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研究生:陳國豐
研究生(外文):Guo-Feng Chen
論文名稱:壹、連翹之成分研究貳、超微細化中草藥指標成分檢測技術之開發參、蝴蝶蘭花色成分與定量分析
論文名稱(外文):1.The constituents of Forsythia suspensa2.Development of techniques of examination for the indicator compounds in the traditional Chinese medicine prepared by ultrafining3.Flower pigment constituents and their quantitative analysis of Phalaenopsis speci
指導教授:郭賓崇
學位類別:碩士
校院名稱:國立虎尾科技大學
系所名稱:光電與材料科技研究所
學門:工程學門
學類:電資工程學類
論文種類:學術論文
論文出版年:2009
畢業學年度:97
語文別:中文
論文頁數:174
中文關鍵詞:連翹高效能液相層析蝴蝶蘭花色成分
外文關鍵詞:Forsythia suspensaHPLCPhalaenopsispigment
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連翹(Forsythia suspensa)為木犀科連翹屬植物。因文獻報導其具有木脂體類化合物,與木脂體類化合物在體內代謝形成mammalian lignans有著相當的關連性,故被選定為研究標的。因此本研究將著重於連翹之木脂體成分研究,希望能發現之更佳前驅物。由連翹甲醇抽取物分離得到22個化合物,其中含量較多的化合物將進一步篩選其抗氧化活性,以評估其是否可以成為新的醫藥資源。

中草藥超微細化能使得藥物顆粒更細小化,對中草藥而言,可節省大量原料成本,大幅提高中藥材的利用率,另一方面亦可增加中草藥劑型的多樣性。超微細化技術將甘草及丹參粉碎至顆粒的大小接近奈米,可以使得主要成分如甘草酸與丹參酚酸B被大量的溶出。腸道細胞(caco-2)進行的穿透測試結果,發現超微細化甘草經由腸道細胞進行穿透測試,穿透液中甘草酸含量結果為0.48 mg/g;而傳統粉碎的甘草穿透液中,甘草酸的含量則低於儀器偵測極限。

由紅色系蝴蝶蘭(Dtps. Tinny Ribbon × Dtps. Plum Rose)的甲醇抽取物共分離鑑定出12個化合物,其中包含2個類黃酮醣苷,1個花青素,及另外9個其他類化合物。在這些化合物中,有1個類黃酮碳苷為首次分離得到的新化合物。利用高效能液相層析法,成功發展出對於多個台灣原生種與商業品種主要花色成分進行定量分析的方法,希望藉此可以加速培育新花色的目的。
Forsythia suspensa (Oleaceae) was reported to contain lignans in the previous reports so that it was selected as the target. Totally twenty two compounds were characterized from the methanol extracts of the F. suspensa and the isolates with more quantities would be subjected into antioxidant activity examination to discover the new medicine resources.

Traditional Chinese medicine prepared by ultrafining could make the particles smaller, and it would save the cost and improve the utility rate of the medicine plant materials. In addition, it would provide more choices of the forms of a drug. The particles of Glycyrrhiza uralensis and Salvia miltiorrhiza were grounded to submicroscale by ultrafining, and it resulted in the more release of the major constituents, such as glycyrrhizic acid and salvianolic acid B. The Caco-2 cell lines assay displayed that quantification of the liquid in the basolateral side showed that the amount of glycyrrhizic acid was 0.48 mg/g in the samples prepared by ultrafining, but it was not detectable in the samples grounded traditionally.

Two flavone glycosides, one anthocyanidins, and nine other compounds were characterized from the methanolic extracts of Phalaenopsis hybrids (Dtps. Tinny Ribbon × Dtps. Plum Rose). Among these metabolites, one flavone C-glycoside was reported for the first time. Moreover, it was successful to develop quantitative analytical method by HPLC for the major pigments in the Taiwan native and commercial hybrids species. It would be helpful to facilitate the incubation of new colors of Phalaenopsis species.
目錄
中文摘要..................................................i
英文摘要 ................................................ii
誌謝....................................................iii
目錄.....................................................iv
表目錄.................................................viii
圖目錄...................................................ix

