跳到主要內容

臺灣博碩士論文加值系統

(3.231.230.177) 您好!臺灣時間:2021/07/28 23:21
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果 :::

詳目顯示

我願授權國圖
: 
twitterline
研究生:梁菁萍
研究生(外文):Ching-Ping Liang
論文名稱:整合空間資訊分析攝食烏腳病盛行地區養殖魚貝類之人體健康風險評估及管理
論文名稱(外文):Integration of spatial information in assessing and managing potential carcinogenic health risk via ingestion of farmed fish and shellfish in blackfoot disease hyperendemic areas
指導教授:劉振宇劉振宇引用關係
指導教授(外文):Chen-Wuing Liu
學位類別:博士
校院名稱:國立臺灣大學
系所名稱:生物環境系統工程學研究所
學門:工程學門
學類:土木工程學類
論文種類:學術論文
論文出版年:2008
畢業學年度:97
語文別:英文
論文頁數:112
中文關鍵詞:烏腳病標的致癌風險地理資訊系統逐步指標模擬法不確定性養殖魚貝類
外文關鍵詞:ArsenicBlackfoot diseaseTarget cancer riskGISSequential indicator simulationUncertaintyAquaculture fish and shellfish
相關次數:
  • 被引用被引用:1
  • 點閱點閱:226
  • 評分評分:
  • 下載下載:0
  • 收藏至我的研究室書目清單書目收藏:0
海鮮食物中經常因含有高量的砷(As),造成人類健康的威脅並引起大眾之高度關切,砷之暴露途徑眾多包括食物、水、土壤及空氣等,其中藉由攝入海鮮類食物之砷暴露為最重要之途徑。本研究主要針對台灣烏腳病盛行地區,估算因攝食高砷污染地區之養殖魚貝類(包括吳郭魚、虱目魚、烏魚、文蛤及牡蠣)所致之潛在致癌風險;考量養殖魚貝類之無機砷濃度及合理之攝食量,本研究建構一以風險為基礎之合理攝食風險機率估算地圖,以地理資訊系統(GIS)地圖所提供之養殖資訊結合地下水砷濃度之機率分布,採用人體健康風險估算模式,評估食用受砷污染之養殖魚貝類之標的致癌風險(Target cancer risk)及合理攝食量之估算。由於受限於有限之實測資料,本研究使用蒙地卡羅(MC)模擬法及逐步指標模擬法(SIS)估算人體健康風險模式中所使用之參數並探討模式之不確定性。
本研究首先估算攝食養殖牡蠣之無機砷所造成的人體健康風險(Chapter 2),研究結果顯示四鄉鎮的養殖牡蠣中,平均無機砷濃度佔總砷濃度大約為1.64%。以95%的發生機率,每日攝取18.6-56公克的牡蠣,估算攝入無機砷之致癌風險為1.26×10-5 – 3.82×10-5。此外,每日攝取18.6-56公克的牡蠣,攝入無機砷之非致癌風險(危害商數,THQ)介於 0.071-0.214。以致癌風險模式估算,符合致癌風險為10-6建議之每日牡蠣攝取量為1.6公克。第三章(Chapter 3)探討文蛤、底泥和養殖池水之砷和物種砷含量,並針對在砷暴露環境中文蛤的生物累積效應進行估算,並採機率的方式估算攝入養殖文蛤所致砷之潛在致癌風險。結果指出文蛤體內無機砷含量佔總砷含量約為12.3%-14%,此值遠高於養殖牡蠣無機砷含量的比值,顯示攝取與牡蠣等量的文蛤將攝入更多的無機砷含量。風險評估結果顯示,攝取烏腳病地區文蛤之潛在致癌風險,介於 4.52×10-6 – 80.7×10-6 均超過可接受的目標風險値(10-6),根據致癌風險模式推估,人體每日攝食烏腳病地區的文蛤安全量建議為0.18公克。第四章(Chapter 4)提出以GIS為基礎之整合空間資訊分析方法,探討經由砷污染地下水地區養殖魚種之食物鏈暴露而攝入無機砷所造成之潛在致癌風險。分析結果顯示,西部沿海地區的養殖文蛤和養殖虱目魚對人體健康有較高的健康風險,而主要在內陸養殖的吳郭魚僅在第95百分位數致癌風險(TR)値為最高。建議在文蛤和虱目魚養殖區域,應減少使用含砷污染的地下水,而由於烏魚對人類呈現較低健康風險,因此砷汙染的地下水建議可繼續提供烏魚養殖用水之使用。最後在論文第五章(Chapter 5)中主要以訂定合理的海鮮攝取量的目標下,納入五種養殖於砷污染地區魚種(包括吳郭魚、虱目魚、烏魚、文蛤和牡蠣),進行以風險為基礎之合理攝取量之估算。根據糧食與農業組織/世界衛生組織所提出之每週砷容許攝取量(每公斤體重15微克),換算為台灣每位成人經由魚貝類攝入砷容許攝取量,約為每日6.37微克。每日飲食攝入砷含量在第5、第25、第50、第75及第95百分位數分別是0.52、1.20、2.17、3.95及9.22微克。第95百分位數之每日攝入砷含量(9.22微克)高於每日容許攝取量(PTDI)。合理的魚貝類攝取量是以人一生所能接受最大風險進行估算,根據無機砷的濃度(Cinorg)與風險為基礎之每日攝取量(RBIRf)之關係,研究中建構圖解法建立風險値介於1×10-5 至6.07×10-5之可接受風險區(acceptable risk zone)訂定合理的魚貝類攝食量。
本研究提出一整合空間資訊分析攝食高砷地區養殖魚貝類之人體健康風險評估方法,並建構一合理攝食風險估算方法以進行快速有效之合理攝食量之估算。研究結果建議可降低高砷污染地區用於養殖魚貝類地下水之使用量,並以提出之合理攝食量之估算法,提供公共衛生決策者進行砷之潛在致癌風險評估、進行養殖區域之風險等級劃分、改變養殖魚貝類之種類,以及針對消費大眾能提供更多資訊以正確選擇海鮮食物,降低因高砷地下水砷用於養殖所致之潛在致癌風險。
