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研究生:吳信緯
研究生(外文):Hsin-Wei Wu
論文名稱:非等向性生醫物質的偏振影像特性探討及應用
論文名稱(外文):Polarimetric Signature Imaging of Anisotropic Bio-medical Tissues
指導教授:倪祖偉邱爾德
指導教授(外文):Tsu-Wei NeeArthur Chiou
學位類別:碩士
校院名稱:國立陽明大學
系所名稱:生醫光電工程研究所
學門:工程學門
學類:生醫工程學類
論文種類:學術論文
論文出版年:2010
畢業學年度:98
語文別:英文
論文頁數:106
中文關鍵詞:偏振
外文關鍵詞:polarizationmueller matrix
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我們發展的偏振影像所產生的Stokes vector ( I ,Q ,U ,V )可以提供獨立的四個訊號來表示在通過樣本之後光波的線偏振與圓偏振情形。經過我們的理論推導後,可以得到物質Mueller matrix的多個訊號特徵。利用這些訊號特徵,我們能夠套用已發展的理論模型來分析並解釋光在物質裡面產生的變化,這個Mueller matrix 影像系統可以提供獨立的光學參數來檢測生醫組織的結構改變,並且可望能夠應用在生醫領域以及臨床的腫瘤組織判別上。
Polarimetric imaging of Stokes vector (I, Q, U, V) can provide 4 independent signatures showing the linear and circular polarization properties of samples of interest including biological tissues and cells. Using a Stokes digital imaging system, we measured the Stokes vector images of tissue samples from sections of rat livers. The derived Mueller matrix elements can quantitatively provide five-signature spectral imaging data of the bio-samples. The imaging of four independent optical properties: anisotropy, scattering, depolarization and retardation phase of the test sample are derived and reported. Our experimental results are consistent with the general trend predicted by the theoretical model. This polarimetric multi-signature optical technology is a new option of bio-sensing technology to inspect the structures of tissue samples and is potentially useful for critical disease discrimination and medical diagnostics applications.
-致謝- i
-摘要- ii
-Abstract- iii
-目錄- iv
Chapter 1 Introduction 5
1.1 History and applications of polarized light 5
1.2 Motivation 7
Chapter 2 Basic theory 9
2.1 Theory of optical polarization 9
2.2 Polarization state representation 13
2.2.1 Jones vector and Jones matrix 13
2.2.2 Stokes vector & Mueller matrix 14
2.2.3 Ellipsometric parameters 16
2.3 Mueller matrix elements 17
Chapter 3 Experiments 20
3.1 Experimental materials 20
3.1.1 Liquid crystal 20
3.1.2 Intravenous fat emulsion 21
3.1.3 Histopathology 22
3.2 Experimental setup 23
3.3 Experimental Method 25
3.3.1 System validation and measurement test 25
3.3.2 Biopsy measurement 25
Chapter 4 Experimental results and discussion 27
4.1 Experimental validation 27
4.2 Bio-materials testing 32
Chapter 5 Conclusion and future work 40
Reference 42
Appendix A A-1
Appendix B B-1


[1] David S. Kliger, James W. Lewis, and Cora E. Randall, “Polarized Light in Optics and Spectroscopy,” Academic Press, New York, New York, 1990.

[2] R. M. A. Azzam and N.M. Bashara, “Ellipsometry and Polarized Light,” 2nd ed., North Holland, 1987.

[3] P. Drude, Wied. Ann. 43, 146, 1891.

[4] P. Drude, Ann. Phys.Chem.38,865, 1889.

[5] J. F. De Boer, T. E. Milner, M. J. van Gemert, J. S. Nelson, "Two-Dimensional Birefringence Imaging in Biological Tissue Using Polarization-Sensitive Optical Coherence Tomography," Proc. SPIE 3196, 32-37, 1998.

