1.The Global Health Observatory (GHO) database Available from: http://apps.who.int/ghodata/.
2.Collaborative overview of randomised trials of antiplatelet therapy--I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists'' Collaboration. BMJ, 1994. 308(6921): p. 81-106.
3.Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med, 1995. 333(24): p. 1581-7.
4.A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee. Lancet, 1996. 348(9038): p. 1329-39.
5.European Stroke Initiative recommendations for stroke management. European Stroke Council, European Neurological Society and European Federation of Neurological Societies. Cerebrovasc Dis, 2000. 10(5): p. 335-51.
6.Interventions for deliberately altering blood pressure in acute stroke. Blood pressure in Acute Stroke Collaboration (BASC). Cochrane Database Syst Rev, 2000(2): p. CD000039.
7.Vasoactive drugs for acute stroke. Cochrane Database Syst Rev, 2000(4): p. CD002839.
8.Adams, H.P., Jr., Emergent use of anticoagulation for treatment of patients with ischemic stroke. Stroke, 2002. 33(3): p. 856-61.
9.Adams, H.P., Jr., G. del Zoppo, M.J. Alberts, D.L. Bhatt, L. Brass, A. Furlan, R.L. Grubb, R.T. Higashida, E.C. Jauch, C. Kidwell, P.D. Lyden, L.B. Morgenstern, A.I. Qureshi, R.H. Rosenwasser, P.A. Scott, and E.F. Wijdicks, Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Circulation, 2007. 115(20): p. 478-534.
10.Ai, J., X. Wang, and M. Nielsen, Honokiol and magnolol selectively interact with GABAA receptor subtypes in vitro. Pharmacology, 2001. 63(1): p. 34-41.
11.Albers, G.W., P. Amarenco, J.D. Easton, R.L. Sacco, and P. Teal, Antithrombotic and thrombolytic therapy for ischemic stroke. Chest, 2001. 119(1 Suppl): p. 300S-320S.
12.Bang, K.H., Y.K. Kim, B.S. Min, M.K. Na, Y.H. Rhee, J.P. Lee, and K.H. Bae, Antifungal activity of magnolol and honokiol. Arch Pharm Res, 2000. 23(1): p. 46-9.
13.Bath, P.M., R. Iddenden, and F.J. Bath, Low-molecular-weight heparins and heparinoids in acute ischemic stroke : a meta-analysis of randomized controlled trials. Stroke, 2000. 31(7): p. 1770-8.
14.Black, S.C., M.R. Gralinski, G.S. Friedrichs, K.S. Kilgore, E.M. Driscoll, and B.R. Lucchesi, Cardioprotective effects of heparin or N-acetylheparin in an in vivo model of myocardial ischaemic and reperfusion injury. Cardiovasc Res, 1995. 29(5): p. 629-36.
15.Broderick, J., S. Connolly, E. Feldmann, D. Hanley, C. Kase, D. Krieger, M. Mayberg, L. Morgenstern, C.S. Ogilvy, P. Vespa, and M. Zuccarello, Guidelines for the management of spontaneous intracerebral hemorrhage in adults: 2007 update: a guideline from the American Heart Association/American Stroke Association Stroke Council, High Blood Pressure Research Council, and the Quality of Care and Outcomes in Research Interdisciplinary Working Group. Circulation, 2007. 116(16): p. 391-413.
16.Brott, T., J. Broderick, R. Kothari, W. Barsan, T. Tomsick, L. Sauerbeck, J. Spilker, J. Duldner, and J. Khoury, Early hemorrhage growth in patients with intracerebral hemorrhage. Stroke, 1997. 28(1): p. 1-5.
17.Bruno, A., S.R. Levine, M.R. Frankel, T.G. Brott, Y. Lin, B.C. Tilley, P.D. Lyden, J.P. Broderick, T.G. Kwiatkowski, and S.E. Fineberg, Admission glucose level and clinical outcomes in the NINDS rt-PA Stroke Trial. Neurology, 2002. 59(5): p. 669-74.
18.Capes, S.E., D. Hunt, K. Malmberg, P. Pathak, and H.C. Gerstein, Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke, 2001. 32(10): p. 2426-32.
19.Castillo, J., A. Davalos, J. Marrugat, and M. Noya, Timing for fever-related brain damage in acute ischemic stroke. Stroke, 1998. 29(12): p. 2455-60.
20.Chang, B., Y. Lee, Y. Ku, K. Bae, and C. Chung, Antimicrobial activity of magnolol and honokiol against periodontopathic microorganisms. Planta Med, 1998. 64(4): p. 367-9.
