(3.239.33.139) 您好!臺灣時間:2021/03/05 18:03
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果

詳目顯示:::

我願授權國圖
: 
twitterline
研究生:趙安基
研究生(外文):An-Ji Chao
論文名稱:奈米銀凝膠對糖尿病大鼠皮膚傷口癒合之研究
論文名稱(外文):The study of topically applied nanonized silver gel enhances wound healing in diabetic rat skin
指導教授:蔡清恩 博士丘宏治 博士
指導教授(外文):Chin-En TsaiAndy Hong-jey Chiou
學位類別:碩士
校院名稱:國立屏東科技大學
系所名稱:獸醫學系所
學門:獸醫學門
學類:獸醫學類
論文種類:學術論文
論文出版年:2009
畢業學年度:97
語文別:中文
論文頁數:80
中文關鍵詞:奈米銀糖尿病鼠傷口癒合糖尿病創傷藥物
外文關鍵詞:nanonized silverSTZ-diabetes ratwound healingdiabetic wound drug
相關次數:
  • 被引用被引用:0
  • 點閱點閱:247
  • 評分評分:系統版面圖檔系統版面圖檔系統版面圖檔系統版面圖檔系統版面圖檔
  • 下載下載:0
  • 收藏至我的研究室書目清單書目收藏:0
本研究目的旨在探討奈米銀凝膠( Nanonized Silver Gel, nAg gel )對糖尿病大鼠皮膚傷口癒合之效應,以作為人類糖尿病患者傷口延遲癒合之比較醫學研究。實驗設計:將24隻體重375 ± 25克的雄性SD大鼠,隨機分為對照組(對照A組與對照B組)與實驗組(實驗C組與實驗D組),每組6隻大鼠。對照組大鼠經腹腔注射0.1 mol/L citrate buffer (1 mL/kg/週)連續3週;實驗組大鼠則腹腔注射streptozotocin (70 mg/kg/週)連續3週,以誘導為糖尿病大鼠。第21天以自創手術台以氣體麻醉(isoflurane)對實驗組與對照組大鼠進行手術時,均在背部全皮開創6個(1 × 1 cm2)傷口。對照A組:大鼠傷口加純凝膠(gel, 50 μL/wound),對照B組:大鼠傷口加奈米銀凝膠(nAg gel, 50 μL/wound)。實驗C組:糖尿病大鼠傷口加純凝膠(gel, 50 μL/wound),實驗D組:糖尿病大鼠傷口加奈米銀凝膠(nAg gel, 50 μL/wound)。於實驗後第0、3、5、7、14、21天測量所有皮膚傷口癒合表面積,並取傷口組織製作病理切片進行光學顯微鏡或電子顯微鏡判讀。結果:1.在糖尿病大鼠創傷癒合不良與組織中膠原蛋白含量減少有關。2.誘導之糖尿病大鼠血糖值均穩定持續超過300 mg/dL。3.臨床症狀顯示糖尿病大鼠體重較正常大鼠體重輕且瘦弱。4.以奈米銀治療的對照組或實驗組大鼠,其傷口癒合表面積和上皮再生程度優於未以奈米銀治療的對照組或實驗組大鼠(p<0.05)。綜合上述研究結果顯示奈米銀可促進糖尿病大鼠創傷癒合效果,因此奈米銀應可作為治療慢性創傷(包括糖尿病患者傷口延遲癒合或其它慢性傷口潰瘍時)的佐劑。
The purpose of this study is to investigate the effects of nanonized silver gel (nAg gel) on the delayed wound healing in diabetic rats. Adult male SD rats (BW: 375 ± 25g) were divided at random into 4 groups (A, B, C and D; six rats per group), Groups A and B, and Groups C and D were injected intraperitoneally with 0.1 mol/L citrate buffer (1 mL/kg/week), and streptozotocin (STZ, 70 mg/kg/week), respectively, for 3 weeks. On day 21 after STZ and buffer injected, the diabetic and non-diabetic control rats were anesthetized with isoflurane in created operation table. The six (1 × 1 cm2) full-thickness skin wounds in the dorsal thorax (3 on each side) in each of groups were created. Nondiabetic rats were served as controls (group A: wounds treated with gel, 50 μL/wound; group B: wounds treated with nAg gel, 50 μL/wound). Diabetic rats were divided into 2 experimental groups (group C: wounds treated with gel, 50 μL/wound; group D: wounds treated with nAg gel, 50 μL/wound). On the 0, 3rd, 5th, 7th and 14th day and 21st day, each of the wound healing areas was measured and the histopathological examination (light microscope and electric microscope) was observed. Results: 1. Poor wound healing in diabetes mellitus was characterized by decreased wound collagen content. 2. The value of blood glucose in diabetic rats was steadily higher than 300 mg/dL. 3. The body weight in diabetic rats was thinner than normal rats. 4. In nAg treated rats, the wound healing areas and re-epithelialization were greater than that in untreated rats (p<0.05). Nanonized silver maybe eventually become a valuable adjunct for chronic wounds, including diabetic or other non-healing chronic ulcer.
摘要 Ⅰ
Abstract Ⅲ
謝誌 Ⅴ
目錄 Ⅵ
圖表目錄 Ⅸ
第1章 前言 1
第2章 文獻回顧 3
2.1 親水性奈米銀凝膠 3
2.1.1 親水性凝膠簡介 3
2.1.2 親水性凝膠形成方式與應用 3
2.1.3 銀及奈米銀之特性 4
2.2 以藥物誘導大、小鼠為糖尿病動物模式 5
2.2.1 大、小鼠為糖尿病動物模式簡介 5
2.2.2 動物試驗之文獻探討 9
2.2.3 糖尿病大鼠之臨床症狀及血糖值 9
2.3 糖尿病大鼠麻醉與創傷動物模式之建立 9
2.3.1 糖尿病簡介 9
2.3.2 傷口延遲癒合為糖尿病患者之併發症 10
2.3.3 糖尿病大鼠麻醉 12
2.3.4 糖尿病大鼠創傷動物模式之建立 12
2.4 膠原蛋白與創傷癒合 12
2.4.1 膠原蛋白之簡介 12
2.4.2 膠原蛋白影響創傷癒合 13
2.5 傷口癒合 13
2.5.1 正常傷口癒合簡介 13
2.5.2 糖尿病患者傷口處理 14
2.6 傷口癒合百分比與組織學分析 16
2.6.1 傷口癒合百分比簡介 16
2.6.2 傷口組織癒合病裡分析 16
第3章 材料與方法 17
3.1 試驗設計 17
3.2 試驗用材料 18
3.2.1 試驗用藥品及飼料 18
3.2.2 試驗用器材 19
3.2.3 試驗用設備 19
3.2.4 試驗用動物 20
3.2.5 實驗組:大鼠腹腔注射鏈尿菌素誘導溶液 21
3.2.6 對照組:大鼠腹腔注射檸檬酸鈉溶液 21
3.3 血糖與體重之監控 21
3.3.1 血糖之監控 21
3.3.2 體重之監控 22
3.4 大鼠手術台之設計、麻醉、背部傷口之開創 22
3.4.1 大鼠手術台之設計 22
3.4.2 大鼠麻醉 22
3.4.3 大鼠背部傷口之開創 23
3.5 大鼠背部傷口處理、傷口面積測量與護理 24
3.5.1 大鼠背部傷口處理 24
3.5.2 測量大鼠背部傷口 24
3.5.3 奈米銀凝膠之投藥劑量與療程 24
3.6 大鼠背部傷口組織採樣及標本製作 26
3.6.1 光學顯微鏡標本之製作 26
3.6.2 蘇木紫及伊紅染色 26
3.6.3 蛋白質纖維染色 26
3.6.4 電子顯微鏡標本之製作 27
3.7 大鼠安樂死 27
第4章 結果 28
4.1 實驗組與對照組之血糖變化 28
4.2 實驗組與對照組之體重變化 28
4.3 實驗組與對照組之傷口癒合情形 28
4.4 穿透式電子顯微鏡標本之判讀 36
4.5 光學顯微鏡標本之判讀 36
4.6 統計分析 36
第5章 討論 40
參考文獻 44
附錄 71
作者簡介 77

