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研究生:李彥甫
研究生(外文):Yen-Fu Lee
論文名稱:視網膜電圖路徑之模擬
論文名稱(外文):Simulation of Electroretinogram Propagation in Retina
指導教授:張寅張寅引用關係
指導教授(外文):Yin Chang
學位類別:碩士
校院名稱:國立陽明大學
系所名稱:生醫光電工程研究所
學門:工程學門
學類:生醫工程學類
論文種類:學術論文
論文出版年:2010
畢業學年度:98
語文別:中文
論文頁數:34
中文關鍵詞:視網膜電圖視網膜模擬
外文關鍵詞:ElectroretinogramRetinaSimulation
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視網膜電路圖是一種非常好用的非侵入性技術,他的特點是,當光線進入眼睛時,會在視網膜上刺激出電訊號,這個訊號會傳導至角膜而到達視網膜電圖的電極中。電訊號的傳導路徑在以前被認為是穿過玻璃體到達角膜的,但在2005年時,我們實驗室發現是沿著視網膜傳導出來,這讓我們更想由視網膜電路圖了解更多視網膜上的生理資訊。
當訊號經過視網膜中的損壞區時,由於損壞區無法傳遞電訊號,訊號必然繞過損壞區,而導致花費更多時間,若訊號激發點位於損壞區中,那電訊號甚至不會產生。
本模擬基於這些理念,利用幾何原理,重建視網膜電路圖可能的路徑,再加上多通道電極的技術,把視網膜中可能的損壞區利用電訊號經過損壞區須花更多時間傳導的方法模擬出來,並利用尺規作圖印證,確立了模擬的結果,未來也可利用此模擬或動物實驗做更多的研究。

The electroretiogram (ERG) is a very valuable noninvasive technique to us to study the outer retinal function in vivo. When the retina is stimulated by light, an electrophysiological signal can be recorded at cornea by an electrode. In the previous study in 2005, it was found by our laboratory that the ERG signal might not be directly delivered from retina to cornea through vitreous body, lens and aqueous humour but by way of the retinal layer. This drives us to figure out more biological information of retina by the study of ERG.
When signal propagates in retina, it can not pass through the lesions but needs to take more time to detour around these areas. If the lesion is stimulated by stimulus, the electrical signal can’t even be induced.
Based on the concept mentioned above, the lesion locations can possibly be identified according to the geometrical theory and the technique of multichannel signal recording that was counted on the signal propagation delay time received at the electrodes. The reconstruction of multi-lesion areas by using ruler and compasses which have been employed in this study shall have more evidences to prove the feasibility by simulation and even by animal study in the future.

摘要 Ⅰ
ABSTRACT Ⅱ
目錄 Ⅳ
圖目錄 Ⅵ
表目錄 Ⅶ
第一章 緒論 1
1-1研究動機 1
1-2研究目的 2
1-3視網膜電圖的文獻回顧 3
第二章 原理 6
2-1視網膜電圖產生之機制 6
2-2視網膜電圖的傳導路徑文獻 7
2-3多通道電極視網膜電圖技術 8
第三章 方法 9
3-1 基本架設 9
3-2 路徑長度判定 1
3-3 掃描法 16
第四章 實驗結果 18
4-1 路徑長度判定 18
4-2 掃描模擬 20
第五章 討論 24
5-1 路徑長度判定 24
5-2 掃描模擬 29
第六章 結論 32
參考文獻 33


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