臺灣博碩士論文加值系統

MicroRNA (miRNA)為不會產生蛋白質的小片段(大約21~23 nt) RNA (small noncoding RNA)，細胞和病毒都會轉錄出miRNA，一般而言miRNA會和target mRNA結合，造成mRNA降解(degradation)或轉譯作用受到抑制(translational repression)。近年來有研究指出細胞性miRNA在病毒感染中扮演了重要的角色，例如：已發現有細胞性miRNA會抑制人類免疫缺陷病毒(human immunodeficiency virus)、以及水疱性口腔炎病毒(vesicular stomatitis virus)等的複製；然而，我們目前對於細胞性miRNA在黃質病毒感染時所扮演角色的瞭解是相當有限的，因此本論文探討miRNA是否具有調控登革病毒第二型(DEN-2)及日本腦炎病毒(JEV)感染的能力。

MicroRNAs (miRNAs) are small noncoding RNAs of approximately 21~23 nucleotides in length. They are derived from cellular or viral transcripts and bind to their target mRNAs in a sequence-specific manner, resulting in either mRNA degradation or translational repression. Recent studies suggest that cellular miRNAs are among the key determinants controlling virus infection in mammalian hosts, for example cellular miRNAs can serve as restriction factors to limit infection by several viruses, including human immunodeficiency virus and vesicular stomatitis virus. However, our understanding on the role played by cellular miRNA on flaviviruses is limited.

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2.Solomon, T., and Vaughn, D. W. (2002) Pathogenesis and clinical features of Japanese encephalitis and West Nile virus infections, Curr Top Microbiol Immunol 267, 171-194.