參考文獻

王大鵬。探討紫雲膏中西藥併用之交互作用。中醫藥年報25(1): 347-374,2007。

王珮憓。椿葉水萃取液在Alloxan所誘發的糖尿病鼠中降血糖作用之研究。高雄醫學大學醫學研究所碩士論文。2001。

丘宏治、林瑋琪、王大鵬、喻永生。微奈米製藥於急性呼吸窘迫症治療之探討。醫院藥學 20: 39-48,2000。

田育彰。固定生醫單體之生物活性與結構穩定性之探討。私立中原大學醫學工程學系博士論文。2000。

艾静、郭健、張永春。四氧嘧啶致大鼠高血糖模型的實驗研究。哈爾濱醫科大學學誌 3594,2001。

李安榮。探討紫雲膏中西藥併用之交互作用。行政院衛生署94年度中醫藥研究計畫成果報告中英文摘要彙編 3: 168-169。2006。

沈育典。達淨磺胺鋅甲胺製劑親水性凝膠型作為局部創傷治療之研究。國防醫學院藥學研究所碩士論文。2004。

李安榮、王大鵬。探討紫雲膏中西藥併用之交互作用。94年度中醫藥研究計畫成果報告中英文摘要彙編。2006。

李建穀、鄭穹翔、王汎熒、張本恆、劉瑞生、周迺寬、徐久忠。 Picro-sirius polarization 應用於不同組織中膠原纖維的探討。中華獸醫誌33: 81-87,2007。

李福倫、李斌、王振宜、范斌、徐文彬、徐蓉。袪痰生肌法對大鼠糖尿病創面新生肉芽組織中Bax和Bcl的影響。中西醫結合學報 5(6): 661-664,2007

范光智、王先震、陳天牧。老年人燙傷。中華民國重建整形外科醫學會雜誌。3(3):122-127,1994。

梁任中。探討含硫酸紫菌素微球-水凝膠製劑作為局部創傷治療之研究。國防醫學院藥學研究所碩士論文。2006。

許宏達、李俊達、孫宗伯、王健興、黃介琦、簡守信。 糖尿病患膝上截肢後的預後。中華民國整形外科醫學會雜誌 16(1): 9-17,2007。

郭俊良。以達淨磺胺銀製劑親水性凝膠型作為局部創傷治療之研究。國防醫學院藥學研究所碩士論文。2004。

陳家全、李家維、楊瑞森。生物電子顯微鏡學。行政院國家科學委員會。2004。

陳錫根、湯有銘、陳天牧、鄭天宇、宋仁宇、王存福、梁偉中、王先震。顏面燒傷處理之臨床經驗350病例分析。3(3):136 -145,1994。

曾水坤、王敏瑩、劉謙美、侯連團。奈米銀和奈米銀牙膏對牙周病相關細菌的影響。 中華民國牙周病醫學會雜誌12(3): 183-189,2007。

葉燕麗、王輝雲、王蓮佳。四氧嘧啶製作大鼠糖尿病模型—劑量探討與方法改進.實驗動物科學與治理 1854,2001。

趙安基、趙德江、丘宏治、蔡清恩。大鼠眼窩採血技術經驗探討。國軍軍醫學術研討會會刊 35: 190,台北,台灣。2008。

鄭秀娟、王大鵬。Deoxycholate親水性凝膠: 新局部藥物運輸系統,醫院藥學 18: 151-155,2001.

蔡倉吾。創傷研究的動物模式。中華民國實驗動物學會會訊。14: 18-19, 2002。

羅文真。彰化秀傳紀念醫院季刊。第22卷第2期,2007。

Ah UV, Wirz D, Pieles U, Daniels AU. Effects of silver nitrate and a silver nanoparticle biomaterial additive on E. coli growth, determined by isothermal micro-nano calorimetry. European Cells and Materials 16(1): 1473-2262, 2008.

