跳到主要內容

臺灣博碩士論文加值系統

(35.172.136.29) 您好!臺灣時間:2021/07/25 00:12
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果 :::

詳目顯示

我願授權國圖
: 
twitterline
研究生:孫啟原
研究生(外文):Chi-Yuan Sun
論文名稱:利用1H-NMR和HPLC對馬兜鈴屬植物之馬兜鈴酸-I和-II及牛樟芝之子實體成分定量研究
論文名稱(外文):The investigation on the quantity of Aristolochic Acids-I and-II in the plants of Aristolochia genus and the constituents from fruiting body of Taiwanofungus camphoratus by 1H-NMR and HPLC methods
指導教授:吳天賞吳天賞引用關係
指導教授(外文):Tian-Shung Wu
學位類別:碩士
校院名稱:國立成功大學
系所名稱:化學系碩博士班
學門:自然科學學門
學類:化學學類
論文種類:學術論文
論文出版年:2009
畢業學年度:97
語文別:中文
論文頁數:116
中文關鍵詞:馬兜鈴酸樟芝
外文關鍵詞:Taiwanofungus camphoratusAristolochic Acid
相關次數:
  • 被引用被引用:2
  • 點閱點閱:1093
  • 評分評分:
  • 下載下載:0
  • 收藏至我的研究室書目清單書目收藏:0
由於馬兜鈴屬植物中所含的馬兜鈴酸成分會造成使用者產生急性腎功能衰竭現象,因此對於藥材中馬兜鈴酸成分的定量更顯得重要。在本論文中,建立了利用1H-NMR做為分析儀器,分析定量中藥材中所含馬兜鈴酸I及II的含量。定量方法採用質子吸收訊號的相對積分面積與化學位移在8.45ppm的內標準品蒽做比較,偵測極限為0.0107 mg/mL。NMR光譜法具有快速分析及簡單操作的優點,但靈敏度卻不如HPLC靈敏,在本論文中也利用HPLC來確認實驗的結果。
第二部份則是利用HPLC搭配UV偵測器,發展出對樟芝子實體中三萜類及單苯環類的定量分析方法。當中首次建立的9種三萜類及4種單苯環類的HPLC指紋圖譜也被應用在區分野生樟芝及人工培養樟芝的差別,除此之外,此定量分析方法也可對野生樟芝及人工培養樟芝的三萜類及單苯環類成分做定量。
The determination and quantification of aristolochic acids I and II, which will cause acute renal failure, in the plants of the genus Aristolochia is important. In the present study, a quantitative determination of aristolochic acids I and II in plants using 1H NMR spectroscopy was reported. The quantification was performed by relative integration of two proton singlets resonating at δ 8.45 of anthracene. The detection limit was determined to be 0.0107 mg/mL. The 1H NMR spectroscopy is a fast analytical method and relatively easy to perform, but lack the sensitivity that can be achieved with HPLC. Thus, the accuracy of this method was ensured by HPLC.
The second part is a method, which was developed for quantitative determination of triterpene acids and benzenoids from the fruiting body of Taiwanofungus camphorates, based on HPLC with UV detector. The HPLC fingerprint of the nine triterpene acids and four benzenoids were developed for the first time and applied to distinguish the wild and cultured species of T. camphoratus. Furthermore, the quantifications of triterpene acids and benzenoids were accomplishment for the wild and cultured species.
Abstrsct………………III
摘要……………IV
誌謝……………V
表目錄…………VIII
圖目錄……………………IX
第一部份………1
第一章 緒論…………3
第二章 文獻回顧……………………4
第一節 馬兜鈴的使用……………………………4
第二節 馬兜鈴植物的介紹……………6
第三節 馬兜鈴酸藥理活性……………………7
第四節 馬兜鈴酸分析方法回顧…………………12
FDA concerned about botanical products, containing aristolochic acid…………………..17
第三章 研究目的……………………………18
第四章 研究方法……………………………………………20
第一節 實驗使用儀器及藥品…………………………………20
第二節 馬兜鈴酸(Aristolochic acid)提取方式…………21
第三節 1H-NMR操作條件……………22
第四節 HPLC操作條件……………………23
第五章 結果與討論………………………………24
第一節 馬兜鈴酸抽取與1H-NMR分析馬兜鈴酸訊號………24
第二節 馬兜鈴酸之檢量線………………………25
第三節 1H-NMR偵測馬兜鈴酸之偵測極限……………31
第四節 以1H-NMR定量馬兜鈴酸之含量…………………36
第六章 結論…………………………………………43
第二部份………………………………44
第一章 緒論…………………………………………………46
第二章 文獻回顧…………………………47
第一節 牛樟芝的使用…………………………47
第二節 牛樟芝的介紹………………………………48
第三節 牛樟芝的化學成分…………………………………50
第四節 牛樟芝的藥理活性………………………………52
第三章 研究方法………………………………58
第一節 實驗使用儀器及藥品………………………58
第二節 HPLC操作條件……………………………………59
第三節 牛樟芝純化合物分類…………………………60
第四章 結果與討論…………………………62
第一節 各化合物之檢量線及再線性…………………………62
第二節 HPLC偵測各化合物之偵測極限(LOD)及定量極限(LOQ).71
第三節 各化合物之回收率……………………72
第四節 樟芝初萃物之成分分析…………………………73
第五章 結論…………………………………80
附錄一……………81
附錄二………………………………………………82
參考文獻1…………………………………………100
參考文獻2……………………………………………110
參考文獻1
1.唐.蘇敬等,新修本草,國立中國醫藥研究所,p.256,1964。
2.宋.盧多遜、李昉等撰,開寶本草,安徽科學技術出版社,p.351,1998。
3.宋.蘇頌,圖經本草,福建科學技術出版社,p.248,1994。
4.宋.寇宗奭,本草衍義,華夏文獻資料出版社,p.125,1987。
5.明.李時珍,本草綱目,國立中國醫藥研究所,p.125,1976。
6.宋.唐慎微,重修政和經史證類備用本草,南天書局有限公司p117,1984。
7.清.吳其濬,植物名實圖考,台南北一出版社,p224,1974。
8.國家中醫藥管理局《中華本草》編委會,中華本草(第三冊),上海科學技術出版社,p226,1998。
9.Perry, L. M. ; Medicinal Plants of the East and Southeast Asia; MIT press, Cambridge, 1980.
10.Chopra, R. N. ; Nayer, S. L. ; Chopra, I. C. Glossary of Indian Medicinal Plants, 1956 , p.24.
11.Kirtikar, K. R. ; Basu, B. D. , Indian Medicinal Plants III, L. M. Basu Ed.; Periodical Experts, Allahabad, 1935, p. 2123.
12.Biswas, K. P. ; Ghosh, A. , Bharatiya Bonousadhi IV; Calcutta University, India, 1973 , p. 385.
13.Mukerji, B. , The Indian Pharmaceutical Codex – Indigenous Drugs; Council of Scientific and Industrial Research, New Delhi, India, 1953 , p. 21.
14.Irvine, F. R. , Woody Plants of Ghana with Special Reference to their Uses, Oxford University Press, London, 1961, p. 878.
15.Daiziel, J. M. , The Useful Plants of West Tropical Africa, Grown Agents for the Colony, London, 1937, 6, p. 612.