Arsenic (As) in seafood receives public attention because it is potential hazardous to human health and frequently presents at high concentration levels. Humans are exposed to various sources of As (food, water, soil and air), but exposure via ingesting seafood is by far the most important one. This study estimates the potential carcinogenic risk of ingesting inorganic As in aquacultural fish and shellfish in the blackfoot disease (BFD) hyperendemic areas of Taiwan, using geostatistical methods and geographic information systems. Five aquacultural species, tilapia (Oreochromis mossambicus), milkfish (Chanos chanos), mullet (Mugil cephalus), clams (Meretrix lusoria) and oysters (Crassostrea gigas), are taken into account. We herein construct a rational ingestion risk diagram with considering the concentration of inorganic As and risk-based daily ingestion rate of aquaculture species. Moreover, the rational consumption rates of fish and shellfish farmed in As-affected groundwater areas are evaluated. Target cancer risks (TRs) of ingesting As contents in aquaculture fish and shellfish are spatially mapped to assess potential risks to human health and to elucidate the safety of As-polluted groundwater use in fish ponds. Owing to sparse measured data, Monte Carlo simulation and sequential indicator simulation are used to propagate the uncertainty and assessed parameters. For the first assessment (Chapter 2), the human health risk associated with ingesting inorganic As through consumption of farmed oysters in Taiwan is estimated. The results reveal that the ratio of mean concentration among the four townships of inorganic As to total concentration of As in oysters is approximately 1.64%. The estimated target cancer risks (TR), based on a 95% occurrence probability from ingesting inorganic As by consuming oysters at a rate of 18.6–56 g/day, range from 1.26×10-5 to 3.82×10-5. Moreover, a target hazard quotient (THQ) associated with ingesting inorganic As through oyster consumption at a rate of 18.6–56 g/day range from 0.071 to 0.214. Based on the estimation of the TR model, an ingestion rate of 1.6 g/day is recommended to meet the 95th percentile of carcinogenic risk, 10-6, for exposure to inorganic As through the consumption of oysters in Taiwan. Furthermore, this study investigated the relationship between As content in clams and their environment, including sediment and pond water (Chapter 3). The bioaccumulation of As in clams in their exposure environment and the potential carcinogenic risks associated with the ingestion of As in aquaculture clams are probabilistically evaluated. The average ratios of inorganic As contents to total As contents in clams ranged from 12.3% to 14.0% which are much higher than that found in the farmed oysters, indicating that humans may expose to larger quantities of inorganic As by ingesting the same amount of clams as oysters. The results of the risk assessment indicate that potential carcinogenic risks associated with consumption of clams from the BFD area rangs from slightly (4.52×10-6) to largely (80.7×10-6) exceeding the acceptable target risk. Based on the estimation of the TR model, a 0.18 g/day-person of the safe