Ajabnoor MA Tilmisany AK. Effect of Trigonella foenum graecum on blood glucose levels in normal and alloxan-diabetic mice. Journal of Ethnopharmacology 22: 45-49, 1988.

Ajgaonkar SS. Ancient Indian Medicines and diabetes mellitus. All India Medical Sciences, Mehta Offset Works 3-10, 1984.

Akbarzadeh A , Noruzian D, Jamshidi S, Farhangi A, Mehrabi MR, Rad BL, Mofidian M, Allahverdi A.. Treatment of streptozotocin induced diabetes in male rats by immunoisolated transplantation of islet cells. Indian Journal of Clinical Biochemistry 22(1) 71-76, 2007.

Alsalami H, Grant B, Ian T, Ranko S, Svetlana G and Momir M. Probiotic Treatment Proceeded by a Single Dose of Bile Acid and Gliclazide Exert the Most Hypoglycemic Effect in Type 1 Diabeti Rat.Med. Hypotheses Res 4: 93-101, 2008.

Amano H, Yamamoto H, Senba M, Oishi K, Suzuki S, Fukushima K. Impairment of endotoxin-induced macrophage inflammatory protein 2 gene expression in alveolar macrophages in streptozotocininduced diabetes in mice. Infect Immun 68: 2925-9. 2000.

Angelopoulos AP, Goaz PW. Incidence of diphenylhydration gingival hyperplasia. Oral Surg Oral Med Oral Pathol 31: 808-906, 1972.

Annette BW, Staiano CL, Grinnell F. Wound fluid from chronic leg ulcers contains elevated levels of metalloproteinases MMP-2 and MMP-9. J. Invest Dermatol 101: 468, 1993.

Anthony H, James W, John K. Cholinergic Reversal of Isoflurane Anesthesia in Rats as Measured by Cross-approximate Entropy of the Electroencephalogram. Anesthesiology 99(5): 1125-1131, 2003.

Ashcroft GS, Horan MA, Ferguson MW. The effects of ageing on cutaneous wound healing in mammals. J. Anat 187(1): 1-26, 1995.

Asheesh G, Ram R. Energy metabolism in the granulation tissue of diabetic rats during cutaneous wound healing. Molecular and cellular Biochemistry 270: 71-77, 2005.

Azad AK, Sermsintham N, Chandrkrachang S, Stevens WF., Chitosan membrane as a wound-healing dressing: Characterization and clinical application. J. Biomed. Mater. Res. Part B: Appl Biomater 69: 216-222, 2004.

Bailey CJ, Flatt PR. Animal models in non-insulin dependent diabetes mellitus. Blackwell Scientific Publications. 235, 1991.

Bell RH, Hye RJ: Animal models of diabetes mellitus: physiology and pathology. J. Surg Res 35: 433-460, 1983.

Bennett RA, Pegg AE. Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res 41: 2786-2790, 1981.

Berlanga J, Cibrian D, Guillen I, Freyre F. Methylglyoxal administration induces diabetes-like microvascular changes and perturbs the healing process of cutanous wounds. Clinical Sci 109: 83-95, 2005.

Bhattacharya R, Mukherjee P. Biological properties of “naked” metal nanoparticles. Advanced Drug Delivery Reviews. Advanced Drug Delivery Reviews 60(11): 1289-1306, 2008.

Birkedal-Hansen H. From tadpole collagenase to family of matrix metalloproteinases. Oral Pathol 17: 45-45, 1988.

Birkedal-Hansen H, Moore WG, Bodden MK, Windsor U, irkedal-Hansen B, DeCarlo A.. Matrix metalloproteinases: a review. Crit Rev Oral Biol Med 4: 97-250, 1993.

Bitar MS. Glucocortioid dynamics and impaired wound healing in diabetes mellitus. Am J. Pathol. 152: 547-555, 1998.

Bjarnsholt T, Kirketerp-Møller K, Kristiansen S, Phipps R, Nielsen AK, Østrup Jensen P, Høiby N, Givskov M. Silver against Pseudomonas aeruginosa biofilms. APMIS 115: 921-8, 2007.

Bragg PD, Rainnie DJ. The effect of silver ions on the respiratory chains of Escherichia coli. Can. J. Microbiol. 20: 83, 1974.

Brem H, Balledux J, Bloom T, Kerstein MD, Hollier L. Healing of diabetic foot ulcers and pressure ulcers with human skin equivalent. Arch Surg 135: 627-634, 2000.

Brown GL, Nanney LB, Griffen J, Cramer AB, Yancey JM, Curtsinger LJ, Holtzin L, Schultz GS, Jurkiewicz MJ, Lynch JB. Enhancement of wound healing by topical treatment with epidermal growth factor. N Engl J. Med 321: 76, 1989.

Buzea C, Pacheco II, Robbie K. Nanomaterials and nanoparticles: Sources and toxicity. Biointerphases 2(4): 17-71, 2007.

Calvin M. Cutaneous Wound Repair. Wounds 10(1): 2-32, 1998.

Calvin M. Tissue Repair Research Unit, Department of Anatomy and Cell Biology. Guy's Hospital Wounds 10(1): 2-32, 1998.

Clark RAF, Basis of cuetaneous wound repair. J Dermatol Surge Oncol 19: 693-706, 1993.

Capucci MS, Hoffmann ME, Zdzienicka MZ, Natarajan AT. Streptozotocin-induced chromosomal aberrations, SCEs and mutations in CHO-9 parental cells and in EM-C11 mutant cell line. Mutation Research 326(2): 227-234, 1995.

Carvalho EN, Carvalho NAS, Ferreira LM. Experimental model of induction of diabetes mellitus in rats. Acta Cir Bras 18: 60-64, 2003.

Cervantes C, Silver S. Metal resistance in Pseudomonas: genes and mechanisms. In: Nakazawa T, Furukawa K, Haas D, Silver S, editors. Molecular Biology of Pseudomonas. Washington: American Society for Microbiology, Washing D.C., 521, 1996.