16.Watt, J. M. ; Breyer-Brandwijk, M. G. , Meicinal and Poisonous Plants of Southern and Eastern Africa, 2nd Ed.; E. and S. Livingstone Ltd, Edinburgh, 1962 , p. 118.
17.Hieronymus, J. , Plantae diaphoricae florae argentinae; Bol. Acad. Nac. Ciencias, Cỏrdoba, 1882 , 4, pp. 199-598.
18.Dominguez, J. A. , Contribuciones a la Materia Medica Argentina Peuser, Buenos Aires, 1928.
19.Chopra, R. N. ; Nayer S. L. ; Chopra, I. C. , Glossary of Indian Medicinal Plants; CSIR, New Delhi, 1956 , p. 24.
20.Martinez, M. , Las Plants Medicinales de Mẻxico, 6th Ed.; D. F. Mẻxico, Botas, 1991 , p. 270.
21.Navas, L. E. , Flora de la Cuenca de Santiago de Chile;, 1976, 2.
22.Murillo, A. , Memoria sobre plantas medicinales de Chile y el uso que de ellas se hace en el pais; Imprentadel Ferrocarril, Santiago de Chile, 1861.
23.Hong, L. ; Sakagami, Y. ; Marumo S. ; Xinmin, C. ,“Eleven aristolochic acid derivatives from Aristolochia cinnabarina” Phtochemistry, 1994, 37, 237-239.
24.Velasco, J. , Historia del Rein de Quito, La Historia Natura , Empresa Editoria EI Comercio, Quito, Ecuador, 1946 , 1.
25.Branch, L. C. ; Do Silva, M. F. , “Survival and behavior of four species of Ambystoma larvae under hypoxic conditions”Acta Amazonica, 1983, 13, 737.
26.Montes, M. ; Wilkcomirsky, T. , Medicina Traditional Chilena; Editorial de la Universidad de Concepciỏn, Chile, 1985 , pp. 15, 23, 52.
27.Diaz, J. L. , Usos de las Plantas Medicinales de Mẻxico; Monografias Cientificas II, Instituto Mexicano para el Estudio de las Plantas Medicinales, D. F. Mẻxico, Mẻxico, 1976 , p. 11.
28.Del Amo, S. , Plantas Medicinales del Estado de Veracruz; Instituto Nacional de Investigationes sobre Recursos Bioticos, Xalapa, Mẻxico, 1979 , p. 15.
29.Jiangsu New Medical College, Encyclopedia of Chinese Materia Medica; Shanghai Science and Technology Press, Shanghai, 1977 , 1, p. 976.
30.Parker, J. Mil plantas medicinales; Bilblioteca Nueva, Buenos Aires, 1949 , p. 170.
31.Ratera, E. L ; Ratera, M. O. , Plantas de la flora argentina empleadas en Medicina Popular; Hemisferio Sur, Buenos Aires, 1980 , pp. 57–190.
32.Toursarkissian, M. , Plantas medicinales de la Argentina, sus nombres bota´nicos, vulgares, usos y disribucio´n geogra´fica, Hemisferio Sur, Buenos Aires, 1980 , pp. 1–178.
33.Boelcke, Q. , Plantas vasculares de la Argentina, Fundacio´n para la educacio´n, laciencia y la cultura (FECIC), Buenos Aires, 1981 , p. 201.
34.Compilation of Chinese Herb Medicine , Peoples Publishing House, Beijing, 1978 , 2, p.43.
35.The Great Lexicon of Chinese Medicinal Plants , Scientific and Technical Press, Shanghai, 1978 ,.2, p. 1557.
36.Watson, L. ; Dallwitz, M. J. , The Families of Flowering Plants , 1992.
37.Gonzalez, F. , A phylogenetic analysis of the Aristolochioideae (Aristolochiaceae), Ph. D thesis, 1999.
38.Hutchinson, J. , The Familes of Flowering Plants, 3rd Ed., Clarendon Press, Oxford, 1973, p. 510.
39.張永勳:台灣產馬兜鈴、土青木香及天仙藤之生藥學研究,中國醫藥學院中國藥學研究所,台中市,1977。
40.Kupchan, S. M. ; Doskotsch, R. W. , “TUMOR INHIBITORS. I. ARISTOLOCHIC ACID, THE ACTIVE PRINCIPLE OF ARISTOLOCHIA INDICA”J. Med. Pharm. Chem., 1962, 5, 657-659.
41.Komatsu, N. ; Nawata, H. ; Kimino, T. ; Shoji, J. ; Tada, A. , “Biological activities of aristolochic acid. II. Effects on experimental tumor, bacterial infection, and RES [reticuloendothelial system] function”Showa Igakkai Zasshi, 1973, 33, 776-782.
42.Moese, J. R. ; Porta, J. ,“Aristolochic acid. 1.” Arzneim. Forsch., 1974, 24, 52-54.
43.Matsui, K. ; Wada, K. ; Munakata, K. , “Insect antifeeding substances in Parabenzoin praecox and Piper futokadzura.”Agric. Biol. Chem., 1976, 40, 1045-1046.
44.Pakrashi, A. ; Chakrabarty, B. ,“Antifertility effect of aristolic acid from Aristolochia indica (Linn) in female albino rabbits.” Experientia, 1978, 34, 1377.
45.Pakrashi, A. ; Shaha, C. ,“Effect of methyl ester of aristolic acid from Aristolochia indica Linn. on fertility of female mice.” Experientia, 1978, 34, 1192-1193.
46.Moretti, C. ; Rideau, M. ; Chenieux, J. C. ; Viel, C. , “Isolation of aristolochic acid from two Madagascar Aristolochiaceae. Determination of its toxicity on vegetal cells. Comparison with animal cells (author's transl).”Planta Med., 1979, 35, 360-365.
47.Tsai, L. H. ; Yang, L. L. ; Chang, C. , “Inactivation of Formosan snake venoms in vivo by aristolochic acid, the chemical component of Aristolochia radix.”Taiwan K’o Hsueh, 1980, 34, 40-44.
48.Wang, H. W. ; Zheng, J. H. , “The pregnancy terminating effect and toxicity of an active constituent of Aristolochia mollissima Hance, aristolochic acid A.”Acta Pharm. Sinica, 1984, 19, 405-409.
49. Xu, L. Z. ; Sun, N. J. , “Chemical constituents of Aristolochia moupinensis Franch.”Yaoxue Xuebao, 1984, 19, 48-55.
50.Ganguly, T. ; Pakrashi, A. ; Pal, A. K. , “Disruption of pregnancy in mouse by Aristolic acid: I. Plausible explanation in relation to early pregnancy events”Contraception, 1986, 34, 625-637.
51.Mengs, U. , “Acute toxicity of aristolochic acid in rodents.”Arch. Toxicol., 1987, 59, 328-331.
52.Sun, N. J. ; Antoun, M. ; Chang, C. J. ; Cassady, J. M. , “New cytotoxic aristolactams from Pararistolochia flos-avis.”J. Nat. Prod., 1987, 50, 843-846.
53.Viswanath, B. S. ; Gowda, T. V. , “Interaction of aristolochic acid with Vipera russelli phospholipase A2: its effect on enzymatic and pathological activities.”Toxicon., 1987, 25, 929-937.
