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研究生:張瑋騰
研究生(外文):Wei-Teng Chang
論文名稱:母貓中性化之後之葡萄糖耐受性試驗
論文名稱(外文):The Effect of Intravenous Glucose Tolerance Test in Neutralized Female Cats
指導教授:李衛民李衛民引用關係
指導教授(外文):Wei-Ming Lee
學位類別:碩士
校院名稱:國立中興大學
系所名稱:獸醫學系暨研究所
學門:獸醫學門
學類:獸醫學類
論文種類:學術論文
論文出版年:2009
畢業學年度:97
語文別:中文
論文頁數:48
中文關鍵詞:胰島素葡萄糖中性化肥胖
外文關鍵詞:catinsulinglucoseneutralizationobesity
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在1991年,Crane等人首先發表了貓隻中性化與肥胖的相關性,攝食量的上升和代謝率下降是中性化後肥胖的主要原因。在人和貓,肥胖都會導致胰島素阻抗和葡萄糖耐受性異常,而胰島素阻抗和葡萄糖耐受性異常則被認為是第二型(非胰島素依賴型)糖尿病發生的前置因子。本實驗目的在觀察母貓中性化後六個月內的體重、胰島素敏感性和葡萄糖耐受性的變化,藉此觀察母貓中性化與糖尿病之間的關係。本實驗使用四隻三歲齡未中性中性化的母貓,中性化後每天測量其體重並計算BMI,在中性化後第一至六個月,每個月進行一次靜脈內葡萄糖耐受性試驗(intravenous glucose tolerance test),採血前先置入頭靜脈留置針,採血的時間點為葡萄糖注射前和葡萄糖注射後10、20、30、60及120分鐘,血中胰島素和葡萄糖分別以商品化之Mercodia Feline Insulin ELISA和ACCU-CHECK® Active血糖機進行檢測,胰島素敏感性以禁食後胰島素和HOMA值進行觀察,其值越高則胰島素敏感性越低,HOMA值之計算方法為禁食後血糖乘以禁食後胰島素濃度除以22.5,葡萄糖耐受性則以曲線下面積進行觀察。結果可見體重和BMI在中性化後第二個月顯著高於中性化後初始之時(p<0.05),四隻母貓六個月內的體重分別增加36%、36%、59%和25%,平均為38±5.46%。葡萄糖的曲線下面積則可見到在四號母貓第一、第五和第六個月明顯低於其他三隻母貓。禁食後胰島素濃度和HOMA值則呈現波動且六個月內並無顯著差異。本實驗證實中性化會使得母貓的體重上升,體重過重會導致葡萄糖耐受性異常,而胰島素敏感性的指標在六個月內並無顯著差異,推測在肥胖發生的初期,葡萄糖耐受性異常較胰島素阻抗早發生。而貓隻的胰島素分泌的變異係數大,故在未來的實驗中增加實驗的樣本數是必須的。
In 1991, it was first reported that obesity in feline was associated with neutering. Increased food intake and decreased metabolic rate after neutering might be the reason leading to obesity. Obesity will lead to insulin resistance and impaired glucose tolerance in human and feline. Type 2 diabetes mellitus (non-insulin dependent diabetes mellitus) is preceded by insulin resistance and impaired glucose tolerance. The aim of this study is to investigate the relationship between neutralization and diabetes mellitus in female cats. In our study, four 3-year-old female neutered cats were enrolled into this observation. Body weight of cats was measured every day. Intravenous glucose tolerance test was performed at 1, 2, 3, 4 and 5 months after neutering. Blood samples were collected at 0 and 10, 20, 30, 60 and 120 minutes from intravenous catheter after glucose administration. Plasma insulin and glucose were measured by Mercodia Feline Insluin ELISA and ACCU-CHECK® Active, respectively.In the results, body weight and BMI of cats were significantly higher at 2, 3, 4 and 5 months after neutering in comparison to the time after neutering (p<0.05). The weight gain in 4 cats was 36%, 36%, 59% and 25% respectively. The area under curve of plasma glucose was lower in cat no.4 at 5 and 6 months after neutering in comparison to other cats. The results of fasting insulin and HOMA fluctuated in 6 months observation.In our study, ovariohysterectomy leads to increased body weight and BMI. Overweight in female cats is associated impaired glucose tolerance. Insulin resistance is not found in this study. We suggest that glucose intolerance precedes insulin resistance in the early stage of obesity. Because of the variation of insulin secretion in feline is wide, increase in sample size is necessary in future study.
