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研究生:林瑋琪
研究生(外文):Wei-Chi Lin
論文名稱:巴金森氏症患者在物體概念缺損之探討
論文名稱(外文):The investigation of object concept in patients with Parkinson''s disease
指導教授:許儷絹許儷絹引用關係
學位類別:碩士
校院名稱:中國醫藥大學
系所名稱:神經科學與認知科學研究所
學門:醫藥衛生學門
學類:醫學學類
論文種類:學術論文
論文出版年:2009
畢業學年度:97
語文別:中文
論文頁數:85
中文關鍵詞:物體概念巴金森氏症物體判斷作業生物會動的
外文關鍵詞:Parkinson’s diseaseAnimateObject conceptObject decision taskMoveable
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概念(concept)是協助我們了解語言意涵的基本元素,概念本身是以「語義屬性」來表徵(representation)的。不同物體語義屬性(例如:聽覺、視覺等等)加以描述後形成物體概念。物體概念的組織包含有視覺與功能二特徵。許多研究顯示物體概念的表徵與人類動作有關。巴金森氏症 (Parkinson disease,以下簡稱PD)病人除了動作障礙的問題外,也有研究者發現相較於正常人,病人的物體概念表徵有問題,尤其在生物類別。另一方面,PD病人對於呈現圖片的動作唸名相較正常人而言正確率比較低,表示PD病人在處理動作的相關概念有問題。本研究推論:大多數的生物皆會動;大多數的非生物皆不會動,PD病人的生物與非生物類別處理的問題是否混淆了動或不動的因素。因此,本研究想探討PD的動作障礙是否會影響其物體概念的表徵,尤其是生物與非生物及動或不動的概念。我們首先進行評定收集材料(實驗一),之後邀請正常大學生(實驗二)、PD病人(實驗三)、正常老人(實驗四)三組受試進行物體辨識作業。受試者需要判斷電腦螢幕所呈現的物體是否為真實的物體。本研究為2x2(生物/非生物x動/不動)受試者內與受試者間的混合設計,並收集反應時間及正確率。結果顯示:(1) 相較於非生物類別,正常大學生對於生物類別的處理比較快。此點與文獻的結果一致。當物體會動時,其反應時間也比不會動來的快。當生物且會動的物體,大學生的表現最快(實驗二)。(2)相較於非生物的類別,PD病人在生物類別處理較慢。相較於不動的物體,他們對動態的物體處理也比較慢。而且當生物且會動的物體,PD病人表現最慢(實驗三)。(3)正常老人的資料型態與正常大學相似(實驗四)。研究意涵PD病人的動作障礙可能會影響其物體概念表徵,導致其與生物及動態物體概念的缺損,PD病人動作障礙的缺損也可能會影響病人處理與身體化相關的概念。
Concept is the basic element that helps us to understand the language of hought. Different object semantic attributes was described to object concept. Concepts includes visual and functional features. The similar concepts may be represented in similar ways. Parkinson’s disease (PD) is a neurodegeneration disease that caused by neural loss in substantia nigra, leading to the neurotransmitter, dopamine, decreases in the mid brain. Previous studies found that PD patients have deficits in identifying animate objects ( Antal, et al., 2002 ; Righi, et al., 2007). It was also found that PD patients have deficits in naming actions (Cotelli, et al., 2007). Since most animate objects are movable and most inanimate objects are unmovable, the main purpose here is to investigate whether PD’s deficit in categorizing animate or inanimate objects would confound with the movable/unmovable variable. We use the object decision task in which participants have to decide whether pictures represented real objects or non-objects.. It was a 2 (animate and inanimate) x2 (moveable and unmovable) experimental design. The reaction time and correct rate were both recorded and a repeated-measures ANOVA analysis was adopted. Preliminary results showed that :(1)The reaction time of processing animate objects in PD was slower than that of processing inanimate ones.;(2) The reaction time of processing movable objects in PD was also slower than that of processing unmovable ones. (3) There is interaction between animate/inanimate and movable/unmovable variables. We can conclude that PD patients have deficit in categorizing animate or inanimate objects,the moveable variable may be the influence factor.
目次
第一章 緒論 1
研究背景與動機 1
第二章 文獻回顧 2
物體概念 2
物體概念的組織 2
人類動作與物體概念表徵之探究 5
巴金森氏症 10
巴金森氏症病人在物體概念之表現 15
研究目的 21
研究架構 23
第三章 研究方法與結果討論 24
實驗一A、真實物體的評定作業 24
方法 24
受試者 24
材料 24
程序25
結果與討論26
實驗一B、圖片材料評定作業29
方法 29
受試者 29
材料 29
程序30
結果與討論30
實驗二、物體判斷作業32
實驗二A、非物體材料評定作業32
方法 32
受試者 33
材料 33
程序33
結果與討論34
實驗二B、物體判斷作業大學生組36
方法36
受試者. 36
材料 36
實驗設計 36
程序37
結果與討論38
實驗三、物體判斷作業PD病人組42
方法 43
受試者 43
材料 43
實驗設計 43
程序44
結果與討論45
實驗四、物體判斷作業正常老人組49
方法49
受試者 50
材料 50
實驗設計 50
程序50
結果與討論50
實驗三與實驗四整合分析 54
研究設計與統計方法 54
結果與討論 54
第四章 綜合討論 61
PD病人在生物類別有缺損的可能原因 62
PD病人在生物類別的概念層次上處理可能有缺損 63
PD病人在會動類別有缺損的可能原因 63
結論 65
本研究貢獻、限制及未來走向 65
參考文獻 66
附錄 74