54.Pezzuto, J. M. ; Swanson, S. M. ; Mar, W. ; Che, C. T. ; Cordell, G. A. ; Fong, H. H. , “Evaluation of the mutagenic and cytostatic potential of aristolochic acid (3,4-methylenedioxy-8-methoxy-10-nitrophenanthrene-1-carboxylic acid) and several of its derivatives.”Mutat. Res., 1988, 206, 447-454.
55.Viswanath, B. S. ; Fawzy, A. A. ; Franson, R. C. , “Edema-inducing activity of phospholipase A2 purified from human synovial fluid and inhibition by aristolochic acid.”Inflammation, 1988, 12, 549-561
56.Ustunes, L. ; Laekeman, G. M. ; Gözler, B. ; Vlietink, A. J. ; ÖZer, A. ; Herman, A. G. ,“In vitro study of the anticholinergic and antihistaminic activities of protopine and some derivatives.” J. Nat. Prod., 1988, 51,1021-1022.
57.Hinou, J. ; Demetzos, C. ; Harvala, C. ; Roussakis, C. , “Cytotoxic and antimicrobial principles from the roots of Aristolochia longa.”Int. J. Crude Drug Res., 1990, 28, 149-151.
58.Zhang, J. ; He, L. X. , “Structure of versicolactone A. A novel sesquiterpene lactone from Aristolochia versicolor S.M. Hwang.”Chin. Chem. Lett., 1990, 1, 223-224.
59.Yamaguchi, T. ; Ogino, T. ; Sato, S. ; Chin, N. , Jpn. KoKai Tokkyo Koho JP 04159225, 1992.
60.Urzua, M. A. ; Rodriguez, A. R. , “Germination-inhibiting terpenes from the roots of Aristolochia chilensis.”Bol. Soc. Chil. Quim., 1992, 37, 183-187.
61. Pistelli, L. ; Nieri, E. ; Bilia, A. R. ; Marsili, A. ,“Chemical constituents of Aristolochia rigida and mutagenic activity of aristolochic acid IV.” J. Nat. Prod., 1993, 56, 1605-1608.
62.Lajide, L. ; Escoubas, P. ; Mizutani, J. , “Antifeedant activity of metabolites of Aristolochia albida against the tobacco cutworm, Spodoptera litura.”J. Agric. Food Chem., 1993, 41, 669-673.
63.Wang, X. H. ; Han, G. Q. , “The Chemical Constituents of Aristolochia kunmingensis”Acta Bot. Yunnan., 1993, 15, 306-308.
64.Matsuda, M. ; Endo, Y. ; Fushiya, S. ; Endo, T. ; Nozoe, S. ,“Cytotoxic 6-substituted 5,6-dihydro-2H-pyran-2-ones from a Brazilian medicinal plant, Chorisia crispiflora.” Heterocycles, 1994, 38, 1229-1232.
65.Schimmer, O. ; Drewello, U. , “9-Methoxytariacuripyrone, a naturally occurring nitro-aromatic compound with strong mutagenicity in Salmonella typhimurium.”Mutagenesis, 1994, 9, 547-551.
66.Rastrelli, L. ; Capasso, A. ; Pizza, C. ; Ommasi, N. D. , “New protopine and benzyltetrahydroprotoberberine alkaloids from Aristolochia constricta and their activity on isolated guinea-pig ileum.”J. Nat. Prod., 1997, 60, 1065-1069.
67.Wu, T. S. ; Chan, Y. Y. ; Leu, Y. L. , “The constituents of the root and stem of Aristolochia cucurbitifolia Hayata and their biological activity.”Chem. Pharm. Bull., 2000, 48, 1006-1009.
68.Wu, T. S. ; Ou, L. F. ; Teng, C. M. , “Aristolochic acids, aristolactam alkaloids and amides from Aristolochia kankauensis.”Phytochemistry, 1994, 36, 1063-1068.
69.Wu, T. S. ; Leu, Y. L. ; Chan, Y. Y. , “Constituents from the stem and root of Aristolochia kaempferi.”Biol. Pharm. Bull. 2000, 23, 1216-1219.
70.Wu, P. L. ; Su, G. C. ; Wu, T. S. , “Constituents from the stems of Aristolochia manshuriensis.”J. Nat. Prod., 2003, 66, 996-998.
71.Negi, P. S. ; Anandharamakrishnan, C. ; Jayaprakasha, G. K. ,“Antibacterial activity of Aristolochia bracteata root extracts.” J Med Food. 2003, 6, 401-3
72.Velázquez, E. ; Tournier, H. A .; Mordujovich de Buschiazzo, P. ; Saavedra, G. ; Schinella, G. R. , “Antioxidant activity of Paraguayan plant extracts.”Fitoterapia. 2003, 1-2, 91-7.
73.Nascimento, I. R. ; Murata, A. T. ; Bortoli, S. A. ; Lopes, L. M. , “Insecticidal activity of chemical constituents from Aristolochia pubescens against Anticarsia gemmatalis larvae.”Pest Manag Sci. 2004, 4, 413-6.
74.Zhai, H. ;Nakatsukasa, M. ;Mitsumoto, Y. ;Fukuyama, Y. ; “Neurotrophic effects of talaumidin, a neolignan from Aristolochia arcuata, in primary cultured rat cortical neurons.”Planta Med. 2004, 7, 598-602.
75.Jiménez-Ferrer, J. E. ; Pérez-Terán, Y. Y. ; Román-Ramos, R. ; Tortoriello, J. , “Antitoxin activity of plants used in Mexican traditional medicine against scorpion poisoning.”Phytomedicine. 2005, 1-2, 116-22.
76.Ravikumar, S. ; Nazar, S. ; Nuralshiefa, A. ; Abideen, S. , “Antibacterial activity of traditional therapeutic coastal medicinal plants against some pathogens.”J Environ Biol. 2005 , 2, 383-6.
77.Nok, A. J. ; Sallau, B. A. ; Onyike, E. ; Useh, N. M. , “Columbin inhibits cholesterol uptake in bloodstream forms of Trypanosoma brucei-A possible trypanocidal mechanism.”J Enzyme Inhib Med Chem. 2005, 4, 365-8.
78.Wen, Y. J. ; Su, T. ; Tang, J. W ; Zhang, C. Y. ; Wang, X. ; Cai, S. Q. ; Li, X. M. , “Cytotoxicity of phenanthrenes extracted from Aristolochia contorta in human proximal tubular epithelial cell line.”Nephron Exp Nephrol. 2006, 103, 3, 95-102.
79.Messiano, G. B. ; Vieira, L. ; Machado, M. B. ; Lopes, L. M. ; de Bortoli, S. A. ; Zukerman-Schpector, J. , “Evaluation of insecticidal activity of diterpenes and lignans from Aristolochia malmeana against Anticarsia gemmatalis.”J Agric Food Chem. 2008, 56, 2655-9.
80.Alviano, W. S. ; Alviano, D. S. ; Diniz, C. G. ; Antoniolli, A. R. ; Alviano, C. S. ; Farias, L. M. ; Carvalho, M. A . ; Souza, M. M. ; Bolognese, A. M. ,“In vitro antioxidant potential of medicinal plant extracts and their activities against oral bacteria based on Brazilian folk medicine.” Arch Oral Biol. 2008, 53, 6, 545-52.