摘要....................................................................................................................................i
Abstract.............................................................................................................................ii
目次..................................................................................................................................iii
圖表目次...........................................................................................................................v
第一章 序言...................................................................................................................1
第二章 文獻探討
第一節、胰島素的生理功能及訊息傳遞路徑.........................................................2
第二節、雌性素﹝estrogen﹞與肥胖的關係............................................................3
第三節、肥胖與胰島素阻抗的關係.........................................................................4
第四節、雌性素與胰島素阻抗的關係.....................................................................6
第五節、貓的非胰島素依賴型糖尿病﹝non-insulin-dependent diabetes
mellitus﹞..................................................................................................7
第六節、胰島素敏感性測定
一、葡萄糖敏感性﹝glucose sensitivity,Sg﹞..................................................8
二、以動力學模式定量胰島素敏感性.............................................................9
三、以非動力學的數學模式定量估計胰島素敏感性...................................10
四、簡化胰島素敏感性測定在家貓的應用...................................................10
第三章 材料與方法
第一節、實驗動物...................................................................................................13
第二節、實驗設計及靜脈內葡萄糖耐受性試驗之進行.......................................13
第三節、血清中葡萄糖及胰島素之檢測...............................................................14
第四節、葡萄糖耐受性...........................................................................................14
第五節、胰島素敏感性...........................................................................................15
第六節、統計方法...................................................................................................15
第四章 結果
第一節、母貓中性化後的體重及BMI變化...........................................................16
第二節、IVGTT後血中葡萄糖的變化...................................................................16
第三節、IVGTT血中胰島素的變化.......................................................................16
第五章 討論
第一節、母貓中性化後的體重變化.......................................................................27
第二節、IVGTT後的血中葡萄糖變化...................................................................28
第三節、IVGTT後的血中胰島素及各月份HOMA值的變化..............................31
第四節、未來的研究方向.......................................................................................32
第五節、結論...........................................................................................................35
參考文獻.........................................................................................................................36
Allan FJ, Pfeiffer DU, Jones BR, Esslement DHB, Wiseman MS. A cross-sectional
study of risk factors for obesity in cats in New Zealand. Prev Vet Med 46:183-196, 2000
Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA.
Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 15:6541-6551, 1996.
Alessi DR, Kozlowski MT, Weng QP, Morrice N, Avruch J.
3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro. Curr Biol Jan 15:69-81, 1998.
Alonso A, González C. Relationship between non-genomic actions of estrogens and
insulin resistace. Infect Disord Drug Targets 8:48-51, 2008.
Amiel SA, Caprio S, Sherwin RS, Plewe G, Haymond MW, Tamborlane WV. Insulin
resistance of puberty: a defect restricted to peripheral glucose metabolism. J Clin Endocrinol Metab 72:277-282, 1991.
Andjelković M, Alessi DR, Meier R, Fernandez A, Lamb NJ, Frech M, Cron P, Cohen P,
Lucocq JM, Hemmings BA. Role of translocation in the activation and function of protein kinase B. J Biol Chem 272:31515-31524, 1997.
Appleton DJ, Rand JS, Sunvold GD. Basal plasma insulin and homeostasis model
assessment (HOMA) are indicators of insulin sensitivity in cats. J Feline Med Surg 7:183-193, 2005.
Appleton DJ, Rand JS, Sunvold GD. Insulin sensitivity decreases with obesity, and lean
cats with low insulin sensitivity are at greatest risk of glucose intolerance with weight gain. J Feline Med Surg 3:211-228, 2001.
Barden TP, Knowles HC Jr. Diagnosis of diabetes in pregnancy. Clin Obstet Gynecol
24:3-19, 1981.
Bastard JP, Robert JJ, Jardel C, Bruckert E, Grimaldi A, Hainque B. Is quantitative
insulin sensitivity check index, a fair insulin sensitivity index in humans? Diabetes Metab 27:69-70, 2001.
Beck-Nielson H, Alford F, Hother-Nielsen O. Insulin resistance in glucose disposal and
production in man with specific reference to metabolic syndrome and type 2 diabetes. In: Kumar S, O’Rahilly S, eds. Insulin resistance. John Wiley & Sons, Ltd, London, 155-178, 2005.
