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研究生:曾正傑
研究生(外文):Chen-Jai Tseng
論文名稱:LED光照對Monascus rubber 31542液態發酵二次產物之影響
論文名稱(外文):Effect of LED Lightening on the Secondary Metabolites Production of Monascus rubber 31542 Liquid Fermentation
指導教授:鄭建瑋鄭建瑋引用關係
指導教授(外文):Chien-Wei Cheng
學位類別:碩士
校院名稱:銘傳大學
系所名稱:生物科技學系碩士班
學門:生命科學學門
學類:生物科技學類
論文種類:學術論文
論文出版年:2010
畢業學年度:98
語文別:中文
論文頁數:136
中文關鍵詞:發光二極體紅麴毒素莫那可寧k紅麴
外文關鍵詞:Light-Emitting Diodecitrininmonacolin kMonascus rubber
相關次數:
  • 被引用被引用:10
  • 點閱點閱:483
  • 評分評分:
  • 下載下載:101
  • 收藏至我的研究室書目清單書目收藏:3
本研究主要目的是利用發光二極體(Light Emitting Diode, LED)光照方法控制氣舉式發酵槽內的紅麴生長,以及提高二次代謝物monacolin k的含量,同時降低紅麴毒素citrinin之生成,並探討LED光照條件對液態培養之紅麴色素生成之影響。本研究利用搖瓶,以及氣舉式發酵培養,在35 ℃、28 ℃及20 ℃溫度下經過照度500Lux、1000Lux及1500Lux的藍、紅與綠光之LED光射培養,並以不照光作為控制組,結果發現以28 ℃,1000Lux紅光照射下的Monascus rubber,可產出最佳抗氧化活性的產物。同時在二次代謝產物部分,以35 ℃,500 Lux紅光組所培養的M. rubber,可產出較佳的monacolin k含量(5965.348 ppm),與較低的citrinin含量(0.27 ppm),此外在照度500 Lux下,利用紅光照射也可得到較深的紅色。
The purpose of this study was to investigate the effect of light emitting diode (LED) lightening on the growth of Monascus rubber in an air-lift liquid culture system. M. rubber stains were incubated in shaking flasks and in an air-lift bioreactor at 20, 28 and 35 ℃ under different illuminate conditions. The LED lights investigated were blue, red and green lights under different strengths of lightening, such as 500, 1000 and 1500Lux, etc., while a dark culture was used as a control. It was found that 1000Lux red light illuminated air-lift culture at 28℃ could improve the antioxidant activities of the M. rubber biomass. Red light luminances for 500 Lux on the culture at 35℃could result in the highest monacolin k (5965.35 ppm) and the lowest citrinin (0.27 ppm) contents among the studied conditions. At the same time, 500Lux red light illuminates could also result in a deeper color on M. rubber in an air-lift liquid system.
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摘要
Abstract
第一章 緒論
1.1 研究動機
1.2 研究目的
第二章 文獻回顧
第一節 紅麴之簡介
1.1 紅麴菌介紹
1.2 紅麴的製作
1.2 紅麴菌的代謝產物
1.2.1 紅麴色素(pigment)
1.2.2 莫那可林k(monacolin k)
