pathway in astrocytes. Glia 56:619-632.
Hsieh HL, Yen MH, Jou MJ, Yang CM (2004). Intracellular signalings underlying bradykinin-induced matrix metalloproteinase-9 expression in rat brain astrocyte-1. Cell Signal 16:1163-1176.
Hu W, Li F, Mahavadi S, Murthy KS (2009). Up-regulation of RGS4 expression by interleukin-1 in colonic smooth muscle is enhanced by ERK1/2 and p38 MAPK and inhibited by PI3K/Akt/GSK3 pathway. Am J Physiol Cell Physiol.
Huang WC, Chen JJ, Inoue H, Chen CC (2003). Tyrosine phosphorylation of IB kinase / by protein kinase C-dependent c-Src activation is involved in TNF--induced cyclooxygenase-2 expression. J Immunol 170:4767-4775.
Huang YL, Shi GY, Lee H, Jiang MJ, Huang BM, Wu HL, Yang HY (2009). Thrombin induces nestin expression via the transactivation of EGFR signalings in rat vascular smooth muscle cells. Cell Signal 21:954-968.
Huet E, Cauchard JH, Berton A, Robinet A, Decarme M, Hornebeck W, Bellon G (2004). Inhibition of plasmin-mediated prostromelysin-1 activation by interaction of long chain unsaturated fatty acids with kringle 5. Biochem Pharmacol 67:643-654.
Hug H, Sarre TF (1993). Protein kinase C isoenzymes: divergence in signal transduction? Biochem J 291:329-343.
Huhtala P, Tuuttila A, Chow LT, Lohi J, Keski-Oja J, Tryggvason K (1991). Complete structure of the human gene for 92-kDa type IV collagenase. Divergent regulation of expression for the 92- and 72-kilodalton enzyme genes in HT-1080 cells. J Biol Chem 266:16485-16490.
Hulboy DL, Rudolph LA, Matrisian LM (1997). Matrix metalloproteinases as mediators of reproductive function. Mol Hum Reprod 3:27-45.
Hunt JS, Andrews GK, Fishback JL, Feess M, Wood GW (1988). Amnion membrane epithelial cells express class I HLA and contain class I HLA mRNA. J Immunol 140:2790-2795.
Hurtado M, Lozano JJ, Castellanos E, Lopez-Fernandez LA, Harshman K, Martinez A, Ortiz AR, Thomson TM, Paciucci R (2007). Activation of the epidermal growth factor signalling pathway by tissue plasminogen activator in pancreas cancer cells. Gut 56:1266-1274.
Hynes NE, Horsch K, Olayioye MA, Badache A (2001). The ErbB receptor tyrosine family as signal integrators. Endocr Relat Cancer 8:151-159.
Hynes RO (1992). Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69:11-25.
Hynes RO (2002). Integrins: bidirectional, allosteric signaling machines. Cell 110:673-687.
Ichinose A, Fujikawa K, Suyama T (1986). The activation of pro-urokinase by plasma kallikrein and its inactivation by thrombin. J Biol Chem 261:3486-3489.
Ihanamaki T, Pelliniemi LJ, Vuorio E (2004). Collagens and collagen-related matrix components in the human and mouse eye. Prog Retin Eye Res 23:403-434.
Ikeo K, Takahashi K, Gojobori T (1995). Different evolutionary histories of kringle and protease domains in serine proteases: a typical example of domain evolution. J Mol Evol 40:331-336.
Ilic D, Furuta Y, Kanazawa S, Takeda N, Sobue K, Nakatsuji N, Nomura S, Fujimoto J, Okada M, Yamamoto T (1995). Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 377:539-544.
Iniesta P, Moran A, De JC, Gomez A, Hernando F, Garcia-Aranda C, Frias C, az-Lopez A, Rodriguez-Jimenez FJ, Balibrea JL, Benito M (2007). Biological and clinical significance of MMP-2, MMP-9, TIMP-1 and TIMP-2 in non-small cell lung cancer. Oncol Rep 17:217-223.
Irigoyen JP, Munoz-Canoves P, Montero L, Koziczak M, Nagamine Y (1999). The plasminogen activator system: biology and regulation. Cell Mol Life Sci 56:104-132.