ingestion rate of clams in the BFD region is recommended. For integration of spatial information, an integrated GIS-based approach for assessing potential carcinogenic risks via food-chain exposure of ingesting inorganic As in aquaculture species in the As-affected groundwater areas is presented (Chpater 4). The analyzed results reveal that clams farmed in the western coastal ponds and milkfish farmed in the southwestern coastal ponds have the high risks to human health and tilapia cultivated mainly in the inland ponds only has high risks at the 95th percentile of TR. As-contaminated groundwater used for clams and milkfish ponds should be significantly reduced. The fact that mullet has low risks to human health revealed that As-affected groundwater can be used successively in mullet ponds. Finally, with the goal to propose the suitable consumption rates of seafood, five aquacultural species, tilapia, milkfish, mullet, clams and oysters farmed in As-affected groundwater areas are taken into account to estimate the risk-based rational consumption rates (Chapter 5). Based on the provisional tolerable weekly intake (PTWI) of 15 μg inorganic As/kg body weight suggested by the Food and Agriculture Organization/World Health Organization (FAO/WHO), the daily basis of inorganic As intake of 6.37 μg/day for provisional tolerable daily intake for fish and shellfish (PTDI ) for an adult Taiwanese is transformed. The total dietary intakes estimate for inorganic As in fish and shellfish are 0.52, 1.20, 2.17, 3.95 and 9.22 μg/day, respectively, for 5th, 25th, 50th, 75th and 95th percentiles.The 95th percentile of 9.22 μg/day is higher than PTDI. The rational consumption rate of fish and shellfish is evaluated based on the maximum acceptable lifetime risk. According to the relationship between concentrations of inorganic As (Cinorg) and risk based daily ingestion rate (RBIRf), a tolerance zone with risk range from 1×10-5 to 6.07×10-5 is graphically constructed to define the rational consumption rate of fish and shellfish for general public in Taiwan
The study concludes that the integration of spatial information in assessing and managing potential carcinogenic health risk via ingestion of farmed fish and shellfish in blackfoot disease hyperendemic areas has been proposed. It suggests an effective framework for public health officials in Taiwan in assessing potential carcinogenic risks and informs consumers to wisely choose aquacultural products from As-affected groundwater areas.
TABLE OF CONTENTS
Abstract……..……………..……………………………………...……………………………I
摘要…………..……………..………………………………………………..………………IV
Table of contents......……..…………………………………………………………..………VII
List of Tables.....……..…………………………………………………………..………….VIII
List of Figures.....……..…………………………………………………………..………...…Χ
Nomenclature……..…………………………………………………………..………......... ΧII