Belsito KR, Vester BM, Keel T, Graves TK, Swanson KS. Impact of
ovariohysterectomy and food intake on body composition, physical activity, and adipose gene expression in cats. J Anim Sci 87:594-602, 2009.
Bergman RN, Finegood DT, Ader M. Assessment of insulin sensitivity in vivo. Endocri
Rev 6:45-86; 1985.
Bergman RN, Ider YZ, Bowden CR, Cobelli C. Quantitative estimation of insulin
sensitivity. Am J Physiol 236:E667-677, 1979.
Best JD, Kahn SE, Ader M, Watanabe RM, Ni TC, Bergman RN. Role of glucose
effectiveness in the determination of glucose tolerance. Diabetes Care 19:1018-1030, 1996
Biourge V, MacDonald MJ, King L. Feline hepatic lipidosis: pathogenesis and
nutritional management. Compendium on Continuing Education for the Practicing Veterinarian 12:1244, 1990.
Biourge V, Nelson RW, Feldman EC, Willits NH, Morris JG, Rogers QR. Effect of
weight gain and subsequent weight loss on glucose tolerance and insulin response in healthy cats. J Vet Intern Med 11:86-91, 1997.
Björntorp P, Rosmond R. Obesity and cortisol. Nutrition 16:924-936, 2000.
Bonner-Weir S, Baxter LA, Schuppin GT, Smith FE. A second pathway for regeneration
of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes 42:1715-1720, 1993.
Brennan CL, Hoenig M, Ferguson DC. GLUT4 but not GLUT1 expression decreases
early in the development of feline obesity. Domest Anim Endocrinol 26:291-301, 2004.
Burger HG, Dudley EC, Hopper JL, Shelley JM, Green A, Smith A, Dennerstein L,
Morse C. The endocrinology of the menopausal transition: a cross-sectional study of a population-based sample. J Clin Endocrinol Metab 80:3537-3545, 1995.
Bergman RN, Ider YZ, Bowden CR, Cobelli C. Quantitative estimation of insulin
sensitivity. Am J Physiol 236:E667-677, 1979.
Catalano PM, Tyzbir ED, Wolfe RR, Calles J, Roman NM, Amini SB, Sims EA.
Carbohydrate metabolism during pregnancy in control subjects and women with gestational diabetes. Am J Physiol 264:E60-67, 1993.
Cerasi E, Luft R. Insulin response to glucose infusion in diabetic and non-diabetic
monozygotic twin pairs. Genetic control of insulin response? Acta Endocrinol (Copenh) 55:330-345, 1967.
Chrousos GP. Stressors, stress, and neuroendocrine integration o the adaptive response.
The 1997 Hans Selye Memorial Lecture. Ann N Y Acad Sci 851:311-335, 1998.
Cinti S, Mitchell G, Barbatelli G, Murano I, Ceresi E, Faloia E, Wang S, Fortier M,
Greenberg AS, Obin MS. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 46:2347-2355, 2005.
Clark A, Wells CA, Buley ID, Cruickshank JK, Vanhegan RI, Matthews DR, Cooper
GJ, Holman RR, Turner RC. Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes. Diabetes Res 9:151-159, 1988.
Coderre L, Vallega GA, Pilch PF, Chipkin SR. In vivo effects of dexamethasone and
sucrose on glucose transport (GLUT-4) protein tissue distribution. Am J Physiol 271:E643-648, 1996.
Crane SW. Occurrence and management of obesity in companion animals. J Small
Anim Pract 32:275-282, 1991.
DeFronzo RA, Jacot E, Jequier E, Maeder E, Wahren J, Felber JP. The effect of insulin
on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes 30:1000-1007, 1981.
DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying
insulin secretion and resistance. Am J Physiol 237:E214-223, 1979.
Di Gregorio GB, Yao-Borengasser A, Rasouli N, Varma V, Lu T, Miles LM,
Ranganathan G, Peterson CA, McGehee RE, Kern PA. Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone. Diabetes 54:2305-2313, 2005.
Domin J, Waterfield MD. Using structure to define the function of phosphoinositide
3-kinase family members. FEBS Lett 410:91-95, 1997.
Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic beta-cells are formed by
self-duplication rather than stem-cell differentiation. Nature 429:41-46, 2004.
Dötsch J, Rascher W, Meissner U. New insights into leptin resistance by modifying
cytokine receptor signal transduction. Eur J Endocrinol 152:333-334, 2005.
