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研究生:陸雯馨
研究生(外文):Wen-HsinLu
論文名稱:以紅外光譜法探討離子對雙親分子∕雙十八碳鏈陽離子型界面活性劑∕膽固醇之混合Langmuir單分子層的分子排列特性
論文名稱(外文):A study on the molecular packing characteristic of mixed ion pair amphiphile/dioctadecyl chain cationic surfactant/cholesterol Langmuir monolayers by infrared spectroscopy
指導教授:張鑑祥教授
指導教授(外文):Chien-Hsiang Chang
學位類別:碩士
校院名稱:國立成功大學
系所名稱:化學工程學系碩博士班
學門:工程學門
學類:化學工程學類
論文種類:學術論文
論文出版年:2010
畢業學年度:98
語文別:中文
論文頁數:99
中文關鍵詞:氣∕液界面反射吸收式紅外光譜技術離子對雙親分子鬆弛行為混合單分子層單分子層
外文關鍵詞:air/water interfaceinfrared reflection-absorption spectroscopyion pair amphiphilerelaxation behaviormixed monolayermonolayer
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本研究利用反射吸收式紅外光譜技術(infrared reflection-absorption spectroscopy, IRRAS),探討氣∕液界面上的離子對雙親分子(ion pair amphiphile, IPA)單分子層在添加雙十八碳鏈陽離子型界面活性劑與膽固醇之情況下的分子排列特性。IPA是由十?烷基三甲基溴化銨(hexadecyltrimethylammonium bromide, HTMAB)和十二烷基?酸鈉(sodium dodecylsulfate, SDS)製備而成的hexadecyltrimethylammonium-dodecylsulfate(HTMA-DS),在氣∕液界面上的HTMA-DS單分子層經壓縮後可形成緊密的膜,但是單分子層鬆弛行為的分析顯示有自由分子損失的情形。隨著IPA∕雙十八碳鏈陽離子型界面活性劑混合單分子層中界面活性劑的比率增加,在壓縮過程中分子碳氫鏈的排列逐漸形成更緊密有秩序的狀態,在混合單分子層的鬆弛過程中,自由分子的損失則變得較不明顯,可能的原因是添加雙十八碳鏈陽離子型界面活性劑可以有效提升分子碳氫鏈間的疏水作用。當提高添加在IPA或IPA∕雙十八碳鏈陽離子型界面活性劑混合單分子層中的膽固醇莫耳分率時,雖然混合單分子層無法被壓縮至緊密規則的分子排列狀態,但在混合單分子層的鬆弛過程中,能減少自由分子的損失。推測是膽固醇提升了分子間的疏水作用而減少自由分子的損失,但膽固醇的環狀結構與單分子層中分子碳氫鏈間不佳的配位性,似乎阻礙了分子碳氫鏈緊密有序的排列。
This study investigated the molecular packing characteristic of ion pair amphiphile (IPA) monolayers with the addition of dioctadecyl chain cationic surfactant and cholesterol at the air/water interface by the infrared reflection-absorption spectroscopy (IRRAS). The IPA, hexadecyltrimethylammonium-dodecylsulfate (HTMA-DS), was prepared from hexadecyltrimethylammonium bromide (HTMAB) and sodium dodecylsulfate (SDS). The IPA monolayer at the air/water interface could form a condensed film after the compression stage. However, the analysis of monolayer relaxation behavior indicated the loss of free molecules. With the increase of the surfactant molar fraction in the mixed monolayers of IPA/dioctadecyl chain cationic surfactant, the molecular alkyl chains became much packed during the compression stage, and the loss of free molecules was less significant in the relaxation process. This is probably because the presence of dioctadecyl chain cationic surfactant could effectively enhance the hydrophobic interaction between the molecular alkyl chains. When the molar fraction of cholesterol added into the IPA or mixed IPA/dioctadecyl chain cationic surfactant monolayers was increased, the mixed monolayers could not be compressed to a state with well-packed molecules, but the loss of free molecules in the monolayer relaxation process was decreased. Cholesterol might enhance the hydrophobic interaction between molecules and thus decrease the loss of free molecules. However, the mismatch of the rigid cyclic structure of cholesterol and the molecular alkyl chains in the monolayers seemed to restrict the ordered arrangement of the alkyl chains.
總目錄

中文摘要.........I
Abstract........III
誌謝.............V
總目錄...........VI
表目錄...........IX
圖目錄...........XI
符號說明.........XVI

第一章 緒論...1
1.1 前言...1
1.2 研究動機與目的...1
1.3 文獻回顧...2
1.3.1 反射吸收式紅外光譜技術的應用...2
1.3.2 陰陽離子界面活性劑的單分子層行為...5
1.3.3 膽固醇的影響...6
第二章 實驗...11
2.1 藥品...11
2.2 儀器...11
2.3 實驗方法...15
2.3.1 藥品配製...15
2.3.2 衰減全反射式紅外光譜分析的操作...16
2.3.3 反射吸收式紅外光譜分析的操作...16
2.3.3.1 壓縮等溫線的量測...18
2.3.3.2 鬆弛等溫線的量測...20
第三章 結果與討論...25
3.1 HTMA-DS單分子層...25
3.1.1 衰減全反射式紅外光譜分析...25
3.1.2 反射吸收式紅外光譜分析...26
3.1.2.1 壓縮等溫線...26
3.1.2.2 鬆弛等溫線...28
3.2 雙十八碳鏈陽離子型界面活性劑單分子層...31
3.2.1 衰減全反射式紅外光譜分析...31
3.2.2 反射吸收式紅外光譜分析...31
3.2.2.1 壓縮等溫線...31
3.2.2.2 鬆弛等溫線...33
3.3 HTMA-DS∕雙十八碳鏈陽離子型界面活性劑混合單分子層...34
3.3.1 反射吸收式紅外光譜分析之壓縮等溫線...34
3.3.2 反射吸收式紅外光譜分析鬆弛等溫線...38
3.4 HTMA-DS∕雙十八碳鏈陽離子型界面活性劑∕膽固醇混合單分子層...42
3.4.1 膽固醇的紅外光譜分析...42
3.4.2 反射吸收式紅外光譜分析...42
3.4.2.1 壓縮等溫線...42
3.4.2.2 鬆弛等溫線...49
3.4.3 反射吸收式紅外光譜的半高寬分析...53
第四章 結論...89
參考文獻...91
自述...99
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