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研究生:羅敏慈
研究生(外文):Min-Tzu Luo
論文名稱:以濃度相轉換方式製備石蠟油O/W型奈米乳液
論文名稱(外文):Preparation of Paraffin Oil-in-Water Emulsions by Phase Inversion Concentration
指導教授:徐治平徐治平引用關係
學位類別:碩士
校院名稱:國立臺灣大學
系所名稱:化學工程學研究所
學門:工程學門
學類:化學工程學類
論文種類:學術論文
論文出版年:2008
畢業學年度:97
語文別:中文
論文頁數:72
中文關鍵詞:濃度相轉換法奈米乳液O/W 型乳液動態粒徑分析NOVA實驗設計
外文關鍵詞:Phase inversion concentration(PIC)Nano-emulsionO/W type emulsionsDynamic light scatteringANOVADesign of experiments.
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  • 被引用被引用:1
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本論文以濃度相轉換 (Phase Inversion Concentration, PIC ) 的方式,於固定30℃下將水緩慢加入油相製備成乳液,其中油相所包含的藥品為石蠟油及Span80/Tween80 兩種界面活性劑,且以改Span80 的含量、油與界面活性劑的比例及水的含量多寡作為操作變因,並以動態粒徑分析儀(Dynamic light scattering)Zetasizer Nano 及實驗設計軟體Design-Expert 7 進行分析並討論。
本研究所製成之石蠟油乳液為O/W型乳液,其pH 值介於5~6 之間,粒徑小於200nm。奈米乳液最佳配方為油與界面活性劑比例為1.5~2之間,水含量為70wt%,HLB 值為11.3。另透過實驗設計軟體分析得知本研究之顯著變因為A,B,AB,BC,ABC,其中 A 為Span80 的含量,B為油與界面活性劑的比例,C為水的含量多寡。
Emulsions of the paraffin oil were prepared from Tween 80/Span 80 and water at 30°C using the phase inversion concentration method. The influences of the key parameters on the nature of the emlsions prepared, in particular, its size distribution, are investigated. These include the amount of surfactant (%Span, A) and the corresponding HLB value, the oil/surfactant (O/S) ratio (B), the amount of water (C), and the pH of the bulk liquid phase. Paraffin oil emulsions with droplet size below 200 nm were O/W type emulsion and pH value 5~6. The best formed of the makeup nano-emulsions were 70wt% of the distilled water with oil/surfactant between 1.5 and 2 as well as the HLB value 11.3. The main and interactive effects of the process parameters have been studied by using analysis of variance (ANOVA) method. In this case, A, B, AB, BC, ABC are significant model terms. The three process control parameters (%Span, Oil/Surfactant (O/S) and water) termed as A, B, and C.
中文摘要 .......................................I
英文摘要 .......................................II
目錄 ...........................................III
表目錄 .........................................V
圖目錄 .........................................V
第一章 緒論 ....................................1
1-1 前言 .......................................1
1-2 乳液的形成 .................................2
1-2-1 乳化的定義及影響因素 .....................2
1-2-2 乳液的型態及影響穩定性因素 ...............3
1-3 界面活性劑 .................................4
1-3-1 界面活性劑的基本性質及種類 ...............4
1-3-2 界面活性劑的HLB 值 .......................5
1-3-3 界面活性劑的功能及應用 ...................6
1-4 統計分析 ...................................6
1-4-1 變異數分析 ...............................6
1-4-2 實驗設計法 ...............................7
1-5 研究動機與目的 .............................8
第二章 文獻回顧
2-1 奈米乳液的製備 .............................9
2-1-1 高能量乳化 ...............................9
2-1-2 相轉變溫度 ...............................10
2-2 乳化條件對乳液物性的影響 ...................10
2-3 奈米乳液相關文獻 ...........................11
第三章 實驗
3-1 實驗藥品 ...................................13
3-2 實驗儀器 ...................................14
