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研究生:劉顓瑜
研究生(外文):Zhuan-yu Liu
論文名稱:醫療生化無塵室之模擬分析與量測驗證
論文名稱(外文):Numerical Simulation and Field Measurement Validation of cleanrooms for bio-medical application
指導教授:王輔仁王輔仁引用關係
指導教授(外文):Fu-jen Wang
學位類別:碩士
校院名稱:國立勤益科技大學
系所名稱:冷凍空調系
學門:工程學門
學類:其他工程學類
論文種類:學術論文
論文出版年:2010
畢業學年度:98
語文別:中文
論文頁數:126
中文關鍵詞:潔淨室手術室疫苗冷藏室現場測量數值模擬
外文關鍵詞:CleanroomOperating roomVaccine cold storage cleanroomField measurementNumerical simulation
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生醫用潔淨室為能源集中且高度複雜之空調系統型式,而且其通常為
全年24 小時運轉並須引進大量的新鮮空氣用以處理病菌感染問題及稀釋
空氣中的微生物,亦使室內空氣品質及能源消耗問題更顯複雜。然而,僅
極少數的節能系統以及室內環境品質研究資料及量測研究整合出來。因此,
本研究將藉由實地測量數據以評估生醫用潔淨室之空調系統節能可行性,
在變風量空調系統進行節能潛力的同時並考量對室內環境參數包括空氣中
微塵粒子數、微生物數量、正負壓、溫度和濕度之影響。吾人並在台灣某
一地區醫院之手術室進行全面性之手術室現場測量,並用數值模擬評估氣
流分佈及濃度分佈及濃度衰減狀態,以檢視手術室在閒置時降低風量節能
之可行性。此外,亦針對生物潔淨室之疫苗冷藏室做了現場測量和數值模
擬。結果發現電腦模擬改善及量測分析結果節能策略是可行的,在醫院手
術室方面,在閒置時的手術室減少送風量(或送風速度)在,並使用HEPA
過濾器及改變可變風量終端裝置之風門開度,可在影響室內環境狀態極小
之狀態下減少能源的消耗。而在疫苗冷藏室方面,使用不同的送風風量和
改變送風溫度之節能策略,透過暫態電腦模擬氣流分佈,在不影響疫苗儲
存溫度 0~4℃之規範下亦可獲致節能之可行性,更期本研究可提供生醫潔
淨室在感染控制、能源節約及環境舒適整體考量時之重要參考。
The HVAC systems for bio-cleanroom are energy-intensive and sophisticated in that they operate 24 hours per day year-round and use large amount of fresh air to deal with infectious problems and to dilute microorganisms. However, little quantitative information has been investigated about trade-off between energy-efficient HVAC system and indoor environment quality. The objective of this study is to present the field measurement approach on performance evaluation of the HVAC system for an cleanroom. Variable air volume terminal box was conducted to verify the compromise of energy-saving potential and indoor environment parameters including particle counts, microbial counts, pressurization, temperature and humidity. Field measurements of a full-scale operating room have been carried out at a district hospital in Taiwan. Numerical simulation has been applied to evaluate the air flow distribution and concentration contours while conducting the velocity reduction approach in the unoccupied operating room. Another field measurement and numerical simulation of a full-scale bio-cleanroom for vaccine cold storage cleanroom has been carried out as well. The results revealed that it is feasible to achieve satisfactory indoor environment by reducing the supply air volume (or velocity) in the unoccupied operating room. Optimal face velocity of HEPA filter and percentage of damper opening for the variable air volume terminal box could be obtained. Different velocity and temperature of supply air could be assessed not only by airflow distribute but also by transient simulation to achieve the design specification of 4℃ for vaccine storage. It will stimulate a more robust investigation of infection-controlled, energy-efficient and environment-comfortable HVAC system of cleanroom specific for unoccupied bio-medical application .
中文摘要 i
英文摘要 ii
誌謝 iii
目錄 iv
圖目錄 vi
表目錄 ix
符號說明 x
第1章 緒論 1
1.1 研究目的與動機 1
1.2 文獻回顧 2
第2章 生化潔淨室系統及環境參數 16
2.1 無塵潔淨室之相關法規 16
2.2 VAV系統概述 26
2.3 汙染濃度及熱舒適參數 31
第3章 潔淨室量測系統介紹 36
3.1 醫院潔淨室系統描述 36
3.2 疫苗潔淨室系統描述 46
3.3 實驗之量測儀器 51
第4章 CFD數值模擬分析 65
4.1 STAR-CD軟體 65
4.2 醫院潔淨室系統模擬 67
4.3 疫苗培養室系統模擬 73
第5章 結果與討論 79
5.1 醫院潔淨室 79
5.2 疫苗培養冷藏室 101
第6章 結論與建議 117
6.1 結論 117
6.2 建議 118
參考文獻 119


[1] U.S. Federal Standard 209 – Version E, Airborne Particulate Cleanliness Classes for Cleanrooms and Clean Zones, Washington, USA, 1992.
