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研究生:郭哲庭
研究生(外文):Che-Ting Kuo
論文名稱:以二維數值模型模擬細胞的擴散及調整空間立體障礙效應與結合機制
論文名稱(外文):A Two-Dimensional Mathematical Model Simulating Intracellular Diffusion Quantifies Contributions of Steric Hindrance and Binding Effect
指導教授:張厚謙
學位類別:碩士
校院名稱:國立中興大學
系所名稱:化學工程學系所
學門:工程學門
學類:化學工程學類
論文種類:學術論文
畢業學年度:97
語文別:中文
論文頁數:90
中文關鍵詞:立體空間障礙細胞結合效應黏度
外文關鍵詞:steric hindrancecellbinding effectviscosity
相關次數:
  • 被引用被引用:0
  • 點閱點閱:198
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由於細胞之間的訊息傳遞對生物體很重要,當訊息傳遞發生問題,生物將會發生疾病。所以分子在細胞內的擴散變得很重要,之前有文獻已將結合效應獨立量化。本研究致力於二維空間障礙因子將表觀擴散係數中獨立出來。觀察胞器的大小和位置與擴散速度的關係。從研究的結果中了解空間障礙在擴散程序中所扮演的角色並且也成功的將空間障礙從表觀擴散係數中獨立出來。接著本研究調控空間障礙效應與結合機制效應擬合實驗的數據。
Intracellular mass transport plays as critical role in biological function, a variety of genetic diseases are related to the mal function of intracellular transport. Previous research on quantification of cytoplasmic diffusion coefficient has isolated the binding effect as one of the factor in determination of apparent diffusion coefficient. This research further isolated steric hindrance from factor such a viscosity and binding .Contribution of retarder from diffusion obstacle such as cytoskeleton and organelles are calculated and quantified. Results of the mathematical model are compared with experimental data from literature and satisfactory agreements are obtained.
中文摘要 4
Abstract 5
目錄 6
圖目錄 8
表目錄 12
第一章 前言 13
第二章 文獻回顧 15
2-1細胞的構造 15
2-2細胞質的內部環境 16
2-3細胞內分子的擴散方式 17
2-4影響擴散速率的因子 18
2-5定量分析影響擴散的因子 24
第三章 研究方法 28
3-1細胞內分子擴散的計算理論 28
3-2計算方法 32
第四章 模擬數據 42
4-1 胞器障礙物位於中心 42
4-2 胞器障礙物位於非中心 43
4-3實驗數據比較 49
第五章 結論 63
第六章 未來工作 68
文獻參考 69
附錄 72
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