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研究生:林彥佑
研究生(外文):Yen-Yon Lin
論文名稱:海洋天然物11-epi-sinulariolideacetate對於佐劑誘發類風濕性關節炎治療之影響
論文名稱(外文):Therapeutic Effects of the Marine Natural Product 11-epi-sinulariolide acetate on Rats with Adjuvant-induced Arthritis
指導教授:溫志宏溫志宏引用關係
指導教授(外文):Zhi-Hong Wen
學位類別:碩士
校院名稱:國立中山大學
系所名稱:海洋生物科技暨資源學系研究所
學門:自然科學學門
學類:海洋科學學類
論文種類:學術論文
論文出版年:2009
畢業學年度:97
語文別:中文
論文頁數:83
中文關鍵詞:酯多醣誘發型一氧化氮合成酶類風濕性關節炎第二型環氧化酶
外文關鍵詞:cyclooxygenase-2lipopolysacchariderheumatoid arthritis (RA)nitric oxide synthetase
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  • 被引用被引用:2
  • 點閱點閱:193
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中文摘要.........................................................IV
英文摘要..........................................................V
第一章、前言.................................................1
第二章、實驗方法與程序..........................13
第三章、實驗結果.......................................25
第四章、實驗討論.......................................57
第五章、參考文獻.......................................66
Abad M.J., Luis M.B., and Bermejo P., (2008) Natural marine anti-inflammatory Product. Mini-Review in Medicinal Chemistry. 8:740-54.
Aneiros A., and Garateix A., (2004) Bioactive peptides from marine sources: pharmacological properties and isolation procedures. Journal of chromatography. B, Analytical Technologies in The Biomedical and Life Sciences. 803:41-53.
Badger A.M., Griswold D.E., Kapadia R., Blake S., Swift B.A., Hoffman S.J., Strop G.B., Webb E., Rieman D.J., Gowen M., Boehm J.C., Adams J.L., and Lee J.C., (2000) Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis. Arthritis and Rheumatism. 43:175-83.
Baharav E., Mor F., Halpern M., and Weinberger A., (2003) Lactobacillus GG Bacteria ameliorate arthritis in Lewis rats. The Journal of Nutrition. 134: 1964-9.
Balasubramanian T., and Ajmal K.S., (2007) Multidisciplinary approach for studying marine biology and biotechnology through decelopment and application of marine bioinformatics. SDNP – ENVIS Newsletter Vol. 2.
Ben A.P., Crofford L.J., Wilder R.L., and Hla T., (1995) Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin-1: a potential mechanism for inflammatory angiogenesis. FEBS Letters. 372:83-7.
Bergmann W., and Feeney R.J., (1950) The Isolation of A New Thymine pentoside from sponges. Journal of the American Chemical Society. 72: 2809-10.
Bergmann W., and Feeney R.J., (1951) Contribution to the study of marine products. XXXII. The nucleosides of sponges. I. The Journal of Organic Chemistry 16: 981-7.
Bergmann W., and Burke R., (1955) Contribution to The study of marine products XXXIX. The nucleosides of sponges. III 1 spongothymidine and spongouridine. The Journal of Organic Chemistry. 20:1501-7.
Bernan V.S., Greenstein M., and Carter G.T., (2004) Mining marine microorganisms as a source of new antimicrobials and antifungals. Current Medicinal Chemistry - Anti-Infective Agents. 3:181-95.
Béress L., (2004) Biologically active polypeptides of anemonia sulcata-and of other sea anemones¬-tools in the study of exitable membranes. Journal of toxicology- Toxin reviews. 23: 451-66.
Blunt J.W., Copp B.R., Hu W.P., Munro M.H., Northcote P.T., and Prinsep M.R., (2007) Marine natural products. Natural Product Reports. 24: 31-86.
Carte B.K., (1996) Biomedical potential of marine natural products. BioScience. 46:271-86
Chao C.H., Wen Z.H., Wu Y.C., Yeh H.C., and Sheu J.H., (2008) Cytotoxic and anti-inflammatory cembranoids from the soft coral Lobophytum crassum. Journal of Natural Products. 71:1891-24.
Cheng S.Y., Wen Z.H., Wang S.K., Chiou S.F., Hsu C.H., Dai C.F., and Duh C.Y., (2009) Anti-inflammatory cembranolides from the soft coral Lobophytum durum. Bioorganic and Medicinal Chemistry. 17:3763-9.