Chapter 1 Introduction……….…………..……………………………………………………1
1.1 Background…..……..….……………………….………………………………......1
1.2 Research objectives……..……………………..………….……………………….10
References……………………………………………………………………..…...11

Chapter 2 Assessing the human health risks from exposure of inorganic arsenic through oyster (Crassostrea gigas) consumption in Taiwan…………………………...……………………..16
(published in Science of the Total Environment)

Chapter 3 Bioaccumulation of arsenic compounds in aquacultural clams (Meretrix lusoria) and assessment of potential carcinogenic risks to human health by ingestion……………….27
(published in Chemosphere)

Chapter 4 An integrated GIS-based approach in assessing carcinogenic risks via food-chain exposure in arsenic-affected groundwater areas………….…………………….…………….35
(submitted to Environmental Toxicology)

Chapter 5 Rational consumption rates of fish and shellfish farmed in arsenic-affected groundwater areas………….………………………………………………………….……...69
(submitted to Environmental Research)

Chapter 6 Conclusions and Suggestion
6.1 Conclusions……..………………………………….……………………….……108
6.2 Suggestion……..………………………………….…………………….………..110
References
Abernathy, C.O., Thomas, D.J., Calderon, R.L., 2003. Health effects and risk assessment of arsenic. J. Nutr.133, 1536S–8S.
ATSDR, 2000. Toxicological profile for arsenic (update). Atlanta, GA: U.S. Public Health Service, Agency for Toxic Substances and Disease Registry.
Castrignanò, A., Goovaerts, P., Lulli, L., Bragato, G.., 2000. A geostatistical approach to estimate probability of occurrence of Tuber melanosporum in relation to some soil properties. Geoderma. 98, 95-113.
Chen, K.P., Wu, H.Y., Wu, T.C., 1962. Epidemiologic studies on blackfoot disease in Taiwan. 3. Physicochemical characteristics of drinking water in endemic blackfoot disease area. Memoirs. Coll. Med. National Taiwan University. 8, 115-129.
Chen, S.L., Dzeng, S.R., Yang, M.H., Chiu, K.H., shieh, G.M., Wai, C.M., 1994. Arsenic species in groundwaters of the blackfoot disease area, Taiwan. Environ. Sci. Technol. 28, 877–81.
Chen, C.J., 1997. Epidemiological study of residents associated with arsenic in drinking water in the Lanyang Plain (I). Taipei, Taiwan: National Science Council, ROC. NSC86-2314-B-002-336. (in Chinese)
Ch’i, I.C., Blackwell, R.Q., 1968. A controlled retrospective study of blackfoot disease, an endemic peripheral gangrene disease in Taiwan. American J. Epidem. 88, 7-24.
Falcó G., Llobet, J.M., Bocio, A., Domingo, J.L., 2006. Daily intake of arsenic, cadmium, mercury, and lead by consumption of edible marine species. J. Agric. Food Chem. 54, 6106-6112.
FAO/WHO, 1989. Evaluation of Certain Food Additives and Contaminants, Technical Report Series 759. World Health Organization, Geneva, Switzerland.
Goovaerts, P., AvRuskin, G., Meliker, J., Slotnick, M., Jacquez, G.., Nriagu, J., 2005. Geostatistical modeling of the spatial variability of arsenic in groundwater of southeast Michigan. Water Resour. Res. 41: 10.1029/2004WR003705.
Goovaerts, P., Semrau, J.M., Lontoh, S., 2001. Monte Carlo analysis of uncertainty attached to microbial pollutant degradation rates. Environ. Sci. Technol. 35: 3924-3930.
Han, B.C., Jeng, W.L., Chen, R.Y., Fang, G..T., Hung, T.C., Tseng, R.J., 1998. Estimation of target hazard quotients and potential health risks for metals by consumption of seafood in Taiwan. Arch. Environ. Contam. Toxicol. 35, 711-720.
Huang, Y.K., Lin, K.H., Chen, H.W., Chang, C.C., Liu, C.W., Yang, M.H., Hsueh, Y.M., 2003. Arsenic species contents at aquacultural farm and in farmed mouthbreeder (Oreochromis mossambicus) in blackfoot disease hyperendemic areas. Food Chem. Toxicol. 41, 1491-1500.
Jang, C.S., Liu, C.W., Lin, K.H., Huang, F.M., Wang, S.W., 2006. Spatial analysis of potential carcinogenic risks associated with ingesting arsenic in aquacultural tilapia (Oreochromis Mossambicus) in blackfoot disease hyperendemic areas. Environ. Sci. Technol. 40, 1707-1713.
Juang, K.W. and Lee, D.Y., 1998. Simple indicator kriging for estimating the probability of incorrectly delineating hazardous areas in a contaminated site. Environ. Sci. Technol. 32, 2487–2493.
