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研究生:陳偉民
研究生(外文):Chen, Weimin
論文名稱:大腦中前額葉與類情節記憶中的時間要素
論文名稱(外文):Medial Prefrontal Cortex and the Temporal Element in Episodic-Like Memory
指導教授:李季湜李季湜引用關係
指導教授(外文):Jay-Shake Li
口試委員:蕭世朗謝淑蘭黃智偉
口試日期:2011.07.05
學位類別:碩士
校院名稱:國立中正大學
系所名稱:心理學研究所
學門:社會及行為科學學門
學類:心理學類
論文種類:學術論文
論文出版年:2011
畢業學年度:99
語文別:英文
論文頁數:47
中文關鍵詞:情節記憶中前額葉感覺前制約時間線索
外文關鍵詞:episodic memorymedial prefrontal cortexsensory preconditioningtime of day
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人類的情節記憶指的是個體有意識地回想過去在特定時空背景下親身經歷的事件,而在動物模式中,學者很難以行為實驗方式掌握意識這個概念,故我們定義類情節記憶為匯集事件,空間,時間三要素的整合性記憶。過去曾有研究指出,大腦中前額葉被電燒破壞的大鼠無法回憶起一段足部電擊事件的空間環境。然而,我們無法區辨這個記憶缺損是因為動物喪失了整合空間要素的能力,還是因為無法處理時間線索。故在本實驗中,我們進行了三個實驗,企圖更進一步探究大腦中前額葉和情節記憶的關係。在實驗一中,我們用連結論裡面的感覺前制約概念拆解了類情節記憶實驗,以運送方式取代時間線索,觀察中前額葉受損大鼠的記憶表現。我們發現實驗組大鼠依舊能夠成功地結合情境和運送方式這兩個刺激,成功地展現出感覺前制約能力。在實驗二中,我們改良了一個情緒古典制約實驗,在一天中不同的時間點重複呈現聲音線索三次,企圖觀察到手術操弄對動物時間點感受能力的影響。然而不論實驗組還是對照組的動物,都沒有成功地表現出對於一天中不同時間點的敏感度。在實驗三中,我們用時間和空間因素的簡單連結來解釋類情節記憶實驗,並修改了原本的實驗流程,以分別觀察時間和空間這兩個因子對於足部電擊事件記憶的個別影響。我們發現,時間因素在這個類情節記憶的典範中扮演了一個比較強的角色。綜合這三個實驗的結果,我們推測大腦中前額葉可能負責處理事件記憶的時間因素,並因此導致腦傷大鼠在先前的類情節記憶實驗中表現較差。
Episodic memory is defined as a mnemonic process of an organism to recall the experience in a unique spatial and temporal context. In animal model, researchers established in several studies episodic-like memory tests by combining three elements: “what”, “where”, and “when”. Previous findings revealed that lesion of medial prefrontal cortex (mPFC) impaired the episodic-like memory of rats for a fear conditioning experience. However, it was unknown whether the impairment destroyed the ability of binding multiple elements to form an integrated memory system, or the manipulation handicapped animals’ capability in processing the temporal element of the conditioning event. In the present study we carried out three experiments to clarify the relationships between mPFC and the temporal element in an episodic-like memory. In experiment 1, we used a salient stimulus, the transport cue, to replace the temporal element in the episodic-like memory test developed by O’Brien and Sutherland. The result suggested that lesions of mPFC did not impair the sensory preconditioning. In experiment 2 we tried to examine the role of mPFC in processing the time of day using the classical fear conditioning. Neither lesioned nor control animals showed a freezing pattern correlated with the time of day. Thus, the result of experiment 2 was not conclusive. In experiment 3 we modified the episodic-like memory produced by separating the contextual and the temporal elements. The result suggested that the temporal element may play a more important role than the contextual element in encoding the memory for the conditioning event. In conclusion, the present study suggested that the mPFC involved more in the integration of the temporal element of an episodic-like memory.
Abstract I
中文摘要 III
Contents V
List of Figures VI
Figure 1 14
Figure 2 16
Figure 3 18
Figure 4 23
Figure 5 25
Figure 6 26
Figure 7 27
Figure 8 32
Figure 9 34
List of Table VI
Table 1 7
1. Introduction 1
2. General Material and methods 6
2.1. Subject 6
2.2. Surgery 8
2.3. Apparatus and Testing Environment 9
2.4. Data Analysis 10
2.5. Histology 11
3. Experiment 1: Sensory Preconditioning 12
3.1. Procedure 12
3.2. Result 15
3.2.1. Histology 15
3.2.2. Data Result 17
3.3. Discussion 19
4. Experiment 2: Classical Fear Conditioning 21
4.1. Procedure 21
4.2. Result 24
4.3. Discussion 28
5. Experiment 3: Episodic-like Memory 30
5.1. Procedure 30
5.2. Result 33
5.3. Discussion 35
6. General Discussion 37
7. Reference List 41