81.Slade, N. ; Moll, U. M. ; Brdar, B. ; Zorić, A. ; Jelaković, B. , “p53 mutations as fingerprints for aristolochic acid: an environmental carcinogen in endemic (Balkan) nephropathy.”Mutat Res. 2009, 663, 1-6.
82.Pharmacopoeia of the People’s Republic of China, English Edition, The Pharmacopeia Commission of PROC, Beijing, 1977.
83.Hashimoto, K. ; Higuchi, M. ; Makino, B. ; Sakakibara, I. ; Kubo, M. ; Komatsu, Y. ; Maruno, M. ; Okada, M. ,“Quantitative analysis of aristolochic acids, toxic compounds, contained in some medicinal plants.” J. Ethnopharmacol., 1999, 64, 185-189.
84.Ong, E. S. ; Yong, Y. L. ; Woo, S. O. , “Pressurized liquid extraction of berberine and aristolochic acids in medicinal plants.”J. Chromatogr. A, 2000, 904, 57-64.
85.Rao, K. V. ; Tanrikut, Y. ; Killion, K. , “Fluorometric and GLC analyses of aristolochic acid.”J. Pharm. Sci., 1975, 64, 345-347.
86.Makuch, B. ; Gazda, K. ,“Isolation of aristolochic acids HAsI and HAsII by preparative liquid chromatography.” J. Chromatogr., 1992, 594, 145-151.
87.Cateni, F. ; Mamolo, M. G. , I.l “Rapid HPLC analysis for quantitative determination of aristolochic acids.”Farmaco, 1992, 47, 1335-1342.
88.Zhang, Y. ; Xu, G. ; Jin, R. ; Xu, L. ; Zhao, L. , “Determination of aristolochic acid A in drugs from Aristolochia by RP-HPLC.”Journal of China Pharmaceutical University, 1993, 24, 56-57.
89.Hashimoto, K. ; Higuchi, M. ; Makino, B. ; Sakakibara, I. ; Kubo, M. ; Komatsu, Y. ; Maruno, M. ; Okada, M. , “Quantitative analysis of aristolochic acids, toxic compounds, contained in some medicinal plants.”J Ethnopharmacol., 1999, 64, 185-189.
90.Ong, E. S. ; Woo, S. O. , “Determination of aristolochic acids in medicinal plants (Chinese) prepared medicine using capillary zone electrophoresis.”Electrophoresis, 2001, 22, 2236-2241.
91.Lee, T. Y. ; Wu, M. L. ; Deng, J. F. ; Hwang, D. F. , “High-performance liquid chromatographic determination for aristolochic acid in medicinal plants and slimming products”J. Chromatogr. B, 2002, 766, 169-174.
92.Kite, G. C. ; Yule, M. A. ; Leon, C. ; Simmonds, M. S. , J. “Detecting aristolochic acids in herbal remedies by liquid chromatography/serial mass spectrometry.”Rapid Commun. Mass Spectrum, 2002, 16, 585-590.
93.Ioset, J. R. ; Raoelison, G. E. ; Hosetettmann, K. , “An LC/DAD-UV/MS method for the rapid detection of aristolochic acid in plant preparations.”Planta Med., 2002, 68, 856-858.
94.Vanhaelen, M. ; Vanhaelen-Fastre, R. , “Identification of aristolochic acid in Chinese herbs.”The Lancet, 1994, 343, 174.
95.Chen, H. ; Jin, R. ; Xu, L. , “Determination of aristolochic acid I and total alkaloids in Fangji.”Zhongguo Zhogyao Zazhi, 1994, 19, 323-324.
96.Ioset, J. R. ; Raoelison, G. E. ; Hostettmann, K. , “Detection of aristolochic acid in Chinese phytomedicines and dietary supplements used as slimming regimens.”Food Chem. Toxicol., 2003, 41, 29-36.
97.Singh, D. V. ; Singh, B. L. ; Verma, R. K. ; Gupta, M. M. ; Banerji, S. ; Kumar, S. ,“Quantitation of aristolochic acid using high performance liquid chromatography with photodiode array detection.” J. Indian Chem. Soc., 2001, 78, 487-488.
98.Singh, D. V. ; Singh, B. L. ; Verma, R. K. ; Gupta, M. M. ; Kumar, S. , “Reversed phase high performance liquid chromatographic analysis of aristolochic acid.”J. Med. Aromat. Plant Sci., 2001, 29, 29-31.
99.Shang, M. ; Li, J. ; Hu, B. ; Yang, S. ; Li, C. ; Zheng, J. ,“Determination of total aristolochic acid in the stem of Aristolochia manshuriensis.” Zhongcaoyao, 2000, 31, 899-900.
100.Zhao, N. ; Lai, J. ; Bi, K. ,“Determination of aristolochic acid A in Aristolochia debilis by RP-HPLC.” Shenyang Yaoke Dzxue Xuebao, 2001, 18, 125-127.
101.Mohamed, O. A. ; Wang, Z. ; Yu, G. ; Khalid, H. E. ; Abu-Elrish, B. I. ,“Determination of aristolochic acid A in the roots and rhizomes of Aristolochia from Sudan and China by HPLC.” Zhongguo Yaoke Daxue Xuebao, 1999, 30, 288-290.
102.Zhang, H. ; Wang, C. , “Callus formation of Aristolochia tuberosa and determination of aristolochic acid of callus by HPLC.”Huaxi yike Daxue Xuebao, 1997, 28, 170-173.
103.Seto, T. ; Hamano, T. ; Shioda, H. ; Kamimura, H. , “Analysis of aristolochic acid I and II in Kampo medicine preparations.”Journal of Health Science, 2002, 48, 412-417.
104.Jong, T. T. ; Lee, M. R. ; Hsiao, S. S. ; Hsai, J. L. ; Wu, T. S. ; Chiang, S. T. ; Cai, S. Q. , “Analysis of aristolochic acid in nine sources of Xixin, a traditional Chinese medicine, by liquid chromatography/atmospheric pressure chemical ionization/tandem mass spectrometry.”J. Pharm. Biomed. Anal., 2003, 33, 831-387.
105.Jou, J. H. ; Li, C. Y. ; Schelonka, E. P. ; Lin, C. H. ; Wu, T. S. , “Analysis of the analogues of aristolochic acid and aristolactam in the plant of Aristolochia genus by HPLC. ”J. Food Drug Anal., 2004, 12, 40-45.
106.Jou, J. H. ; Chen, S. ; Wu, T. S. , “Facile reversed-phase HPLC resolution and quantitative determination of aristolochic acid and aristolactam analogues in traditional chinese medicine.”J. Liq. Chromatogr. & Rel. Tech., 2003, 26, 3057-3068.
107.Hanna, G. M. ,“NMR regulatory analysis: determination and characterization of Chinese-herb aristolochic acids.” Pharmazie, 2004, 59, 170-174.
108.Li, W. ; Gong, S. ; Wen, D. ; Che, B. ; Liao, Y. ; Liu, H. ; Feng, X. ; Hu, S. , “Rapid determination of aristolochic acid I and II in Aristolochia plants from different regions by beta-cyclodextrin-modified capillary zone electrophoresis.”J Chromatogr A. 2004, 1049, 1-2, 211-7.