Chan RK, Liu PH, Pietramaggiori G, Ibrahim SI, Hechtman HB, Orgill DP. Effect of recombinant platelet-derived growth factor (Regranex) on wound closure in genetically diabetic mice. J. Burn Care Res 27: 202-5, 2006

Chao AJ, Tsai CE. The study of topically applied nonanized silver gel enhances wound healing in diabetic rat skin. The Chinese Society of Veterinary Science Symposium oral presentation: 41, 2008.

Chao AJ, Tsai CE. The study of topically applied nonanized silver gel enhances wound healing in diabetic rat skin. The Chinese Society of Veterinary Science Symposium poster: 84, 2008.

Chao AJ, Tsai CE, Chiou AH, Hu CS. Study the effects of wound agent on wound agent on wound healing in diabetic rats. The Chinese Taipei Society of Animal Sciences of Annual Symposium : 46, 2008.

Chao AJ, Tsai CE, Chiou AH, Hu CS. Study the nursing on wound healing in diabetic rats. 35th Annual Military Medicine Symposium : 92, 2008.

Chao AJ, Tsai CE, Chiou AH, Hu CS. The study of topically applied nanonized silver gel enhances wound healing in diabetic rat skin. The 3th Small Animal Practice and The 4th Traditional Medicine International Symposium 26(1): 38, 2008.

Chiou AH, Cheng HC, Wang DP. Micronization and microencapsulation of felodipine by supercritical carbon dioxide. 35th Annual Military Medicine Symposium 173, 2008.

Chiou AH, Yeh MK, Chen CY, Wang DP. Micronization of meloxicam using a supercritical fluids process. J. Supercritical Fluids 42(1): 120-128, 2007.

Chithra P, Sajithlal GB, Chandrakasan G . Influence of aloe vera on the healing of dermal wounds in diabetic rats. J. Ethnopharmacol 59(3): 195-201, 1998.

Cho YW, Cho YN, Chung SH, yoo G, Ko S. Water-soluble chitin as a wound healing accelerator. Biomaterials 20: 2139-2145, 2001.

Cho CH, Sung HK, Kim KT, Cheon HG, Oh GT, Hong HJ, Yoo OJ, Koh GY. COMP-angiopoietin-1 promotes wound healing through ehanced angiogenesis, lymphangiogenesis, and blood flow in adiabetic mouse model. PNAS 103(13): 14946-4951, 2006.

Clark RAF. Potential role of fibronectin in cutaneous wound repair. Arch Dermatol 124: 201-206, 1988.

Clarkson P, Celermajer DS, Donald AE, Sampson M, Sorensen KE, Adams M, Yue DK, Betteridge DJ, Deanfield JE. Impaired vascular reactivity in insulin-dependent diabetes mellitus is related to disease duration and low density lipoprotein cholesterol levels. J. Am Coll Cardiol 28: 573-579, 1996.

Coleman DL. Diabetes-obesity syndromes in mice. Diabetes 31: 1-6, 1982.

Coleman DL, Hummel KP. Effects of parabiosis of normal with genetically diabetic mice. Am J. Physiol 217: 1298-304, 1969.

Cornell RP, Hinck BK, Halley RE. Hepatocyte and Kupffer cell functions during liver regeneration in streptozotocin-diabetic rats. Hepatology 1(5): 424-430, 2006.

Curcio F, Ceriello A. Decreased cultured endothelial cell proliferation in high glucose medium is reversed by antioxidants: new insights on the pathophysiological mechanisms of diabetic vascular complications. In Vitro Cell Dev Biol 28: 78-90, 1992.

Darby IA, Bisucci T, Pittet B, Garbin S, Gabbiani G, Desmoulière A. Skin flap-induced regression of granulation tissue correlates with reduced growth factor and increased metalloproteinase expression. J. Pathol 197(1): 17-27, 2002.

Davidson JM, Klagsbrun M, Hill KE, Brewer PS, Woodward SC. Accelerated wound repair, cell proliferation and collagen accumulation are produced by cartilage derived growth factor. J. Cell Biol 10: 1219-1221, 1985.

Day PL. Blood sugar in rats rendered cataractous by dietary proceduees. J. nutrition 395-404, 1936.

Decarvalho E, Decarvalho N, Ferreira L. Experimental model of induction of diabetes mellitus in rats. Acta Cirugica Brasileira 18: 120-167, 2003.

Deekert T, Grenfel A. Epidemiology and natural history of diabetic nephropathy, In: Pickup JC, Williams G. eds. Textbook of Diabetes . London: Black well Scientific Publications. 2(64): 651-6, 1991.

Demling RH, DeSanti L, Effects of silver on wound management. Wounds 13: 4, 2001.

Dilullodagger GA, Sweeney SM, Korkko J, Alakokko L, Sanantonio JD. Mapping the ligand-binding sites and disease-associated mutations on the most abundant protein in the human, type I collagen. J. Biol Chem 277(6): 4223-4231, 2002.

Dorjnamjin D, Ariunaa M, and Shim YK. Synthesis of silver nanoparticles using hydroxyl functionalized ionic liquids and their antimicrobial activity. Int. J. Mol. Sci 9: 807-820, 2008.

Dubey GP, Dixit SP, Alok S. Alloxan-induced Diabetes in Rabbits and Effect of a Herbal Formulation D-400. Indian Journal of Pharmacology 26: 225-226, 1994.

Dyck PJ, Kratz KM, Karnes JL, Litchy WJ, Klein R, Pach JM, Wilson DM, Obrien PC, Melton LJ 3rd, Service FJ. The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population-based cohort:the Rochester diabetic neuropathy study. Neurology 43(4): 817-24, 1993.

Espinosa Y, Nieves B, Quintana A. Aerobic and anaerobic bacteria in diabetic foot disease. Anaerobe 5: 405-407, 1999.

Eyre DR. Collagen: molecular diversity in the body's protein scaffold. Science. 207(4437): 1315-1322, 1980.