1.2.3 紅麴毒素(citrinin)
1.2.4 γ-胺基丁酸(γ-amino butyric acid, GABA)
1.2.5 綜合紅麴有益成份
1.3 紅麴在醫療上的功用
1.4 紅麴產品的介紹
1.5 紅麴國內研究概況
1.6 近年紅麴國外研究與未來展望
1.6.1 紅麴二次代謝物分析萃取研究
1.6.2 降低紅麴毒素citrinin之研究
1.6.3 紅麴食品加工研究
1.6.4 紅麴抗氧化研究
1.6.5 紅麴功能性評估
第二節 Light-Emitting Diode(LED) 之簡介
2.1 LED
2.2 生物產業的應用
2.3 光照對微生物的影響與應用
第三節 照光對真菌生長之影響
3.1光照對Monascus在液態發酵中monacolin k及citrinin的影響
3.2 光照對Aspergillus在液態發酵中phytase的影響
3.3光照對Penicillium在液態發酵中mycophenolic acid的影響
3.4 光照對真菌色素產出之影響
3.5 脈衝光對真菌分生孢子之影響
3.6 光波長對真菌分生孢子之影響
第三章 材料與方法
第一節 實驗架構
1.1 實驗總體架構
1.2 菌體及菌液處理流程
1.3 抗氧化活性分析
1.4機能性成分分析
第二節 材料與方法
2.1材料
2.1.1 試驗菌株
2.1.2 培養基組成
2.1.2.1 固態培養基
2.1.2.2 液態培養基
2.1.3 試劑
2.1.4 儀器
2.1.5 醱酵槽相關設備
2.2 方法
2.2.1 種菌之培養
2.2.2 固態培養
2.2.2.1 培養基
2.2.2.2 固態培養之步驟及條件
2.2.3 搖瓶與醱酵槽之液態培養
2.2.3.1 M. rubber液態搖瓶培養試驗
2.2.3.1.1 搖瓶培養之步驟及條件
2.2.3.2 M. rubber液態種瓶培養
2.2.3.2.1 種瓶培養之步驟及條件
2.2.3.3 M. rubber LED 氣舉式醱酵槽液態培養試驗
2.2.3.3.1 氣舉式醱酵槽液態培養之步驟及條件
2.2.4 LED燈串聯系統示意圖
2.2.5 氣舉式發酵裝置
2.2.6 LED氣舉式發酵裝置
2.2.8 發酵液處理流程
2.2.8.1 取樣
2.2.8.2 菌體和菌液的分離
2.2.8.3 菌體乾重測定
2.2.9 還原力分析
2.2.10 清除1,1-Diphenyl-2picrylhydrazyl (DPPH)自由基能力
2.2.11 總多酚分析
2.2.12 Monacolin k之分析方法
2.2.12.1 菌體monacilin k之萃取
2.2.12.2 菌體monacolin k之HPLC分析方法
2.2.12.3 Monacolin k標準品檢量線的製作
2.2.13 Citrinin 之分析方法
2.2.13.1 菌體citrinin之萃取
2.2.13.2 菌體citrinin之HPLC分析方法
2.2.13.3 Citrinin標準品檢量線的製作
第四章 結果
第一節Monascus rubber搖瓶條件試驗
1.1 不同葡萄糖含量之生長影響
1.2 不同光照溫度照度之液態氣舉式發酵生物量之影響
第二節 不同溫度、光源及照度之抗氧化活性分析
2.1 氣舉式液態發酵之還原力含量影響
2.2 氣舉式液態發酵之總多酚含量影響
2.3 氣舉式液態發酵之DPPH含量影響
第三節 不同溫度、光源及照度之monacolin k及citrinin含量分析
3.1 氣舉式液態發酵之monacolin k含量影響
3.2 氣舉式液態發酵之citrinin含量影響
第四節 不同溫度、光源及照度對M. rubber色素生成變化之影響
4.1 氣舉式液態發酵之色素變化影響
第五節 抗氧化分析及HPLC分析
1.1 照度500 Lux、1000 Lux及1500 Lux下,不同溫度及光源對抗氧化活性之影響
1.2 照度500 Lux、1000 Lux及1500 Lux下,不同溫度及光源對monacolin k之影響
1.3 照度500 Lux、1000 Lux及1500 Lux下,不同溫度及光源對citrinin之影響
第五章 討論
第一節 葡萄糖含量對Monascus rubber生長及生物量產率之影響
1-1 葡萄糖含量與M. rubber生長之比較
1-2 M. rubbe在氣舉式發酵後之生物量
第二節 M. rubber之抗氧化活性生成影響
第三節 光照、溫度及照度對M. rubber之代謝物活性
3-1 Monacolin k之生成影響
3-2 Citrinin之生成影響
3-3 色素變化之影響
第四節 光照、溫度及照度對M. rubber之抗氧化成分影響
第五節 光照、溫度及照度對M. rubber之機能性成分影響
第六章 結論
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