21.Chang, G.J., M.J. Su, T.S. Wu, W.P. Chen, and C.M. Kuo, Electromechanical characterization of cinnamophilin, a natural thromboxane A2 receptor antagonist with anti-arrhythmic activity, in guinea-pig heart. Br J Pharmacol, 2008. 153(1): p. 110-23.
22.Chen, C.L., P.L. Chang, S.S. Lee, F.C. Peng, C.H. Kuo, and H.T. Chang, Analysis of magnolol and honokiol in biological fluids by capillary zone electrophoresis. J Chromatogr A, 2007. 1142(2): p. 240-4.
23.Chen, Y.H., S.J. Lin, J.W. Chen, H.H. Ku, and Y.L. Chen, Magnolol attenuates VCAM-1 expression in vitro in TNF-alpha-treated human aortic endothelial cells and in vivo in the aorta of cholesterol-fed rabbits. Br J Pharmacol, 2002. 135(1): p. 37-47.
24.Chiu, J.H., J.C. Wang, W.Y. Lui, C.W. Wu, and C.Y. Hong, Effect of magnolol on in vitro mitochondrial lipid peroxidation and isolated cold-preserved warm-reperfused rat livers. J Surg Res, 1999. 82(1): p. 11-6.
25.Dhalla, N.S., A.B. Elmoselhi, T. Hata, and N. Makino, Status of myocardial antioxidants in ischemia-reperfusion injury. Cardiovasc Res, 2000. 47(3): p. 446-56.
26.Diener, H.C., J. Bogousslavsky, L.M. Brass, C. Cimminiello, L. Csiba, M. Kaste, D. Leys, J. Matias-Guiu, and H.J. Rupprecht, Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet, 2004. 364(9431): p. 331-7.
27.Globus, M.Y., O. Alonso, W.D. Dietrich, R. Busto, and M.D. Ginsberg, Glutamate release and free radical production following brain injury: effects of posttraumatic hypothermia. J Neurochem, 1995. 65(4): p. 1704-11.
28.Gueyffier, F., J.P. Boissel, F. Boutitie, S. Pocock, J. Coope, J. Cutler, T. Ekbom, R. Fagard, L. Friedman, K. Kerlikowske, M. Perry, R. Prineas, and E. Schron, Effect of antihypertensive treatment in patients having already suffered from stroke. Gathering the evidence. The INDANA (INdividual Data ANalysis of Antihypertensive intervention trials) Project Collaborators. Stroke, 1997. 28(12): p. 2557-62.
29.Hacke, W., G. Donnan, C. Fieschi, M. Kaste, R. von Kummer, J.P. Broderick, T. Brott, M. Frankel, J.C. Grotta, E.C. Haley, Jr., T. Kwiatkowski, S.R. Levine, C. Lewandowski, M. Lu, P. Lyden, J.R. Marler, S. Patel, B.C. Tilley, G. Albers, E. Bluhmki, M. Wilhelm, and S. Hamilton, Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet, 2004. 363(9411): p. 768-74.
30.Hacke, W., M. Kaste, C. Fieschi, D. Toni, E. Lesaffre, R. von Kummer, G. Boysen, E. Bluhmki, G. Hoxter, M.H. Mahagne, and et al., Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS). JAMA, 1995. 274(13): p. 1017-25.
31.Hacke, W., M. Kaste, C. Fieschi, R. von Kummer, A. Davalos, D. Meier, V. Larrue, E. Bluhmki, S. Davis, G. Donnan, D. Schneider, E. Diez-Tejedor, and P. Trouillas, Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators. Lancet, 1998. 352(9136): p. 1245-51.
32.He, Y.Y., C.Y. Hsu, A.M. Ezrin, and M.S. Miller, Polyethylene glycol-conjugated superoxide dismutase in focal cerebral ischemia-reperfusion. Am J Physiol, 1993. 265(1 Pt 2): p. 252-6.
33.Ho, K.Y., C.C. Tsai, C.P. Chen, J.S. Huang, and C.C. Lin, Antimicrobial activity of honokiol and magnolol isolated from Magnolia officinalis. Phytother Res, 2001. 15(2): p. 139-41.
34.Hou, Y.C., P.D. Chao, and S.Y. Chen, Honokiol and magnolol increased hippocampal acetylcholine release in freely-moving rats. Am J Chin Med, 2000. 28(3-4): p. 379-84.