Coll J.C., Bowden. B.F., and Dianne M.T., (1982a) In situ isolation of allelochemicalsed from soft corals (coelenterate octocorallia) atotally submwesible sampling appartus. Journal of Experimental Marine Biology and Ecology. 60:293-9.
Coll J.C., La Barrel S., and Sammarco P.W., Williams W.T., and Bakus G.J., (1982b) Chemical defences in soft corals (Coelenterata: Octocorallia) of the great barrier reef: a study of comparative toxicities. Marine Ecology Progress Series. 8:271-8.
Coval S.J., Cross S., Gerald B., and Charles W.J., and Brianthein V., (1988) A new cytotoxic and antiviral diterpene isolated from briareum asbestinum. Journal of Natural Products. 51:981-4.
Drayton D.L., Liao S., Mounzer R.H. and Ruddle N.H. (2006) Lymphoid organ development: from ontogeny to neogenesis. Nature Immunology. 7:344-53.
Duh C.Y., El-Gamal Ali A. H., Song P.Y., Wang S.K., and Dai C.F. (2004) Steroids and sesquiterpenoids from the soft corals Dendronephthya gigantea and Lemnalia cervicorni. Journal of Natural Products. 67:1650-3.
Farrell A.J., Blake D.R, Palmer R.M.J., and Moncada S., (1992) Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases. Annals of the Rheumatic Diseases. 51:1219-22.
Faulkner, D.J., (1995) Chemical riches from the ocean. British Journal of Pharmacology and Chemotherapy. 680-4.
Feldmann M., Brennan F.M., and Maini R.N., (1996) Rheumatoid arthritis. Cell. 85: 307–10.
Firestein G.S., (2003) Evolving concepts of rheumatoid arthritis. Nature 423(6937): 356-61.
Gautam R., and Jachak S.M., (2009) Recent developments in anti-inflammatory natural products. Medicinal Research Reviews. 29:767-820.
Goetzl E.J., An S., and Zeng L., (1995) Specific suppression by prostaglandin E2 of activation-induced apoptosis of human CD4+CD8+ T lymphoblasts. The Journal of Immunology. 154:1041-7.
Guerrero P.P., Read R.W., Batley M., and Janairo G.C., (1995) The structure of a novel cembranoid diterpene from a philippine collection of the soft coral Sinularia flexibilis. Journal of Natural Products. 58:1185-91.
Handy R.L., and Moore P.K., (1998) Effects of selective inhibitors of neuronal nitric oxide synthase on carrageenan-induced mechanical and thermal hyperalgesia. Neuropharmacology. 37:37-43.
Herin M., Colin M., and Tursch B., (1976) Chemical student of marine invertebrates. XXV. Flexibiliene, an unprexedebted fiftee-membered ring diterpene htdrocarbon from the soft coral Sinularia flexibilis (Coelenterata, Octocorallia, Alcyonacea). Bulletin Des Sociétés Chimiques Belges. 85:801-3.
Hooper G.J., Davies-Coleman M.T., and Schleyer M., (1997) New diterpenes from the South African soft coral Eleutherobia aurea. Journal of Natural Products. 60:889-93.
Huber L.C., Distler, O., Tarner, I., Gay, R.E., Gay S., and Pap T., (2006) Synovial fibroblasts: key players in rheumatoid arthritis. Rheumatology. 45:669-75.
Hung D.T., Chen J., and Schreiber S.L., (1996) (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest. Chemistry & Biology. 3:287-93.
Jean Y.H., Chen W.F., Duh C.Y., Huang S.Y., Hsu C.H., Lin C.S., Sung C.S., Chen I.M., and Wen Z.H., (2008) Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory and analgesic effects of the natural marine compound lemnalol from Formosan soft coral Lemnalia cervicorni. European Journal of Pharmacology. 578:323-31.
Jones T.C., and Hunt R.D., (1983) Veterinary pathology fifth edition. Philadelphia : Lea & Febiger.
Jüngel A., Distler O., Schulze-Horsel U., Huber L.C., Ha H.R., Simmen B., Kalden J.R., Pisetsky D.S., Gay S., and Distler J.H., (2007) Microparticles stimulate the synthesis of prostaglandin E(2) via induction of cyclooxygenase 2 and microsomal prostaglandin E synthase 1. Arthritis and Rheumatism. 56:3564-74.
Kang R.Y., Freire-Moar J., Sigal E., and Chu C.Q., (1996) Expression of cyclooxygenase-2 in human and an animal model of rheumatoid arthritis. British Journal of Rheumatology.35:711-8.
