跳到主要內容

臺灣博碩士論文加值系統

(3.231.230.177) 您好!臺灣時間:2021/07/28 23:24
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果 :::

詳目顯示

: 
twitterline
研究生:廖純宜
研究生(外文):Chun-Yi Liao
論文名稱:溫度對心臟電生理影響的數值探討
論文名稱(外文):Numerical Simulation for Temperature Effect on Cardiac Electrophysiological
指導教授:田慧君
指導教授(外文):Hui-Chun Tien
學位類別:碩士
校院名稱:靜宜大學
系所名稱:應用數學研究所
學門:數學及統計學門
學類:數學學類
論文種類:學術論文
論文出版年:2010
畢業學年度:98
語文別:中文
論文頁數:51
中文關鍵詞:恢復曲線溫度係數 Q10
外文關鍵詞:restitution curvetemperature coefficient Q10
相關次數:
  • 被引用被引用:0
  • 點閱點閱:284
  • 評分評分:
  • 下載下載:10
  • 收藏至我的研究室書目清單書目收藏:0
當人體處於低溫的環境之下時,心臟中的某些離子機制 ( ionic mechanism ) 會受到影響,因而產生心律不整 ( arrhythmia ) 和心房顫動 ( atrial fibrillation ) 等等問題。
本研究利用 D.S.LindBlad etc. 發展的兔子心房細胞模型進行電生理數值實驗,藉由數值程式模擬,在程式中可依溫度修改離子通道的反應速率及電流強弱程度,以觀察其電流的變化,並討論其反應之心臟生理現象及生理機制。
At low temperature, the human cardiac ionic mechanism will be affected, and may produce arrhythmia and atrial fibrillation under certain condition.
In our study, we used the rabbit atrial cell model developed by D.S.LindBlad (1996) to proceed numerical simulation. The main advantage for numerical simulation is that we can modify the time constant and conductance of ion channels corresponding to temperature changes to investigate the resulting physiological phenomenon. The numerical results for single cell are discussed.
感謝詞 ................................. Ⅰ
中文摘要 ............................... Ⅱ
英文摘要 ............................... Ⅲ
目錄 .................................. Ⅳ
圖目錄 ................................. Ⅴ
表目錄 ................................. Ⅵ
第一章 研究動機 ......................... 1
第二章 心臟電生理模型介紹 ................ 6
2.1 Hodgking-Huxley model ............. 6
2.2 兔子心房細胞電生理模型 ............... 10
2.3 溫度係數 的定義及使用方法 ........... 18
第三章 動物實驗中心臟細胞對溫度變化的反應 ... 20
第四章 數值結果 .......................... 31
4.1 單一細胞的動作電位和離子電流 ........... 31
4.2 APD Restitution Curve .............. 36
4.2.1 S1- S2恢復曲線 .................... 36
4.2.2 Single cell S1- S2恢復曲線 ........ 37
第五章 結論 .............................. 39
參考文獻
附 錄
[1] Arrhenius equation,http://en.wikipedia.org/wiki/Arrhenius_equation .
[2] Bioengineering Notes,http://www.esc.auckland.ac.nz/Academic/Texts/bio-notes
.html September 29, (2003).
[3] CAVALIE1, A., MCDONALD, T. F., PELZER, D. & TRAUTWEIN, W. (1985). “ Temperature-induced transitory and steady-state changes in the calcium current of guinea pig ventricular myocytes. ”
[4] Fedorov W, Li L, Glukhov A, et al. (2005). “ Hibernator Citellus undulatus maintains safe cardiac conduction and is protected against tachyarrhythmias during extreme hypothermia: possible role of Cx43 and Cx45 up-regulation. ”
[5] H. ZHANG, A. V. HOLDEN, I. KODAMA, H. HONJO, M. LEI, T. VARGHESE, AND M. R. BOYETT (2001). “ Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node. ”
[6] J. C. Herve, K. Yamaoka, V. W. Twist, T. Powell, J. C. Ellory, and L. C. H. Wang (1992). “ Temperature dependence of electrophysiological properties of guinea pig and ground squirrel myocytes. ”
[7] Jose’ L. Puglisi, Weilong Yuan, Jose’ W.M. Bassani, Donald M. Bers (1999). “ Influx Through Channels in Rabbit Ventricular Myocytes During Action Potential Clamp Influence of Temperature. ”
[8] Jinglin Zeng & Yoram Rudy (1995). “ Early Afterdepolarizations In Cardiac Myocytes: Mechanism and Rate Dependence. ”
[9] K. H. W. J. ten Tusscher, D. Noble, P. J. Noble, and A. V. Panfilov (2003). “ A model for human ventricular tissue . ”
[10] KIRSCH, G. E. & SYKES, J. S. (1987). “ Temperature dependence of Na currents in rabbit and frog muscle membrane. ” Journal of General Physiology 89, 239-251.
[11] K.D. KNIFFKI, D. SIEMEN AND W. VOGEL (1980). “ Development Of Sodium Permeability Inactivation In Nodal Membranes. ”
[12] Lisa A. Irvine, M. Saleet Jafri, and Raimond L. Winslow (1999). “ Cardiac Sodium Channel Markov Model with Temperature Dependence and Recovery from Inactivation. ”
[13] Marcella Rocchetti, Alessandra Besana, Georgina B. Gurrola ,Lourival D. Possani and Antonio Zaza (2001). “ Rate dependency of delayed rectifier currents during the guinea-pig ventricular action potential. ”
[14] Nagatomo, Toshihisa, Zheng Fan, Bin Ye, Gayle S. Tonkovich, Craig T. January, John W. Kyle, and Jonathan C. Makielski (1998). “ Temperature dependence of early and late currents in human cardiac wild-type and long Q-T ΔKPQ channels. ”
[15] Trine Krogh-Madsen,Peter Schaffer,Anne D. Skriver,Louise Kold Taylor,Brigitte Pelzmann,Bernd Koidl, and Michael R. Guevara (2005). “ An ionic model for rhythmic activity in small clusters of embryonic chick ventricular cells. ”
[16] T. Kiyosue, M. Arita, H. Muramatsu, A. J. Spindler and D. Noble (1992). “ Ionic Mechanisms Of Action Potential Prolongation At Low Temperature In Guinea-Pig Ventricular Myocytes. ”
[17] Q10,http://en.wikipedia.org/wiki/Q10_(temperature_coefficient)
[18] 台中榮總 心臟血管中心 謝育整 鄭凱元 蔡炫育 吳茲睿 醫生(2007). “ The Effect of Hypothermia on Wave Front Characteristics and Defibrillation Threshold of Ventricular Fibrillation in Isolated Rabbit Hearts: An Optical Mapping Study . ”
[19] 陳進賢 (2008). “ 人類心臟電生理的數值模擬”私立靜宜大學應用數學系碩士論文 ”
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top