3-3 實驗參數選擇 ...............................15
3-4 實驗步驟 ...................................15
3-4-1 奈米乳液的製備 ...........................15
3-4-2 粒徑量測 .................................16
3-4-2.1 動態粒徑分析儀 .........................16
3-4-2.2 雷射粒徑分析儀 .........................17
3-5 統計分析軟體 ...............................17
3-6 實驗架構圖 .................................18
第四章 結果與討論
4-1 乳液的型態 .................................19
4-2 水、油與界面活性劑比率及HLB值的影響 ........20
4-2-1 水的含量對乳液粒徑的影響 .................20
4-2-2 油與界面活性劑比例對乳液粒徑的影響 .......21
4-2-3 HLB 值對乳液粒徑的影響 ...................22
4-3 以esing-Expert7 分析實驗各變因對粒徑的影響 .22
4-3-1 變異數分析 ...............................22
4-3-2 單因子對乳液粒徑的影響 ...................23
4-3-3 兩極端值各因子交互作用對乳液粒徑的影響 ...24
4-3-4 多數值各因子交互作用對乳液粒徑的影響 .....25
第五章 結論 ....................................26
第六章 參考文獻 ................................27
1. 林清安、林德培、丁幸一,界面活性劑化學,逢甲書局(1979)。
2. 王鳳英,界面活性劑的原理與應用,高立圖書有限公司(1993)。
3. 陳崇賢,乳液概論,界面科學會誌,19 (1),1-11(1996)。
4. 趙承琛,界面科學基礎,復文書局(2001)。
5. 賴碧玉,乳液安定性控制因素,元智大學化學工程學系碩士論文(2002)。
6. 林江珍、顏孝欽、黃世吉,非離子型界面活性劑應用於精油乳化之原理,化工技術,6(2),164-174(1998)。
7. 黎正中,謝源榭,實驗設計與分析,高立圖書有限公司 (2003)。
8. 潘南飛,工程統計,全威圖書有限公司(2003)。
9. 蕭明達,含美白成分奈米乳化產品之製備及其性質研究。嘉南藥理科技大學化妝品科技研究所博士論文(2006)。
10. 邱文慧,荷荷芭油奈米乳液之製備及物性探討,靜宜大學應用化學研究所博士論文(2006)。
11. 孫宛如,奈米乳液的開發與特性探討,長庚大學生化與生醫工程研究所碩士論文(2007)。
12. Wang, D. C. : A study on identifying emulsifying agent type, China SurfactantDetergent and Cosmetics, 2(5), (2001).
13. Ivanov, I. B., Danov, K. D., Kralchevsky, P. A. : Flocculation and coalescence of micron-size emulsion droplets, Colloid Surf. A:Physicochem. Eng. Asp., 152(1-2),
161-182, (1999).
14. Taylor, P. : Ostwald ripening in emulsions, Colloid Surf. A:Physicochem. Eng. Asp.,99(2-3), 175-185,(1995).
15. Jiao, J., Burgess, D. J. : Ostwald ripening of water-in-hydrocarbon emulsions, J.Colloid Interface Sci., 264(2), 509-516, (2003).
16. Taylor, P. : Ostwald ripening in emulsions: estimation of solution thermodynamics of the disperse phase, Adv. Colloid Interface Sci., 106(1-3), 261-285, (2003).
17. Guzey, D., Kim, H., McClement, D. J. : Factors influencing the production of O/W emulsions stabilized by β-lactoglobulin-pectin membranes, Food Hydrocolloids., 18(6), 967-975, (2004).
18. Dai, L., Li, W., Hou, X. : Effect of the molecular structure of mixed nonionic surfactants on the temperature of mini-emulsions formation, Colloid Surf. A:Physicochem. Eng. Asp., 125(1), 27-32,(1997).
19. Špiclin, P., Gašperlin, M., Kmetec, V. : Stability of ascorbyl palmitate in topical micro-emulsions, Int. J. Pharm., 222(2), 271-279, (2001).
20. Špiclin, P., Solans, C., González, C., Martínez, A., Guinart, A., Gutiérrez, J. M. : Studies of formation of W/O nano-emulsions, Colloid Surf. A:Physicochem. Eng. Asp., 249(1-3), 115-118,( 2004).
21. Momtgomert, Runger, Hubele, Engineering Statistics, Wiley, Thirs edition, (2003).
22. Meyer, J. : Preparing PIC emulsions with a very fine particle size, Cosmetics and Toiletries magazine, 122(1), 61-70, (2007).
23. Nakajima, H., Solans, C. Konieda, H. (Eds.), Industrial Applications of Microemulsions, Marcel Dekker, 66, 175-197, (1997).