109.Li, L. ; Gao, H. M. ; Wang, Z. M. ; Wang, W. H. , “Determination of aristolochic acid a in guanxinsuhe preparations by RP- HPLC.”Zhongguo Zhong Yao Za Zhi. 2006, 2, 122-4.
110.Li, W. ; Chen, Z. ; Liao, Y. ; Liu, H. , “Study on separation of aristolochic acid I and II by micellar electrokinetic capillary chromatography and competition mechanism between SDS and beta-cyclodextrin.”Electrophoresis. 2006, 27, 4, 837-41.
111.Koh, H. L. ; Wang, H. ; Zhou, S. ; Chan, E. ; Woo, S. O. ,“Detection of aristolochic acid I, tetrandrine and fangchinoline in medicinal plants by high performance liquid chromatography and liquid chromatography/mass spectrometry.” J Pharm Biomed Anal. 2006, 3, 653-61.
112.Jacob, S. S. ; Smith, N. W. ; Legido-Quigley, C. , “Assessment of Chinese medicinal herb metabolite profiles by UPLC-MS-based methodology for the detection of aristolochic acids.”Sep Sci. 2007, 8, 1200-6.
113.Huang, F. ; Clifton, J. ; Yang, X. ; Rosenquist, T. ; Hixson, D. ; Kovac, S. ; Josic, D. ,“SELDI-TOF as a method for biomarker discovery in the urine of aristolochic-acid-treated mice.” Electrophoresis. 2009,7, 1168-74.
114.Yue, H. ; Chan, W. ; Guo, L. ; Cai, Z. , “Determination of aristolochic acid I in rat urine and plasma by high-performance liquid chromatography with fluorescence detection.”J Chromatogr B Analyt Technol Biomed Life Sci. 2009, 10, 995-9..
115.Vanherweghem, J. L. ; Tielemans, C. ; Abramowicz, D. ; Depierreux, M. ; Vanhaelen-Fastre, R. ; Vanhaelen, M. ; Dratwa, M. ; Richard, C. ; Vandervelde, D. ; Verbeelen, D. ; Jadoul, M. ,“Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs.” Lancet. 1993, 341, 387-391.
116.van Beek, T. A. ; Lelyveld, G. P. ,“Thin-layer chromatography of bilobalide and ginkgolides A, B, C and J on sodium acetate-impregnated silica gel.” Phytochem. Anal. 1993, 4, 109–114.
117.George, M. H. ,“Determination of ephedrine, pseudoephedrine, and norephedrine in mixtures (bulk and dosage forms) by proton nuclear magnetic resonance spectroscopy.” J. AOAC Int. 1995, 78, 946–954.
118.Duarte, I. ; Barros, A. N. ; Belton, P. S. ; Righelato, R. ; Spraul, M. ; Humpfer, E. ; Gil, A. M. , “High-resolution nuclear magnetic resonance spectroscopy and multivariate analysis for the characterization of beer.”J. Agric. Food Chem. 2002, 50, 2475–2481.
119.Kim, H. K. ; Choi, Y. H. ; Chang, W. T. ; Verpoorte, R. ,“Quantitative analysis of ephedrine analogues from ephedra species using 1H-NMR.” Chem. Pharm. Bull. 2003, 51, 1382–1385.
120.Choi, Y. H. ; Choi, H. K. ; Hazekamp, A. ; Bermejo, P. ; Schilder, Y. ; Erkelens, C. ; Verpoorte, R. ,“Quantitative analysis of bilobalide and ginkgolides from Ginkgo biloba leaves and Ginkgo products using (1)H-NMR.” Chem. Pharm. Bull. 2003, 51, 158–161.
121.Bala, L. ; Nagana Gowda, G. A. ; Ghoshal, U. C. ; Misra, A. ; Bhandari, M. ; Khetrapal, C. L. , “ 1H NMR spectroscopic method for diagnosis of malabsorption syndrome: a pilot study.”NMR Biomed. 2004, 17, 69–75.
122.Kim, H. K. ; Choi, Y. H. ; Teus Luijendijk, J. C. ; Vera Rocha, R. A. ; Verpoorte, R. , “Comparison of extraction methods for secologanin and the quantitative analysis of secologanin from Symphoricarpos albus using 1H-NMR.”Phytochem. Anal. 2004, 15, 257–261.
123.Holtman, K. M. ; Chang, H. M. ; Kadla, J. F. ,“Solution-state nuclear magnetic resonance study of the similarities between milled wood lignin and cellulolytic enzyme lignin.” J. Agric. Food Chem. 2004, 52, 720–726.
124.Gall, G. L. ; Colquhoun, I. J. ; Defernez, M. , “Metabolite profiling using (1)H NMR spectroscopy for quality assessment of green tea, Camellia sinensis (L.).”J. Agric. Food Chem. 2004, 52, 692–700.
125.Duarte, I. F. ; Barros, A. N. ; Almeida, C. U. ; Spraul, M. ; Gil, A. M. , “Multivariate analysis of NMR and FTIR data as a potential tool for the quality control of beer.”J. Agric. Food Chem. 2004, 52, 1031–1038.
126.Choi, Y. H. ; Kim, H. K. ; Hazekamp, A. ; Erkelens, C. A. ; Lefeber, W. M. ; Verpoorte, R. ,“Metabolomic differentiation of Cannabis sativa cultivars using 1H NMR spectroscopy and principal component analysis.” J. Nat. Prod. 2004, 67, 953–957.
127.Hanna, G. M. , “NMR regulatory analysis: determination and characterization of chinese-herb aristolochic acids.”Pharmazie. 2004, 59, 170–174.
128.Li, C. Y. ; Lin, C. H. ; Wu, C. C. ; Lee, K. H. ; Wu, T. S. ,“Efficient 1H Nuclear Magnetic Resonance Method for Improved Quality Control Analyses of Ginkgo Constituents.” J. Agric. Food Chem. 2004, 52, 3721–3725.
129.Li, C. Y. ; Tsai, S. I. ; Damu, A. G. ; Wu, T. S. ,“A rapid and simple determination of protoberberine alkaloids in Rhizoma Coptidis by 1H NMR and its application for quality control of commercial prescriptions.” J Pharm Biomed Anal. 2009, 49, 1272-6.
130.Li, C. Y. ; Xu, H. X. ; Han, Q. B. ; Wu, T. S. ,“Quality assessment of Radix Codonopsis by quantitative nuclear magnetic resonance.” J Chromatogr. A . 2009, 1216, 2124-2129


參考文獻2
1.Zang, M. ; Su, Q. ,“Ganoderma camphoratum, a new taxon in genus Ganoderma from Taiwan”China. Acta Bot., 1990, 12, 395-396
2.Osman, E. ; Owen, J. S. ; Burroughs, A. K. ,“Review article: S-adenosyl-L- methionine--a new therapeutic agent in liver disease?”Aliment Pharmacol Ther., 1993, 7, 21-8.Review.
