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研究生:彭淑慧
研究生(外文):Shu-Hui Peng
論文名稱:白質纖維路徑在成年憂鬱症的表現
論文名稱(外文):White matter tract integrity in adult depression
指導教授:劉益瑞
指導教授(外文):Yi-Jui Liu
學位類別:碩士
校院名稱:逢甲大學
系所名稱:生醫資訊暨生醫工程碩士學位學程
學門:工程學門
學類:生醫工程學類
論文種類:學術論文
論文出版年:2009
畢業學年度:97
語文別:中文
論文頁數:60
中文關鍵詞:核磁共振聯絡白質纖維不等向性擴散張量影像憂鬱症
外文關鍵詞:depressiondiffusion tensor image (DTI)fraction anisotropy (FA)association pathwaysmagnetic resonance image (MRI)
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本研究目的為探討比較憂鬱症患者和健康對照組間腦內聯絡神經纖維(association pathways)在形態上量化後的差異。利用磁振擴散張量影像(Diffusion Tensor Image, DTI),觀察大腦組織水分子的擴散狀態,其藉由水分子擴散方向來推算神經纖維路徑。運用神經纖維追蹤法的技術,呈現左右兩邊大腦各五條聯絡白質纖維(association pathways),包含丘腦前束(Anterior Thalamic Radiations, ATR)、上縱束(Superior Longitudinal Fasciculus, SLF)、下縱束(Inferior Longitudinal Fasciculus, ILF) 、下枕額束(Inferior Fronto-Occipital Fasciculus, IFO)、鉤束(Uncinate Fasciculus, UNC)。進而得知每束纖維水分子非等向性指標(fractional anisotropy, FA)、表面擴散係數值(Apparent Diffusion Coefficient, ADC)、主軸擴散(axial diffusivity)、橫軸擴散(transverse diffusivity),觀察兩組影像形態的差異狀態。結果顯示成年憂鬱症和左腦聯絡白質神經纖維的完整性及整體的微細結構(microstructure)有重大的關聯。
The aim of this study was to quantitatively compare healthy volunteers with depressed adults regarding possible morphological differences in the association pathways of the brain. Diffusion tensor images (DTI) have been used to evaluate the status of water diffusion in brain tissue. DTI provides more information about the orientation of the white matter tract of the brain. Diffusion tensor tractography (DTT) was performed to delineate and quantify bilaterally five major association pathways: anterior thalamic radiations (ATR)、superior longitudinal fasciculus (SLF)、inferior longitudinal fasciculus (ILF)、inferior fronto-occipital fasciculus (IFO)、uncinate fasciculus (UNC)。And further, using the information of the fractional anisotropy (FA), apparent diffusion coefficient (ADC), axial diffusivity and transverse diffusivity to compare the differences of morphology between depressions and healthy brain tissue. This study indicate microstructure in the integrity of the left brain white matter tracts an important neural basis of adult depressions。
誌謝 i
中文摘要 ii
Abstract iii
目錄 iv
圖目錄 v
表目錄 vii
第一章 概論 1
1.1研究背景與重要性 1
1.2相關腦部解剖生理 1
1.3相關研究文獻 4
第二章 研究理論 7
2.1分子擴散(Molecular Diffusion) 7
2.2在生物組織中的擴散(Diffusion in Biological Tissues) 8
2.3擴散加權影像(Diffusion Weight Imaging, DWI) 8
2.4擴散張量影像(Diffusion Tensor Image, DTI) 10
2.5神經纖維追蹤術(Tractography) 16
第三章 研究材料與方法 18
3.1受試者之選取準則 18
3.2影像掃描(MRI Data Acquisition) 18
3.3影像分析(MRI Image Analysis) 19
第四章 研究結果與討論 26
4.1研究結果 26
4.2討論 45
參考文獻 49
1.Connor, T.J. and B.E. Leonard, Depression, stress and immunological activation: the role of cytokines in depressive disorders. Life Sci, 1998. 62(7): p. 583-606.
2.Afifi AK, B.R., Functional Neuroanatomy: Text and Atlas. 1997: McGraw-Hill Professional Publishing.
3.Filley, C.M., The Behavioral Neurology of White Matter. 2001, London/New York: Oxford University Press.
