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研究生:陳柏任
研究生(外文):Po-Jen Chen
論文名稱:濃縮大氣微粒對心肌損傷大鼠之心血管毒性研究
論文名稱(外文):Subchronic Effects of Concentrated Ambient Particles on Cardiovascular Toxicity in Myocardial Injury Rats
指導教授:鄭尊仁鄭尊仁引用關係
指導教授(外文):Tsun-Jen Cheng
學位類別:碩士
校院名稱:國立臺灣大學
系所名稱:職業醫學與工業衛生研究所
學門:醫藥衛生學門
學類:公共衛生學類
論文出版年:2009
畢業學年度:97
語文別:中文
論文頁數:61
中文關鍵詞:心臟衰竭心肌損傷大氣濃縮微粒細粒徑微粒濃縮器心跳變異性
外文關鍵詞:Congestive heart failureMyocardial injuryConcentrated ambient particlesUltrafine particle concentratorHeart rate variability
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流行病學研究指出,大氣微粒會造成心臟衰竭住院率及死亡率的上升,然而機轉還不清楚。本研究目的在探討,長期暴露濃縮大氣微粒,對心肌損傷大鼠心血管系統的亞慢性效應。
將SD大鼠注射 isoproterenol (150mg/kg)後造成心肌損傷,作為心肌受損疾病動物模式,再以細粒徑微粒濃縮器 (濃縮倍率約6.4倍),進行長期微粒全身性呼吸暴露 (每天五小時,每週四天,共三個月),並以呼吸過濾空氣之大鼠作為對照組。結果發現,大氣濃縮微粒暴露會使凝血功能指標 Fibrinogen上升 (190.7 ± 15.0 vs 160.5 ± 24.2 mg/dL, p < .05),心跳變異性指標HF顯著上升(0.77 ± 0.15 vs 0.31 ± 0.05ms2, p < .05),而心臟衰竭指標BNP及發炎指標CRP則無顯著變化。
本研究發現以心肌受損大鼠暴露大氣微粒,對左心室功能並無顯著的急性與慢性效應,但有明顯凝血功能指標fibrinogen上升及心臟自律調節功能改變,顯示在目前大氣微粒濃度下,經慢性暴露後心血管危險因子仍可能上升,微粒空氣污染對心血管的效應值得進一步研究。
Epidemiologic studies have shown that ambient particulate matter (PM) is associated with the mortality and hospital admissions of congestive heart failure. However, the mechanism is still unclear. The goal of this study is to investigate the subchronic effects of concentrated ambient particles (CAPs) on cardiovascular toxicity in rats with myocardial injury.
Male SD rats received 150 mg/kg isoproterenol by subcutaneous injection to induce myocardial injury. Ultrafine particle concentrator (UFPC) was used for subchronic CAPs exposure (Whole body inhalation exposure, 5hours/day, 4days/week for 13 weeks). Compared to filter air inhalation controls, CAPs exposure group had significantly higher fibrinogen level (190.7 ±15.0 vs 160.5 ±24.2 mg/dL, p < .05); heart rate variability parameters, HF level, was higher in CAPs exposure group than controls (0.77 ± 0.15 vs 0.31 ± 0.05ms2, p < .05). CAPs group also had higher BNP and CRP level but not significant.
Our results showed that PM exposure in rats with myocardial injury had no obvious acute or chronic effect in left ventricle, but increased fibrinogen level and altered cardiac autonomic function. Our results suggest cardiovascular risk factors may increase after chronic exposure to ambient particle under present PM concentration.
目錄 I
表目錄 IV
圖目錄 V
摘要 1
Abstract 2
一、研究目的 3
二、文獻探討 4
2-1微粒空氣汙染相關研究 4
2-1-1大氣微粒流行病學研究 4
2-1-2大氣微粒對心血管疾病之流病研究 4
2-1-3大氣微粒對心血管疾病之毒理研究 5
2-1-4大氣微粒對心血管效應之機轉 6
2-2大氣微粒對心衰竭之相關研究 6
2-2-1大氣微粒對心衰竭之流病研究 6
2-2-2大氣微粒對心衰竭之毒理研究 7
2-2-3心臟衰竭之病生理 7
2-2-4左心室功能不全指標-Brain Natriuretic Peptide (BNP) 8
2-2-5循環生理指標(hemodynamic) 8
2-2-6心肌損傷大鼠模式 9
2-3 心肺功能相關指標 10
2-3-1系統性發炎指標-C reactive protein (CRP) 10
2-3-2血液凝集指標-Fibrinogen 10
2-3-3肺部傷害及發炎指標 11
2-4 大氣微粒對心律變異性之相關研究 11
2-4-1心律變異性 11
2-4-2大氣微粒對心律變異性影響之流病研究 12
2-4-3大氣微粒對心律變異性影響之毒理研究 13
2-5 暴露方式與暴露系統 14
2-5-1呼吸暴露方式 14
2-5-2全身暴露系統 (Whole-Body Exposure system) 15
2-5-3細粒徑微粒濃縮器 15
三、材料與方法 17
3-1動物飼養及動物模式 17
3-2暴露方法 17
3-3左心室功能與系統發炎指標測量 18
3-4血液凝集指標測量 19
3-5肺部發炎反應生化值(肺泡灌洗液)測量 19
3-6血行動力學指標測量 20
3-7心跳變異性指標測量 20
3-8統計分析方法 21
3-9實驗流程 22
四、結果 24
4-1 暴露系統 24
4-2 心臟重量 24
4-3 肺部發炎指標 25
4-4 血行動力學 25
4-5 心跳變異性指標 (HRV) 26
4-6 左心室功能不全指標 (BNP) 26
4-7 系統性發炎指標 (CRP) 27
4-8 血液凝集指標 (Fibrinogen) 27
五、討論 28
六、結論與建議 39
七、表格與圖片 40
八、參考文獻 48
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