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研究生:何善竺
研究生(外文):Shan-Chu Ho
論文名稱:硫醇抗亞硝化作用之動力學研究
論文名稱(外文):Kinetic Study on the Anti-nitrosative Effect of Thiols
指導教授:胡德民胡德民引用關係
指導教授(外文):Teh-Min Hu
學位類別:碩士
校院名稱:國防醫學院
系所名稱:藥學研究所
學門:醫藥衛生學門
學類:藥學學類
論文種類:學術論文
論文出版年:2010
畢業學年度:98
語文別:中文
論文頁數:121
中文關鍵詞:動力學氧化氮壞血酸高濃度穀胱甘
外文關鍵詞:GSHnitrosation
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一氧化氮(nitric oxide,NO)於人體中扮演著多重的角色,在正常生理狀態下,低濃度的NO具細胞調節功能;然而在病理狀態下,高濃度的NO可能造成細胞損害。當發炎反應發生,體內產生大量的NO與超氧自由基(superoxide,O2•),兩者相互反應可產生peroxynitrite (ONOO),進而衍生出各種活性物質(reactive oxygen species, ROS; reactive nitrogen species, RNS),這些物質可能導致氧化(oxidation),硝化(nitration)或亞硝化(nitrosation)反應,造成細胞毒性等。近年來研究發現,亞硝化及氧化具有密切的相關性,且抗氧化物質(antioxidants)如抗壞血酸(ascorbic acid)及穀胱甘肽(glutathione,GSH)亦可影響亞硝化反應。
Nitric oxide (NO) plays both physiologic and pathophysiologic roles in the body. Under normal physiologic conditions, low levels of NO regulate many biological functions; however, under pathophysiologic conditions, high levels of NO can be deleterious. During inflammation, high levels of NO and superoxide (O2•) are generated and both radicals react with each other to form peroxynitrite (ONOO), from which various reactive oxygen species or reactive nitrogen species are derived. These species may cause cytotoxicity by modifying biomolecules via oxidation, nitration and/or nitrosation reactions. Recent studies have suggested that nitrosation and oxidation are closely related, and antioxidants, such as ascorbic acid and glutathione (GSH ), can affect nitrosation reaction.
正文目錄 II
圖目錄 VII
表目錄 X
附圖目錄 XI
中文摘要 XIII
英文摘要 XV
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