4.Geschwind, N., Disconnexion syndromes in animals and man. II. Brain, 1965. 88(3): p. 585-644.
5.Mesulam, M.M., Large-scale neurocognitive networks and distributed processing for attention, language, and memory. Ann Neurol, 1990. 28(5): p. 597-613.
6.Mesulam, M.-M., Behavioral neuroanatomy: large-scale neural networks, association cortex, frontal syndromes, the limbic system, and hemispheric specializations. Second edition ed. In Principles of Behavioral and Cognitive Neurology. 2000, London/New York.: Oxford University Press.
7.Wakana, S., et al., Fiber tract-based atlas of human white matter anatomy. Radiology, 2004. 230(1): p. 77-87.
8.Moseley, M., R. Bammer, and J. Illes, Diffusion-tensor imaging of cognitive performance. Brain Cogn, 2002. 50(3): p. 396-413.
9.Taylor, W.D., et al., Diffusion tensor imaging: background, potential, and utility in psychiatric research. Biol Psychiatry, 2004. 55(3): p. 201-7.
10.Le Bihan, D., et al., MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology, 1986. 161(2): p. 401-7.
11.Warach, S., et al., Fast magnetic resonance diffusion-weighted imaging of acute human stroke. Neurology, 1992. 42(9): p. 1717-23.
12.Cleveland, G.G., et al., Nuclear magnetic resonance measurement of skeletal muscle: anisotrophy of the diffusion coefficient of the intracellular water. Biophys J, 1976. 16(9): p. 1043-53.
13.Moseley, M.E., et al., Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system. Radiology, 1990. 176(2): p. 439-45.
14.Rose, S.E., et al., Loss of connectivity in Alzheimer''s disease: an evaluation of white matter tract integrity with colour coded MR diffusion tensor imaging. J Neurol Neurosurg Psychiatry, 2000. 69(4): p. 528-30.
15.Ballmaier, M., et al., Anterior cingulate, gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: an MRI-based parcellation of the prefrontal cortex. Am J Psychiatry, 2004. 161(1): p. 99-108.
16.Krishnan, K.R., et al., Magnetic resonance imaging of the caudate nuclei in depression. Preliminary observations. Arch Gen Psychiatry, 1992. 49(7): p. 553-7.
17.Lai, T., et al., Reduction of orbital frontal cortex volume in geriatric depression. Biol Psychiatry, 2000. 48(10): p. 971-5.
18.Steffens, D.C., et al., Hippocampal volume and incident dementia in geriatric depression. Am J Geriatr Psychiatry, 2002. 10(1): p. 62-71.
19.Taylor, W.D., et al., Smaller orbital frontal cortex volumes associated with functional disability in depressed elders. Biol Psychiatry, 2003. 53(2): p. 144-9.
20.Kumar, A., et al., Atrophy and high intensity lesions: complementary neurobiological mechanisms in late-life major depression. Neuropsychopharmacology, 2000. 22(3): p. 264-74.
21.Aizenstein, H.J., et al., The relation of White Matter Hyperintensities to implicit learning in healthy older adults. Int J Geriatr Psychiatry, 2002. 17(7): p. 664-9.
22.Boone, K.B., et al., Neuropsychological correlates of white-matter lesions in healthy elderly subjects. A threshold effect. Arch Neurol, 1992. 49(5): p. 549-54.
23.Lesser, I.M., et al., Cognition and white matter hyperintensities in older depressed patients. Am J Psychiatry, 1996. 153(10): p. 1280-7.
24.Hickie, I., et al., Subcortical hyperintensities on magnetic resonance imaging: clinical correlates and prognostic significance in patients with severe depression. Biol Psychiatry, 1995. 37(3): p. 151-60.
25.Pompili, M., et al., Periventricular white matter hyperintensities as predictors of suicide attempts in bipolar disorders and unipolar depression. Prog Neuropsychopharmacol Biol Psychiatry, 2008. 32(6): p. 1501-7.
26.Taylor, W.D., et al., Late-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matter. Am J Psychiatry, 2004. 161(7): p. 1293-6.
