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研究生:蕭羽筑
研究生(外文):Yu-Chu Hsiao
論文名稱:新生兒痛覺哭聲與心率變異之關聯性分析
論文名稱(外文):Relations Between Pain Cry and Heart Rate Variability in Healthy Neonates
指導教授:高材高材引用關係
指導教授(外文):Tsair Kao
學位類別:碩士
校院名稱:國立陽明大學
系所名稱:醫學工程研究所
學門:工程學門
學類:生醫工程學類
論文種類:學術論文
論文出版年:2009
畢業學年度:97
語文別:中文
論文頁數:57
中文關鍵詞:新生兒痛覺哭聲心率變異度短時傅立葉分析相關性
外文關鍵詞:NeonatePain CryHRVSTFTCorrelation
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 本研究的目標是探討新生兒在接受針刺的痛覺刺激時,產生的哭聲與心率變異度之變化與相關性。擷取新生兒在休息狀態下至少5分鐘的心電圖並延續到打針時間點後的5分鐘,在打針時同時錄製新生兒的哭聲,以得到哭聲及心跳兩個生理參數。使用聲學處理軟體以求得哭聲中的基頻、共振峰等參數。使用短時傅立葉分析方法來取得心率變異度中有代表性之參數。對於在正常休息狀態下的新生兒,其心率變異度分析結果顯示,主要能量坐落在極低頻區,其次是低頻區,而高頻區則幾乎沒有能量。打針時,極低頻頻段的能量變化沒有固定模式,低頻頻段的能量會下降,高頻頻段則會下降或是沒有顯著變化。但高頻頻段正規化能量在打針後反而會上升,相對的,低頻頻段正規化能量在打針後會下降。研究結果顯示,新生兒在接受針刺後心率變異度的反應與其哭聲中的參數指標大都呈現負相關的趨勢。
Our research tried to discuss the change in neonate’s HRV during injection and the correlations between the pain cry and HRV parameters.We collected ECG data for at least 5 minutes from the neonate in rest status and ended collection 5 minutes after injection. In the meanwhile, we recorded the cry sound due to injection. We used the voice processing software to analyze fundamental frequency and first formant in the cry sound. For observing the change in physiology, we evaluated representative parameters in HRV among time using short time Fourier transform (STFT). We expected to get further understanding of neonate by discussing the change and the correlation within cry sound parameters and HRV parameters.
The frequency HRV analysis shows that during resting, the dominant energy is in VLF band and the LF band is next. There is barely energy in HF band. The respiratory sinus arrhythmia peak, which is commonly seen in adult’s high frequency band in HRV spectrum, is rarely found in neonate’s HRV spectrum. After injection, the VLF band energy changed irregularly and the LF band energy significantly decreased. The HF band energy decreased or not changed a lot. While we transferring energy to normalized units, we found that after injection, the HF band energy is increased and LF band energy decreased relatively. We found a negative correlation between cry sound and HRV parameters.
中文摘要 ....................................I
Abstract ...................................II
目錄 ......................................III
表目錄 ....................................VII
第一章 緒 論 ...........................1
第二章 背景知識............................3
2-1 前言 ...................................3
2-2 痛覺與痛覺傳遞路徑 .....................3
2-3 心臟與自律神經系統 .....................4
2-4 肺與自律神經系統 .......................6
2-5 喉部肌肉與自律神經系統 .................7
2-6 發聲機制與新生兒哭泣模型...............10
2-7 新生兒休息時的心率變異.................13
2-8 新生兒的痛覺哭聲與心率變異.............14
第三章 實驗與方法 ........................16
3-1 實驗流程 ..........................16
3-2 分析流程 ..........................17
3-3 分析方法 ..........................19
3-3-1 哭聲分析 ..........................19
3-3-2 心率變異度分析 ....................22
第四章 結果與討論 ........................26
4-1 休息的心律變異 ........................26
4-2 打針後的心律變異 ......................27
4-3 反應時間、哭總長與第1哭特質的關係 .....28
4-4 前3哭與後3哭及前5哭與後5哭的比較 ......31
4-5 調節前後哭聲參數的變化.................33
4-6 哭聲參數與心率變異度的關聯 ............37
4-7 結論 ..................................44
參考文獻 ...................................47
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