Kannan K., Ortmann R.A., and Kimpel D., (2005) Animal models of rheumatoid arthritis and their relevance to human disease. Pathophysiology 12:167-81.
Kashman Y., Bodner M., Loya Y., and Benayahu, Y., (1977) Cembranolides from marine origin (Red Sea), survey, and isolation of a new sinulariolide derivative. Israel Journal of Chemistry. 16:1-3.
Katori M., and Majima M., (2000) Cyclooxygenase-2: its rich diversity of roles and possible application of its selective inhibitors. Inflammation Research. 49: 367-92.
Kawai S., Nishida, S., Kato M., Furumaya Y., Okamoto R., Koshino T., and Mizushima Y., (1998) Comparison of cyclooxygenase-1 and -2 inhibitory activities of various nonsteroidal anti-inflammatory drugs using human platelets and synovial cells. European Journal of Pharmacology. 347:87-94.
Kijjoa A., and Sawangwong P., (2004) Drugs and Cosmetics from the sea. Marine Drugs. 2:73-8.
Klein L.E., Freeze B.S., Smith A.B. 3rd, and Horwitz S.B., (2005) The microtubule stablizing agent discodermolide is a potent inducer of accelerated cell senescence. Cell Cycle. 4:501-7.
Knedla A., Neumann E., and Müller-Ladner U., (2007) Developments in the synovial biology field 2006. Arthritis Research & Therapy. 9:209.
Kumar V., Cotran R.S. and Robbins, S.L., (2003) Robbins Basic Pathology (Saunders).
Lawson C.A., Brown A.K., Bejarano V., Douglas S.H., Burgoyne C.H., Greenstein A.S., Boylston A.W., Emery P., Ponchel F., and Isaacs J.D., (2006) Early rheumatoid arthritis is associated with a deficit in the CD4+CD25high regulatory T cell population in peripheral blood. Rheumatology, 45:1210-7.
Leslie D., Lipsky P., and Notkins A.L., (2001) Autoantibodies as predictors of disease. The Journal of Clinical Investigation. 108:1417-22.
Leipe J., Skapenko A., Lipsky P.E., and Schulze-Koops H., (2005) Regulatory T cells in rheumatoid arthritis. Arthritis Research & Therapy, 7:93-9.
Lowik C.W., Nibbering P.H., Van der Ruit M., and Papapoulos S.E., (1994) Inducible production of nitric oxide in osteoblast-like cells and in fetal mouse bone explants is associated with suppression of osteoclastic bone resorption. Journal of Clinical Investigation. 93:1465-72.
Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. (1951) Protein measurement with the Folin phenol reagent. The Journal of Biology Chemistry. 193: 265-75.
Lu Y., Huang C.Y., Lin Y.F., Wen Z.H., Su J.H., Kuo Y.H., Chiang M.Y.,and Sheu J.H., (2008) Anti-inflammatory cembranoids from the soft corals Sinularia querciformis and Sinularia granosa. Journal of Natural Products. 71: 1754-9.
Ma Y., and Pope R.M., (2005) The role of macrophages in rheumatoid arthritis. Current Pharmaceutical Design. 11: 569-580.
Matsubara K., (2004) Recent advances in marine algal anticoagulants. Current medicinal chemistry. Cardiovascular and hematological agents. 2:13-9.
Mayer A.M., and Hamann M.T., (2002) Marine pharmacology in 1999: compounds with antibacterial, anticoagulant, antifungal, anthelmintic, anti-inflammatory, antiplatelet, antiprotozoal and antiviral activities affecting the cardiovascular, endocrine, immune and nervous systems, and other miscellaneous mechanisms of action. Comparative biochemistry and physiology. Toxicology & pharmacology:CBP. 132: 315-39.
Mayer A.M., and Hamann M.T., (2004) Marine pharmacology in 2000: marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antituberculosis, and antiviral activities; affecting the cardiovascular, immune, and nervous systems and other miscellaneous mechanisms of action. Marine biotechnology. 6:37-52.
Mayer A.M., and Hamann MT., (2005) Marine pharmacology in 2001-2002: marine compounds with anthelmintic, antibacterial, anticoagulant, antidiabetic, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems and other miscellaneous mechanisms of action. Comparative biochemistry and physiology. Toxicology & pharmacology:CBP. 140: 265-86.