Feldhahn JR, Rand JS, Martin G. Insulin sensitivity in normal and diabetic cats. J Feline
Med Surg 1:107-115, 1999a.
Feldhahn JR, Rand JS, Kinnaird E. The effect of interday variation and a short-term
stressor on insulin sensitivity in clinically normal cats. J Feline Med Surg 1:233-240, 1999b.
Fettman MJ, Stanton CA, Banks LL, Hamar DW, Johnson DE, Hegstad RL, Johnston S.
Effects of neutering on bodyweight, metabolic rate and glucose tolerance of domestic cats. Res Vet Sci 62:131-136, 1997.
Finegood DT, Hramiak IM, Dupre J. A modified protocol for estimation of insulin
sensitivity with the minimal model of glucose kinetics in patients with insulin-dependent diabetes. J Clin Endocrinol Metab 70:1538-1549, 1990.
Fisher SJ, Kahn CR. Insulin signaling is required for insulin''s direct and indirect action
on hepatic glucose production. J Clin Invest 111:463-468, 2003.
Flynn MF, Hardie EM, Armstrong PJ. Effect of ovariohysterectomy on maintenance
energy requirement in cats. J Am Vet Med Assoc 209:1572-1581, 1996.
Frank G, Anderson W, Pazak K. Use of a high-protein diet in the management of feline
diabetes mellitus. Vet Ther 2:238-246, 2002.
Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature
395:763-770, 1998.
Fujita Y, Herron AL Jr, Seltzer HS. Confirmation of impaired early insulin response to
glycemic stimulus in nonobese mild diabetics. Diabetes 24:17-27, 1975.
Gordillo-Moscoso A, Valadez-Castillo JF, Mandeville PB, Hernandez-Sierra JF.
Comparison of equivalence and determination of diagnostic utility of min-mod and clamp methods for insulin resistance in diabetes free subjects: a meta-analysis. Endocrine 25:259-263.
Harper EJ, Stack DM, Watson TD, et al. Effects of feeding regimens on bodyweight,
composition and condition score in cats following ovariohysterectomy. J Small Anim Pract 42:433-438, 2001.
Harris MI, Flegal KM, Cowie CC, Eberhardt MS, Goldstein DE, Little RR, Wiedmeyer
HM, Byrd-Holt DD. Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey, 1988-1994. Diabetes Care 21:518-524, 1998.
Heine PA, Taylor JA, Iwamoto GA, Lubahn DB, Cooke PS. Increased adipose tissue in
male and female estrogen receptor-alpha knockout mice. Proc Natl Acad Sci USA 97:12729-12734, 2000.
Hoenig M, Reusch C, Peterson ME. Beta cell and insulin antibodies in treated and
untreated diabetic cats. Vet Immunol Immunopathol 77:93-102, 2000.
Hoenig M, Hall G, Ferguson D, Jordan K, Henson M, Johnson K, O''Brien T. A feline
model of experimentally induced islet amyloidosis. Am J Pathol 157:2143-2150, 2000.
Hoenig M, Thomaseth K, Waldron M, Ferguson DC. Insulin sensitivity, fat distribution,
and adipocytokine response to different diets in lean and obese cats before and after weight loss. Am J Physiol Regul Integr Comp Physiol 292:R227-234, 2007.
Holgado-Madruga M, Emlet DR, Moscatello DK, Godwin AK, Wong AJ. A
Grb2-associated docking protein in EGF- and insulin-receptor signalling. Nature 379:560-564, 1996.
Hollingsworth DR. Alterations of maternal metabolism in normal and diabetic
pregnancies: differences in insulin-dependent, non-insulin-dependent, and gestational diabetes. Am J Obstet Gynecol 146:417-429, 1983.
Holmäng A, Björntorp P. The effects of cortisol on insulin sensitivity in muscle. Acta
Physiol Scand 144:425-431, 1992.
Hosomi Y, Shii K, Ogawa W, Matsuba H, Yoshida M, Okada Y, Yokono K, Kasuga M,
Baba S, Roth RA. Characterization of a 60-kilodalton substrate of the insulin receptor kinase. J Biol Chem 269:11498-11502, 1994.
Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis
factor-alpha: direct role in obesity-linked insulin resistance. Science 259:87-91, 1993.