[6] Chivukula, Mamatha, “Pathologic Quiz Case: Crystal Deposition Disease of the Knee Joint,” Archives of Pathology & Laboratory Medicine. (http://findarticles.com/p/articles/mi_qa3725/is_200105/ai_n8949446/)

[7] Gang Yao and Lihong V. Wang, “Propagation of Polarized Light in Turbid Media,” Opt. Exp., Vol. 7, No. 5, Aug. 2000.

[8] A. H. Hielscher, A. A. Eick, J. R. Mourant, D. Shen, J. P. Freyer and I. J. Bigio, "Diffuse Backscattering Mueller Matrices of Highly Scattering Media," Opt. Exp., 1, 441-453 , 1997.

[9] S. Jiao and L. V. Wang, “Two-Dimensional Depth-Resolved Mueller Matrix of Biological Tissue Measured with Double-Beam Polarization-Sensitive Optical Coherence Tomography,” Optics Letters, 27, 101-103, 2002.

[10] J. S. Baba, J-R. Chung, A. H. DeLaughter, B. D. Cameron, G. L. Cote “Development and Calibration of an Automated Mueller Matrix Polarization Imaging System,” J. Biomed. Opt. 7, 341-349, 2002.

[11] T.-W. Nee, S.-M. F. Nee, S. H. Wu, D.-M. Yang, and A. Chiou, "Anisotropic and Highly Photon-Scattering Optical Property of Bio-Medium. I. Theory,” submitted to J. Opt. Soc. Am. A.(shown in Appendix I)

[12] S.-M. F. Nee, "Polarization Measurement," the Measurement, Instrumentation and Sensors Handbook, J. G. Webster, Ed (CRC Press and IEEE Press), 60.1 - 60.24, 1999.

[13] S.-M. F. Nee and T.-W. Nee, "Principal Mueller Matrix of Reflection and Scattering Measured for a One-Dimensional Rough Surface,” Opt. Eng. 41, 994 -1001, 2002.

[14] H. J. van Staveren, C. J. M. Moes, Jan van Marie, S. A Prahl, and M. J. C. van Gemert, “Light Scattering in Intralipid-10% in the Wavelength Range of 400-1100nm,” Appl. Opt., 30, 4507-4514, 1991.

[15] T.-W. Nee, S.-M. F. Nee, D.-M. Yang, and Y.-S. Huang, "Scattering Polarization by Anisotropic Biomolecules," J. Opt. Soc. Am. A 25, 1030-1038, 2008.

[16] T.-W. Nee, S.-M. F. Nee, D.-M. Yang and A. Chiou, "Optical Scattering Depolarization in a Bio-Medium with Anisotropic Bio-Molecules," J. Opt. Soc. Am. A, 26, 1101-1108, 2009.

[17] Lihong Wang, Steven L. Jacques, Liqiong Zheng, “MCML-Monte Carlo Modeling of Light Transport in Multi-Layered Tissues” Computer Methods and Programs in Biomedicine, 47, 131-146, 1995.

[18] R. Splinter, B. A. Hooper, “An Introduction to Biomedical Optics,” Chap. 5~7, Taylor & Francis, New York & London, 2007.

[19] Xinxin Guo, Michael F. G. Wood, and Alex Vitkin, “Monte Carlo Study of Pathlength Distribution of Polarized Light in Turbid Media” Opt. Exp., Vol. 15, No. 3,1348, 2007.

[20] C. C. Wu, Y. M. Wang, L. S. Lu, C. W. Sun, C. W. Lu, M. T. Tsai, C. C. Yang, “Optical Birefringence of the Hyperlipidemic Rat Liver with Polarization-Sensitive Optical Coherence Tomography,” J. Biomed. Opt. 12, 64022, 2007.

[21] C. Benecke, H. Seiverle and M. Schadt. “Determination of Director Distributions in Liquid Crystal Polymer-Films by Means of Generalized Anisotropic Ellipsometry,” Jpn. J. Appl. Phys, Vol.39, 2000.

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