Ishikawa S, Takenaka K, Yanagihara K, Miyahara R, Kawano Y, Otake Y, Hasegawa S, Wada H, Tanaka F (2004). Matrix metalloproteinase-2 status in stromal fibroblasts, not in tumor cells, is a significant prognostic factor in non-small-cell lung cancer. Clin Cancer Res 10:6579-6585.
Itoh T, Tanioka M, Matsuda H, Nishimoto H, Yoshioka T, Suzuki R, Uehira M (1999). Experimental metastasis is suppressed in MMP-9-deficient mice. Clin Exp Metastasis 17:177-181.
Itoh T, Tanioka M, Yoshida H, Yoshioka T, Nishimoto H, Itohara S (1998). Reduced angiogenesis and tumor progression in gelatinase A-deficient mice. Cancer Res 58:1048-1051.
Iwakura Y (2002). Roles of IL-1 in the development of rheumatoid arthritis: consideration from mouse models. Cytokine Growth Factor Rev 13:341-355.
Jaken S (1996). Protein kinase C isozymes and substrates. Curr Opin Cell Biol 8:168-173.
Jang IK, Ahn JI, Shin JS, Kwon YS, Ryu YH, Lee JK, Park JK, Song KY, Yang EK, Kim JC (2006). Transplantation of reconstructed corneal layer composed of corneal epithelium and fibroblasts on a lyophilized amniotic membrane to severely alkali-burned cornea. Artif Organs 30:424-431.
Jiang Y, Goldberg ID, Shi YE (2002). Complex roles of tissue inhibitors of metalloproteinases in cancer. Oncogene 21:2245-2252.
Jo M, Thomas KS, O'Donnell DM, Gonias SL (2003). Epidermal growth factor receptor-dependent and -independent cell-signaling pathways originating from the urokinase receptor. J Biol Chem 278:1642-1646.
Johannes FJ, Prestle J, Eis S, Oberhagemann P, Pfizenmaier K (1994). PKCu is a novel, atypical member of the protein kinase C family. J Biol Chem 269:6140-6148.
Johnson GL, Lapadat R (2002). Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298:1911-1912.
Johnson MD, Okedli E, Woodard A, Toms SA, Allen GS (2002). Evidence for phosphatidylinositol 3-kinase-Akt-p7S6K pathway activation and transduction of mitogenic signals by platelet-derived growth factor in meningioma cells. J Neurosurg 97:668-675.
Jones PH, Watt FM (1993). Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell 73:713-724.
Jorissen RN, Walker F, Pouliot N, Garrett TP, Ward CW, Burgess AW (2003). Epidermal growth factor receptor: mechanisms of activation and signalling. Exp Cell Res 284:31-53.
Jumper C, Cobos E, Lox C (2004). Determination of the serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in patients with either advanced small-cell lung cancer or non-small-cell lung cancer prior to treatment. Respir Med 98:173-177.
Kakazu A, Chandrasekher G, Bazan HE (2004). HGF protects corneal epithelial cells from apoptosis by the PI-3K/Akt-1/Bad- but not the ERK1/2-mediated signaling pathway. Invest Ophthalmol Vis Sci 45:3485-3492.
Kalmes A, Vesti BR, Daum G, Abraham JA, Clowes AW (2000). Heparin blockade of thrombin-induced smooth muscle cell migration involves inhibition of epidermal growth factor (EGF) receptor transactivation by heparin-binding EGF-like growth factor. Circ Res 87:92-98.
Kamio N, Hashizume H, Nakao S, Matsushima K, Sugiya H (2008). IL-1 stimulates urokinase-type plasminogen activator expression and secretion in human dental pulp cells. Biomed Res 28:315-322.
Kanse SM, Benzakour O, Kanthou C, Kost C, Lijnen HR, Preissner KT (1997). Induction of vascular SMC proliferation by urokinase indicates a novel mechanism of action in vasoproliferative disorders. Arterioscler Thromb Vasc Biol 17:2848-2854.
Karin M (1995). The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem 270:16483-16486.
Karin M, Cao Y, Greten FR, Li ZW (2002). NF-B in cancer: from innocent bystander to major culprit. Nat Rev Cancer 2:301-310.
Kashiwagi M, Tortorella M, Nagase H, Brew K (2001). TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5). J Biol Chem 276:12501-12504.
Keates S, Han X, Kelly CP, Keates AC (2007). Macrophage-inflammatory protein-3 mediates epidermal growth factor receptor transactivation and ERK1/2 MAPK signaling in Caco-2 colonic epithelial cells via metalloproteinase-dependent release of amphiregulin. J Immunol 178:8013-8021.