3.楊書威:中藥樟菇活性成分之研究。台灣大學藥學研究所 碩士論文,1991
4.Hseu, Y. C. ; Chang, W. C. ; Hseu, Y. T. ; Lee, C. Y. ; Chen, P. C. ; Chen, J. Y. ; Yang, H. L. ,“Protection of oxidative damage by aqueous extract from Antrodia camphorata mycelia in normal human erythrocytes”Life Sciences., 2002, 71, 469-482.
5.Nakamura, N. ; Hirakawa ,A .; Gao, J. J. ; Kakuda, H .; Shiro, M. ; Komatsu, Y . ; Sheu, C. C. ; Hattori, M. ,“Five new maleic and succinic acid derivatives from the mycelium of Antrodia camphorata and their cytotoxic effects on LLC tumor cell line”J Nat Prod., 2004, 67, 46-8.
6.Hsu, Y. L. ; Kuo, P. L. ; Cho, C. Y. ; Ni, W. C. ; Tzeng, T. F. ; Ng, L. T. ; Kuo, Y. H. ; Lin, C. C. ,“Antrodia cinnamomea fruiting bodies extract suppresses the invasive potential of human liver cancer cell line PLC/PRF/5 through inhibition of nuclear factor kappaB pathway”Food Chem Toxicol., 2007, 45, 1249-57.
7.Hseu, Y. C. ; Chen, S. C. ; Tsai, P. C. ; Chen, C. S. ; Lu, F. J. ; Chang, N. W. ; Yang, H. L. ,“Inhibition of cyclooxygenase-2 and induction of apoptosis in estrogen-nonresponsive breast cancer cells by Antrodia camphorata”Food Chem Toxicol., 2007, 45, 1107-15.
8.Lee, I. H. ; Huang, R. L. ; Chen, C. T. ; Chen, H. C. ; Hsu, W. C. ; Lu, M. K. ,“Antrodia camphorata polysaccharides exhibit anti-hepatitis B virus effects” FEMS Microbiology Letters, 2002, 209, 63-67.
9.Chang, T. T. ; Chou, W. N. ,“Antrodia cinnamomea sp. nov. on Cinnamomum kanehirai in Taiwan”Mycol. Res., 1995, 99, 756-758
10.Wu, S. H. ; Ryvarden, L. ; Chang, T. T. , “Antrodia camphorata ('niu-chang-chih'), new combination of a medicinal fungus in Taiwan.”Bot.Bull.Acad.Sin., 1997, 38, 273-275
11.Wu, S. H. ; Yu, Z. H. ; Dai, Y. C. ; Chen, C. T. ; Su, C.H. ; Chen,L.C. ; Hsu, W.C. ; Hwang, G. Y. ,“Taiwanofungus, a polypore new genus”Fung. Sci., 2004, 19, 106-116.
12.高曉薇:台灣靈芝屬新種樟芝三萜類成份研究。台北醫學院天然物醫學研究所碩士論文,1991。
13.簡秋源、姜宏哲、陳淑貞:牛樟菇培養性狀及其三萜類成分分析之研究。牛樟生物學及育林技術研討會論文集。林業叢刊。1997,72, 133-137。
14.程一華:樟芝成分之研究。國立師範大學研究所碩士論文,1994。
15.Mizuno, T. , “Bioactive biomolecules of mushrooms: Food function and medicinal effect of mushroom fungi.”Food Rev. Int., 1995, 11, 7-21.
16.水野卓、川合正允(賴慶亮譯),菇類的化學生化學。國立編譯館,1997,P349-390。
17.黃鈴娟:牛樟芝與姬松茸之抗氧化性質及其多醣組成分析。中興大學食品科學系碩士論文,2000。
18.Cherng, I. H. ; Chiang, H. C. ; Cheng, M. C. ; Wang, Y. ,“Three new triterpenoids from Antrodia cinnamomea.”J.Nat. prod., 1995, 58, 365-71.
19.Chiang, H. C. ; Wu, D. ; Cherng, I. W. ; Ueng, C. H. ,“A sesquiterpene lactone, phenyl and biphenyl compounds from Antrodia cinnamomea.”Phytochemistry, 1995, 39, 613-616.
20.Chen, C. H. ; Yang, S. W. ; Shen, Y. C. ,“New steroid acids from Antrodia cinnamomea, a fungal parasite of Cinnamomum micranthum.”J Nat Prod., 1995, 58, 1655-61.
21.Cherng, I. H. ; Wu, D. P. ; Chiang, H. C. ,“Triterpenoids from Antrodia cinnamomea.”Phytochemistry, 1996, 41, 263-7.
22.Yang, S. W. ; Shen, Y. C. ; Chen, C. H. ,“Steroids and triterpenoids of Antrodia cinnamomea-a fungus parasitic on Cinnamomum micranthum.”Phytochemistry, 1996, 41, 1389-92.
23.Shen, Y. C. ; Yang, S. W. ; Lin, C. S. ; Chen, C. H. ; Kuo, Y. H. ; Chen, C. F. ,“Zhankuic acid F: a new metabolite from a formosan fungus Antrodia cinnamomea”Planta Med., 1997, 63, 86-8.
24.Chen, C. C. ; Shiao, Y. J. ; Lin, R. D. ; Shao, Y. Y. ; Lai, M. N. ; Lin, C. C. ; Ng, L. T. ; Kuo, Y. H. ,“Neuroprotective diterpenes from the fruiting body of Antrodia camphorata”J Nat Prod., 2006, 69, 689-91.
25.Shao, Y. Y. ; Chen, C. C. ; Wang, H. Y. ; Chiu, H. L. ; Hseu, T. H. ; Kuo, Y. H. , “Chemical constituents of Antrodia camphorata submerged whole broth”Nat Prod Res., 2008, 22, 1151-7.
26.吳德鵬:樟芝微量成分的研究。國立台灣師範大學化學研究所碩士論文,1990。
27.Liu, D. Z. ; Liang, Y. C. ; Lin, S. Y. ; Lin, Y. S. ; Wu, W. C. ; Hou, W. C. ; Su, C. H. ,“Antihypertensive activities of a solid-state culture of Taiwanofungus camphoratus (Chang-chih) in spontaneously hypertensive rats”Biosci Biotechnol Biochem., 2007, 71, 23-30.
28.Ryhanen, L. ; Stenback, F. ; Ala-Kokko, L. ; Savolainen, E. R. ,“The effect of malotilate on type III and type IV collagen, laminin and fibronectin metabolism in dimethylnitrosamine-induced liver fibrosis in the rat.”J. Hepatol., 1996, 24, 238-45.
29.Lieber, C. S. ,“Prevention and treatment of liver fibrosis based on pathogenesis.”Alcohol Clin Exp Res., 1999, 23, 944-9.Review.
30.Mato, J. M. ; Camara, J. ; Fernandez de Paz J. ; Caballeria,L. ; Coll, S. ; Caballero, A. ; Buey, L. ; Beltran, J. ; Benita, V. ; Caballeria, J. ; Sola, R. ; Moreno-Otero, R. ; Barrao,F. ;Martin-Duce, A. ; Correa, J. A. ; Pares, A. ; Barrao, E. ; Garcia-Magaz, I. ; Puerta, J. L. ; MorenO, J. ; Boissard, G. ; Ortiz, P. ; Rodes, J. ,“S-Adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial”J. Hepatol., 1999, 30, 1081-9.