[2] International Standard ISO 14644, Cleanrooms and Associated Controlled Environments-Part 1:Classification of Air Cleanliness, International Organization for Standardization (ISO), New York, USA, 1999.
[3] IEST-RP-CC006.2, Testing Cleanrooms, Institute of Environmental Sciences and Technology, Illinois, USA, 1993.
[4] NEBB, Procedural Standards for Certified Testing of Cleanrooms, 2nd Edition, National Environmental Balancing Bureau, Maryland, USA, 1996.
[5] International Standard ISO 14698-1, Cleanrooms and associated controlled environments-Biocontamination control-Part 1: General principles and methods, International Organization for Standardization (ISO), New York, USA, 2003.
[6] ASHRAE Handbook - HVAC Applications, American Society of Heating Refrigerating and Air-Conditioning Engineers, Atlanta, Georgia, USA, 2007.
[7] Guidance for Industry, Sterile Drug Products Produced by Aseptic Processing — Current Good Manufacturing Practice (Pharmaceutical CGMPs), U.S. Department of Health and Human Services, Food and Drug Administration, 2004.
[8] EC GGMP, European Commission Guide to Good Manufacturing Practice Revision to annex 1: Manufacture of Sterile Medicinal Products, European Commission, Brussels, 2003.
[9] 現行藥品優良製造規範-空調系統卻效作業指導手冊,行政院衛生署,1992。
[10] Pharmaceutical Inspection Convention and Pharmaceutical Inspection Co-operation Scheme, GUIDE TO GOOD MANUFACTURING PRACTICE FOR MEDICINAL PRODUCTS ANNEXES, 2009
[11] 行政院國家科學委員會,基因重組實驗守則,2003。
[12] 李龍湖,疫苗發展技術與實驗,教務部顧問室「生物技術科技教育改進計畫」,2003
[13] World Health Organization (WHO),實驗室生物安全手冊,第三版,日內瓦, 2004。
[14] 行政院衛生署疾病管制局,生物安全第三等級實驗室安全規範,1.0版,2004
[15] Z. L. Xu and J. M. Shen, Clean operating room control, ASHRAE Transactions, Vol. 111, No. 2, pp. 646-651, 2005.
[16] R. Zhang, G. Tu and J. Ling, Study on biological contaminant control strategies under different ventilation mondels in hospital operating room, Building and Environment, Vol. 43, No.92, pp. 793-803, 2008.
[17] M. L. Pereira and A. Tribess, “A review of air distribution patterns in surgery rooms under infection control focus”, Thermal Engineering, Vol. 4, No. 2, pp. 113-121, 2005.
[18] J. M. Shen, Controlled clean operating room area, ASHRAE Transactions, Vol. 110, No. 2, pp. 776-780, 2004.
[19] T. T. Chow and X. Y. Yang, Ventilation performance in operating theatres against airborne infection: review of research activities and practical guidance, Journal of Hospital Infection, Vol. 56, No. 2, pp. 85-92, 2004.
[20] M. Agarwal, P. Hamilton-Stewart and R. A. Dixon, Contaminated operating room boots: The potential for infection, AJIC, Vol. 30, No.3, pp. 179-183, 2002.
[21] C. A. Balaras, E. Dascalaki, A. Gaglia, HVAC and indoor thermal conditions in hospital operating rooms, ENERGY and BUILDINGS, Vol. 39,No. 4, pp.454-470, 2007.
[22] 蔣安仁,開刀房利用最佳化之研究,國立中山大學醫務管理研究所,碩士論文,2002。
[23] A. Landrin, A. Bissery, G. Kac, Monitoring air sampling in operating theatres: can particle counting replace microbiological sampling?, Journal of Hospital Infection, Vol. 61, No.1, pp. 27-29, 2005.
[24] R. Perez and S. Yuan, Multiple-zone ventilation and temperature control of a single-duct VAV system using model predictive strategy, ENERGY and BUILDINGS, Vol. 38, pp. 1248-1261, 2006.
