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研究生:賴建龍
研究生(外文):Jian-Long Lai
論文名稱:中西藥交互作用知識管理資訊系統架構之研究-利用資料探勘技術建置
論文名稱(外文):Construct a Knowledge Management Information System of Chinese Herb and Drug Interaction-Utilizing Data Mining Technique
指導教授:李明明李明明引用關係林聖興林聖興引用關係王經篤王經篤引用關係
指導教授(外文):Min-Min LeeSheng-Sing LinJing-Doo Wang
學位類別:碩士
校院名稱:亞洲大學
系所名稱:生物資訊學系碩士班
學門:生命科學學門
學類:生物訊息學類
論文種類:學術論文
論文出版年:2009
畢業學年度:97
語文別:中文
論文頁數:89
中文關鍵詞:中西藥交互作用資料探勘文字特徵中西藥併用資訊系統
外文關鍵詞:Chinese herbsDrugInformation systemData MiningChinese herbs and Drug interaction
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國內外對於中西藥交互作用的期刊研究已如雨後春筍般發表,表示中藥在國內的使用普及現象已經對民眾的西藥治療達到標竿性的影響,再加上電腦資訊科技的進步,許多專家學者甚至醫療院所也開始建立中西藥交互作用資料庫網站供民眾用藥安全查詢。然而,卻受限於仰賴專家知識萃取結果,而使得中西藥物交互作用資訊效益降低,因此若能將大量期刊論文中對中西藥併用的結果利用資料探勘技術作有關藥物作用文字描述之「效用(Effect)」、「作用機轉(Mechanism)」、「處方處置(Management)」等欄位段落整理,則可以即時將量化資料傳送至電腦資料庫,且透過資訊系統提供臨床醫師做中西藥物併用查詢,甚至達到處方修改建議之積極性目標。
本研究目地則為達到上述結果,結合藥理學專家知識及臨床處方專家知識,以文字特徵來萃取段落,將收集到的期刊論文自動匯入知識庫中,利用程式開發中西藥物交互作用資訊服務系統,直接為臨床醫師提供民眾的用藥安全資訊。
The domestic and international periodical research to the Chinese and Western medicine reciprocation has already been popular, it was shown that the traditional Chinese medicine popularizes the phenomenon and already treats and reaches model influence to the people's Western medicine in domestic use, combine with computer progress, information of science and technology, a lot of experts and scholars medical institutes set up Chinese and Western medicine reciprocation database website support people to require safely to use. However, it is limited to expert's knowledge result, and make the Chinese and Western medicine reciprocation information benefit reduce. Our study can utilize materials prospect technology utility to make medicine information from a large number of periodical thesis of international research reports, and that immediately quantization convey to computer database materials, offer a clinician to do the Chinese and Western medicine through the information system, even reach the goal of the prescription modification.
目 錄
中文摘要 ………………………………………………………I
Abstract ……………………………………………………II
誌謝 …………………………………………………………III
目錄 ……………………………………………………………V
表目錄 …………………………………………………………VII
圖目錄 …………………………………………………………VIII
第一章 緒論 ………………………………………………………1
第一節 研究背景與動機……………………………………………1
第二節 研究目地……………………………………………………7
第三節 論文架構……………………………………………………8
第二章 相關背景知識 …………………………………………………9
第一節 知識與知識管理簡介………………………………9
第二節 知識庫簡介………………………………………………10
第三節 知識庫工程簡介…………………………………………10
第四節 專家系統簡介……………………………………………11
第五節 資料探勘簡介……………………………………………14
第六節 資訊系統簡介……………………………………………17
第三章 研究方法 …………………………………………………18
第一節 研究架構……………………………………………………19
第二節 系統架構……………………………………………………43
第三節 資料庫設計…………………………………………………44
第四節 實驗方法……………………………………………………55
第四章 結果 ………………………………………………………60
第五章 問題與討論 …………………………………………………64
第一節 建構資料庫系統內容之探討………………………………64
第二節 中西藥交互作用接受的程度……………………………65
第三節 文字特徵關鍵字之筆數……………………………………65
第四節 文字特徵萃取完畢時............................................................66
第五節 開發此系統後,構制在醫院可行性………………………66
第六節 臨床上常用西藥類別取得不易………...........................66
第七節 轉存格式之出處、題目、作者位置不一的情況…………67
第八節 轉存後,出現無法顯示文獻出處的問題…………………71
第六章 結論與未來方向 ………………………………………………75
第七章 參考文獻 ………………………………………………………77



表 目 錄
表3.1-1 資料庫內容資料表………………………………………………20
表3.1-2 測試資料表………………………………………………………26
表3.1-3 訓練資料表………………………………………………………34
表3.3-1 中藥名稱資料表…………………………………………………45
表3.3-2 方劑類別表………………………………………………………47
表3.3-3 方劑名稱表………………………………………………………47
表3.3-4 方劑內容表………………………………………………………47
表3.3-5 西藥名稱資料表…………………………………………………48
表3.3-6 中西藥交互作用種類表…………………………………………49
表3.3-7 中西藥交互作用匯出結果表……………………………………49
表3.3-8 病歷資料表……………………………………………………50
表3.3-9 Effect結果輸出表………………………………………………51
表3.3-10 Mechanism結果輸出表………………………………………52
表3.3-11 Management結果輸出表...........................................................53







圖 目 錄
圖1.2 中西藥交互作用知識管理資訊系統醫院行徑路線圖....................7
圖2.4-1人工智慧領域包含了許多創新.....................................................11
圖2.4-2 專家系統概念圖............................................................................13
圖3.1 架構流程圖(1)...................................................................................18
圖3.1.1架構流程圖(2)……………………………………………………20
圖3.1.2中西藥交互作用系統樹狀圖(1) ………………………………23
圖3.1.3中西藥交互作用系統樹狀圖(2) …………………………………24
圖3.1.4中西藥交互作用系統樹狀圖(3) …………………………………25
圖3.1.5 資料庫主要、次要欄位設計……………………………………29
圖3.1.6 架構流程圖(3)……………………………………………………31
圖3.2 系統架構圖.......................................................................................43
圖3.3-1 中西藥交互作用知識管理資訊系統資料庫關聯圖....................45
圖3.4.1 PDF檔..............................................................................................55
圖3.4.2 轉存格式(1)....................................................................................56
圖3.4.3 轉存格式(2)....................................................................................56
圖3.4.4 轉存格式(3)....................................................................................57
圖3.4.5 轉存格式(4)....................................................................................57
圖3.4.6 轉存格式(5)....................................................................................58
圖3.4.7 轉存格式(6)....................................................................................58
圖4.1 Effect匯入資料庫結果………………………………………60
圖4.2 Mechanism匯入資料庫結果……………………………………61
圖4.3 Management匯入資料庫結果…………………………………63
圖5.7.1 轉存格式問題(1)………………………………………………68
圖5.7.2 轉存格式問題(2)………………………………………………68
圖5.7.3 轉存格式問題(3)………………………………………………69
圖5.7.4 轉存格式問題(4)………………………………………………69
圖5.7.5 轉存格式問題(5)………………………………………………70
圖5.8.1 轉存格式問題(6)………………………………………………71
圖5.8.2 轉存格式問題(7)………………………………………………72
圖5.8.3 轉存格式問題(8)………………………………………………72
圖5.8.4 轉存格式問題(9)………………………………………………73
圖5.8.5 轉存格式問題(10)……………………………………………73
圖5.8.6 轉存格式問題(11)……………………………………………74
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