表目次
表一、各類別選出各30張圖... 27
表二、大學生平均正確反應時間 39
表三、大學生平均正確率 41
表四、PD病人受試者基本資料 42
表五、PD病人平均正確反應時間 46
表六、PD病人平均正確率 48
表七、正常老人受試者基本資料 49
表八、正常老人平均正確反應時間 52
表九、正常老人平均正確率 53
表十、PD病人與正常老人相關量表 55
表十一、PD病人與正常老人正確反應時間 57
表十二、PD病人與正常老人正確反應時間變異數摘要表 58
表十三、PD病人與正常老人正確率 60
表十四、PD病人與正常老人正確率變異數摘要表 60









圖目次
圖一:譯自Collins & Quillian (1969)階層狀的語意結構3
圖二:正常人基底核迴路圖12
圖三:巴金森氏症病人基底核迴路圖13
圖四:Antal, Keri, Dibo, Benedek, Janka,16
Vecsei, & Bodis-Wollner (2002)實驗結果圖16
圖五:Righi, Viggiano, Paganini, Ramat, & Marini (2007)17
實驗刺激材料圖17
圖六:Righi等人(2007)實驗結果圖18
圖七:Righi等人(2007)經過15個月後未服藥組19
與正常人實驗後其對動物類別辨識結果圖19
圖八:Cotelli, Borron , Manent , Zanett, Arevalo,20
Cappa, & Padovan (2007)實驗結果圖20
圖九:研究架構23
圖十A:程序圖25
圖十B:評定量表 26
圖十C:實驗材料26
圖十一A:植物類28
圖十一B:生活物品類28
圖十二:綜合實驗一A與一B的結果31
圖十三:非物體製作32
圖十四A:程序圖34
圖十四B:評定量表34
圖十五:非物體的例子35
圖十六:實驗二程序圖37
圖十七:正常大學生正確反應時間39
圖十八:正常大學生正確率41
圖十九:實驗三程序圖44
圖二十:PD病人正確反應時間46
圖二十一:PD病人正確率48
圖二十二:正常老人正確反應時間51
圖二十三:正常老人正確率53
圖二十四:PD病人與正常老人正確反應時間結果156
圖二十五:PD病人與正常老人正確反應時間結果257
圖二十六:PD病人與正常老人正確率59
圖二十七:基底核至額葉的五條平行路徑64











附錄
附錄一、物體類別評定量表74
附錄二、物體評定量表80
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