31.戴宇昀:樟芝菌絲體與子實體對四氯化碳及酒精誘導之慢性及急性肝損傷之保肝功能評估。國立中興大學食品科學系碩士論文,2001。
32.Song, T. Y. ; Yen, G. C. ,“Protective effects of fermented filtrate from Antrodia camphorata in submerged culture against CCl4-induced hepatic toxicity in rats” J.Agric. Food Chem., 2003, 51, 1571-1577.
33.Dai, Y. Y. ; Chuang, C. H. ; Tsai, C. C. ; Sio, H. M. ; Huang, S. C. ; Chen, J. C. ; Hu, M. L. ,“The Protection of Anthrodia camphorata against AcuteHepatotoxicity of Alcohol in Rats”J. Food Drug Ana., 2003, 11, 177-185
34.Song, T. Y. ; Hsu, S. L. ; Yeh, C. T. ; Yen, G. C. ,“Mycelia from Antrodia camphorata in Submerged culture induce apoptosis of human hepatoma HepG2 cells possibly through regulation of Fas pathway”J Agric Food Chem., 2005, 53, 5559-64
35.Han, H. F. ; Nakamura, N. ; Zuo, F. ; Hirakawa, A. ; Yokozawa, T. ; Hattori, M. ,“Protective effects of a neutral polysaccharide isolated from the mycelium of Antrodia cinnamomea on Propionibacterium acnes and lipopolysaccharide induced hepatic injury in mice”Chem Pharm Bull (Tokyo)., 2006, 54 , 496-500.
36.Kuo, P. L. ; Hsu, Y. L. ; Cho, C.Y. ; Ng, L. T. ; Kuo, Y. H. ; Lin, C. C. ,“Apoptotic effects of Antrodia cinnamomea fruiting bodies extract are mediated through calcium and calpain-dependent pathways in Hep 3B cells”Food Chem Toxicol., 2006, 44, 1316-26.
37.Lu, Z. M. ; Tao, W. Y. ; Zou, X. L. ; Fu, H. Z. ; Ao, Z. H. ,“Protective effects of mycelia of Antrodia camphorata and Armillariella tabescens in submerged culture against ethanol-induced hepatic toxicity in rats”J Ethnopharmacol., 2007, 110, 160-4.
38.Huang, L. C. ; Huang, S. J. ; Chen, C. C. ; Mau, J. L. ; 3rd International conference on Mushroom Biology and Mushroom Product&AMGA`s 26th National Mushroom Industry conference , 1999 Oct.12-16,sydeny,Australia.
39.葉怡真:樟芝對血管內皮細胞之影響及保心血管疾病之機制探討。中國醫藥學院營養研究所,2002。
40.Hsiao, G. ; Shen ,M. Y. ; Lin, K. H. ; Lan, M. H. ; Wu, L. Y. ; Chou, D. S. ; Lin, C. H.;Su, C. H. ; Sheu, J. R. ,“Antioxidative and hepatoprotective effects of Antrodia camphorata extract”J Agric Food Chem., 2003, 51, 3302-8.
41.Phuong, do T. ; Ma, C. M. ; Hattori, M. ; Jin, J. S. ,“Inhibitory effects of antrodins A-E from Antrodia cinnamomea and their metabolites on hepatitis C virus protease”Phytother Res., 2009, 23, 582-4.
42.Mizuno, T. ; Kinoshita, T. ; Zhuang, C. ; Ito, H. ; Mayuzumi, Y. ,“Antitumor- active heteroglycans from Niohshimeji mushroom, Tricholoma giganteum.”Biosci Biotechnol Biochem., 1995, 59, 568-71.
43.曹巧吟,樟芝中免疫調節蛋白的純化與其生理活性之探討,國立台灣大學園藝學研究所碩士論文,2003。
44.蔡敬民,樟芝菌絲體及發酵液對於血糖及血脂的影響,行政院國家科學委員會九十年度保健食品研究開發計畫,2001。
45.楊新玲,樟芝對人類臍帶血管內皮細胞之影響及作用之探討,行政院國家科學委員會九十年度保健食品研究開發計畫,2001。
46.Chen, C. H. ; Yang, S. W. ; Shen, Y. C. ,“New steroid acids from Antrodia cinnamomea, a fungal parasite of Cinnamomum micranthum”J.Nat.Prod., 1995, 58, 1655-1661
47.劉俊仁,中草藥抗癌機制研究,第二部分, 樟芝活性多醣體之生物活性分析及其經由免疫調節抑制腫瘤生長之研究。國立台灣大學生物化學暨分子生物學研究所,2003。
48.賴鈺菁:樟芝發酵液之抗發炎及其誘導癌細胞凋亡機制之探討。中國醫藥大學營養研究所,2004。
49.Hseu, Y. C. ; Yang, H. L. ; Lai, Y. C. ; Lin, J. G. ; Chen, G. W. ; Chang, Y. H. ,“Induction of apoptosis by Antrodia camphorata in human premyelocytic leukemia HL-60 cells”Nutr Cancer., 2004, 48, 189-97.
50.Liu, J. J. ; Huang ,T. S. ; Hsu, M. L. ; Chen, C. C. ; Lin, W. S. ; Lu, F. J. ; Chang, W. H. ,“Antitumor effects of the partially purified polysaccharides from Antrodia camphorata and the mechanism of its action”Toxicol Appl Pharmacol., 2004, 201, 186-93.
51.Hsu, Y. L. ; Kuo, Y. C. ; Kuo, P. L. ; Ng, L. T. ; Kuo, Y. H. ; Lin, C. C. ,“Apoptotic effects of extract from Antrodia camphorata fruiting bodies in human hepatocellular carcinoma cell lines”Cancer Lett., 2005, 221, 77-89.
52.Song, T. Y. ; Hsu, S. L. ; Yen, G. C. ,“Induction of apoptosis in human hepatoma cells by mycelia of Antrodia camphorata in submerged culture”J Ethnopharmacol., 2005, 100, 158-67.
53.Chen, S. C. ; Lu, M. K. ; Cheng, J. J. ; Wang, D. L. ,“Antiangiogenic activities of polysaccharides isolated from medicinal fungi”FEMS Microbiol Lett., 2005, 249, 247-54.
54.Yang, H. L. ; Chen, C. S. ; Chang, W. H. ; Lu, F. J. ; Lai, Y. C. ; Chen, C. C. ; Hseu, T. H. ; Kuo, C. T. ; Hseu, Y. C. ,“Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by Antrodia camphorata”Cancer Lett., 2006, 231, 215-27.
55.Lu, M. K. ; Cheng, J. J. ; Lai, W. L. ; Lin, Y. R. ; Huang, N. K. ,“Adenosine as an active component of Antrodia cinnamomea that prevents rat PC12 cells from serum deprivation-induced apoptosis through the activation of adenosine A(2A) receptors”Life Sci., 2006, 79, 252-8.
56.Peng, C. C. ; Chen, K. C. ; Peng, R. Y. ; Su, C. H. ; Hsieh-Li, H. M. ,“Human urinary bladder cancer T24 cells are susceptible to the Antrodia camphorata extracts”Cancer Lett., 2006, 243, 109-19.