Falanga V. Wound healing and its impairment in the diabetic foot. Lancet 366: 1736- 43, 2005

Fatema J, Kanak C, Jahanara B, Mohammed S, Tahminur R, Sohel A, Azharul KR, Muhammad GM, Farida H. Multiresistant Staphylococcus aureus isolated from the wound of diabetic patients. J. infect Dis Antimicrob Agents 15: 15-18, 1998.

Feng QL, Wu J, Old GQ, Cui FZ, Gold TN, Gold JO. Study the right influence of silver ion of anti-bacterium in a mechanics Escherichia coli golden yellow staphylococcus. Journal of Biomedical Materials Research Part A: 662-668, 2002.

Ferrari L, Turrini G, Rostello C, Guidi A, Casartelli A, Piaia A. Sartori M. Evaluation of two combinations of Domitor, Zoletil 100, and Euthatal to obtain long-term nonrecovery anesthesia in Sprague-Dawley rats. Comp Med 55(3): 56-64. 2005.

Forrester JC. Mechanical, biochemical and architectural features of surgical repair. Adv Biol Med Phys 14: 1-34, 1973.

Fox CL, Jr. Silver sulfadiazine-A new topical therapy for Pseudomonas in burns. Arch Surg 96: 184-188, 1968.

Fuji A, Kobayashi S, Yamamoto H, Tamura T. Augmentation of wound healing by royal jerry in streptozotocin-diabetic rats. Jpn J. Pharmacol 53: 331-337, 1990.

Funk JR, Hale Joseph E, Carmines D, Lee GH, Hurwitz SR. Biomechanical evaluation of early fracture healing in normal and diabetic rats J. Orthopaedic Res 18: 126-132, 2000.

Gear AJL, Hellewell TB, Wright HR, Mazzarese PM, Arnold GT. Rodeheaver GT, Edlich RF. A new silver sulfadiazine water soluble gel. Burn 23: 387-391, 1997.

Gebauer GP, Linar AJL, Hellewell TB, Wright HR, Mazzarese PM, Arnold GT. Rodeheaver GT, Edlich RF. Anew silver sulfadiazine water soluble gel. Burn 23: 387-391, 1997.

Gebauer GP, Lin ss, Beam HA, Vieira P, Parsons JR. Low-intensity pupsed ultrasound increases the fracture callus strength in diabetic BB Wistar rats but does not affect cellular proliferation. J. orthop Res 20(3): 587-92, 2002.

Ghannam N, Kingston M, Al-Meshaal IA, Tariq M, Parman NS, Woodhouse N. The Antidiabetic Activity of Aloes: Preliminary Clinical and Experimental Observations. Horm Res 24: 288-294, 1986.

Gherzi R, Melioli G, De Luca M, D’Agostino Distefano G, Guastella M, D’Anna F, Franzi AT, Cancedda R. ‘HepG2/Erythroid/Brain’ type glucose transporter (GLUT1) is highly expressed in human epidermis: keratinocyte differentiation affects GLUT1 levels in reconstituted epidermis. J. Cell Physiol 150: 463-74, 1992.

Giglio MJ, Lama MA. Effects of experimental diabetes on mandible growth in rats. Eur J. Oral Sci 109: 193-197, 2001.

Goepel JR. Responses to cellular injury. Churchill Livingstone, 121-122, 1996.

Goodson WH, Hunt TK. Wound healing and the diabetic patient. Surg Gynecol Obstet 149: 690-708, 1979.

Greenhalgh DG, Sprugel KH, Murry MJ, Ross R. PDGH and FGF stimulate healing in the genetically diabetic mouse. Am J. Pathol 136: 1235, 1990.

Greenhalgh DG. Wound healing and diabetes mellitus. Clinics in Plastic Surgery 30(1): 37-45, 2003.

Grenfel A. Clinical features and management of established diabetic nephropathy. In: Pickup JC, Williams G. eds. Textbook of Diabetes. London: Black Well Scientific Publications 267: 677-97, 1991.

Grier N, Silver and its compounds. In: Block SS, editor. Disinfection, Sterilization and Preservation, 3rd ed. Philadelphia, PA: Lea & Febiger, 1983.

Guo SS, Liang XC, Yin FH, Wang XD, Guo SQ. Determination of blood flow in the lower leg of patients with diabetes mellitus and the effects of treatment with the principle of vitalizing blood and solubilizing thrombus. CJIM 1(2): 87-90, 1995.

Gurney AM, Howarth FC. Effects of streptozotocin-induced diabetes on the pharmacology of rat conduit and resistance intrapulmonary arteries. Cardiovascular Diabetology 8(4): 1-10, 2009.

Guzmán MG, Dille J, Godet S. Synthesis of silver nanoparticles by chemical reduction method and their antibacterial activity. Proceedings of world academy of science, engineering and technology 33: 2070-3740, 2008.

Hannan MA, Rokeya B, Faruque O, Nahar N, Mosihuzzaman M, Khan AKA , Ali and L. Effect of soluble dietary fibre fraction of Trigonella foenum graecum on glycemic, insulinemic, lipidemic and platelet aggregation status of type 2 diabetic model rats. Journal of Ethnopharmacology 88(1): 73-77, 2003.

Haralson MA. Transforming growth factor-13, other growth factors, and the extracellular matrix. J. Lab Clin Med 130: 455-8, 1997.

Hedges AR, Parsons ME. The effect of anaesthesia on the inhibition of pentagastrin-evoked gastric acid secretion induced by atropine in the rat. J. Physiol 267(1): 181-194, 1977.

Hinman CD, Maibach H. Effect of air exposure and occlusion on experimental human skin wounds. Nature 200: 377-378, 1963.

Hirabara Y, Araki M, Fukuda M, Katafuchi S, Honda K, Saito R, Takano Y. A High-sodium diet in streptozotocin-induced diabetic rats impairs endothelium-derived hyperpolarizing factor-mediated vasodilation. J. Pharmacol Sci 104: 402-405, 2007.

Hirsch T, Spielmann M, Zuhaili B, Koehler T, Fossum M, Steinau HU, Yao F, Steinstraesser L, Onderdonk AB, Eriksson E. Enhanced susceptibility to infections in a diabetic wound healing model. BMC Surgery 8(5): 1-8, 2008.