Juang, K.W., Chen, Y.S., Lee, D.Y., 2004. Using sequential indicator simulation to assess the uncertainty of delineating heavy-metal contaminated soils. Environ. Pollut. 127, 229-238.
Liao, C.M., Ling, M.P., 2003. Assessment of human health risks for arsenic bioaccumulation in tilapia (Oreochromis mossambicus) and large-scale mullet (Liza macrolepis) from blackfoot disease area in Taiwan. Arch. Environ. Contam. Toxicol. 45, 264-272.
Lin, K.H., 2004. Spatiotemporal distribution and bioaccumulation of arsenic species in the aquacultural ecosystem in the coastal areas of southwestern Taiwan. (Ph.D. Dissertation), Institute of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, p 176-197. (in Chinese)
Lin, T.H., Huang, Y.L., Wang, M.Y., 1998. Arsnic species in drinking water, hair, fingernails, and urine of patients with blackfoot disease. J. Toxicol. Environ. Health Part A. 53, 85-93.
Lin, M.C., Cheng, H.H., Lin, H.Y., Chen, Y.C., Chen, Y.P., Chang-Chien, G.P., 2004. Arsenic accumulation and acute toxicity in aquacultural juvenile milkfish (Chanos chanos) from blackfoot disease area in Taiwan. Bull. Environ. Contam. Toxicol. 72, 248–54.
Liu, C.W., Jang, C.S., Liao, C.M., 2004. Evaluation of arsenic contamination potential using indicator kriging in the Yun-Lin aquifer (Taiwan). Sci. Total Environ. 321, 173-188.
Liu, C.W., Huang, F.M., Hsueh, Y.M., 2005. Revised cancer risk assessment of inorganic arsenic upon consumption of tilapia (Oreochromis mossambicus) from blackfoot disease hyperendemic areas. Bull. Environ. Contam. Toxicol. 74, 1037-1044.
Liu, C.W., Liang, C.P., Huang, F.M., Hsueh, Y.M., 2006. Assessing the human health risks from exposure of inorganic arsenic through oyster (Crassostrea gigas) consumption in Taiwan. Sci. Tot. Environ. 361, 57-66.
Liu, C.W., Liang, C.P., Lin, K.H., Jang, C.S., Wang, S.W., Huang, Y.K. Hsueh, Y.M., 2007. Bioaccumulation of arsenic compounds in aquacultural clams (Meretrix lusoria) and assessment of potential carcinogenic risks to human health by ingestion. Chemosphere 69, 128-134.
Liu, C.W., Huang, Y.K., Hsueh, Y.M., Lin, K.H., Jang, C.S. Huang, L.P., 2008. Spatiotemporal distribution of arsenic species of oysters (Crassostrea Gigas) in the coastal area of southwestern Taiwan. Environ. Monit. Assess. 138, 181-190.
Lu, F.J., 1990. Blackfoot Disease: Arsenic or Humic Acid? Lancet. 336, 115-116.
Oremland, R.S., Stotlz, J.F., 2003. The ecology of arsenic. Science. 300, 939-944.
Taiwan COA, 2006. Taiwanese Food Supply and Demand Annual Report; Council of Agriculture, Executive Yuan: Taiwan
Taiwan COA, 2007. Taiwan Fisheries Yearbook; Council of Agriculture, Executive Yuan: Taiwan. Available from: http://www.fa.gov.tw/eng/index.php
Taiwan EPA, 1998. Classification and Standards of Water Quality in Surface Water. Taiwan Environmental Protection Agency, Taiwan, (in Chinese)
Taiwan Fishery Agency. 2003. Annual report of fishery agency in 2003 - establishment of geographical information systems in aquacultural fish. Taipei: Taiwan Fishery Agency. p. 47.
Tseng, W.P., 1977. Effects and dose-response relationships of skin cancer and blackfoot disease with arsenic. Environ. Health Persp. 19, 109-119.
US EPA, 1988. Special report on ingested inorganic arsenic: Skin cancer; nutritional essentiality. EPA/625/3-87/013, U.S. Environmental Protection Agency, Risk Assessment Forum, Washington, DC.
US EPA, 2002a. List of drinking water contaminants and MCLs. Washington, DC: United States Environmental Protection Agency. EPA-816-F-02-013.
US EPA, 2002b. Child-specific exposure factors handbook (Interim report). Washington, DC: United States Environmental Protection Agency. EPA-600-P-00-002B.
van Meirvenne M, Goovaerts P., 2001. Evaluating the probability of exceeding a site-specific soil cadmium contamination threshold. Geoderma. 102, 75-100.
WHO, 1985. Guidelines for the study of dietary intakes of chemical contaminants. Geneva, Switzerland.
Yu, W.H., Harvey, C.M., Harvey, C.F., 2003. Arsenic in groundwater in Bangladesh: A geostatistical and epidemiological framework for evaluating health effects and potential remedies. Water Resour. Res. 39, 1146. doi:10.1029/2002WR001327.
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top
無相關期刊