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研究生:關羽峻
研究生(外文):Yu-Chung Kwan 關羽峻
論文名稱:大豆蛋白對於餵食高膽固醇飲食倉鼠之血脂質與肝臟脂質的影響
論文名稱(外文):Effects of soy protein on plasma and hepatic lipid in hamsters fed with high cholesterol diet
指導教授:陳俊榮陳俊榮引用關係
學位類別:碩士
校院名稱:臺北醫學大學
系所名稱:保健營養學研究所
學門:醫藥衛生學門
學類:營養學類
論文種類:學術論文
論文出版年:2009
畢業學年度:97
語文別:中文
論文頁數:50
中文關鍵詞:大豆蛋白高膽固醇血症脂質代謝
外文關鍵詞:Soy proteinhypercholesterolemiclipid metabolism
相關次數:
  • 被引用被引用:3
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  • 下載下載:294
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摘 要
本研究的目的是探討在高膽固醇飲食條件下,市售大豆蛋白(MIKI Protein 95)對於倉鼠之血脂質與肝臟脂質的影響。將24隻雄性倉鼠隨機分為三組:H 組 (19.7% 酪蛋白)、S1 組 (5% 大豆蛋白 + 14.7% 酪蛋白)以及 S2 組 (10% 大豆蛋白 + 9.7% 酪蛋白)。實驗為期八週,所有飼料中均添加 0.5% 膽固醇。結果發現:飲食中以大豆蛋白取代50% 酪蛋白作為蛋白質來源時,可顯著降低血漿總膽固醇、LDL-C 濃度及肝臟中三酸甘油酯濃度,同時可減少肝臟中膽固醇堆積的情況;然而在血液中三酸甘油酯濃度方面,則不具有改善效果。此外,在糞便的中性固醇與膽酸排出量方面,各組間並無顯著差異。由結果推論,市售大豆蛋白雖可能因加工過程導致蛋白質變性或添加其他配方物質,而影響部分生理活性,但飲食中攝取大豆蛋白,仍可有效降低血脂質與肝臟脂質濃度,因此認為可用於心血管疾病之預防與保健。

關鍵詞:大豆蛋白、高膽固醇血症、脂質代謝
Abstract
The aim of this study is to investigate the effects of commercial soy protein on plasma and hepatic lipid in hamster fed high cholesterol diet. Twenty-four hamsters were divided into three groups: H group (19.7% casein), S1 group (5% commercial soy protein + 14.7% casein), and S2 group (10% commercial soy protein + 9.7% casein). All groups were fed 0.5% cholesterol diet. After the 8-week experimental period, the results showed that soy protein could significantly lower plasma total cholesterol and LDL-C concentrations. Liver cholesterol and triglyceride contents were also significantly lower than H group (p < 0.05). However, there were no differences between fecal excretion of neutral steroids and bile acids of each group. In conclusion, commercial soy protein may lower plasma and hepatic lipid that may be useful for prevention of cardiovascular disease.

Key words: Soy protein, hypercholesterolemic, lipid metabolism
目 錄
摘 要 I
ABSTRACT II
目 錄 III
表目錄 V
前 言 1
第一章 研究動機與目的 3
第一節 高血脂症 3
第二節 高血脂症的治療與預防 6
第三節 食品蛋白質對於血脂質的影響 8
第四節 大豆蛋白簡介 9
第五節 大豆蛋白對血脂質的影響 11
第六節 大豆蛋白降低血脂質之可能機轉 13
第二章 材料與方法 17
第三章 結果 26
第四章 討論 31
第一節 體重、攝食量 31
第二節 大豆蛋白對於血脂質的影響 32
第三節 大豆蛋白對於肝臟脂質代謝的影響 34
第四節 大豆蛋白對於糞便中性固醇與膽酸排出量的影響 35
第五章 總結 36
參考文獻 37

表目錄
表 一、各組飼料組成百分比 (%) 46
表 二、不同飼料對倉鼠體重與攝食量的影響 47
表 三、不同飼料對倉鼠血脂與肝功能指數的影響 48
表四、不同飼料對倉鼠肝重及肝中脂質濃度的影響 49
表 五、不同飼料對倉鼠糞便中性固醇與糞便膽酸的影響 50
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