Hoffman AS. Hydrogels for biomedical applications. Adv. Drug Deliv. Res 43: 3-12, 2002.

Ignotz RA, Massague J: Transforming growth factor-: stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J. Biol Chem 261: 4337-4345, 1986.

Ikebukuro K, Adachi Y, Yamada Y, Fujimoto S, Seino Y, Oyaizu H, Hioki K, Ikehara S. Treatment of streptozotocin-induced diabetes mellitus by transplantation of islet cells plus bone marrow cells via portal vein in rats, Transplantation. 73(4): 512-8, 2002.

Imai A, Steffey EP, Farver TB, Ilkiw JE. Assessment of isoflurane- induced anesthesia in ferrets and rats. Am J. Vet Res 60(12): 1577-83, 1999.

Jacobi J, Jang JJ, Sundram U, Dayoub H, Fajardo LF, Cooke JP. Nicotine accelerates angiogenesis and wound healing in genetically diabetic mice. Am J. Pathol 161: 97-104, 2002.

Jarrahi M, Alivafaei A, Effect of topical phenytoin cream on linear incisional wound healing in albino rats. DARU 12(4): 156-58, 2004.

Jia J, Duan YY, Wang SH, Zhang SF, Wang ZY. Preparation and characterization of antibacterial silver-containing nanofibers for wound dressing applications. J. US-China Med Sci 4(2): 52-4, 2007.

Joseph WS, Lefrock JL, The pathogenesis of diabetic foot infection-immunopathy. J. Foot Surg 26(1): 7-11, 1987.

Jonathan M. Hypothesis for the Formation and Maintenance of Chronic Wounds. Advances in skin & Wound Care 22(4): 158-60, 2009.

Jung WK, Koo HC, Kim KW, Shin S, Kim SH, Park YH. Antibacterial activity and mechanism of action of the silver ion in Staphylococcus aureus and Escherichia coli. Appl Environ Microbiol 74(7): 2171-8, 2008.

Junqueira LCU, Montes GS, Sanchez EM. The Influence of Tissue Section Thickness on the Study of Collagen by the icrosirius-Polarization Method. Histochemistry 74: 153-156, 1982.

Kagan RJ, Manumadass M, Jonassan O. Serious wound infectious in Burned patients. Surgery 98: 640-647, 2002.

Kaiser N, Sasson S, Feener EP, Boukobza-Vardi N, Higashi S,Moller DE, Davidheiser S, Przybylski RJ, King GL. Differential regulation of glucose transport and transporters by glucose in vascular endothelial and smooth muscle cells. Diabetes 42: 80-89, 1993.

Kanter M , Uysal H, Karaca T , Sagmanligil HO. Depression of glucose levels and partial restoration of pancreatic β-cell damage by melatonin in streptozotocin-induced diabetic rats. Archives of Toxicology 80(6): 362-369, 2006.

Kim NN, Stankovic M, Cushman TT, Goldstein I, Munarriz R, Traishm AM. Streptozotocin-induced diabetes in the rat is associated with changes in vaginal hemodynamics, morphology and biochemical markers. BMC Physiology 6: 4, 2006.

King H, Aubert , RE, Herman WH. Global burden of diabetes, prevalence, numerical estimates, and projections. Diab Care 21: 1995-2025, 1998.

King H, Rewers M, Diabetes in adults is now a Third World problem. The WHO Ad Hoc Diabetes Reporting Group. World Health Organ 69: 643, 1991.

Korolkiewicz RP, Fujita A, Seto K, Suzuki K, Takeuchi K. Polaprezinc exerts a salutary effect on impaired healing of acute gastric lesions in diabetic rats. Digestive diseases and sciences 45(6): 1200-1209, 2000.

Kucine A, Ramamuryhy NS, McClain S, McNamara TF, Golub LM. A temporal study of wound healing in normal and diabetic rats. J. Dent Res 76: 445, 1997.

Kumar N, Ravikumar MNV, Domb AJ. Biodegradable block copolymers. Adv. Drug Deliv. Rev. 53: 23-44, 2001.

Lauerfields JL, Juska D, Fields GB. Matrix metalloproteinases and collagen catabolism. Biopolymers 66(1): 19-32, 2002.

Lerman OZ, Galiano RD, Armour M, Levine JP, Gurtner GC. Cellular dysfunction in the diabetic fibroblast: impairment in migration, vascular endothelial growth factor production, and response to hypoxia. Am J. Pathol 162: 303-12, 2003.

LoGerfo FW, Coffman Coffman. Current concepts. Vascular and microvascular disease of the foot in diabetes. Implications for foot care. N Engl J. Med 311: 1615-1619, 1984.

Loke WK. Lau SK, Yong LL, Khor E, Sum CK. Wound dressing with sustained anti-microbial capability. J. Biomed. Mater. Res 53: 8-17, 2000.

Loomans CJ, Koning EJ, Staal FJ, Rookmaaker MB, Verseyden C, Boer HC. Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabetes. Diabetes 53:195-9, 2004.

Lopez JG, Moral-Sanz J, Frazziano G, Gomez-Villalobos MJ, Flores-Hernandez J, Monjaraz E, Cogolludo A, Perez-Vizcaino F. Diabetes induces pulmonary artery endothelial dysfunction by NADPH oxidase induction. Am J. Physiol 295: 727-732, 2008.

Lorenzi M, Cagliero E, Toledo S. Glucose toxicity for human endothelial cells in culture: delayed replication, disturbed cell cycle, and accelerated death. Diabetes 34: 621-7, 1985.

Lorenzi M, Nordberg JA, Toledo S. High glucose prolongs cell-cycle traversal of cultured human endothelial cells. Diabetes 36: 1261-7, 1987.

Mansford KR, OPIE L. Comparison of metabolic abnormalitiesn in diabetes mellitus induced by streptozotocin or by alloxan. Lancet 1:670-1, 1968.

