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研究生:李文貽
研究生(外文):Wen-Yi Li
論文名稱:中部科學工業園區附近居民室內外空氣中苯、甲苯、乙苯與二甲苯濃度與苯生物偵測之相關性
論文名稱(外文):Correlation between indoor and outdoor BTEX levels and biomarkers of benzene metabolite among residents in the vicinity of Central Taiwan Science Park
指導教授:蔡清讚蔡清讚引用關係
學位類別:碩士
校院名稱:中國醫藥大學
系所名稱:環境醫學研究所碩士班
學門:醫藥衛生學門
學類:公共衛生學類
論文種類:學術論文
論文出版年:2009
畢業學年度:97
語文別:中文
論文頁數:117
中文關鍵詞:甲苯乙苯二甲苯tt-MA
外文關鍵詞:benzenetolueneethylbenzenexylenett-MA
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中部科學工業園區於民國91年正式核定興建,該產業中可能產生之揮發性有機污染物(volatile organic compounds, VOCs),造成附近環境之污染,其中以BTEX中之苯(benzene)、甲苯(toluene)、乙苯(ethylbenzene)及二甲苯(xylene)較為常見。苯環類之有機物具有高度的揮發性,可經由吸入、皮膚接觸進入人體,引起頭痛、噁心、暈眩、神經系統及協調功能之減弱。而為瞭解苯的人體暴露,可利用苯經人體代謝後之產物trans, trans-muconic acid( t,t-MA)作為本代謝之生物指標。因此,本研究之目的在探討中部科學工業園區正式量產或增加附近交通流量後,評估附近居民暴露於室內空中之BTEX濃度與其苯代謝產物之相關性。研究對象分別以問卷進行訪視,分為中科附近居民(當作暴露組)與新社鄉 (當作對照組)兩族群,問卷內容包含基本資料、生活習慣、居家環境,並收集其尿液。且由問卷訪視中徵求自願以家庭做居家室內、外空氣中BTEX濃度測定、同時收取尿液進行苯代謝物t,t-MA之偵測,作為相關指標。結果顯示高暴露組t,t-MA濃度最高(76.9±121.2μg/g cre)而低暴露組及對照組分別為(47.8±47.0, 48.8±47.3 μg/g cre),經分析發現性別、年齡、教育程度、BMI、拜拜習慣、空氣清靜機使用與否皆可能影響t,t-MA濃度。將兩組民眾之性別及年齡配對後以減少個人屬性之變異,得知兩組間t,t-MA濃度亦有顯著性之差異(p=0.012),進一步比較95與、96兩年當地暴露組民眾之t,t-MA濃度呈現增加趨勢且有達顯著性之差異,是否與中部科學工業園區之排放污染物有關,應再深入之調查兩者之相關性。
In order to promote island wide economic development, the government established a program of Central Taiwan Scientific Park (CTSP) in 2002 to upgrade the industry in Central Taiwan. Volatile Organic Compounds (VOCs) used in industrial process may induce harmful effects for human. BTEX stands chemicals for benzene, toluene, ethylbenzene and xylene. Aromatic compound are highly volatile.The urinary level of trans, trans-muconic acid (t,t-MA) can be used as the biomarker of exposure to benzene. Exposure to these chemicals by respiratory absorption or skin contact may cause adverse health effects including headache, nausea, dizzy and weakness coordination ability.
The objectives of this study are to assess the relationship between the indoor exposure of BTEX and the biological level of benzene (t,t-MA) among residents living near the park. We recruited 155 residents in the exposure area and 38 residents in the control area. For the comparability of demographic status, subjects recruited to the tow groups were matched by gender and age. We interviewed them using a structured questionnaire for collecting information on demographic, life style and environmental factors etc. Five houses in the vicinity of CTSP and five houses in the control area were selected and monitored for BTEX concentrations in the indoor and outdoor air and analyzed using GC/FID. The mean level of t,t-MA in the high-exposure group (76.9±121.2 μg/g cre.) was significant higher than that in the low-exposure group (47.8±47.0 μg/g cre.) and in the control group (48.8±47.3 μg/g cre.). Factors including age, education level, body mass index, use of incense, use of air cleaner affected the t,t-MA level. There was a significant difference on the mean levels of t,t-MA between the two groups. In exposure group, t,t-MA levels in this year were significantly high than in the last year. However, it is necessary to verify the association between the emission of VOCs from CTSP and metabolites of benzene in residents living near CTSP.
中文摘要---------------------------------------------------------------------------Ⅲ
英文摘要---------------------------------------------------------------------------Ⅳ
目錄---------------------------------------------------------------------------------Ⅵ
表目錄------------------------------------------------------------------------------Ⅸ
附圖目錄---------------------------------------------------------------------------XI
附件目錄---------------------------------------------------------------------------XII

第一章 緒論
第一節 研究緣起與動機-------------------------------------------------1
第二節 研究目的----------------------------------------------------------4
第二章 文獻探討
第一節 中部科學工業園區背景資料-----------------------------------5
第二節 VOCs之暴露評估------------------------------------------------8
第三節 大氣中BTEX及生物偵測相關研究查證-------------------18
第三章 研究材料與方法
第一節 研究方法-----------------------------------------------------------29
第二節 研究對象-----------------------------------------------------------31
第三節 問卷之調查--------------------------------------------------------35
第四節 空氣中BTEX濃度之測定--------------------------------------36
第五節 尿中苯代謝物之測定--------------------------------------------41
第六節 資料統計與分析--------------------------------------------------44
第四章 研究結果
第一節 中科附近居民問卷調查及生物偵測---------------------------45
第二節 高暴露組與對照組家戶空氣中BTEX濃度------------------51
第三節 比較高暴露組、對照地區及環境家戶採樣尿中t,t-MA之濃度----------------------------------------------------------------------55
第四節 高暴露組及對照組家戶室內空氣中BTEX濃度之相關矩陣-------------------------------------------------------------------------56
第五節 95、96兩年暴露組尿中t,t-MA濃度之比較------------------57
第五章 討論
第一節 樣本代表性--------------------------------------------------------- 58
第二節 尿中t,t-MA濃度之影響因素------------------------------------61
第三節 環境中BTEX之影響因素---------------------------------------66
第四節 尿中t,t-MA濃度與環境中苯濃度之相關---------------------73
第五節 研究限制-------------------------------------------------------------75
第六章 結論與建議
第一節 結論------------------------------------------------------------------76
第二節 建議------------------------------------------------------------------77
參考文獻------------------------------------------------------------------------------78
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