Jones ME, Thorburn AW, Britt KL, Hewitt KN, Wreford NG, Proietto J, Oz OK, Leury
BJ, Robertson KM, Yao S, Simpson ER. Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity. Proc Natl Acad Sci USA 97:12735-12740, 2000.
Jump DB, Clarke SD, Thelen A, Liimatta M. Coordinate regulation of glycolytic and
lipogenic gene expression by polyunsaturated fatty acids. J Lipid Res 35:1076-1084, 1994.
Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, Quon MJ.
Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 85:2402-2410, 2000
Kelley DE. Overview: what is insulin resistance? Nutr Rev 58(3 Pt 2):S2-3, 2000.
Kern PA, Ranganathan S, Li C, Wood L, Ranganathan G. Adipose tissue tumor necrosis
factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab 280:E745-51, 2001.
Kern PA, Di Gregorio GB, Lu T, Rassouli N, Ranganathan G. Adiponectin expression
from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-alpha expression. Diabetes 52:1779-1785, 2003.
Killinger DW, Perel E, Daniilescu D, Kharlip L, Lindsay WR. The relationship between
aromatase activity and body fat distribution. Steroids 50:61-67, 1987.
Klöppel G, Löhr M, Habich K, Oberholzer M, Heitz PU. Islet pathology and the
pathogenesis of type 1 and type 2 diabetes mellitus revisited.Surv Synth Pathol Res 4:110-125, 1985.
Kohn AD, Takeuchi F, Roth RA. Akt, a pleckstrin homology domain containing kinase,
is activated primarily by phosphorylation. J Biol Chem 271:21920-21926, 1996.
Krssak M, Falk Petersen K, Dresner A, DiPietro L, Vogel SM, Rothman DL, Roden M,
Shulman GI. Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia 42:113-116, 1999.
Kubota N, Terauchi Y, Yamauchi T, Kubota T, Moroi M, Matsui J, Eto K, Yamashita T,
Kamon J, Satoh H, Yano W, Froguel P, Nagai R, Kimura S, Kadowaki T, Noda T. Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem 277:25863-25866, 2002.
Kumagai S, Holmäng A, Björntorp P. The effects of oestrogen and progesterone on
insulin sensitivity in female rats. Acta Physiol Scand 149:91-97, 1993.
Lambillotte C, Gilon P, Henquin JC. Direct glucocorticoid inhibition of insulin
secretion. An in vitro study of dexamethasone effects in mouse islets. J Clin Invest 99:414-423, 1997.
Lavan BE, Fantin VR, Chang ET, Lane WS, Keller SR, Lienhard GE. A novel 160-kDa
phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family. J Biol Chem 272:21403-21407, 1997.
Link KR, Rand JS. Arginine and phentolamine response tests in cats. J Vet Intern Med
10:185, 1998.
Lund EM, Armstrong PJ, Kirk CA, Kolar LM, Klausner JS. Health status and
population characteristics of dogs and cats examined at private veterinary practices in the Uinted States. J Am Vet Med Assoc 214:1336-1341, 1999
Lund EM, Armstrong PJ, Kirk CA, Klausner JS. Prevalence and risk factors for obesity
in adult cats from private US veterinary practices. Int J Appl Res Vet Med 3:88-96, 2005
Maeda N, Shimomura I, Kishida K, Nishizawa H, Matsuda M, Nagaretani H, Furuyama
N, Kondo H, Takahashi M, Arita Y, Komuro R, Ouchi N, Kihara S, Tochino Y, Okutomi K, Horie M, Takeda S, Aoyama T, Funahashi T, Matsuzawa Y. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 8:731-737, 2002.
Marshall RD ,Rand JS. Treatment with glargine results in higher remission rates than
lente or protamine zinc insulins in newly diagnosed diabetic cats [abstract]. J Vet Intern Med 19:425, 2005.
Martin BC, Warram JH, Krolewski AS, Bergman RN, Soeldner JS, Kahn CR. Role of
glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet 340:925-929, 1992.
Martin GJ, Rand JS. Evaluation of a polyurethane jugular catheter in cats placed using a
modified Seldinger technique. Aust Vet J 77(4):250-254, 1999.
Massillon D, Barzilai N, Hawkins M, Prus-Wertheimer D, Rossetti L. Induction of
hepatic glucose-6-phosphatase gene expression by lipid infusion. Diabetes 46:153-157, 1997.