Kenny PA (2007). Tackling EGFR signaling with TACE antagonists: a rational target for metalloprotease inhibitors in cancer. Expert Opin Ther Targets 11:1287-1298.
Kenyon KR, Tseng SC (1989). Limbal autograft transplantation for ocular surface disorders. Ophthalmology 96:709-722.
Khodadoust AA, Silverstein AM, Kenyon DR, Dowling JE (1968). Adhesion of regenerating corneal epithelium. The role of basement membrane. Am J Ophthalmol 65:339-348.
Khokha R, Denhardt DT (1989). Matrix metalloproteinases and tissue inhibitor of metalloproteinases: a review of their role in tumorigenesis and tissue invasion. Invasion Metastasis 9:391-405.
Kim HS, Luo L, Pflugfelder SC, Li DQ (2005). Doxycycline inhibits TGF-1-induced MMP-9 via Smad and MAPK pathways in human corneal epithelial cells. Invest Ophthalmol Vis Sci 46:840-848.
Kim HS, Shang T, Chen Z, Pflugfelder SC, Li DQ (2004). TGF-1 stimulates production of gelatinase (MMP-9), collagenases (MMP-1, -13) and stromelysins (MMP-3, -10, -11) by human corneal epithelial cells. Exp Eye Res 79:263-274.
Kim JC, Tseng SC (1995b). The effects on inhibition of corneal neovascularization after human amniotic membrane transplantation in severely damaged rabbit corneas. Korean J Ophthalmol 9:32-46.
Kim JC, Tseng SC (1995a). Transplantation of preserved human amniotic membrane for surface reconstruction in severely damaged rabbit corneas. Cornea 14:473-484.
Kim JS, Kim JC, Na BK, Jeong JM, Song CY (2000b). Amniotic membrane patching promotes healing and inhibits proteinase activity on wound healing following acute corneal alkali burn. Exp Eye Res 70:329-337.
Kim KS, Hong YK, Joe YA, Lee Y, Shin JY, Park HE, Lee IH, Lee SY, Kang DK, Chang SI, Chung SI (2003). Anti-angiogenic activity of the recombinant kringle domain of urokinase and its specific entry into endothelial cells. J Biol Chem 278:11449-11456.
Kim YM, Jang JW, Lee OH, Yeon J, Choi EY, Kim KW, Lee ST, Kwon YG (2000a). Endostatin inhibits endothelial and tumor cellular invasion by blocking the activation and catalytic activity of matrix metalloproteinase. Cancer Res 60:5410-5413.
Kinoshita S, Nakamura T (2004). Development of cultivated mucosal epithelial sheet transplantation for ocular surface reconstruction. Artif Organs 28:22-27.
Kirchheimer JC, Christ G, Binder BR (1989). Growth stimulation of human epidermal cells by urokinase is restricted to the intact active enzyme. Eur J Biochem 181:103-107.
Kiyan J, Kiyan R, Haller H, Dumler I (2005). Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-. EMBO J 24:1787-1797.
Klaesner JW, Pou NA, Parker RE, Finney C, Roselli RJ (1997). Optical measurement of isolated canine lung filtration coefficients at normal hematocrits. J Appl Physiol 83:1976-1985.
Klaesner JW, Pou NA, Parker RE, Finney C, Roselli RJ (1998). Optical measurement of isolated canine lung filtration coefficients after alloxan infusion. J Appl Physiol 84:1381-1387.
Kleiner DE, Jr., Stetler-Stevenson WG (1993). Structural biochemistry and activation of matrix metalloproteases. Curr Opin Cell Biol 5:891-897.
Kobayashi H, Schmitt M, Goretzki L, Chucholowski N, Calvete J, Kramer M, Gunzler WA, Janicke F, Graeff H (1991). Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (Pro-uPA). J Biol Chem 266:5147-5152.
Kodate M, Kasai T, Hashimoto H, Yasumoto K, Iwata Y, Manabe H (1997). Expression of matrix metalloproteinase (gelatinase) in T1 adenocarcinoma of the lung. Pathol Int 47:461-469.
Koff JL, Shao MX, Ueki IF, Nadel JA (2008). Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium. Am J Physiol Lung Cell Mol Physiol 294:L1068-L1075.