Mayer A.M., Jacobson P.B., Fenical W., Jacobs R.S., and Glaser K.B., (1998) Pharmacological characterization of the pseudoptersoins novel anti-inflammatory natural products isolated from the Caribbean soft coral, Pseudopterogorgia elisabethae. Life Sciences. 62: PL401-7.
Mclnnes I.B., and Schett G., (2007) Cytokines in the pathogenesis of rheumatoid arthritis. Nature Reviews. Immunology.7:429-42.
Medzhitov R., (2008) Origin and physiological roles of inflammation. Nature. 454: 428-35.
Meinecke I., Rutkauskaite E., Gay S., and Pap T., (2005) The role of synovial fibroblasts in mediating joint destruction in rheumatoid arthritis. Current pharmaceutical design. 11:563-8.
Nagy G., Clark J.M., Buzás E.I, Gorman C.L, and Cope A.P., (2007) Nitric oxide, chronic inflammation and autoimmunity. Immunology Letters 111: 1-5
Nathan C. (2006) Neutrophils and immunity: challenges and opportunities. Nature Review Immunology. 6:173-82.
Noguchi M., Kimoto A., Kobayashi S., Yoshino T., Miyata K., and Sasamata M., (2005) Effect of celecoxib, a cyclooxygenase-2 inhibitor, on the pathophysiology of adjuvant arthritis in rat. European journal of pharmacology. 513: 229-35.
Pearson C.M., (1959) Development of arthritis in the rat following injection with adjuvant. In: Shaffer J.H., Lo Grippo G.A., and Chase M.W., (eds). Mechanism of hypersensitivity. Boston. Little Brown & Co. (also London J & A Churchill Limited), 647-71.
Pincus T., and Callahan L.F., (1993) What is the natural history of rheumatoid arthritis? Rheumatic diseases clinics of North America. 19:123-51.
Li Q., and Verma I.M., (2002) NF-κB regulation in the immune system. Nature Review Immunology. 2:725-34
Ralston S.H., Ho L.P., Helfrich M.H., Grabowski P.S., Johnston P.W., and Benjamin N., (1995) Nitric oxide: a cytokine-induced regulator of bone resorption. Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research.10:1040-9.
Robbins S.L., Cotran R.S., and Kumar V., (1984) Pathologic basis of disease. Philadelphia : Saunders.
Ross M.H., Pawlina Wojciech Histology : a text and atlas with correlated cell and molecular biology. Fifth Edition.
Roussis V., Vagias C., and Tziveleka L.A., (2004) in Plants That Fight Cancer, ed. Spridon S.E. and Barberaki M.G.. CRC Press LLC, Boca Raton, FL, 195, 274.
Ruth J.H., Volin M.V., Haines G.K., Woodruff D.C., Katschke K.J., Woods J.M., Park C.C., Morel J.C., and Koch A.E., (2001) Fractalkine, a novel chemokine in rheumatoid arthritis and in rat adjuvant-induced arthritis. Arthritis and Rheumatism. 44:1568-81.
Sano H., Hla T., Maier J.A., Crofford L.J., Case J.P., Maciag T., and Wilder R.L., (1992) In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis. Journal of Clinical Investigation. 89:97-108.
Sato A., Fenical W., Zheng Q., and Clardy J., (1985) Norcembreme diterpenoids from pacific soft coral of the genus Sinularia (alcyonacea; octocorallia). Tetrahedron 19:4303-8.
Scherl D.S., Afflitto J., and Gaffar A., (1999) Influence of OAS-1000 on mediators of inflammation. Journal of clinical periodontology. 26:246-51.
Scheuer P.J.,(1996) Marine metabolites as drug leads-retrospect and prospect: In Biochemical Aspects of Marine Pharmacology. Lazarovici, P.; Spira, M. E.; Zlotkin, Eliahu Eds.; Alaken, Inc.: Fort Collins, Colorado, 1-12.
Serhan C.N. and Savill, J. (2005) Resolution of inflammation: the beginning programs the end. Nature Immunology. 6:1191-7.
Serhan C.N. (2007) Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways. Annual Review of Immunology. 25:101-37.
Seibert K., Zhang, Y., Leahy, K., Hauser, S., Masferrer, J., Perkins, W., Lee, L., and Isakson, P., (1994) Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proceedings of the National Academy of Sciences of the United States of America. 91:12013-7.
Shin J., Park M., and Fenical W., (1989) The junceellolldes new antiinflammatory diterpenoids of the briarane class from the chinese gorgonian junceella fragilis. Tetrahedron. 45:1633-8.