27.Alexopoulos, G.S., et al., Frontal white matter microstructure and treatment response of late-life depression: a preliminary study. Am J Psychiatry, 2002. 159(11): p. 1929-32.
28.Elderkin-Thompson, V., et al., Neuropsychological deficits among patients with late-onset minor and major depression. Arch Clin Neuropsychol, 2003. 18(5): p. 529-49.
29.Alexopoulos, G.S., et al., Clinical presentation of the "depression-executive dysfunction syndrome" of late life. Am J Geriatr Psychiatry, 2002. 10(1): p. 98-106.
30.Lockwood, K.A., G.S. Alexopoulos, and W.G. van Gorp, Executive dysfunction in geriatric depression. Am J Psychiatry, 2002. 159(7): p. 1119-26.
31.Nebes, R.D., et al., Dual-task performance in depressed geriatric patients. Psychiatry Res, 2001. 102(2): p. 139-51.
32.Murphy, C.F., et al., White-matter integrity predicts stroop performance in patients with geriatric depression. Biol Psychiatry, 2007. 61(8): p. 1007-10.
33.Kalayam, B. and G.S. Alexopoulos, Prefrontal dysfunction and treatment response in geriatric depression. Arch Gen Psychiatry, 1999. 56(8): p. 713-8.
34.Drevets, W.C., Neuroimaging studies of mood disorders. Biol Psychiatry, 2000. 48(8): p. 813-29.
35.Bae, J.N., et al., Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression. Biol Psychiatry, 2006. 60(12): p. 1356-63.
36.MacFall, J.R., et al., Medial orbital frontal lesions in late-onset depression. Biol Psychiatry, 2001. 49(9): p. 803-6.
37.Nobuhara, K., et al., Frontal white matter anisotropy and symptom severity of late-life depression: a magnetic resonance diffusion tensor imaging study. J Neurol Neurosurg Psychiatry, 2006. 77(1): p. 120-2.
38.Lim, K.O. and J.A. Helpern, Neuropsychiatric applications of DTI - a review. NMR Biomed, 2002. 15(7-8): p. 587-93.
39.Hasan, K.M., et al., White matter microstructural abnormalities in children with spina bifida myelomeningocele and hydrocephalus: a diffusion tensor tractography study of the association pathways. J Magn Reson Imaging, 2008. 27(4): p. 700-9.
40.Yu, C., et al., White matter tract integrity and intelligence in patients with mental retardation and healthy adults. Neuroimage, 2008. 40(4): p. 1533-41.
41.Le Bihan, D., et al., Imaging of diffusion and microcirculation with gradient sensitization: design, strategy, and significance. J Magn Reson Imaging, 1991. 1(1): p. 7-28.
42.Beaulieu, C., The basis of anisotropic water diffusion in the nervous system - a technical review. NMR Biomed, 2002. 15(7-8): p. 435-55.
43.Le Bihan D, B.E., Imagerie de diffusion in vivo par re´sonance magne´tique nucle´aire. CR Acad Sci, 1985. 301(Paris): p. 1109–1112.
44.Merboldt KD, H.W., Frahm J., Self-diffusion NMR imaging using stimulated echoes. J Magn Reson, 1985. 64: p. 479-486.
45.Taylor, D.G. and M.C. Bushell, The spatial mapping of translational diffusion coefficients by the NMR imaging technique. Phys Med Biol, 1985. 30(4): p. 345-9.
46.Stejskal EO, T.J., Spin diffusion measurements: spin echoes in the presence of a time-dependent field gradient. J Chem Phys Med Biol, 1965. 42: p. 288–292.
47.Watts, R., et al., Fiber tracking using magnetic resonance diffusion tensor imaging and its applications to human brain development. Ment Retard Dev Disabil Res Rev, 2003. 9(3): p. 168-77.
48.Bammer, R., Basic principles of diffusion-weighted imaging. Eur J Radiol, 2003. 45(3): p. 169-84.
49.Le Bihan, D., et al., Diffusion tensor imaging: concepts and applications. J Magn Reson Imaging, 2001. 13(4): p. 534-46.
50.Jellison, B.J., et al., Diffusion tensor imaging of cerebral white matter: a pictorial review of physics, fiber tract anatomy, and tumor imaging patterns. AJNR Am J Neuroradiol, 2004. 25(3): p. 356-69.