Melhem MF, Craven PA, Liachenko J and DeRubertis FR. -Lipoic Acid Attenuates Hyperglycemia and Prevents Glomerular Mesangial Matrix Expansion in Diabetes. J. Am Soc Nephrol 13:108-116, 2002.

Minaeian S, Shahverdi AR, Nohi AS, Shahverdi HR. Extracellular biosynthesis of silver nanoparticles by some bacteria. J. Sci 17(66): 1-4, 2008.

Mishra M, Kumar H, Tripathi K, Diabetic delayed wound healing and the role of silver nanoparticles. Digest Journal of Nanomaterials and Biostructures 3(2): 49-54, 2008.

Modak SM, Fox CL, Binding of silver sulfadiazine to the cellular components of Pseudomonas aeruginosa. Biochem Pharmacol 22: 2391, 1973.

Monafo WW, Moyer CA, The treatment of extensive thermal burns with 0.5 % silver nitrate solution. Ann NY Acad. Sci. 150: 937, 1968.

Mooney EK, Lippitt C, Friedman J. Plastic & Reconstructive Surgery. Plastic Surgery Educational Foundation DATA Committee 117(2): 666-669, 2006.

Morain WD, Colen LB. Wound healing in diabetes mellitus. Clin Plast Surg 17: 493-501, 1990.

Obara K, Ishihara M, Ishizuka T, Fujita M, Ozeki Y, Maehara T, Saito Y, Yura H, Matsui T, Hattorei H, Kikuchi M, Kurita A.Photocrosslinkable chitosan hidrogel containing fibronlast growth factor-2 stimulates wound healing in healing-impaired db/db mice. Biomaterials 24: 3444-47, 2003.

Paolo SD, Gesualdo L, Ranieri, E, Grandaliano G, Schena. High glucose concentration induces the overexpression of transforming growth factor-beta through the activation of a platelet-derived growth factor loop in human mesangial cells. Am J. Pathol 149(6): 2095-2106, 1996.

Pari L, Saravanan R. Beneficial effect of succinic acid monoethyl ester on erythrocyte membrane bound enzymes and antioxidant status in streptozotocin–nicotinamide induced type 2 diabetes. Chemico-Biological Interactions 169(1): 15-24, 2007.

Park K, Shalaby WSW, Park H. Biodegradable hydrogels for drug delivery, Technomic Publishing Company, U.S.A., 1993.

Parving HH, Nielsen FS, Bang LE, Smidt UM, Svendsen TL , Chen J-W, Gall MA, Rossing P. Macro-microangiopathy and endothelial dysfunction in NIDDM patients with and without diabetic nephropathy. Diabetologia 39: 1590-1597, 1996.

Pieper AA, Brat DJ, Krug DK, Poly(ADP ribose)polymerase deficient mice are protected from streptozotocin induced diabetes. Proc Natl Acad Sci 96: 33059-33064, 1999.

Peiro C and Sanchez-Ferrer CF. Cellular mechanisms of diabetic vasculopathy. Methods and findings in experimental and clinical Pharmacology 24: 61, 2002.

Pietramaggiori G, Scherer SS, Mathews JC, Alperovich M, Yang HJ, Neuwalder J. Healing modulation induced by freeze-dried platelet-rich plasma and micronized allogenic dermis in a diabetic wound model. Wound Repair Regen 16: 218-25, 2008.

Pipeleers DG, Pipeleers MM, Vanbrabandt B, Duys AS. Transplantation of purified islet cells in diabetic rats. Diabetes 40: 920-30, 1991.

Rajasekaran S, Sivagnanam K, Ravi K, Subramanian S. Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. J. Medicinal Food 7(1): 61-66, 2004.

Ramamurthy NS, Golub LM. Diabetes increases collagenase activity in extracts of rat gingiva and skin. J. Periodont Res 18: 23-30, 1983.

Ramamurthy NS, Kucine AJ, McClain SA, McNamara TF and Golub LM. Topically applied CMT-2 enhances wound healing in streptozotocin diabetic rat skin. Adv Dent Res 12: 144-148, 1998.

Ramamurthy NS, Kucine AJ, McCLAIN SA, McNamara TF and Golub LM. Top jasekaran S, Sivagnanam K, Ravi K, Subramanian S. Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. J. Medicinal Food 7(1): 61-66, 2004.

Ramsey SD, Newton K, Blough D, McCulloch DK, Sandhu N, Reiber GE. Incidence, outcomes, and cost of foot ulcers in patients with diabetes. Diabetes Care 22: 382-7, 1999.

Rees RS, Robson MC, Smiell JM, Perry BH. Becaplemin gel in the treatment of pressure ulcers. Wound repair and regenerastion 7(3): 141-147, 2002.

Reinila A, Koivisto VA, Akerblom HK: Lipids in the pulmonary artery and the lungs of severely diabetic rats. A histochemical and chemical study. Diabetologia 13: 305-310, 1977.

Reinila A. Long-term effects of untreated diabetes on the arterial wall in rat. Diabetologia 20: 205-212, 1981.

Rendell MS, Kelly ST, Finney DF, Luu T, Kahler K, McIntyre SF, Terando JV. Decreased skin blood flow early in the course of streptozotocin-induced diabetes mellitus in the rat. Diabetologia 36(10): 907-911, 2006.

Rerup CC: Drugs producing diabetes through damage of the insulin secreting cells. Pharmacol Rev 22: 485-518, 1970.

Rosenkranz HS, Rosenkranz S, Silver sulfadiazine: interaction with isolated deoxyribonucleic acid. Antimicrob Agents Chemother 2: 373, 1972.

Ross R, Benditt EP. Wound healing and collagen formation:I. Sequential changes in components of guinea pig skin wounds observed in the electron microscope. J. Biophys And Biochem Cytol 11: 677-700, 1961.

Rovee DT, Kurowsky CA, Labun J. Lacal wound environment and epidermal healing. Arch Dermatol 106(3): 330-334, 1972.

Russ RD, Tobin BW: Differential pulmonary vascular effects of streptozotocin diabetes in male and female rats. Proc Soc Exp Biol Med 217: 74-80, 1998.