Sievers E.L., Appelbaum F.R., Spielberger R.T., Forman S.J., Flowers D., Smith F.O., Shannon-Dorcy K., Berger M.S., and Bernstein, I.D., (1999) Selective ablation of acute myeloid leukemia using antibody-targeted chemotherapy: a phase I study of an anti-CD33 calicheamicin immunoconjugate. Blood. 3678-84.
Silverman G.J., and Carson D.A., (2003) Roles of B cells in rheumatoid arthritis. Arthritis research and therapy. 54:S1-6.
Simmons D.L., Botting R.M., and Hla T., (2004) Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. Pharmacological reviews. 56: 387-437.
Skapenko A., Leipe J., Lipsky P.E., and Schulze-Koops H., (2005) The role of the T cell in autoimmune inflammation. Arthritis research and therapy. 7:S4-14.
Suzanne W., Raphael L., Wei D.D., George A.E., and Daniel K., (1992) Cleavage behavior of calicheamicin gamma and calicheamicin T. Proceedings of the National Academy of Sciences of the United States of America. 89:4608-12.
Toriyabe M., Omote K., Kawamata T., and Namiki A., (2004) Contribution of interaction between nitric oxide and cyclooxygenases to the production of prostaglandins in carrageenan-induced inflammation. Anesthesiology. 101:983-90.
Tunctan B., and Altug S., (2004) The use of nitric oxide synthase inhibitors in inflammatory diseases: a novel class of anti-inflammatory agents. Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents. 3:271-301.
Turull N., and Queralt J., (2000) Effect of the COX-2 selective inhibitor l-745,337 on inflammation and organ prostaglandin E2 (PGE2) levels in adjuvant arthritic rats. Inflammation. 24:533-45.
Ueki Y., Miyake S., Tominaga Y., and Eguchi K., (1996) Increased nitric oxide levels in patients with rheumatoid arthritis. The Journal of rheumatology. 23:230-6.
Vane J.R., Bakhle Y.S., and Botting R.M., (1998) Cyclooxygenase 1 and 2. Annual Review of Pharmacology and Toxicology. 38:97-120.
Walker S., Landovitz R., Ding W.D., Ellestad G.A., and Kahne D., (1992) Cleavage behavior of calicheamicin gamma 1 and calicheamicin T. Proceedings of the National Academy of Sciences of the United States of America. 89:4608-12.
Weinheimer A.J., Matson J.A., Hossain, M.B., and Vander H.D., (1977) Marine anticancer agents: Sinularin and dihydrosinularin, new cembranolides from the soft coral Sinularia flexibilis. Tetrahedron Letters. 18:2923-6.
Wratten S.J., Fenical W., cand Faulkner D.J., (1977) Ptilosarcone, The toxin from the sea pen Ptilosarcus gurneyi. Tetrahedron Letters. 18:1559-62.
Wu T., (2006) Cyclooxygenase-2 in hepatocellular carcinoma. Cancer Treatment Reviews. 32:28-44.
Yocum D.E., Allen J.B., Wahl S.M., Calandra G.B., and Wilder R.L., (1986) Inhibition by cyclosporin A of streptococcal cell wall-induced arthritis and hepatic granulomas in rats. Arthritis and Rheumatism. 29:262-73.
Yokoyama C., and Tanabe T., (1989) Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme. Biochemical and biophysical research communications. 165:888-94.
Yuan G., Wahlqvist M.L., He G., Yang M., and Li D., (2006) Natural products and anti-inflammatory activity. Asia Pacific Journal of Clinical Nutrition. 15:143-152
張東杰等編著 (1992) 組織學圖譜 (Atlas of histology) 藝軒出版社。
蘇瑞欣 2007 臺灣海域軟珊瑚Nephthea chabrolii、Sinularia manaarensis、Sinularia leptoclados和柳珊瑚Briareum sp.所含天然化合物的研究。國立中山大學海洋生物科技暨資源學系博士論文。中華民國96年。
林妤芳 中華民國97年(2008) 野外型與養殖型柔軟指型軟珊瑚所含天然物之研究。國立中山大學海洋生物科技暨資源學系碩士論文。。
盧 詣 中華民國97年(2008) 臺灣產指型軟珊瑚Sinularia querciformis所含Cembranoids之天然化合物研究。國立中山大學海洋生物科技暨資源學系碩士論文。
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