Koizumi N, Inatomi T, Quantock AJ, Fullwood NJ, Dota A, Kinoshita S (2000). Amniotic membrane as a substrate for cultivating limbal corneal epithelial cells for autologous transplantation in rabbits. Cornea 19:65-71.
Koizumi N, Inatomi T, Suzuki T, Sotozono C, Kinoshita S (2001). Cultivated corneal epithelial stem cell transplantation in ocular surface disorders. Ophthalmology 108:1569-1574.
Kook YH, Adamski J, Zelent A, Ossowski L (1994). The effect of antisense inhibition of urokinase receptor in human squamous cell carcinoma on malignancy. EMBO J 13:3983-3991.
Koopman JL, Slomp J, de Bart AC, Quax PH, Verheijen JH (1998). Mitogenic effects of urokinase on melanoma cells are independent of high affinity binding to the urokinase receptor. J Biol Chem 273:33267-33272.
Kopczynska E, Dancewicz M, Kowalewski J, Kardymowicz H, Tyrakowski T (2007). The serum concentration of metalloproteinase 9 and 2 in non-small cell lung cancer patients. Pol Merkur Lekarski 22:539-541.
Kopp EB, Ghosh S (1995). NF-B and rel proteins in innate immunity. Adv Immunol 58:1-27.
Koroma BM, Yang JM, Sundin OH (1997). The Pax-6 homeobox gene is expressed throughout the corneal and conjunctival epithelia. Invest Ophthalmol Vis Sci 38:108-120.
Koshelnick Y, Ehart M, Hufnagl P, Heinrich PC, Binder BR (1997). Urokinase receptor is associated with the components of the JAK1/STAT1 signaling pathway and leads to activation of this pathway upon receptor clustering in the human kidney epithelial tumor cell line TCL-598. J Biol Chem 272:28563-28567.
Koshikawa N, Giannelli G, Cirulli V, Miyazaki K, Quaranta V (2000). Role of cell surface metalloprotease MT1-MMP in epithelial cell migration over laminin-5. J Cell Biol 148:615-624.
Koukourakis MI, Giatromanolaki A, O'Byrne KJ, Cox J, Krammer B, Gatter KC, Harris AL (1999). bcl-2 and c-erbB-2 proteins are involved in the regulation of VEGF and of thymidine phosphorylase angiogenic activity in non-small-cell lung cancer. Clin Exp Metastasis 17:545-554.
Kracht M, Saklatvala J (2002). Transcriptional and post-transcriptional control of gene expression in inflammation. Cytokine 20:91-106.
Kruse FE, Joussen AM, Rohrschneider K, You L, Sinn B, Baumann J, Volcker HE (2000). Cryopreserved human amniotic membrane for ocular surface reconstruction. Graefes Arch Clin Exp Ophthalmol 238:68-75.
Kubo M, Sonoda Y, Muramatsu R, Usui M (2001). Immunogenicity of human amniotic membrane in experimental xenotransplantation. Invest Ophthalmol Vis Sci 42:1539-1546.
Kunigal S, Lakka SS, Gondi CS, Estes N, Rao JS (2007). RNAi-mediated downregulation of urokinase plasminogen activator receptor and matrix metalloprotease-9 in human breast cancer cells results in decreased tumor invasion, angiogenesis and growth. Int J Cancer 121:2307-2316.
Kupferman ME, Fini ME, Muller WJ, Weber R, Cheng Y, Muschel RJ (2000). Matrix metalloproteinase 9 promoter activity is induced coincident with invasion during tumor progression. Am J Pathol 157:1777-1783.
Kurpakus MA, Quaranta V, Jones JC (1991). Surface relocation of 64 integrins and assembly of hemidesmosomes in an in vitro model of wound healing. J Cell Biol 115:1737-1750.
Kurpakus MA, Stock EL, Jones JC (1990). Expression of the 55-kD/64-kD corneal keratins in ocular surface epithelium. Invest Ophthalmol Vis Sci 31:448-456.
Kurpakus-Wheater M (2001). Laminin-5 is a component of preserved amniotic membrane. Curr Eye Res 22:353-357.
Kusch A, Tkachuk S, Lutter S, Haller H, Dietz R, Lipp M, Dumler I (2002). Monocyte-expressed urokinase regulates human vascular smooth muscle cell migration in a coculture model. Biol Chem 383:217-221.