51.Wiegell, M.R., H.B. Larsson, and V.J. Wedeen, Fiber crossing in human brain depicted with diffusion tensor MR imaging. Radiology, 2000. 217(3): p. 897-903.
52.Song, S.K., et al., Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia. Neuroimage, 2003. 20(3): p. 1714-22.
53.Budde, M.D., et al., Axial diffusivity is the primary correlate of axonal injury in the experimental autoimmune encephalomyelitis spinal cord: a quantitative pixelwise analysis. J Neurosci, 2009. 29(9): p. 2805-13.
54.Song, S.K., et al., Demyelination increases radial diffusivity in corpus callosum of mouse brain. Neuroimage, 2005. 26(1): p. 132-40.
55.Mori, S. and P.C. van Zijl, Fiber tracking: principles and strategies - a technical review. NMR Biomed, 2002. 15(7-8): p. 468-80.
56.Basser, P.J., et al., In vivo fiber tractography using DT-MRI data. Magn Reson Med, 2000. 44(4): p. 625-32.
57.Mori, S., et al., Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging. Ann Neurol, 1999. 45(2): p. 265-9.
58.Mori, S., et al., Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking. Magn Reson Med, 2002. 47(2): p. 215-23.
59.Poustchi-Amin, M., et al., Principles and applications of echo-planar imaging: a review for the general radiologist. Radiographics, 2001. 21(3): p. 767-79.
60.Henriques, J.B. and R.J. Davidson, Left frontal hypoactivation in depression. J Abnorm Psychol, 1991. 100(4): p. 535-45.
61.Bell, I.R., et al., Differential resting quantitative electroencephalographic alpha patterns in women with environmental chemical intolerance, depressives, and normals. Biol Psychiatry, 1998. 43(5): p. 376-88.
62.Davidson, R.J., D.C. Jackson, and N.H. Kalin, Emotion, plasticity, context, and regulation: perspectives from affective neuroscience. Psychol Bull, 2000. 126(6): p. 890-909.
63.Hagemann, D., et al., Frontal brain asymmetry and affective style: a conceptual replication. Psychophysiology, 1998. 35(4): p. 372-88.
64.Grimm, S., et al., Imbalance between left and right dorsolateral prefrontal cortex in major depression is linked to negative emotional judgment: an fMRI study in severe major depressive disorder. Biol Psychiatry, 2008. 63(4): p. 369-76.
65.Pascual-Leone, A., et al., Rapid-rate transcranial magnetic stimulation of left dorsolateral prefrontal cortex in drug-resistant depression. Lancet, 1996. 348(9022): p. 233-7.
66.George, M.S., et al., Mood improvement following daily left prefrontal repetitive transcranial magnetic stimulation in patients with depression: a placebo-controlled crossover trial. Am J Psychiatry, 1997. 154(12): p. 1752-6.
67.Triggs, W.J., et al., Effects of left frontal transcranial magnetic stimulation on depressed mood, cognition, and corticomotor threshold. Biol Psychiatry, 1999. 45(11): p. 1440-6.
68.Lisanby, S.H., et al., Daily Left Prefrontal Repetitive Transcranial Magnetic Stimulation in the Acute Treatment of Major Depression: Clinical Predictors of Outcome in a Multisite, Randomized Controlled Clinical Trial. Neuropsychopharmacology 34(2):522-34. , 2009.
69.Vataja, R., et al., Magnetic resonance imaging correlates of depression after ischemic stroke. Arch Gen Psychiatry, 2001. 58(10): p. 925-31.
70.Hama, S., et al., Post-stroke affective or apathetic depression and lesion location: left frontal lobe and bilateral basal ganglia. Eur Arch Psychiatry Clin Neurosci, 2007. 257(3): p. 149-52.
71.Jorge, R.E., et al., Major depression following traumatic brain injury. Arch Gen Psychiatry, 2004. 61(1): p. 42-50.
72.Whalley, M.G., et al., Incidental retrieval of emotional contexts in post-traumatic stress disorder and depression: An fMRI study. Brain Cogn, 2008.
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