McEwen BS. Protective and damaging effects of stress mediators: the good and bad
sides of the response to stress. Metabolism 51:2-4, 2002
Mevorach M, Giacca A, Aharon Y, Hawkins M, Shamoon H, Rossetti L. Regulation of
endogenous glucose production by glucose per se is impaired in type 2 diabetes mellitus. J Clin Invest 102:744-753, 1998.
Milarski KL, Lazar DF, Wiese RJ, Saltiel AR. Detection of a 60 kDa
tyrosine-phosphorylated protein in insulin-stimulated hepatoma cells that associates with the SH2 domain of phosphatidylinositol 3-kinase. Biochem J 308 (Pt 2):579-83, 1995.
Misso ML, Jang C, Adams J, Tran J, Murata Y, Bell R, Boon WC, Simpson ER, Davis
SR. Adipose aromatase gene expression is greater in older women and is unaffected by postmenopausal estrogen therapy. Menopause 12:210-215, 2005.
Monzillo LU, Hamdy O. Evaluation of insulin sensitivity in clinical practice and in
research settings. Nutr Rev 61:397-412, 2003.
Morgan K, Obici S, Rossetti L. Hypothalamic responses to long-chain fatty acids are
nutritionally regulated. J Biol Chem 279:31139-31148, 2004.
Nagasaka S, Tokuyama K, Kusaka I, Hayashi H, Rokkaku K, Nakamura T, Kawakami
A, Higashiyama M, Ishikawa S, Saito T. Endogenous glucose production and glucose effectiveness in type 2 diabetic subjects derived from stable-labeled minimal model approach. Diabetes 48:1054-1560, 1999.
Nawrocki AR, Rajala MW, Tomas E, Pajvani UB, Saha AK, Trumbauer ME, Pang Z,
Chen AS, Ruderman NB, Chen H, Rossetti L, Scherer PE. Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. J Biol Chem 281:2654-2660, 2006.
Navé BT, Siddle K, Shepherd PR. Phorbol esters stimulate phosphatidylinositol
3,4,5-trisphosphate production in 3T3-L1 adipocytes: implications for stimulation of glucose transport. Biochem J 318(Pt 1):203-5, 1996.
Nelson RW, Himsel CA, Feldman EC, Bottoms GD. Glucose tolerance and insulin
response in normal-weight and obese cats. Am J Vet Res 51:1357-1362, 1990.
Obici S, Feng Z, Arduini A, Conti R, Rossetti L. Inhibition of hypothalamic carnitine
palmitoyltransferase-1 decreases food intake and glucose production. Nat Med 9:756-761, 2003.
Panciera DL, Thomas CB, Eicker SW, Atkins CE. Epizootiologic patterns of diabetes
mellitus in cats: 333 cases (1980-1986). J Am Vet Med Assoc 197:1504-1508, 1990.
Park YW, Zhu S, Palaniappan L, Heshka S, Carnethon MR, Heymsfield SB. The
metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994. Arch Intern Med 163:427-436, 2003.
Pedersen SB, Kristensen K, Hermann PA, Katzenellenbogen JA, Richelsen B. Estrogen
controls lipolysis by up-regulating alpha2A-adrenergic receptors directly in human adipose tissue through the estrogen receptor alpha. Implications for the female fat distribution. J Clin Endocrinol Metab 89:1869-1878, 2004.
Porte D Jr. Banting lecture 1990. Beta-cells in type II diabetes mellitus. Diabetes
40:166-180, 1991.
Potteiger JA, Jacobsen DJ, Donnelly JE. A comparison of methods for analyzing
glucose and insulin areas under the curve following nine months of exercise in overweight adults. Int J Obes Relat Metab Disord 26:87-89, 2002.
Petrus DJ, Jackson MW, Kemnitz JW, Finegood DT, Panciera D. Assessing insulin
sensitivity in the cat: evaluation of the hyperinsulinemic euglycemic clamp and the minimal model analysis. Res Vet Sci 65:179-181, 1998.
Prahl A, Glickman L, Guptill L, Glickman N, Tetrick M.Time trends and risk factors for
diabetes mellitus in cats. (Abstract). J Vet Intern Med 17:434, 2003.