Kwitko S, Marinho D, Barcaro S, Bocaccio F, Rymer S, Fernandes S, Neumann J (1995). Allograft conjunctival transplantation for bilateral ocular surface disorders. Ophthalmology 102:1020-1025.
LaFlamme SE, Auer KL (1996). Integrin signaling. Semin Cancer Biol 7:111-118.
Laiho M, Keski-Oja J (1989). Growth factors in the regulation of pericellular proteolysis: a review. Cancer Res 49:2533-2553.
Lambert V, Wielockx B, Munaut C, Galopin C, Jost M, Itoh T, Werb Z, Baker A, Libert C, Krell HW, Foidart JM, Noel A, Rakic JM (2003). MMP-2 and MMP-9 synergize in promoting choroidal neovascularization. FASEB J 17:2290-2292.
Lappalainen U, Whitsett JA, Wert SE, Tichelaar JW, Bry K (2005). Interleukin-1 causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung. Am J Respir Cell Mol Biol 32:311-318.
Latvala T, Paallysaho T, Tervo K, Tervo T (1996). Distribution of 6 and 4 integrins following epithelial abrasion in the rabbit cornea. Acta Ophthalmol Scand 74:21-25.
Lavker RM, Dong G, Cheng SZ, Kudoh K, Cotsarelis G, Sun TT (1991). Relative proliferative rates of limbal and corneal epithelia. Implications of corneal epithelial migration, circadian rhythm, and suprabasally located DNA-synthesizing keratinocytes. Invest Ophthalmol Vis Sci 32:1864-1875.
Lavker RM, Tseng SC, Sun TT (2004). Corneal epithelial stem cells at the limbus: looking at some old problems from a new angle. Exp Eye Res 78:433-446.
Leal EC, Roselli A (1961). Pathology of the gallbladder in patients with lithiasis. Rev Bras Cir 42:154-157.
Lee CW, Lin CC, Lin WN, Liang KC, Luo SF, Wu CB, Wang SW, Yang CM (2007). TNF- induces MMP-9 expression via activation of Src/EGFR, PDGFR/PI3K/Akt cascade and promotion of NF-B/p300 binding in human tracheal smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 292:L799-L812.
Lee DH, Yang Y, Lee SJ, Kim KY, Koo TH, Shin SM, Song KS, Lee YH, Kim YJ, Lee JJ, Choi I, Lee JH (2003b). Macrophage inhibitory cytokine-1 induces the invasiveness of gastric cancer cells by up-regulating the urokinase-type plasminogen activator system. Cancer Res 63:4648-4655.
Lee HK, Lee JH, Kim M, Kariya Y, Miyazaki K, Kim EK (2006). Insulin-like growth factor-1 induces migration and expression of laminin-5 in cultured human corneal epithelial cells. Invest Ophthalmol Vis Sci 47:873-882.
Lee IT, Wang SW, Lee CW, Chang CC, Lin CC, Luo SF, Yang CM (2008). Lipoteichoic acid induces HO-1 expression via the TLR2/MyD88/c-Src/NADPH oxidase pathway and Nrf2 in human tracheal smooth muscle cells. J Immunol 181:5098-5110.
Lee SB, Li DQ, Tan DT, Meller DC, Tseng SC (2000). Suppression of TGF- signaling in both normal conjunctival fibroblasts and pterygial body fibroblasts by amniotic membrane. Curr Eye Res 20:325-334.
Lee SH, Tseng SC (1997). Amniotic membrane transplantation for persistent epithelial defects with ulceration. Am J Ophthalmol 123:303-312.
Lee SJ, Jang JW, Kim YM, Lee HI, Jeon JY, Kwon YG, Lee ST (2002). Endostatin binds to the catalytic domain of matrix metalloproteinase-2. FEBS Lett 519:147-152.
Lee YJ, Lee EB, Kwon YE, Lee JJ, Cho WS, Kim HA, Song YW (2003a). Effect of estrogen on the expression of matrix metalloproteinase (MMP)-1, MMP-3, and MMP-13 and tissue inhibitor of metalloproternase-1 in osteoarthritis chondrocytes. Rheumatol Int 23:282-288.
Legrand C, Gilles C, Zahm JM, Polette M, Buisson AC, Kaplan H, Birembaut P, Tournier JM (1999). Airway epithelial cell migration dynamics. MMP-9 role in cell-extracellular matrix remodeling. J Cell Biol 146:517-529.
