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研究生:陳至嘉
論文名稱:利用銀奈米柱增強表面電漿共振生物感測器之靈敏度
論文名稱(外文):Enhanced sensitivity of surface plasmon resonance biosensor by using silver nanorod
指導教授:江海邦
指導教授(外文):Hai-Pang Chiang
學位類別:碩士
校院名稱:國立臺灣海洋大學
系所名稱:光電科學研究所
學門:工程學門
學類:電資工程學類
論文種類:學術論文
論文出版年:2010
畢業學年度:98
語文別:中文
論文頁數:72
中文關鍵詞:表面電漿銀奈米柱生物感測器
外文關鍵詞:surface plasmonsilver nanorodbiosensor
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本論文目的是在探討奈米柱增強表面電漿共振生物感應器之靈敏度。利用斜向蒸鍍( oblique angle deposition)的方式在平面銀膜上製作銀奈米柱(Ag nanorod),此製程方式簡單、快速且無需加熱。
實驗分成兩部分,第一部分為製作不同參數的樣品銀奈米柱/平面銀膜(Ag nanorod / Ag film)的結構,我們利用表面電漿共振的相位偵測系統去測量表面電漿共振生物感應器的靈敏度。再將這些樣品對不同折射率葡萄糖溶液做銀膜的表面電漿共振相位靈敏度量測,所得到的結果在與先前平面銀膜50nm的靈敏度做比較;發現在入射光1150nm雷射,平面銀膜50nm斜向長度12.5nm,其電漿共振相位靈敏度比起單層銀膜(Ag film)提升至10-8。由此可以得知斜向蒸鍍製作銀奈米柱陣列,可以有效的提升表面電漿生物感測器的靈敏度。
第二部分為製作光纖式表面電漿生物感測器,此感測器是將光纖側邊研磨至核心部分,然後再利用斜向蒸鍍度上平面銀膜50nm斜向長度10nm。利用此感測器感測葡萄糖濃度的變化,觀察表面電漿波長的位移,計算靈敏度,其值為4.06×10-6 RIUs。
In this thesis, we study the enhancement of the sensitivity of surface plasmon resonance (SPR) biosensor by using silver nanorods. Silver nanorods on silver films (Ag Nanorods / Ag film) are fabricated by using oblique angle deposition (OAD). There is two parts in our experiments.
In the first part, we measure the sensitivity of phase signal from SPR sensor with Ag nanorods / Ag film at different refractive index of glucose solution. The results are compared with the phase sensitivity of bare Ag film. The sensitivity of SPR sensor with Ag nanorods / Ag film is more sensitive than that of bare Ag film under specific condition of evaporation with laser wavelength of 1150nm. For Ag film 50nm in thickness and the length of nanorods 12.5nm in length, the sensitivity of SPR sensor down to 10-8 could be achieved.
In the second part, we fabricate surface plasmon resonance (SPR) fiber biosensor. The SPR fiber biosensor is side polished until the half core, then coated with Ag film 50nm in thickness and length of nanorods 10nm in length by oblique angle deposition (OAD). The SPR dips are shifted accompanied with the change of glucose concentration. The sensitivity of SPR fiber biosensor with nanorods is 4.06×10-6 refractive index units (RIUs).
中文摘要…………………………………………………………………I
英文摘要………………………………………………………………….II
目錄………………………………………………………………………III
圖目錄…………………………………………………………………….V
表目錄…………………………………………………………………...IX
第一章 簡介……………………………………………………………1
1-1 前言………………………………………………………………...1
1-2 研究動機…………………………………………………………...2
第二章 表面電漿理論…………………………………………………3
2-1 表面電漿共振簡介………………………………………………...3
2-2 表面電漿傳播函數………………………………………………...3
2-3 激發表面電漿的方法……………………………………………...9
2-4 表面電漿多層系統的反射率…………………………………….11
2-4-1 多層系統的反射係數…………………………………………..11
2-4-2 多層系統的相位……………………………………………….12
第三章 實驗架構……………………………………………………..14
3-1 外差干涉術……………………………………………………….14
3-2 使用電光晶體調制外差光源…………………………………….15
3-3 實驗架構………………………………………………………….16
3-3-1 外差干涉式表面電漿生物感測器…………………………….16
3-3-2 光纖表面電漿共振生物感測器……………………………….21
第四章 樣品製作……………………………………………………..24
第五章 實驗結果與討論……………………………………………..28
5-1 斜向蒸鍍製作銀奈米柱陣列…………………………………….28
5-2-1 AFM掃描結果以及SEM圖…………………………………...30
5-2-2 SPR量測結果…………………………………………………..40
5-2-2-1 以雷射632.8nm入射,SPR量測結果……………………….41
5-2-2-2 以雷射1150nm入射,SPR量測結果………………………....53
5-3 光纖表面電漿共振生物感測器…………………………………..62
第六章 結論…………………………………………………………....68
參考文獻…………………………………………………………………70
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