35.Ikeda, K. and H. Nagase, Magnolol has the ability to induce apoptosis in tumor cells. Biol Pharm Bull, 2002. 25(12): p. 1546-9.
36.Joyeux, M., J.F. Bouchard, D. Lamontagne, D. Godin-Ribuot, and C. Ribuot, Heat stress-induced protection of endothelial function against ischaemic injury is abolished by ATP-sensitive potassium channel blockade in the isolated rat heart. Br J Pharmacol, 2000. 130(2): p. 345-50.
37.Khatri, P., J.P. Broderick, and A.M. Pancioli, Risk of thrombolysis-associated intracerebral hemorrhage: the need to compare apples with apples. Stroke, 2005. 36(6): p. 1109-10; author reply 1110.
38.Ko, F.N., S.M. Yu, Y.F. Kang, and C.M. Teng, Characterization of the thromboxane (TP-) receptor subtype involved in proliferation in cultured vascular smooth muscle cells of rat. Br J Pharmacol, 1995. 116(2): p. 1801-8.
39.Kong, C.W., K. Tsai, J.H. Chin, W.L. Chan, and C.Y. Hong, Magnolol attenuates peroxidative damage and improves survival of rats with sepsis. Shock, 2000. 13(1): p. 24-8.
40.Lee, E.J., H.Y. Chen, Y.C. Hung, T.Y. Chen, M.Y. Lee, S.C. Yu, Y.H. Chen, I.C. Chuang, and T.S. Wu, Therapeutic window for cinnamophilin following oxygen-glucose deprivation and transient focal cerebral ischemia. Exp Neurol, 2009. 217(1): p. 74-83.
41.Lee, E.J., H.Y. Chen, M.Y. Lee, T.Y. Chen, Y.S. Hsu, Y.L. Hu, G.L. Chang, and T.S. Wu, Cinnamophilin reduces oxidative damage and protects against transient focal cerebral ischemia in mice. Free Radic Biol Med, 2005. 39(4): p. 495-510.
42.Lee, M.M., M.T. Hseih, J.S. Kuo, F.T. Yeh, and H.M. Huang, Magnolol protects cortical neuronal cells from chemical hypoxia in rats. Neuroreport, 1998. 9(15): p. 3451-6.
43.Lin, Y.R., H.H. Chen, C.H. Ko, and M.H. Chan, Effects of honokiol and magnolol on acute and inflammatory pain models in mice. Life Sci, 2007. 81(13): p. 1071-8.
44.Lo, Y.C., C.M. Teng, C.F. Chen, C.C. Chen, and C.Y. Hong, Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation. Biochem Pharmacol, 1994. 47(3): p. 549-53.
45.Matsuda, H., T. Kageura, M. Oda, T. Morikawa, Y. Sakamoto, and M. Yoshikawa, Effects of constituents from the bark of Magnolia obovata on nitric oxide production in lipopolysaccharide-activated macrophages. Chem Pharm Bull (Tokyo), 2001. 49(6): p. 716-20.
46.Newman, M.F., H.P. Grocott, J.P. Mathew, W.D. White, K. Landolfo, J.G. Reves, D.T. Laskowitz, D.B. Mark, and J.A. Blumenthal, Report of the substudy assessing the impact of neurocognitive function on quality of life 5 years after cardiac surgery. Stroke, 2001. 32(12): p. 2874-81.
47.Park, J., J. Lee, E. Jung, Y. Park, K. Kim, B. Park, K. Jung, E. Park, J. Kim, and D. Park, In vitro antibacterial and anti-inflammatory effects of honokiol and magnolol against Propionibacterium sp. Eur J Pharmacol, 2004. 496(1-3): p. 189-95.
48.Ray, P.S., G. Maulik, G.A. Cordis, A.A. Bertelli, A. Bertelli, and D.K. Das, The red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injury. Free Radic Biol Med, 1999. 27(1-2): p. 160-9.
49.Su, M.J., W.P. Chen, T.Y. Lo, and T.S. Wu, Ionic mechanisms for the antiarrhythmic action of cinnamophilin in rat heart. J Biomed Sci, 1999. 6(6): p. 376-86.
50.Toni, D., A. Chamorro, M. Kaste, K. Lees, N.G. Wahlgren, and W. Hacke, Acute treatment of ischaemic stroke. European Stroke Initiative. Cerebrovasc Dis, 2004. 17 Suppl 2: p. 30-46.