24. Forgiarini, A. Esquena, J., Gonza’lez, C., Solans, C. : Formation of Nano-emulsions by Low-Energy Emulsification Methods at Constant Temperature, Langmuir, 17, 2076-2083, (2001).
25. Tadros, Tharwat, Izquierdo, P., Esquena, J., Solans, C. : Formation and stability of nano-emulsions, Adv. Colloid Interface Sci., 108 –109,303–318, (2004).
26. Wang, L., Li, X., Zhang, G., Dong, J. : Oil-in-water nanoemulsions for pesticide formulations, J. Colloid and Interface Sci., 314 ,230–235, (2007).
27. Sonneville-Aubrun, O., Simonnet, J.-T., L''Alloret, F. : Nanoemulsions: a newvehicle for skincare products, Adv. Colloid Interface Sci., 108–109, 145–149,(2004).
28. Tadros, Th. F., Vandamme, A., Levecke, B., Booten, K., Stevens, C.V. :Stabilization of emulsions using polymeric surfactants based on inulin, Adv. Colloid Interface Sci., 108 –109, 207–226, (2004).
29. Shinoda, K., Kunieda, H. : Phase properties of emulsion:PIT and HLB in encyclopedias of emulsion technology;P. Oecher, Marcel Dekker:New Your, (1983).
30. Engle, T., Forster, T., von Rybinski, W. : The influence of coemulsifier type on the stability of oil-in-water emulsions, Colloid Surf. A:Physicochem. and Eng. Asp., 99, 141-149, (1995).
31. Morales. D., Gutiérrez, J. M., Garcia-Celma, J. M., Solans, C. : A study of relation between bicontinuous microemulsions and oil/water nano-emulsion formation, Langmuir, 19, 7196-7200, (2003).
32. Izquierdo, P., Esquena, J., Tadros, Th. F., Dederen, J. C., Feng, J., García, M. J. : Phase behavior and nano-emulsion formation by the phase inversion temperature
method, Langmuir, 20, 6598-3598, (2004).
33. Takamura, A., Minowa, T., Noro, S., Kubo, T. : Effect of Tween and Span group emulsifiers on the stability of O/W emulsions, Chem. Pharm. Bull., 27(12), 2921-2925, (1979).
34. Depraetere, P., Florence, A. T., Puisieux, F., Seiller, M. : Some properties of oil in water emulsions stabilized with mixed non-ionic surfactants (Brij92/Brij96), Int. J.
Pharm., 5, 291-304, (1980).
35. Gullapalli, R. P., Sheth, B. B. : Influence of an optimized non-ionic emulsifier blend on properties of oil in water emulsions, Eur. J. Pharm. Biopharm., 48, 233-238,
(1999).
36. Al-Sabagh, A. M. : The relevance HLB of surfactants on the stability of asphalt emulsion, Colloid Surf. A:Physicochem. Eng. Asp., 204(1-3), 7-83, (2002).
37. Forgiarini, A., Esquena, J., González, C., Solans, C. : Formation of nano-emulsions by low-energy emulsification methods at constant temperature, Langmuir, 17, 2076-2083, (2001).
38. Porras, M., Solans, C., González, C., Martínez, A., Guinart, A., Gutiérrez, J. M. : Studies of formation of W/O nano-emulsions, Colloid Surf. A:Physicochem. Eng. Asp., 249(1-3), 115-118, (2004).
39. Fernandez, P., Andr′e, V., Rieger, J., Kühnle, A. : Nano-emulsion formation by emulsion phase inversion, Colloid Surf. A: Physicochem. Eng. Asp., 251, 53–58, (2004).
40. Izquierdo, P., Feng, J., Esquena, J., Tadros, T. F., Dederen, J. C. : The influence of
surfactant mixing ratio on nano-emulsion formation by the PIT method, J. Colloid and Interface Sci., 285, 388-394, (2005).
41. Liu, W., Sun, D., Li, C., Liu, Q., Xu, J. : Formation and stability of paraffin oil-in-water nano-emulsions prepared by the emulsion inversion point method, J. Colloid and Interface Sci., 303 , 557–563, (2006).
42. Pey, C. M., Maestro, A., Sol′e, I., Gonz′alez, C., Solans, C., Guti′errez, J. M. : Optimization of nano-emulsions prepared by low-energy emulsification methods at constant temperature using a factorial design study, Colloid Surf. A: Physicochem. Eng. Asp., 288, 144–150, (2006).
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