臺灣博碩士論文加值系統

暸解熱治療過程於生物組織內的熱傳遞情形，是改善熱治療技術的基本需求。然而，至目前為止，尚有許多關於熱治療的重要問題未能得到完全釐清，特別是治療目標區域內、外的溫度分佈變動情形。唯有能確實掌握溫度分佈的變動狀況，才能發展延伸的支援技術、進階的療程和溫度控制系統，以利於得到適宜的治療溫度，並避免過熱而傷害周圍的正常生物組織。
本文以三維Pennes生物熱傳方程式來描述發生於複層球體的生物熱傳問題。由於腫瘤與正常組織間熱物理參數的差異、界面條件和發生於球心的奇異點效應，將增加解析問題的數學困難度，因此擬應用有限元素法解析統御方程式，並且以商業套裝軟體COMSOL為輔助求解工具。
基於腫瘤位置與大小的檢測，以及腫瘤熱治療過程的溫度監控，本文分析的問題包含穩態與暫態問題。穩態問題主要探討腫瘤新陳代謝熱於乳房的熱效應，以預估腫瘤大小與生長位置；而暫態問題分為兩部份，第一部份探討恆定的生物熱物理性質對腫瘤熱治療過程的效應，第二部份探討溫度因變血流灌注率對熱治療的效應，所解析的是非線性多維生物熱傳問題。

A basic understanding of the heat transport occurring in biological tissues during hyperthermia treatment is essential for its improvement. There are serious problems not sufficiently cleared up. Especially, the temperature distribution inside as well as outside the target region must be known as function of the exposure time in order to provide a level of therapeutic temperature and, on the other hand, to avoid overheating and damaging of the surrounding normal tissue.
In this paper, 3-D Pennes bio-heat transfer equation to describe the biological heat transfer problem in bi-layered solid sphere. The differences of thermal physical parameters between the tumor and normal tissues, the interface conditions, and the effect of singular point at the center of sphere cause more the mathematical difficulties. The finite element method, thus, is applied to solve the governing equation, and the commercial software package COMSOL is to be the auxiliary tool.
For the detection of tumor location and size and the control of tumor temperature during hyperthermia treatment, the problems analyzed in this article contain steady and transient. The steady problem mainly focuses on the thermal effect of metabolic heat generation on breast in order to estimate the location and size of tumor. The transient problem is divided into two parts, the first part explores the effect of constant thermal physical properties on the tumor during hyperthermia treatment, and the second part explores the temperature-dependent effect of blood perfusion on the thermal treatment, the problem is non-linear multi-dimensional bio-heat transfer problem.

誌　　謝 I
中文摘要 II
Abstract III
目　　錄 IV
表 目 錄 VI
圖 目 錄 VII
第一章 緒論 1
1-1 研究動機 1
1-2 研究背景 2
1-3 文獻探討 3
1-4 研究目的 5
1-5 研究方法 7
第二章 腫瘤新陳代謝熱的溫度效應分析 16
2-1 簡介 16
2-2 模擬分析系統的模型 16
2-3 格點建構 19
2-4 結果與討論 21
第三章 腫瘤熱治療的溫度分佈分析 44
3-1 簡介 44
3-2 理論與模型建構 45
3-3 結果與討論 48
第四章 總結與展望 64
4-1 綜合結論 64
4-2 未來展望 65
參考文獻 67
自　　述 70

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