第壹篇、連翹之成分研究
第一章 緒論...............................................1
第二章 研究概況...........................................5
2.1連翹之植物形態.........................................5
2.2連翹屬植物之藥理研究回顧...............................6
2.3連翹屬植物之成分研究回顧..............................10
2.4連翹之成分抽取與分離..................................24
第三章 連翹化學成分之構造研究............................29
3.1 oleanolic acid acetate (63)之構造研究................29
3.2 25-epoxydammarane-24-ol (60)之構造研究...............34
3.3 betulinic acid (59) .................................36
3.4 labda-8(17),13E-dien-15,18-dioic acid 15-methyl ester
(97)之構造研究.......................................38
3.5 Ψ-taraxasterol (98)之構造研究........................43
3.6 quercetin (108)之構造研究............................45
3.7 其它化合物之構造決定.................................48
第四章 實驗部分..........................................49
4.1 本實驗所使用之儀器...................................49
4.2 連翹萃取與分離.......................................50
第五章 光譜數據..........................................52

第貳篇、超微細化中草藥指標成分檢測技術之開發
第一章 緒論..............................................62
1.1 藥材簡介.............................................62
1.1.1甘草介紹............................................62
1.1.2丹參介紹............................................62
1.2超微細化中草藥指標成分檢測技術的研發..................63
1.3 研究背景及目的.......................................67
第二章 結果與討論........................................69
2.1 高效能液相層析法應用於指標成分之分析.................69
2.1.1 甘草指標成分分析...................................69
2.1.2 丹參指標成分分析...................................70
2.2 指標成分定量分析.....................................71
2.2.1 甘草指標成分定量分析...............................71
2.2.2 丹參指標成分定量分析...............................73
2.3 藥物吸收實驗.........................................75
2.3.1 甘草藥物吸收實驗...................................75
2.3.2 丹參藥物吸收實驗...................................77
2.4 結論與未來展望.......................................79
第三章 材料與實驗方法....................................80
3.1本實驗所使用之儀器....................................80
3.2 試劑與藥品...........................................81
3.3 實驗藥材.............................................81
3.4 藥材萃取.............................................82
3.5 高效能液相層析定量分析...............................83
3.6 細胞培養.............................................85
3.6.1 細胞培養...........................................85
3.6.2 細胞繼代培養.......................................85
3.6.3 細胞冷陳保存.......................................85
3.6.4 實驗用細胞準備.....................................85
3.6.5 細胞電導度測定.....................................86
3.7 藥物吸收實驗.........................................87
3.7.1 甘草吸收實驗.......................................87
3.7.2 丹參吸收實驗.......................................88
3.8 藥物吸收定量分析方法.................................89
3.8.1 甘草吸收定量分析方法...............................89
3.8.2 丹參吸收定量分析方法...............................89

第参篇、蝴蝶蘭花色成分與定量分析
第一章 緒論..............................................90
1.1 前言.................................................90
1.2 簡介.................................................91
1.2.1 台灣的蝴蝶蘭原生種.................................91
1.2.2 蝴蝶蘭的型態與生長習性.............................91
1.3 研究背景及目的.......................................92
第二章 蝴蝶蘭之研究概況..................................93
2.1 蝴蝶蘭花色成分研究相關文獻回顧.......................93
2.1.1 蝴蝶蘭花色成分研究.................................93
2.1.2 花青素類化合物文獻探討.............................93
2.1.3 花色色素及其代謝酵素...............................94
2.1.4 花色色素代謝基因與轉錄因子MYB......................96
2.2 蝴蝶蘭之成分回顧.....................................97
2.3 蝴蝶蘭成分之抽取與分離...............................99
第三章 蝴蝶蘭成分之化學構造研究及定性分析...............103
3.1 apigenin 6-C-ribosido-7-O-glucoside (127) ..........103
3.2 saponarin (128).....................................110
3.3 其它化合物之構造決定................................116
3.4 蝴蝶蘭花色成分定性試驗..............................117
3.5 蝴蝶蘭花色成分定量分析..............................120
3.5.1 原生種蝴蝶蘭定量分析..............................120
3.5.2 紅色系商業品種定量分析............................129
第四章 結論.............................................136
第五章 材料與實驗方法...................................137
5.1 儀器設備本實驗所使用之儀器..........................137
5.2 蝴蝶蘭之化學抽取與分配萃取..........................138
5.3 蝴蝶蘭花色成分之定性與定量分析......................141
第六章 光譜數據.........................................142
參考文獻................................................144
英文論文大綱............................................170
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