Prigeon RL, Quddusi S, Paty B, D''Alessio DA. Suppression of glucose production by
GLP-1 independent of islet hormones: a novel extrapancreatic effect. Am J Physiol Endocrinol Metab 285:E701-707, 20
Puder JJ, Monaco SE, Sen Gupta S, Wang J, Ferin M, Warren MP. Estrogen and
exercise may be related to body fat distribution and leptin in young women. Fertil Steril 86:694-699, 2006.
Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G.
Phosphorylation and activation of p70s6k by PDK1. Science 279:707-10, 1998.
Rabasa-Lhoret R, Laville M. [How to measure insulin sensitivity in clinical practice?].
Diabetes Metab 27:201-208, 2001.
Puah JA, Bailey CJ. Effect of ovarian hormones on glucose metabolism in mouse soleus
muscle. Endocrinology 117:1336-1340, 1985.
Radziuk J. Insulin sensitivity and its measurement: structural commonalities among the
methods. J Clin Endocrinol Metab 85:4426-4433, 2000.
Rand J. Current understanding of feline diabetes: part 1, pathogenesis. J Feline Med
Surg 1:143-153, 1993.
Rand JS, Kinnaird E, Baglioni A, Blackshaw J, Priest J. Acute stress hyperglycemia in
cats is associated with struggling and increased concentrations of lactate and norepinephrine. J Vet Intern Med 16:123-132, 2002.
Rasouli N, Kern PA. Adipocytokines and the metabolic complications of obesity. J Clin
Endocrinol Metab 93:S64-73, 2008.
Rincon J, Holmäng A, Wahlström EO, Lönnroth P, Björntorp P, Zierath JR,
Wallberg-Henriksson H. Mechanisms behind insulin resistance in rat skeletal muscle after oophorectomy and additional testosterone treatment. Diabetes 45:615-621, 1996.
Robertson ID. The influence of diet and other factors on owner-percieved obesity in
privately owned cats from Metropolitan Perth, Western Australia. Prev Vet Med 40:75-85, 1999
Robertson RP, Harmon J, Tran PO, Tanaka Y, Takahashi H. Glucose toxicity in
beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes 52:581-587, 2003.
Root MV, Johnston SD, Olson PN. Effect of prepuberal and postpuberal gonadectomy
on heat production measured by indirect calorimetry in male and female domestic cats. Am J Vet Res 57:371-374, 1996.
Russell K, Sabin R, Holt S, Bradley R, Harper EJ. Influence of feeding regimen on
body condition in the cat. J Small Anim Prac 41:12-17, 2000
Salpeter SR, Walsh JM, Ormiston TM, Greyber E, Buckley NS, Salpeter EE.
Meta-analysis: effect of hormone-replacement therapy on components of the metabolic syndrome in postmenopausal women. Diabetes Obes Metab 8:538-554, 2006.
Sehgal SN. Rapamune (Sirolimus, rapamycin): an overview and mechanism of action.
Ther Drug Monit 17:660-665, 1995.
Savage DB, Petersen KF, Shulman GI. Disordered lipid metabolism and the
pathogenesis of insulin resistance. Physiol Rev 87:507-520, 2007.
Scarlett JM, Donoghue S. Associations between body condition and disease in cats. J
Am Vet Med Assoc 212:1725-1731, 1998.
Shao J, Yamashita H, Qiao L, Draznin B, Friedman JE. Phosphatidylinositol 3-kinase
redistribution is associated with skeletal muscle insulin resistance in gestational diabetes mellitus. Diabetes 51:19-29, 2002.
Shepherd PR, Withers DJ, Siddle K. Phosphoinositide 3-kinase: the key switch
mechanism in insulin signalling. Biochem J 333(Pt 3):471-490, 1998.
Shimomura Y, Takahashi M, Shimizu H, Sato N, Uehara Y, Negishi M, Inukai T,
Kobayashi I, Kobayashi S. Abnormal feeding behavior and insulin replacement in STZ-induced diabetic rats. Physiol Behav 47:731-734, 1990.
Smith-Hall J, Pons S, Patti ME, Burks DJ, Yenush L, Sun XJ, Kahn CR, White MF. The
60 kDa insulin receptor substrate functions like an IRS protein (pp60IRS3) in adipose cells. Biochemistry 36:8304-8310, 1997.
Snead DB, Birge SJ, Kohrt WM. Age-related differences in body composition by
hydrodensitometry and dual-energy X-ray absorptiometry. J Appl Physiol 74:770-775, 1993.