Babb, S. J., & Crystal, J. D. (2006). Episodic-like memory in the rat. Current Biology, 16(13), 1317-1321.

Barker, G. R. I., Bird, F., Alexander, V., & Warburton, E. C. (2007). Recognition memory for objects, place, and temporal order: A disconnection analysis of the role of the medial prefrontal cortex and perirhinal cortex. Journal of Neuroscience, 27(11), 2948-2957.

Cain, S. W., Ko, C. H., Chalmers, J. A., & Ralph, M. R. (2004). Time of day modulation of conditioned place preference in rats depends on the strain of rat used. Neurobiology of Learning and Memory, 81(3), 217-220.

Chaudhury, D., & Colwell, C. S. (2002). Circadian modulation of learning and memory in fear-conditioned mice. Behavioural Brain Research, 133(1), 95-108.

Chiba, A. A., Kesner, R. P., & Gibson, C. J. (1997). Memory for temporal order of new and familiar spatial location Sequences: Role of the medial prefrontal cortex. Learning & Memory, 4(4), 311-317.

Clayton, N. S., & Dickinson, A. (1998). Episodic-like memory during cache recovery by scrub jays. Nature, 395(6699), 272-274.

DeVito, L. M., & Eichenbaum, H. (2010). Distinct contributions of the hippocampus and medial prefrontal cortex to the "what-where-when" components of episodic-like memory in mice. Behavioural Brain Research, 215(2), 318-325.

Fanselow, M. S. (1990). Factors governing one-trial contextual conditioning. Animal Learning & Behavior, 18(3), 264-270.

Gewirtz, J. C., & Davis, M. (1998). Application of Pavlovian higher-order conditioning to the analysis of the neural substrates of fear conditioning. Neuropharmacology, 37(4-5), 453-459.

Gewirtz, J. C., & Davis, M. (2000). Using Pavlovian higher-order conditioning paradigms to investigate the neural substrates of emotional learning and memory. Learning & Memory, 7(5), 257-266.

Gilbert, P. E., & Brushfield, A. M. (2009). The role of the CA3 hippocampal subregion in spatial memory: A process oriented behavioral assessment. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 33(5), 774-781.

Gold, A. E., & Kesner, R. P. (2005). The role of the CA3 subregion of the dorsal hippocampus in spatial pattern completion in the rat. Hippocampus, 15(6), 808-814.

Hannesson, D. K., Howland, J. G., & Phillips, A. G. (2004). Interaction between perirhinal and medial prefrontal cortex is required for temporal order but not recognition memory for objects in rats. Journal of Neuroscience, 24(19), 4596-4604.

Hannesson, D. K., Vacca, G., Howland, J. G., & Phillips, A. G. (2004). Medial prefrontal cortex is involved in spatial temporal order memory but not spatial recognition memory in tests relying on spontaneous exploration in rats. Behavioural Brain Research, 153(1), 273-285.

Jo, Y. S., Park, E. H., Kim, I. H., Park, S. K., Kim, H., Kim, H. T., et al. (2007). The medial prefrontal cortex is involved in spatial memory retrieval under partial-cue conditions. Journal of Neuroscience, 27(49), 13567-13578.

Kart-Teke, E., Dere, E., Brandao, M. L., Huston, J. P., & Silva, M. A. D. (2007). Reinstatement of episodic-like memory in rats by neurokinin-1 receptor antagonism. Neurobiology of Learning and Memory, 87(3), 324-331.

Kart-Teke, E., Silva, M., Huston, J. P., & Dere, E. (2006). Wistar rats show episodic-like memory for unique experiences. Neurobiology of Learning and Memory, 85(2), 173-182.

Kesner, R. P. (1998). Neural mediation of memory for time: Role of the hippocampus and medial prefrontal cortex. Psychonomic Bulletin & Review, 5(4), 585-596.

