本論文提出一個應用於深層腦部刺激術(Deep Brain Stimulation)來治療巴金森氏症的電流刺激器。此刺激器使用低功率切換式電容數位-類比轉換器，應用於電壓控制電流轉導放大器的輸入以調整輸出電流。所提出的失真抵消技術可以改善電流刺激器的線性度。定電流雙相輸出使用橋式開關切換的設計，來調控輸出電流脈波。數位電路產生可程式化的脈波來調控輸出電流之波寬長度與頻率的大小。在負載為10KΩ下，刺激電流振幅為0~165uA，波寬為16~128us，頻率為126~244Hz。電刺激器中的電壓控制電流轉導放大器部份，採用TSMC 0.35-um CMOS的積體電路製程製作，工作電壓為3.3V。

In this thesis, the front end of the stimulator applied in the implantable deep brain stimulation (DBS) for the therapy of Parkinson’s disease is developed. This stimulator adopts the low power switched-capacitor DAC accompanying with voltage-to-current transconductance amplifiers to obtain the adjustable output currents. The proposed distortion cancellation technique improves the linearity of the current stimulator. The biphasic stimulation waveform is generated from the bridge switching technique and the programmable pulse. The digital circuit generates the programmable pulse signals with width and frequency adjustments. This stimulation circuit provides the 0~165uA current for a typical loading of 10 KΩ, 16~128us pulse width, and 126~244 Hz frequencies. The key component, voltage to current transconductance amplifier, of this stimulator is fabricated with a TSMC 0.35-um CMOS technology at 3.3V supply voltage.

第一章 緒論 1
1.1研究動機 1
1.2研究目的 1
1.3文獻回顧 2
1.4論文介紹 3
第二章 類比電路設計與模擬 4
2.1線性化全電晶體轉導放大器 5
2.1.1基本電壓-電流轉導放大器 5
2.1.2 PMOS源極隨耦器之改善線性電路 10
2.2雙相輸出電流設計 15
2.3摺疊疊接運算放大器(Folded-Cascode Operational Amplifier) 17
2.4切換電容式數位類比轉換器 23
2.4.1 Flip-Around切換電容式數位類比轉換器 27
2.4.2電容式切換運算放大數位類比轉換器 28
2.4.3非重疊(Non-overlapped)時脈產生電路 36
2.5類比解多工器(Analog Demultiplexer) 38
2.5.1取樣且保持電路(Sample-and-Hold) 39
2.5.2取樣開關精確度之考慮 40
2.5.3取樣開關誤差之改善 41
2.5.4環型計數器(Ring Counter) 43
2.6類比電路系統架構 47
2.6.1輸入端電路設計 47
2.6.2分時多工電路設計 48
第三章 數位電路設計與模擬 53
3.1調頻數位電路 54
3.2調波寬數位電路 54
3.3產生負脈波NEG數位電路 56
3.4數位訊號輸入介面電路設計 58
第四章 電路佈局與量測結果 61
4.1電路整體佈局 62
4.2電路佈局後模擬(Post-Simulation) 64
4.3晶片量測考量 69
4.4晶片量測結果 70
第五章 結論與未來展望 73
5.1結論 73
5.2未來展望 74
參考文獻 75
附錄一 已發表論文 78

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