[25] G. Cook, D. Int-Hout, Air Motion Control in the Hospital Operating Room, ASHRAE Journal, pp. 30-36, 2009.
[26] 林榮培、梁奇鳳、陳玫雅、邱顯閔、蘇杰夫及許天來,2001-2005 年間試驗研究用SPF 雞蛋生產供應與疾病監測,家畜衛試所研報,第41期,pp. 183-192,2006。
[27] 張信、魏樹源、張波及付格,不同品系SPF雞胚細胞對S191朱麻疹病毒的適應性和敏感性比較,中國生物製品學雜誌,第13卷,第3期,pp. 173-175,2000。
[28] 江興華,雞新城疫(La Sota)活疫苗生產中不同時段死亡雞胚胚液效果的研究,福建畜牧獸醫,第28卷,第6期,pp. 34,2006。
[29] B. Lu, H. Zhou, W. Chan, G. Kemble and H. Jin., Single amino acid substitutions in the hemagglutinin of influenza A/Singapore/21/04 (H3N2) increase virus growth in embryonated chicken eggs, Vaccine, Vol. 24, No.44-46, pp. 6691-6693, 2006.
[30] O. Kursteiner , C. Moser, H. Lazar and P. Durrer, Inflexal® V—The influenza vaccine with the lowest ovalbumin content, Vaccine, Vol. 24, pp. 6632-6635, 2006
[31] 莊再成等人, 流感疫苗研究發展先期計畫-流感疫苗先導生產整合計畫,研究報告,財團法人國家衛生研究所 疫苗研發中心,2005年12月。
[32] 王蓉君、李明亮、莊再成, “新型流感疫苗之臨床實驗”,台兒醫誌,第47卷,pp. 18-22,2006。
[33] T. T. Chow, Z. Lin and W. Bai, The integrated effect of medical lamp position and diffuser discharge velocity on ultra-clean ventilation performance in an operating theatre, Indoor and Built Environment, Vol. 15, No. 4, pp. 315-331, 2006.
[34] D. N. Sorensen and P. V. Nielsen, Quality control of computational fluid dynamics in indoor environments, Indoor Air, Vol. 13, No. 1 , pp. 2-17, 2003.
[35] K. C. Noh, M. D. Oh and S. C. Lee, A numerical study on airflow and dynamic cross-contamination in the super cleanroom for photolithography process, Building and Environment, Vol. 40, No. 11, pp. 1431-1440, 2005.
[36] H. Brohus, K. D. Balling and D. Jeppesen, Influence of movements on contaminant transport in an operating room, Indoor Air, Vol. 16, pp. 356-372, 2006.
[37] T. T. Chow and X. Y. Yang, Ventilation performance in the operating theatre against airborne infection: numerical study on an ultra-clean system, Journal of Hospital Infection, Vol.59, pp. 138-147, 2005.
[38] ASHRAE Handbook - HVAC Fundamentals, American Society of Heating Refrigerating and Air-Conditioning Engineers, Atlanta, Georgia, USA, 2009.
[39] K. W. Cheong, Airflow measurements for balancing of air distribution system: tracer-gas technique as an alternative?, Building and Environment, Vol. 36, No. 8, pp. 955-964, 2001.
[40] 吳旭聖,單一空間運用追蹤氣體之換氣量測定法,冷凍空調&熱交換,第61期,pp. 81-84,2004。
[41] 吳旭聖,單一空間運用追蹤氣體之換氣量測定法,冷凍空調&熱交換,第62期,pp. 71-75,2004。
[42] http://zh.wikipedia.org/wiki/H1N1
[43] ISO 7730, Ergonomics of the thermal environment - Analytical determination and interpretation of thermal comfort using calculation of the PMV and PPD indices and local thermal comfort, International Standards Organization, 2003.
[44] ASHRAE Standard 55-1992, Thermal Environmental Conditions for Human Occupancy, ASHRAE , 1992.
[45] Fountain M.E., Using the ASHRAE Thermal Comfort Model, An ASHRAE Special Publication, 1997.
[46] http://www.epa.gov.tw/
[47] CD adapco Group, Methodology STAR-CD Version 4.06, Computational Dynamics Limited Corp, 2008.
[48] ASHRAE Handbook - HVAC Fundamentals, American Society of Heating Refrigerating and Air-Conditioning Engineers, Atlanta, Georgia, USA, 2009.
[49] 台灣費斯科技有限公司,淺談變風量空調系統與應用效益,系統應用部,pp. 1-20。
[50] http://www.flotrend.com.tw/

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