Kesner, R. P., Hunsaker, M. R., & Gilbert, P. E. (2005). The role of CA1 in the acquisition of an object-trace-odor paired associate task. Behavioral Neuroscience, 119(3), 781-786.

Kolb, B., Buhrmann, K., McDonald, R., & Sutherland, R. J. (1994). Dissociation of the medial prefrontal, posterior parietal, and posterior temporal cortex for spatial navigation and recogntiion memory in the rat. Cerebral Cortex, 4(6), 664-680.

Lee, I., Jerman, T. S., & Kesner, R. P. (2005). Disruption of delayed memory for a sequence of spatial locations following CA1- or CA3-lesions of the dorsal hippocampus. Neurobiology of Learning and Memory, 84(2), 138-147.

Lee, I., Rao, G., & Knierim, J. J. (2004). A double dissociation between hippocampal subfields: Differential time course of CA3 and CA1 place cells for processing changed environments. Neuron, 42(5), 803-815.

Li, J. S., & Chao, Y. S. (2008). Electrolytic lesions of dorsal CA3 impair episodic-like memory in rats. Neurobiology of Learning and Memory, 89(2), 192-198.

Maes, J. H. R., Davila, A., & Vossen, J. M. H. (1998). Some empirical data concerning time of day effects on conditioned freezing in an aversive context-conditioning procedure. Behavioural Processes, 42(1), 73-83.

Matus-Amat, P., Higgins, E. A., Barrientos, R. M., & Rudy, J. W. (2004). The role of the dorsal hippocampus in the acquisition and retrieval of context memory representations. Journal of Neuroscience, 24(10), 2431-2439.

McDonald, R. J., Hong, N. S., Ray, C., & Ralph, M. R. (2002). No time of day modulation or time stamp on multiple memory tasks in rats. Learning and Motivation, 33(2), 230-252.

Morgan, M. A., Romanski, L. M., & LeDoux, J. E. (1993). Extinction of emotional learning: contribution of medial prefrontal cortex. Neurosci Lett, 163(1), 109-113.

O'Brien, J., & Sutherland, R. J. (2007). Evidence for episodic memory in a Pavlovian conditioning procedure in rats. Hippocampus, 17(12), 1149-1152.
Rolls, E. T., & Kesner, R. P. (2006). A computational theory of hippocampal function, and empirical tests of the theory. Progress in Neurobiology, 79(1), 1-48.

Rudy, J. W., Huff, N. C., & Matus-Amat, P. (2004). Understanding contextual fear conditioning: insights from a two-process model. Neuroscience and Biobehavioral Reviews, 28(7), 675-685.

Rudy, J. W., & O'Reilly, R. C. (1999). Contextual fear conditioning, conjunctive representations, pattern completion, and the hippocampus. Behavioral Neuroscience, 113(5), 867-880.

Teyler, T. J., & Rudy, J. W. (2007). The hippocampal indexing theory and episodic memory: Updating the index. Hippocampus, 17(12), 1158-1169.

Thorpe, C. M., Bates, M. E., & Wilkie, D. M. (2003). Rats have trouble associating all three parts of the time-place-event memory code. Behavioural Processes, 63(2), 95-110.

Tulving, E. (1984). Precis of Tulving elements of episodic memory (OXFORD-UNIVERSITY-PRESS, 1983). Behavioral and Brain Sciences, 7(2), 223-238.

Tulving, E. (2001). Episodic memory and common sense: how far apart? Philosophical Transactions of the Royal Society of London Series B-Biological Sciences, 356(1413), 1505-1515.

Tulving, E. (2002). Episodic memory: From mind to brain. Annual Review of Psychology, 53, 1-25.

Van der Zee, E. A., Havekes, R., Barf, R. P., Hut, R. A., Nijholt, I. M., Jacobs, E. H., et al. (2008). Circadian time-place learning in mice depends on Cry genes. Current Biology, 18(11), 844-848.

Wang, G. W., & Cai, J. X. (2008). Reversible disconnection of the hippocampal-prelimbic cortical circuit impairs spatial learning but not passive avoidance learning in rats. Neurobiology of Learning and Memory, 90(2), 365-373.

蕭坤元. (2010). 內側前額葉皮質損傷造成大鼠的似情節記憶缺損. 國立中正大學, 嘉義縣.

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