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研究生:沈智民
研究生(外文):Chih-Min Shen
論文名稱:台灣馬桑莖部成分之研究
論文名稱(外文):The constituents of the stems of Coriaria intermedia Matsum.
指導教授:吳天賞吳天賞引用關係
指導教授(外文):Tian-Shung Wu
學位類別:碩士
校院名稱:國立成功大學
系所名稱:化學系碩博士班
學門:自然科學學門
學類:化學學類
論文種類:學術論文
論文出版年:2009
畢業學年度:97
語文別:中文
論文頁數:147
中文關鍵詞:台灣馬桑馬桑內酯
外文關鍵詞:coriaria intermediacoriaria lactone
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由台灣馬桑(Coriaria intermedia Matsum.)之莖部分離得到46個合物,其中44個化合物經由光譜分析,確定其化學結構,分別為braylin、toddanin、7-hydroxycoumarin、angustifolin、scopoletin、coriarintin A、coriarintin B、coriarintin C、coriarintin D、coriarintin E、demethylramosinin、7-hydroxy-3,8-bis(3-methyl-2-butenyl) coumarin、corianin、tutin、coriamyrtin、corinterin A、methyl gallate、gallic acid、ellagic acid、3,4'-O-dimethylellagic acid、3,3'-O-dimethylellagic acid、3,3'-O-dimethylellagic acid-4'-O-��-glucopyranoside、3,3'-O-dimethylellagic acid-4'-O-��-xylopyranoside、methyl 2-(4-hydroxyphenyl) acetate、tetracosyl (E)-ferulate、coriamedin A、coriamedin B、��-sitosterol、stigmasterol、ergosta-7,22-dien-3��-ol、��-sitosteryl 3-O-��-D-glucopyranoside、(24R)-24-ethylcholesta-4,22-dien-3-one、ursolic acid、oleanolic acid、20-epibryonolic acid、5-hydroxymethyl-2-furanocarboxaldehyde、coriamedin C、succinic acid monobutyl ester、(R)-dimethylmalate、2,6-dimethoxybenzoquinone、squalene、brevifolin、glyceryl-1-tetracosanoate。其中coriarintin A、coriarintin B、coriarintin C、coriarintin D、coriarintin E、corinterin A、corinterin B、coriamedin A、coriamedin B和coriamedin C為首次發現的新化合物。demethylramosinin以及7-hydroxy-3,8-bis(3-methyl-2-butenyl) coumarin為天然界首次分離得到的新化合物。上述化合物的結構乃是利用核磁共振光譜、質譜、紫外光譜以及紅外光譜藉以決定,而已知的化合物則是與文獻所報導的物理性質和光譜數據進行比對得到確認。
Phytochemical investigation of the methanol extract of the stems of Coriaria intermedia Matsum. afforded forty-six compounds. Among them, forty-four were identified as braylin, toddanin, 7-hydroxycoumarin, angustifolin, scopoletin, coriarintin A, coriarintin B, coriarintin C, coriarintin D, coriarintin E, demethylramosinin, 7-hydroxy-3,8-bis(3-methyl-2-butenyl) coumarin, corianin, tutin, coriamyrtin, corinterin A, methyl gallate, gallic acid, ellagic acid, 3,4'-O-dimethylellagic acid, 3,3'-O-dimethylellagic acid, 3,3'-O-dimethylellagic acid-4'-O-��-glucopyranoside, 3,3'-O-dimethylellagic acid-4'-O-��-xylopyranoside, methyl 2-(4-hydroxyphenyl) acetate, tetracosyl (E)-ferulate, coriamedin A, coriamedin B, ��-sitosterol, stigmasterol, ergosta-7,22-dien-3��-ol, ��-sitosteryl 3-O-��-D-glucopyranoside, (24R)-24-ethylcholesta-4,22-dien-3-one, ursolic acid, oleanolic acid, 20-epibryonolic acid, 5-hydroxymethyl-2-furanocarboxaldehyde, coriamedin C, succinic acid monobutyl ester, (R)-dimethylmalate, 2,6-dimethoxybenzoquinone, squalene, brevifolin, glyceryl-1-tetracosanoate. Among them, ten compounds neamed coriarintin A, coriarintin B, coriarintin C, coriarintin D, coriarintin E, corinterin A, corinterin B, coriamedin A, coriamedin B and coriamedin C were new compounds. Demethylramosinin and 7-hydroxy-3,8-bis(3-methyl-2-butenyl) coumarin were reported for the first time from the natural sources. Their structures were determined by 1H, 13C, 2D NMR, MS, UV-Vis and IR spectral analyses. The known compounds were identified by comparison of their physical and spectral data with those reported in the literature.
Abstract...III
中文摘要...IV
誌謝...V
第一章 緒論...1
第一節 緒言...1
第二節 台灣馬桑之形態...2
第二章 馬桑屬植物之藥理研究回顧...4
第三章 馬桑屬植物之成分研究回顧...5
第四章 台灣馬桑莖部之萃取與分離...17
第五章 構造研究...25
第一節 Tutin (28)之構造研究...25
第二節 Coriamyrtin (26)之構造研究...31
第三節 Corianin (24)之構造研究...37
第四節 Corinterin A (105)*之構造研究...43
第五節 3,3'-O-Dimethylellagic acid (68)之構造研究...50
第六節 3,3'-O-Dimethylellagic acid-4'-O-��-xylopyranoside (109)之構造研究...53
第七節 Coriamedin B (113)*之構造研究...58
第八節 Angustifolin (39)之構造研究...63
第九節 Coriarintin B (101)*之構造研究...69
第十節 Coriarintin E (104)*之構造研究...75
第十一節 Coriarintin A (100)*之構造研究...81
第十二節 Coriarintin C (102)*之構造研究...87
第十三節 Coriarintin D (103)*之構造研究...93
第十四節 Coriamedin A (112)*之構造研究...99
第十五節 Coriamedin C (118)*之構造研究...106
第十六節 其他化合物之構造研究...111
第六章 藥理活性...112
第七章 結論...113
第八章 實驗部分...115
第一節 本實驗所使用之儀器與藥品...115
第二節 萃取分離與純化...117
第三節 光譜數據...120
參考文獻...142
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