57.Peng, C. C. ; Chen, K. C. ; Peng, R. Y. ; Chyau, C. C. ; Su, C. H. ; Hsieh-Li, H. M. ,“Antrodia camphorata extract induces replicative senescence in superficial TCC, and inhibits the absolute migration capability in invasive bladder carcinoma cells”J Ethnopharmacol., 2007, 109, 93-103.
58.Chen, C. C. ; Chyau, C. C. ; Hseu, T. H. ,“Production of a COX-2 inhibitor, 2,4,5-trimethoxybenzaldehyde, with submerged cultured Antrodia camphorata” Lett Appl Microbiol., 2007, 44, 387-92.
59.Lee, T. H. ; Lee, C. K . ; Tsou, W. L. ; Liu, S. Y. ; Kuo, M. T. ; Wen, W. C. ,“A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata”Planta Med., 2007, 73, 1412-5.
60.Hseu, Y. C. ; Chen, S. C. ; Chen, H. C. ; Liao, J. W. ;Yang, H. L. ,“Antrodia camphorata inhibits proliferation of human breast cancer cells in vitro and in vivo” Food Chem Toxicol., 2008, 46, 2680-8.
61.Lu, M. K. ; Cheng, J. J. ; Lai, W. L. ; Lin, Y. J. ; Huang, N. K. ,“Fermented Antrodia cinnamomea extract protects rat PC12 cells from serum deprivation- induced apoptosis: the role of the MAPK family”J Agric Food Chem., 2008, 56, 865-74.
62.Wu, M. D. ; Cheng, M. J. ; Wang, B. C. ; Yech, Y. J. ; Lai, J. T. ; Kuo, Y. H. ; Yuan, G. F. ; Chen, I. S. ,“Maleimide and maleic anhydride derivatives from the mycelia of Antrodia cinnamomea and their nitric oxide inhibitory activities in macrophages”J Nat Prod., 2008, 71, 1258-61.
63.Chen, Y. S. ; Pan, J. H. ; Chiang, B. H. ; Lu, F. J. ; Sheen, L. Y. ,“Ethanolic extracts of Antrodia cinnamomea mycelia fermented at varied times and scales have differential effects on hepatoma cells and normal primary hepatocytes”J Food Sci., 2008, 73, H179-85.
64.Lu, M. C. ; Du, Y. C. ; Chuu, J. J. ; Hwang, S. L. ; Hsieh, P. C. ; Hung, C. S. ; Chang, F. R. ; Wu, Y. C. ,“Active extracts of wild fruiting bodies of Antrodia camphorata (EEAC) induce leukemia HL 60 cells apoptosis partially through histone hypoacetylation and synergistically promote anticancer effect of trichostatin A”Arch Toxicol., 2009, 83, 121-9.
65.Yang, S. S. ; Wang, G. J. ; Wang, S. Y. ; Lin, Y. Y. ; Kuo, Y. H. ; Lee, T. H. , “New constituents with iNOS inhibitory activity from mycelium of Antrodia camphorata”Planta Med., 2009, 75, 512-6.
66.Yang, C. M. ; Zhou, Y. J. ; Wang, R. J. ; Hu, M. L. ,“Anti-angiogenic effects and mechanisms of polysaccharides from Antrodia cinnamomea with different molecular weights”J. Ethnopharmacol., 2009, 123, 407-12.
67.Chen, Y. J. ; Chou. C. J. ; Chang, T. T. ,“Compound MMH01 possesses toxicity against human leukemia and pancreatic cancer cells”Toxicol In Vitro., 2009, 23, 418-24.
68.Shen, Y. ; Chou ,C. J. ;Wang, Y. H. ; Chen, C. F. ; Chou, Y. C. ; Lu, M. K. , “Anti-inflammatory activity of the extracts from mycelia of Antrodia camphorata cultured with water-soluble fractions from five different Cinnamomum species.”FEMS Microbiol Lett., 2004, 231, 37-43.
69.Shen, Y. C. ; Wang, Y. H. ; Chou, Y. C. ; Chen, C. F. ; Lin, L. C. ; Chang, T. T. ; Tien, J. H. ; Chou, C. J. ,“Evaluation of the anti-inflammatory activity of zhankuic acids isolated from the fruiting bodies of Antrodia camphorata” Planta Med., 2004, 70, 310-4.
70.Hseu, Y. C. ; Wu, F. Y. ; Wu, J. J. ; Chen, J. Y. ; Chang, W. H. ; Lu, F. J. ; Lai, Y. C. ; Yang, H. L. ,“Anti-inflammatory potential of Antrodia Camphorata through inhibition of iNOS, COX-2 and cytokines via the NF-kappaB pathway” Int Immunopharmacol., 2005, 5, 1914-25.
71.Liu, D. Z. ; Liang, H. J. ; Chen, C. H. ; Su, C. H. ; Lee, T. H. ; Huang, C. T. ; Hou, W. C. ; Lin, S. Y. ; Zhong, W. B. ; Lin, P. J. ; Hung, L. F. ; Liang, Y. C. ,“Comparative anti-inflammatory characterization of wild fruiting body, liquid-state fermentation, and solid-state culture of Taiwanofungus camphoratus in microglia and the mechanism of its action”J Ethnopharmacol., 2007, 113, 45-53.
72.Chen, C. C. ; Liu, Y. W. ; Ker, Y. B. ; Wu, Y. Y. ; Lai, E. Y. ; Chyau, C. C. ; Hseu, T. H. ; Peng, R. Y. ,“Chemical characterization and anti-inflammatory effect of polysaccharides fractionated from submerge-cultured Antrodia camphorata mycelia”J Agric Food Chem., 2007, 55, 5007-12.
73.Chen, J. J. ; Lin, W. J. ; Liao, C. H. ; Shieh, P. C. ,“Anti-inflammatory benzenoids from Antrodia camphorata”J Nat Prod., 2007, 70, 989-92.
74.Chien, S. C. ; Chen, M. L. ; Kuo, H. T. ; Tsai, Y. C. ; Lin, B. F. ; Kuo, Y. H. ,“Anti-inflammatory activities of new succinic and maleic derivatives from the fruiting body of Antrodia camphorata”J Agric Food Chem., 2008, 56, 7017-22.
75.Cheng, P. C. ; Hsu, C. Y. ; Chen, C. C. ; Lee, K. M. ,“In vivo immunomodulatory effects of Antrodia camphorata polysaccharides in a T1/T2 doubly transgenic mouse model for inhibiting infection of Schistosoma mansoni”Toxicol Appl Pharmacol., 2008, 227, 291-8.
76.Chen, Y. J. ; Cheng, P. C. ; Lin, C. N. ; Liao, H. F. ; Chen, Y. Y. ; Chen, C. C. ; Lee, K. M. ,“Polysaccharides from Antrodia camphorata mycelia extracts possess immunomodulatory activity and inhibits infection of Schistosoma mansoni”Int Immunopharmacol., 2008, 8, 458-67.
連結至畢業學校之論文網頁點我開啟連結
註: 此連結為研究生畢業學校所提供,不一定有電子全文可供下載,若連結有誤,請點選上方之〝勘誤回報〞功能,我們會盡快修正,謝謝!
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top
無相關期刊