臺灣博碩士論文加值系統

中文摘要
目的：本研究旨在探討靈芝補充對老鼠於衰竭運動後體內抗疲勞及抗氧化能力之影響。方法：以40隻雄性老鼠為研究對象，隨機分成控制組、衰竭運動組、靈芝組和靈芝運動組，共四組，每組10隻。靈芝補充的組別每天以每公斤體重40 mg/kg劑量餵食老鼠，為期四週；運動組適應跑步機一週後隔天以漸增式衰竭運動跑至衰竭。採二因子變異數分析來考驗靈芝補充與衰竭運動對老鼠血液中血糖、乳酸、乳酸去氫酶、肌酸激酶、血尿素氮、肌酸酐、丙二醛、過氧化物歧化酶、榖胱甘肽過氧化酶活性之影響。結果：一、衰竭運動組的乳酸、乳酸去氫酶、肌酸激酶、血尿素氮與肌酸酐含量顯著高於控制組（p＜.05），血糖部分則顯著低於控制組（p＜.05）；且丙二醛活性顯著高於控制組，過氧化物歧化酶及榖胱甘肽過氧化酶活性則顯著低於控制組（p＜.05）。二、靈芝運動組的乳酸去氫酶、血尿素氮與肌酸酐含量皆顯著低於衰竭運動組（p＜.05），血糖值則顯著高於衰竭運動組（p＜.05）；而丙二醛活性顯著低於衰竭運動組（p＜.05），過氧化物歧化酶活性則顯著高於衰竭運動組（p＜.05），榖胱甘肽過氧化酶則無顯著差異（p＞.05）。結論：補充靈芝能有效維持血糖恆定，降低衰竭運動導致乳酸去氫酶、血尿素氮與肌酸酐含量升高，因此有助於減緩因運動導致之疲勞現象；同時，亦能有效防止衰竭運動導致過氧化物歧化酶活性降低及丙二醛濃度升高的情形，有助於增強老鼠體內抗氧化能力，減緩因衰竭運動導致之氧化傷害。

Abstract
Purpose: this study was to investigate the effects of supplementation of Ganoderma lucidum on fatigue and antioxidant activity after exhaustive exercise in rat. Methods: forty male Sprague-Dawley rats were randomly divided into four groups: control (C, n=10), exhaustive exercise (E, n=10), Ganoderma lucidum (G, n=10), Ganoderma lucidum-exhaustive exercise (GE, n=10). The amount of Ganoderma lucidum supplementation was 40 mg/kg body weight for four weeks. In the adaptive period, rats of E and GE were accustomed to treadmill running for a week. Exhaustive exercise was performed on a rodent treadmill with the progressive protocols. Two way ANOVA was performed to examine the effects of exhaustive exercise and Ganoderma lucidum supplementation on glucose, lactate, lactate dehydrogenase (LDH), creatine kinase (CK), blood urea nitrogen (BUN), creatinine (Cre), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities. Results: the level of lactate, LDH, CK, BUN, Cre and MDA in E group were significantly higher (p<.05) than C group, while glucose and the activities of SOD and GPx were significantly lower (p<.05) than C group. Furthermore, the activities of LDH, BUN, Cre and MDA in GE group were significantly lower (p < .05) than E group, while glucose and the activities of SOD were significantly higher (p < .05) than E group except for GPx. Conclusions: the findings of the present study showed that Ganoderma lucidum supplementation could effectively maintain glucose homeostasis and decrease lactate dehydrogenase, blood urea nitrogen and creatinine after exhaustive exercise and could beneficially reduce exercised-induced fatigue. Moreover, Ganoderma lucidum supplementation was beneficial to increase antioxidant status and reduce the elevation of oxidative stress.

目次
第壹章 緒論……………………………………………………………… 1
第一節 問題背景……………………………………………………… 1
第二節 研究目的……………………………………………………… 4
第三節 研究假設……………………………………………………… 4
第四節 研究範圍與限制……………………………………………… 5
第五節 名詞操作性定義……………………………………………… 5
第六節 研究的重要性………………………………………………… 6
第貳章 文獻探討…………………………………………………………... 8
第一節 運動與疲勞…………………………………………………… 8
第二節 運動與抗氧化能力……………………………………………13
第三節 靈芝的簡介…………………………………………………....30
第四節 靈芝的相關文獻………………………………………………37
第五節 本章小結………………………………………………………40
第參章 研究方法與步驟…………………………………………………...41
第一節 研究對象………………………………………………………41
第二節 材料與儀器……………………………………………………42
第三節 實驗設計………………………………………………………43
第四節 實驗流程………………………………………………………46
第五節 生化分析………………………………………………………47
第六節 資料處理………………………………………………………50
第肆章 結果………………………………………………………………...51
第一節 體重與運動時間………………………………………………52
第二節 靈芝補充對衰竭運動後抗疲勞能力之影響…………………53
第三節 靈芝補充對衰竭運動後氧化傷害及抗氧化能力之影響…….60
第伍章 討論………………………………………………………………....64
第一節 體重與運動時間……………………………………………….64
第二節 靈芝補充對衰竭運動後抗疲勞能力之影響………………….64
第三節 靈芝補充對衰竭運動後氧化傷害及抗氧化能力之影響…….69
第陸章 結論與建議………………………………………………………....73
參考文獻…………………………………………………………………….....74
中文部分………………………………………………………………......74
西文部分………………………………………………………………......77

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