Sun XJ, Rothenberg P, Kahn CR, Backer JM, Araki E, Wilden PA, Cahill DA, Goldstein
BJ, White MF. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352:73-77, 1991.
Sun XJ, Wang LM, Zhang Y, Yenush L, Myers MG Jr, Glasheen E, Lane WS, Pierce JH,
White MF. Role of IRS-2 in insulin and cytokine signalling. Nature 377:173-177, 1995.
Taha C, Klip A. The insulin signaling pathway. J Membrane Biol 169:1-12, 1999.
Toth MJ, Tchernof A, Sites CK, Poehlman ET. Effect of menopausal status on body
composition and abdominal fat distribution. Int J Obes Relat Metab Disord 24:226-231, 2000.
Tanaka A, Inoue A, Takeguchi A, Washizu T, Bonkobara M, Arai T. Comparison of
expression of glucokinase gene and activities of enzymes related to glucose metabolism in livers between dog and cat. Vet Res Commun 29:477-485, 2005.
Tonelli J, Kishore P, Lee DE, Hawkins M. The regulation of glucose effectiveness: how
glucose modulates its own production. Curr Opin Clin Nutr Metab Care 8:450-456, 2005.
Trayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white
adipose tissue. Br J Nutr 92:347-355, 2004.
Tremblay F, Lavigne C, Jacques H, Marette A. Defective insulin-induced GLUT4
translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (zeta/lambda) activities. Diabetes 50:1901-1910, 2001.
Van Obberghen E, Ksauga M, Le Cam A, Hedo JA, Itin A, Harrison LC. Biosynthetic
labeling of insulin receptor: studies of subunits in cultured human IM-9 lymphocytes. Proc Natl Acad Sci U S A 78:1052-1056, 1981.
Wajngot A, Khan A, Giacca A, Vranic M, Efendic S. Dexamethasone increases glucose
cycling, but not glucose production, in healthy subjects. Am J Physiol 259:E626-632, 1990.
Walker KS, Deak M, Paterson A, Hudson K, Cohen P, Alessi DR. Activation of protein
kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha. Biochem J 331(Pt 1):299-308, 1998.
Wallance TM, Matthews DR. The assessment of insulin resistance in man. Diabee Med
19:527-534, 2002.
Wallerius S, Rosmond R, Ljung T, Holm G, Björntorp P Rise in morning saliva cortisol
is associated with abdominal obesity in men: a preliminary report. J Endocrinol Invest 26:616-619, 2003.
Warram JH, Martin BC, Krolewski AS, Soeldner JS, Kahn CR. Slow glucose removal
rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Ann Intern Med 113:909-915, 1990.
Weaver KE, Rozanski EA, Mahony OM, Chan DL, Freeman LM. Use of glargine and
lente insulins in cats with diabetes mellitus. J Vet Intern Med 20:234-238, 2006.
Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, Tataranni PA.
Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 86:1930-1935, 2001.
White MF, Maron R, Kahn CR. Insulin rapidly stimulates tyrosine phosphorylation of a
Mr-185,000 protein in intact cells. Nature 318:183-186, 1985.
White MF. The IRS-signalling system: a network of docking proteins that mediate
insulin action. Mol Cell Biochem 182:3-11, 1998.
Yamanashi Y, Baltimore D. Identification of the Abl- and rasGAP-associated 62 kDa
protein as a docking protein, Dok. Cell 88:205-211, 1997.
Yang YJ, Youn JH, Bergman RN. Modified protocols improve insulin sensitivity
estimation using the minimal model. Am J Physiol. 253:E595-602, 1987.
Zamboni M, Armellini F, Milani MP, De Marchi M, Todesco T, Robbi R,
Bergamo-Andreis IA, Bosello O. Body fat distribution in pre- and post-menopausal women: metabolic and anthropometric variables and their inter-relationships. Int J Obes Relat Metab Disord 16:495-504, 1992.
Zhang-Sun G, Yang C, Viallet J, Feng G, Bergeron JJ, Posner BI. A 60-kilodalton protein
in rat hepatoma cells overexpressing insulin receptor was tyrosine phosphorylated and associated with Syp, phophatidylinositol 3-kinase, and Grb2 in an insulin-dependent manner. Endocrinology 137:2649-2658, 1996.
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning
of the mouse obese gene and its human homologue. Nature 372:425-32, 1994.
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