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研究生:蘇紹宇
研究生(外文):Shao-yu Su
論文名稱:用於傷口敷料之藻酸鹽/幾丁聚醣組合物的製備與性質探討
論文名稱(外文):Preparation and characterization of alginate/chitosan composite scaffolds for wound dressings
指導教授:林恆弘林恆弘引用關係
指導教授(外文):Hung-hong Lin
學位類別:碩士
校院名稱:嘉南藥理科技大學
系所名稱:藥物科技研究所
學門:醫藥衛生學門
學類:藥學學類
論文種類:學術論文
論文出版年:2010
畢業學年度:98
語文別:中文
論文頁數:119
中文關鍵詞:藻酸鈉水膠敷料幾丁聚醣
外文關鍵詞:sodium alginatechitosandressinghydrogel
相關次數:
  • 被引用被引用:7
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  • 下載下載:392
  • 收藏至我的研究室書目清單書目收藏:0
傷口疼痛、組織創傷及感染對於傷口管理是主要考量,適當敷料的選擇扮演非常重要的角色。傳統敷料黏附在傷口導致要取下時會對新組織產生顯著的疼痛及外傷。現在很多研究著重在開發有包覆醫療裝置並改善再生的皮膚或結痂組織的功能性或美觀性成果的新型敷料來治療傷口。藻酸鈉和幾丁聚醣為天然的高分子,擁有生物相容性和生物可降解性,也具有加速傷口癒合的能力。本研究目的是發展一個簡單的製程製備藻酸鈉水膠敷料,評估加入幾丁聚醣對水膠的黏度、黏性之影響,並利用熱卡式分析儀(DSC)、物性分析儀(texture analyser)進行物理性質分析。篩選出藻酸鈉-幾丁聚醣溶液用氯化鈣溶液處理所形成的水膠,在乾燥後所形成的傷口敷料是不會皺縮。在黏度結果顯示,當水比例越多時溶液黏度會下降,而隨藻酸鈉濃度增加黏度會也會增加。黏性結果觀察可以發現,當水比例越多,所須的Fmax及AUC減少。藻酸鈉濃度越高,Fmax及AUC越大。且當用氯化鈣處理的處方,Fmax及AUC明顯降低,但處理不同時間並沒有很明顯差異。高分子材料製備的水膠有很好的吸水能力,表示水膠可以在傷口床維持一個濕潤的環境並移除滲出傷口的組織液,促進表皮細胞的游移加速傷口癒合。所以利用藻酸鈉所製備的水膠敷料,對於傷口的癒合是非常有幫助的。
Wound pain, tissue trauma and infection are the main considerations of wound management, and appropriate dressing selection plays an important role in all. Traditional dressings may adhere to wounds resulting in significant pain and trauma to new tissue upon removal. Currently a lot of research is focused on developing newer dressing materials to treat wounds with coated medical devices to improve the functional and aesthetic outcome of the regenerating skin or scar tissue. Alginate and chitosan are natural biopolymers with properties like biocompatibility and biodegradability. In this study, we developed and characterized simple methods to make hydrogel dressing. Hydrogel was made by adding sodium alginate and chitosan and evaluated the viscosity, adhesion and physical property with DSC and TA-XT texture analyser. And choice the hydrogel of alginate-chitosan that treated with calcium chloride solution and not shrink while drying. The results of viscosity test showed that the water content is increased, the viscosity is decreased, and the alginate concentration is increased, the viscosity is increased. The results of adhesion showed that the ratios of PG/water is increased, the Fmax and AUC are decreased, and alginate concentrations is increased, the Fman and AUC are decreased. The formulations which treated with calcium chloride had the lower Fmax and AUC, but treated with calcium chloride in different times had no apparent differences. The water-uptake capacity show that dressing prepared from polymer materials had very pretty water-uptake capacity; The hydrogel can maintain a moist surroundings , remove exudate, promoting migration of epidermis cells, and then accelerating wound healing. So dressing prepared from alginate was useful for wound healing.
中文摘要 Ⅰ
Abstract Ⅱ
誌謝 IV
目錄 V
圖目錄 IX
表目錄 XIV
第一章 緒論1
§1-1研究動機1
§1-2研究目的3
§1-3文獻回顧4
1-3-1藻酸鈉(Sodium alginate)4
1-3-2幾丁聚醣(Chitosan)9
1-3-3水膠(Hydrogel)15
1-3-4 敷料(Dressing)簡介23
1-3-5 黏稠度(viscosity)性質的簡介 36
第二章 材料與方法 39
§2-1 儀器設備及藥品、試劑39
2-1-1 儀器設備39
2-1-2 藥品、試劑40
§2-2 藻酸鈣-幾丁聚醣水膠的製備41
2-2-1 藻酸鈉溶液的製備41
2-2-2 藻酸鈉-幾丁聚醣溶液的製備41
2-2-3 藻酸鈉之固化液配製42
2-2-4 藻酸鈉-幾丁聚醣溶液塗佈於支持體(supporter)上42
2-2-5 氯化鈣溶液處理藻酸鈉-幾丁聚醣溶液支持體 43
§2-3 藻酸鈉-幾丁聚醣溶液及藻酸鈣-幾丁聚醣水膠物理性質評估48
2-3-1 藻酸鈉-幾丁聚醣溶液黏稠度(viscosity)測定48
2-3-2 藻酸鈉-幾丁聚醣溶液及藻酸鈣-幾丁聚醣水膠黏附性 (adhesion)測定48
§2-4 藻酸鈣-幾丁聚醣水膠之外觀檢查51
§2-5 藻酸鈣-幾丁聚醣水膠吸水(water uptake)程度測定52
§2-6 各成分於熱卡式分析儀(DSC)下的熱焓量變化54
第三章 結果與討論 55
§3-1 藻酸鈣-幾丁聚醣水膠之外觀檢查結果55
3-1-1不同比例之PG:水對水膠敷料外觀的影響55
3-1-2 藻酸鈉濃度對水膠敷料外觀的影響 56
3-1-3 幾丁聚醣加入對水膠敷料外觀的影響57
3-1-4 氯化鈣處理時間對水膠敷料外觀的影響58
§3-2 藻酸鈉溶液之三相圖(three phase diagram)60
§3-3 藻酸鈉-幾丁聚醣溶液黏稠度(viscosity)測定結果63
3-3-1 PG及水加入比例對黏稠度之影響63
3-3-2 藻酸鈉含量對黏稠度之影響67
3-3-3 加入幾丁聚醣黏稠度變化的影響69
3-3-4 黏稠度對於藻酸鈉-幾丁聚醣溶液塗佈愛支持體上之影響72
§3-4 以物性分析儀探討藻酸鈉-幾丁聚醣溶液及藻酸鈣-幾丁聚醣水膠黏附性試驗75
3-4-1 物性分析儀最佳參數之設定75
3-4-2 PG:水之比例對於黏附性測定的影響81
3-4-3 藻酸鈉濃度對於黏附性測定的影響 83
3-4-4 幾丁聚醣對於黏附性測定的影響85
§3-5 藻酸鈣水膠吸水測定92
§3-6 各成分於熱卡式分析儀(DSC)下的熱焓量變化93
第四章 結論95
第五章 參考文獻96
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