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研究生:黃奐璋
研究生(外文):Huan-Jang Huang
論文名稱:類比相差極化光學斷層干涉儀之發展與應用
論文名稱(外文):The Development of Analog Differential-Phase Polarization sensitive Optical Coherence Tomography
指導教授:周晟周晟引用關係
指導教授(外文):周晟,Chien Chou
學位類別:博士
校院名稱:國立陽明大學
系所名稱:生物醫學影像暨放射科學系暨研究所
學門:醫藥衛生學門
學類:醫學技術及檢驗學類
論文種類:學術論文
論文出版年:2009
畢業學年度:97
語文別:中文
論文頁數:134
中文關鍵詞:極化感測類比同調相差式
外文關鍵詞:polarization-sensitiveanalogcoherencedifferential-phase
相關次數:
  • 被引用被引用:0
  • 點閱點閱:143
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  • 收藏至我的研究室書目清單書目收藏:0
我們引進了類比式訊差技術的概念,將PS-OCT的相位資訊利用此技術編碼到振幅上,並藉由類比技術的優點及訊差技術的特色,提升訊雜比及靈敏度。由DP-OCR的架構中我們證實了,使用類比相減的技術確實使系統雜訊下降,並大幅提升系統所能量測的精準度(約2 ),與傳統輪廓儀比較起來約提升了10倍的能力。由DP-PSOCT的架構中,我們證實了DP-PSOCT量測雙折射的能力,並藉由實驗證明DP-PSOCT對於延遲角量測上的穩定度為0.58°,同樣較傳統PS-OCT的1.8°-5.16°為佳。而在DP-PSOCT的應用上,我們則發現了對於熱效應的觀察,其延遲角影像與溫度之間能提供接近線性的聯關性來判斷受熱程度,其效果由接近體溫的40℃以上即可觀察出。對於游離輻射效應的觀察,DP-PSOCT仍無法清楚的顯示出其效果,但對於熱與游離輻射效應的綜合影響上,卻可發現到游離輻射有抑制熱效應表現的效果。
以上部分的實驗證實了使用類比相減技術提升系統訊雜比及靈敏度的能力,由提升的訊雜比及靈敏度,我們在DP-OCR能獲得更佳的量測精度,在DP-PSOCT則是獲得更靈敏的延遲角影像,從而判斷受熱後的組織變化。因此希望未來能將此技術應用到頻域的架構中,進而由目前頻域的優勢再配合此技術的優勢而得到整合。
We proposed and demonstrated a novel analog polarization sensitive optical coherence reflectometer (DP-OCR) and differential-phase polarization sensitive optical coherence tomography (DP-PSOCT) in which an analog differential-phase decoder is setup. It enables to convert differential-phase in terms of the demonstrated amplitude of the polarized heterodyne signals. Based on this configuration, the signal-to-noise ratio (SNR) detection sensitivity and the stability of differential-phase measurement are improved significantly, whereas the sensitivity of surface profile measurement at 2 was demonstrated experimentally. In addition, the tomographic images of a porcine tendon on reflectivity, phase retardation and fast axis angle using DP-PSOCT were obtained. Moreover, the stability of phase retardation in DP-PSOCT at 0.58° was achieved. It is in contrast to conventional PS-OCT in a range of 1.8°-5.16°. Additionally, the study of thermal effect on tomographic image of phase retardation of the porcine tendon is linearly to heating temperature. This becomes more sensitive when temperature is higher than 40℃. Furthermore, the ionized radiation effect is also sensitive to phase retardation image according to tomographic images by DP-PSOCT. However, we finally found that radiation effect can suppress thermal effect according to experimental results.
誌謝 i
中文摘要 ii
英文摘要 iii
目錄 iv
圖目錄 ix
表目錄 xii
第一章 緒論 1
1.1 文獻回顧 1
1.1.1 斷層與光學相關回顧 1
1.1.2 極化光學斷層技術相關應用 4
1.2 研究動機 6
第二章 基本理論 7
2.1 類比式運算原理 7
2.2 相差相減振幅調制原理 11
2.3 極化光學斷層干涉儀原理 13
2.3.1 瓊斯向量(Jones vector) 13
2.3.2 麥克森干涉儀(Michelson interferometer) 15
2.3.3 低同調干涉儀(optical coherence tomography,OCT) 18
2.3.4 極化光學斷層干涉儀(polarization-sensitive optical coherence tomography,PS-OCT) 22
第三章 實驗設計與結果討論 25
3.1 Differential-phase optical coherence reflectometer (DP-OCR) 26
3.1.1 架構及原理 26
3.1.2 實驗與討論 33
3.1.3 結論 38
3.2 Differential-phase optical coherence interferometer (DP-OCI) 41
3.2.1 架構及原理 41
3.2.2 實驗與討論 45
3.2.3 結論 57
3.3 Differential-phase polarization sensitive optical coherence tomography (DP-PSOCT) 59
3.3.1 架構及原理 59
3.3.2 實驗與討論 65
3.3.3 結論 72
3.4 Imaging radiated and heated biological tissue by using DP-PSOCT 74
3.4.1 簡介 74
3.4.2 熱效應相關研究 76
3.4.3 游離輻射相關研究 83
3.4.4 實驗與討論 86
3.4.5 結論 107
第四章 總結 108
參考文獻 111
附錄1 116
附錄2 118
附錄3 121
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