臺灣博碩士論文加值系統

Table of Contents
中文摘要 I
Abstract IV
誌謝 VI
List of Table XI
List of Figures XII
Glossary XIII
Chapter 1: Introduction 1
Chapter 2. Literature Review 2
A. Prevalence of atopic disease in Taiwan 2
B. Immune response of atopic diseases 2
C. Umbilical cord blood Immunoglobin E (cbIgE) and atopic diseases 3
D. Candidate genes and atopic diseases 4
D-1. Interleukin (IL)-4 4
D-2. High-affinity IgE receptor beta (FcRI-) 5
D-3. Tumor necrosis factors (TNFs) 6
E. Psychosocial stress and atopic diseases 6
F. Environmental factors for atopic diseases 7
F-1. Outdoor air pollution 7
F-2. Indoor environmental factors 8
F-3. Tobacco smoking 9
G. Objectives 10
Chapter 3: Materials and Methods 12
A. Recruitment of research subjects 12
A-1: Birth cohort in our laboratory (BCL) 12
A-2: Taiwan national birth cohort (TBCS) 13
B. Questionnaire 13
B-1: Prenatal - BCL 13
B-2: Follow-up 14
B-2-1: Phone interview - BCL 14
B-2-2: Home interview - TBCS 15
C. Blood sampling and storing 15
D. IgE measurement 15
E. DNA extraction 16
F. Genotype assay 16
G. Statistic analysis 17
G-1: General analysis 17
G-2: Principle component analysis 17
G-3: Predictive model establishment 18
G-4: Receiver-operator characteristic (ROC) curves 18
Chapter 4: Results 19
A. Subject recruitment 19
A-1: BCL 19
A-2: TBCS 19
B. Effects of potential risk factors for cord blood IgE (cbIgE) levels: Association between Cord Blood IgE and Genetic Polymorphisms of Interleukin-4, the  Subunit of the High-affinity Receptor for IgE, Lymphotoxin-α, and Tumor Necrosis Factor-α 19
C. Effects of potential risk factors for children’s atopic dermatitis 21
C-1: Predicting risk for early infantile atopic dermatitis by hereditary and environmental factors 21
C-2: Prediction of atopic dermatitis in 2-year-old children by cord blood IgE, genetic polymorphisms in cytokine genes, and maternal mentality during pregnancy 24
Chapter 5: Discussion 28
A. summary 28
B. Risk factors of IgE 28
C. Risk factors of AD 31
C-1. Parental atopy 31
C-2. Environmental factors 31
C-3. Cord blood IgE 33
C-3. Psychological stress 34
C-4. Genetic polymorphism of candidate genes 35
D. Limitation 36
Chapter 6: Conclusion 39
Chapter 7: Further Study 40
Chapter 8: References 41
Chapter 9: Publication List 56
A. SCI Articles 56
B. Conference 57
B-1 International 57
B-2 National 57
Appendix I: Prenatal questionnaire of BCL 83
Appendix II: Published SCI articles 94