Santoro MM, Gaudino G. Cellular and molecular facets of keratinocytes reepithelization during wound healing. Exp Cell Res 304: 274-86, 2005 .

Saids G, Lacroix C, Lozeron P, Ropert A, Plante V, Adams D. Inflammatory vasculopathy in multifocal diabetic neuropathy. Diabetologia 126(2): 376-385, 2006.

Schaller M, Laude J, Bodewaldt H, Hamm G, Korting. Toxicity and Antimicrobial Activity of a Hydrocolloid Dressing Containing Silver Particles in an ex vivo Model of Cutaneous Infection. Skin Pharmacol Physiol 17(1): 31-36, 2004.

Schmidt U, Helmchen U. Effect of furosemide on aminopeptidase activity in the rat kidney and urine. CMLS 25(8): 852-853, 1969.

Sentman ML, Jonsson LM, Marklund SL. Enhanced alloxan-induced β-cell damage and delayed recovery from hyperglycemia in mice lacking extracellular-superoxide dismutase. Free Radical Biology and Medicine 27(1): 790-796, 1999.

Shetty A, Rashmi R, Rajan M , Sambaiah K, Salimath P. Antidiabetic influence of quercetin in streptozotocin-induced diabetic rats.
Nutrition Research 24(5): 373-381, 2009.

Shoji T, Koyama H, Morioka T, Tanaka S, Kizu A, Motoyama K. Receptor for advanced glycation end products is involved in impaired angiogenic response in diabetes. Diabetes 55: 2245-55, 2006.

Shrivastava S, Bera T, Roy A, Singh G, Ramachandraraon P and Dash D. Characterization of enhanced antibacterial effects of novel silver nanoparticles. Nanotechnology 18: 1-9, 2007.

Sibbitt WL, Mills RG, Bigler CF, Eaton RP, Griffey RH, Vanderjagt DL. Glucose inhibition of human fibroblast proliferation an response to growth factors is prevented by inhibitiors of aldose reductase.Mech Ageing Dev 47:265-79, 1989.

Singer AJ, Clark RAF. Cutaneous wound healing. Mechanisms of Diseases 341: 738-746, 1999.

Steed DL. Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity ulcers. Plast Reconstr Surg 117: 143-9, 2006.

Suzuki I. Oxidation of inorganic sulfur compounds: Chemical and enzymatic reactions. Can. J. Microbiol. 45(2): 97-105, 1999.

Terashi H, Izumi K, Deveci M, Rhodes LM, Marcelo CL. High glucose inhibits human epidermal keratinocyte proliferation for cellular studies on diabetes mellitus. Int Wound J. 2: 298-304, 2005.

Tung A, Herrera S, Fornal CA, Jacobs BL. The effect of prolonged anesthesia with isoflurane, propofol, dexmedetomidine, or ketamine on neural cell proliferation in the adult rat. Anesth Analg 106: 1772-1777, 2008.

Vavra JJ, Deboer C, Dietz A, Hanka LJ, Sokolski WT. Streptozotocin, a new antibacterial antibiotic. Antibiot Annu 7: 230-5, 1959.

Vlassara H, Bucala R, Striker L. Pathogenic effects of advanced glycosidation: Biochemical, biological, and clinical implication gor diabetes and aging. Lab Invest 70: 138, 1994.

Voldstedlund M, Dabelsteen E. Expression of GLUT1 in stratified squamous epithelia and oral carcinoma from humans and rats. APMIS 105: 537-45, 1997.

Weiss R. Streptozotocin. a review of its pharmacology, efficacy and toxicity. Cancer Treat. 66: 427-438, 1982.

Whitworth C, Morris C, Scott V, Rybak LP. Dose-response relationships for furosemide ototoxicity in rat. Hear Res 71(1): 202-7, 1993.

Winter GD. Formation of the scab and the rate of epithelialization of superficial wounds in the young domestic pig. Nature 193: 293-294, 2004.

Wright JB, Lam K, Hanson D, Burrell RE, Effi- cacy of topical silver against fungal burn wound pathogens. Am J. Inf Cont 27: 344 , 1999.

Yamanaka M, Hara K, Kudo J. Bactericidal Actions of a Silver Ion Solution on Escherichia coli, Studied by Energy-Filtering Transmission Electron Microscopy and Proteomic Analysis. Appl Environ Microbiol 71(11): 7589-7593, 2005.

Yamashiro S, Kawakami K, Uezu K, Kinjo T, Miyagi K, Nakamura K et al. Lower expression of Th1-related cytokines and inducible nitric oxide synthase in mice with streptozotocin-induced diabetes mellitus infected with Mycobacterium tuberculosis. Clin Exp Immunol 139: 57-64, 2005.

Yan XN, Feng, J, Shi BJ. effects of connective tissue growth factor and collagen type Ⅰ scleroderma. Journal of Nanjing Medical University 21(3): 175-179, 2007.

Yanardag R, Ramamurthy NS, Kucine AJ, McCLAIN SA, McNamara TF and Golub LM. Top jasekaran S, Sivagnanam K, Ravi K, Subramanian S. Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. J. Medicinal Food 7(1): 61-66, 2004.

Yang FC, Wu KH, Lin WP. Preparation and antibacterial effect of bamboo charcoal/Ag on Staphylococcus aureus and Pseudomonas aeruginosa. J. Chin Chem Soc 56(2): 1-7, 2009.

Yeo MK, Kang MS. Silver nanoparticles: partial oxidation and antibacterial activities. Journal of biological inorganic chemistry. 12 (4): 527-534, 2008.

Yin HQ, Langford R, Burrell RE, Comparative evaluation of the antimicrobial activity of ActicoatTM antimicrobial barrier dressing. J. Bum Care and Rehab 20: 195, 1999.

連結至畢業學校之論文網頁點我開啟連結
註: 此連結為研究生畢業學校所提供,不一定有電子全文可供下載,若連結有誤,請點選上方之〝勘誤回報〞功能,我們會盡快修正,謝謝!
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top
系統版面圖檔 系統版面圖檔