51.Tosaki, A., D. Bagchi, T. Pali, G.A. Cordis, and D.K. Das, Comparisons of ESR and HPLC methods for the detection of OH. radicals in ischemic/reperfused hearts. A relationship between the genesis of free radicals and reperfusion arrhythmias. Biochem Pharmacol, 1993. 45(4): p. 961-9.
52.Tsai, T.H., T.F. Lee, C.F. Chen, and L.C. Wang, Modulatory effects of magnolol on potassium-stimulated 5-hydroxytryptamine release from rat cortical and hippocampal slices. Neurosci Lett, 1995. 186(1): p. 49-52.
53.Wang, J.P., T.F. Ho, L.C. Chang, and C.C. Chen, Anti-inflammatory effect of magnolol, isolated from Magnolia officinalis, on A23187-induced pleurisy in mice. J Pharm Pharmacol, 1995. 47(10): p. 857-60.
54.WHO, Annual incidence for selected causes, in WHO Regions (a), estimates for 2004. 2004.
55.Williams, L.S., J. Rotich, R. Qi, N. Fineberg, A. Espay, A. Bruno, S.E. Fineberg, and W.R. Tierney, Effects of admission hyperglycemia on mortality and costs in acute ischemic stroke. Neurology, 2002. 59(1): p. 67-71.
56.Xu, Q., L.T. Yi, Y. Pan, X. Wang, Y.C. Li, J.M. Li, C.P. Wang, and L.D. Kong, Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents. Prog Neuropsychopharmacol Biol Psychiatry, 2008. 32(3): p. 715-25.
57.Yu, S.M., F.N. Ko, T.S. Wu, J.Y. Lee, and C.M. Teng, Cinnamophilin, a novel thromboxane A2 receptor antagonist, isolated from Cinnamomum philippinense. Eur J Pharmacol, 1994. 256(1): p. 85-91.
58.Yu, S.M., T.S. Wu, and C.M. Teng, Pharmacological characterization of cinnamophilin, a novel dual inhibitor of thromboxane synthase and thromboxane A2 receptor. Br J Pharmacol, 1994. 111(3): p. 906-12.
59.行政院衛生署, 98年度死因統計. 2010.
60.余舒晴, MA-1 對離體神經元保護:治療窗口與抗神經興奮毒性,抗氧化及清除自由基能力之探討. 生物科技研究所碩博士班, 2007. 碩士: p. 114.
61.李威廷 and L. Wei-ting, 褪黑激素對短暫局部大腦缺氧大鼠的神經再塑性潛力The neuroplasticity potential of melatonin following transient focal cerebral ischemia in rats. 生物科技研究所, 嘉南藥理科技大學,2007. 碩士: p. 64.62.林宣霈, 甘草、北茵陳之代謝動力學、藥物交互作用與白藜蘆醇、厚朴酚之組織分佈, 藥物化學研究所博士班. 2008, 中國醫藥大學. p. 235.63.胡漢華, 台灣腦中風防治指引2008. 2008.
64.翁文章,陸仁安,陳昌明,胡漢華,連立明,陳俊榮,邱浩彰,鍾國屏,郭泰宏,安茂沅,張谷州,陳廷耀,劉嘉為, 台灣急性缺血性腦中風的靜脈注射血栓溶解劑治療. Taiwan Crit Care Med, 2001. 3: p. 9.
65.崔巧琪, Cinnamophilin等藥物抑制人類單核球細胞(THP-1)誘發第九型基質金屬蛋白酵素活化之機轉探討, 醫學研究所. 2002, 臺北醫學大學. p. 117.
66.許靜宜, 厚朴酚於後肢肌肉缺血-再灌流傷害之保護效果研究, 藥學系碩士班. 2007, 中國醫藥大學. p. 63.67.連立明,陳俊榮,陳威宏,葉建宏,汪漢澄,許維志,徐榮隆,吳令治,謝欣如,邱浩彰, 使用組織胞漿素原活化劑靜脈注射治療急性缺血性腦中風之初期經驗. 台灣醫學, 2000. 4: p. 9.
68.黃千芝, 以Cinnamophilin治療暫時性局部腦缺血白鼠有助其電生理及神經行為之改善, 醫學工程研究所碩博士班. 2005, 國立成功大學. p. 71.69.蔡宜殷, 以Melatonin治療暫時性局部腦缺血白鼠有助其電生理及神經行為之改善, 醫學工程研究所. 2002, 國立成功大學. p. 49.
70.魏苑茹, Cinnamophilin 抑制腦血管內皮細胞凋亡之作用機轉探討, 醫學研究所. 2006, 臺北醫學大學. p. 54.