Legrand C, Polette M, Tournier JM, de BS, Huet E, Monteau M, Birembaut P (2001). uPA/plasmin system-mediated MMP-9 activation is implicated in bronchial epithelial cell migration. Exp Cell Res 264:326-336.
Letko E, Stechschulte SU, Kenyon KR, Sadeq N, Romero TR, Samson CM, Nguyen QD, Harper SL, Primack JD, Azar DT, Gruterich M, Dohlman CH, Baltatzis S, Foster CS (2001). Amniotic membrane inlay and overlay grafting for corneal epithelial defects and stromal ulcers. Arch Ophthalmol 119:659-663.
Li DQ, Chen Z, Song XJ, de Paiva CS, Kim HS, Pflugfelder SC (2005). Partial enrichment of a population of human limbal epithelial cells with putative stem cell properties based on collagen type IV adhesiveness. Exp Eye Res 80:581-590.
Li DQ, Tseng SC (1995). Three patterns of cytokine expression potentially involved in epithelial-fibroblast interactions of human ocular surface. J Cell Physiol 163:61-79.
Li W, Hayashida Y, Chen YT, Tseng SC (2007). Niche regulation of corneal epithelial stem cells at the limbus. Cell Res 17:26-36.
Li W, He H, Kuo CL, Gao Y, Kawakita T, Tseng SC (2006). Basement membrane dissolution and reassembly by limbal corneal epithelial cells expanded on amniotic membrane. Invest Ophthalmol Vis Sci 47:2381-2389.
Liang JA, Wu SL, Lo HY, Hsiang CY, Ho TY (2009). Vanillin inhibits matrix metalloproteinase-9 expression through down-regulation of nuclear factor-B signaling pathway in human hepatocellular carcinoma cells. Mol Pharmacol 75:151-157.
Liang KC, Lee CW, Lin WN, Lin CC, Wu CB, Luo SF, Yang CM (2007). Interleukin-1 induces MMP-9 expression via p42/p44 MAPK, p38 MAPK, JNK, and nuclear factor-B signaling pathways in human tracheal smooth muscle cells. J Cell Physiol 211:759-770.
Liang OD, Chavakis T, Linder M, Bdeir K, Kuo A, Preissner KT (2003). Binding of urokinase plasminogen activator to gp130 via a putative urokinase-binding consensus sequence. Biol Chem 384:229-236.
Lijnen HR (2001). Plasmin and matrix metalloproteinases in vascular remodeling. Thromb Haemost 86:324-333.
Lijnen HR, Dewerchin M, De CF, Collen D (1990). Effect of fibrin-targeting on clot lysis with urokinase-type plasminogen activator. Thromb Res 57:333-342.
Lijnen HR, Van HB, Collen D (1987). Activation with plasmin of tow-chain urokinase-type plasminogen activator derived from single-chain urokinase-type plasminogen activator by treatment with thrombin. Eur J Biochem 169:359-364.
Lin CC, Lee CW, Chu TH, Cheng CY, Luo SF, Hsiao LD, Yang CM (2007). Transactivation of Src, PDGF receptor, and Akt is involved in IL-1-induced ICAM-1 expression in A549 cells. J Cell Physiol 211:771-780.
Lin CC, Tseng HW, Hsieh HL, Lee CW, Wu CY, Cheng CY, Yang CM (2008). Tumor necrosis factor- induces MMP-9 expression via p42/p44 MAPK, JNK, and nuclear factor-B in A549 cells. Toxicol Appl Pharmacol 229:386-398.
Lin FH, Lin R (1992). A comparison of single nucleotide primer extension with mispairing PCR-RFLP in detecting a point mutation. Biochem Biophys Res Commun 189:1202-1206.
Lindberg K, Brown ME, Chaves HV, Kenyon KR, Rheinwald JG (1993). In vitro propagation of human ocular surface epithelial cells for transplantation. Invest Ophthalmol Vis Sci 34:2672-2679.
Lipfert L, Haimovich B, Schaller MD, Cobb BS, Parsons JT, Brugge JS (1992). Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets. J Cell Biol 119:905-912.
Lissoni P, Fumagalli L, Paolorossi F, Rovelli F, Roselli MG, Maestroni GJ (1997). Anticancer neuroimmunomodulation by pineal hormones other than melatonin: preliminary phase II study of the pineal indole 5-methoxytryptophol in association with
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